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ONTOLOGY REPORT - ANNOTATIONS


Term:myelin maintenance
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Accession:GO:0043217 term browser browse the term
Definition:The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath.


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myelin maintenance term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd1 ATP binding cassette subfamily D member 1 ISO (MGI:2176408|PMID:11875044), (MGI:3513562|PMID:15489218) RGD PMID:11875044, PMID:15489218 MGI:2176408, MGI:3513562 NCBI chr  X:157,073,860...157,095,652
Ensembl chr  X:157,072,736...157,095,274
JBrowse link
G Abcd2 ATP binding cassette subfamily D member 2 ISS
ISO
GO_REF:0000024
(MGI:3513562|PMID:15489218)
UniProt
RGD
PMID:15489218 GO_REF:0000024, MGI:3513562 NCBI chr 7:132,294,564...132,343,169
Ensembl chr 7:132,294,562...132,343,169
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 ISO (MGI:4458974|PMID:20534485) RGD PMID:20534485 MGI:4458974 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Degs1 delta(4)-desaturase, sphingolipid 1 ISO
ISS
(PMID:30620337), (PMID:30620338)
GO_REF:0000024
RGD
UniProt
PMID:30620337, PMID:30620338 GO_REF:0000024 NCBI chr13:100,665,265...100,672,731
Ensembl chr13:100,666,075...100,672,731
JBrowse link
G Epb41l3 erythrocyte membrane protein band 4.1-like 3 ISO (MGI:5296417|PMID:21966409) RGD PMID:21966409 MGI:5296417 NCBI chr 9:117,314,935...117,666,408
Ensembl chr 9:117,538,009...117,666,410
JBrowse link
central nervous system myelin maintenance term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clu clusterin ISO
ISS
IEA
(PMID:21543606)
GO_REF:0000024
GO_REF:0000107
RGD
Alzheimers_University_of_Toronto
Ensembl
PMID:21543606 GO_REF:0000024, GO_REF:0000107 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Fa2h fatty acid 2-hydroxylase ISO MGI:3829000|MGI:4430585 (MGI:3826747|PMID:18815260), (MGI:4950761|PMID:21491498) RGD PMID:18815260, PMID:21491498 MGI:3826747, MGI:4950761 NCBI chr19:43,545,380...43,596,788
Ensembl chr19:43,545,378...43,596,801
JBrowse link
G Myrf myelin regulatory factor IBA
ISO
PMID:21873635
(MGI:5437779|PMID:22956843)
RGD PMID:22956843, PMID:21873635 MGI:5437779, RGD:13792537 NCBI chr 1:226,260,558...226,292,650
Ensembl chr 1:226,260,558...226,292,480
JBrowse link
G Pten phosphatase and tensin homolog ISO (MGI:3772418|PMID:18082964) RGD PMID:18082964 MGI:3772418 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
peripheral nervous system myelin maintenance term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO (MGI:4454957|PMID:20448149) RGD PMID:20448149 MGI:4454957 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 IEA
ISO
GO_REF:0000107
(MGI:4454957|PMID:20448149)
Ensembl
RGD
PMID:20448149 GO_REF:0000107, MGI:4454957 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Fa2h fatty acid 2-hydroxylase ISO MGI:3829000 (MGI:3826747|PMID:18815260) RGD PMID:18815260 MGI:3826747 NCBI chr19:43,545,380...43,596,788
Ensembl chr19:43,545,378...43,596,801
JBrowse link
G Mpp5 membrane palmitoylated protein 5 ISO (MGI:4441217|PMID:20237282) RGD PMID:20237282 MGI:4441217 NCBI chr 6:101,923,675...102,029,705
Ensembl chr 6:101,923,785...102,028,592
JBrowse link
G Ndrg1 N-myc downstream regulated 1 IEA
ISO
GO_REF:0000002
(MGI:3041895|PMID:15082788)
InterPro
RGD
PMID:15082788 GO_REF:0000002, MGI:3041895 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Prx periaxin IBA
ISO
PMID:21873635
(MGI:1859096|PMID:10839370)
RGD PMID:10839370, PMID:21873635 MGI:1859096, RGD:13792537 NCBI chr 1:84,302,074...84,324,560
Ensembl chr 1:84,304,228...84,324,560
JBrowse link
G Sh3tc2 SH3 domain and tetratricopeptide repeats 2 ISO MGI:4367025 (MGI:4366127|PMID:19805030) RGD PMID:19805030 MGI:4366127 NCBI chr18:57,286,266...57,403,926
Ensembl chr18:57,286,322...57,347,577
JBrowse link
G Sod1 superoxide dismutase 1 ISS
ISO
GO_REF:0000024
MGI:1857872 (MGI:1344528|PMID:10433959)
UniProt
RGD
PMID:10433959 GO_REF:0000024, MGI:1344528 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    cellular process 18792
      ensheathment of neurons 177
        axon ensheathment 177
          myelination 175
            myelin maintenance 16
              central nervous system myelin maintenance 4
              peripheral nervous system myelin maintenance 8
Path 2
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      anatomical structure development 6268
        multicellular organism development 5743
          system development 5279
            nervous system development 2719
              ensheathment of neurons 177
                axon ensheathment 177
                  myelination 175
                    myelin maintenance 16
                      central nervous system myelin maintenance 4
                      peripheral nervous system myelin maintenance 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.