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ONTOLOGY REPORT - ANNOTATIONS


Term:proteasome-mediated ubiquitin-dependent protein catabolic process
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Accession:GO:0043161 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
Synonyms:exact_synonym: proteasomal pathway;   proteasomal ubiquitin-dependent protein breakdown;   proteasomal ubiquitin-dependent protein catabolic process;   proteasomal ubiquitin-dependent protein catabolism;   proteasomal ubiquitin-dependent protein degradation
 related_synonym: proteasomal processing;   proteasome pathway


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Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 130409
    metabolic process 79575
      primary metabolic process 70592
        protein metabolic process 39987
          protein catabolic process 6723
            proteasomal protein catabolic process 3336
              proteasome-mediated ubiquitin-dependent protein catabolic process 2810
                SCF-dependent proteasomal ubiquitin-dependent protein catabolic process + 356
                anaphase-promoting complex-dependent catabolic process + 171
                cytoplasm protein quality control by the ubiquitin-proteasome system 7
                mitochondria-associated ubiquitin-dependent protein catabolic process 5
                negative regulation of proteasomal ubiquitin-dependent protein catabolic process + 274
                nuclear protein quality control by the ubiquitin-proteasome system + 21
                positive regulation of proteasomal ubiquitin-dependent protein catabolic process + 659
                regulation of proteasomal ubiquitin-dependent protein catabolic process + 997
                ribosome-associated ubiquitin-dependent protein catabolic process 11
                stress-induced homeostatically regulated protein degradation pathway 0
                transcription factor catabolic process + 41
                ubiquitin-dependent ERAD pathway + 552
                ubiquitin-dependent protein catabolic process via the N-end rule pathway 15
Path 2
Term Annotations click to browse term
  biological_process 130409
    metabolic process 79575
      nitrogen compound metabolic process 66999
        organonitrogen compound metabolic process 46119
          organonitrogen compound catabolic process 8871
            protein catabolic process 6723
              cellular protein catabolic process 5475
                proteolysis involved in cellular protein catabolic process 5052
                  modification-dependent protein catabolic process 4295
                    ubiquitin-dependent protein catabolic process 4223
                      proteasome-mediated ubiquitin-dependent protein catabolic process 2810
                        SCF-dependent proteasomal ubiquitin-dependent protein catabolic process + 356
                        anaphase-promoting complex-dependent catabolic process + 171
                        cytoplasm protein quality control by the ubiquitin-proteasome system 7
                        mitochondria-associated ubiquitin-dependent protein catabolic process 5
                        negative regulation of proteasomal ubiquitin-dependent protein catabolic process + 274
                        nuclear protein quality control by the ubiquitin-proteasome system + 21
                        positive regulation of proteasomal ubiquitin-dependent protein catabolic process + 659
                        regulation of proteasomal ubiquitin-dependent protein catabolic process + 997
                        ribosome-associated ubiquitin-dependent protein catabolic process 11
                        stress-induced homeostatically regulated protein degradation pathway 0
                        transcription factor catabolic process + 41
                        ubiquitin-dependent ERAD pathway + 552
                        ubiquitin-dependent protein catabolic process via the N-end rule pathway 15
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.