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ONTOLOGY REPORT - ANNOTATIONS


Term:mast cell degranulation
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Accession:GO:0043303 term browser browse the term
Definition:The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell.
Synonyms:exact_synonym: mast cell granule exocytosis


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mast cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cbl Cbl proto-oncogene JBrowse link 8 48,481,256 48,564,775 RGD:11576314
G Chga chromogranin A JBrowse link 6 126,434,226 126,445,569 RGD:1600115
RGD:1624291
G Cplx2 complexin 2 JBrowse link 17 10,756,871 10,828,811 RGD:1600115
G Kit KIT proto-oncogene receptor tyrosine kinase JBrowse link 14 35,072,131 35,149,638 RGD:1624291
RGD:1600115
G Lat linker for activation of T cells JBrowse link 1 197,765,644 197,770,669 RGD:1600115
G Lat2 linker for activation of T cells family, member 2 JBrowse link 12 25,114,099 25,128,381 RGD:1600115
G Milr1 mast cell immunoglobulin-like receptor 1 JBrowse link 10 94,944,243 94,961,795 RGD:1624291
RGD:1600115
G Mrgprx2 MAS related GPR family member X2 JBrowse link 1 103,743,746 103,760,945 RGD:1624291
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 JBrowse link 5 63,781,801 63,822,890 RGD:1624291
RGD:1600115
G Pla2g3 phospholipase A2, group III JBrowse link 14 83,724,828 83,730,614 RGD:1624291
RGD:1600115
G Rasgrp1 RAS guanyl releasing protein 1 JBrowse link 3 108,984,029 109,044,420 RGD:1624291
RGD:1600115
G Tac4 tachykinin precursor 4 JBrowse link 10 83,081,168 83,089,487 RGD:1600115
histamine secretion by mast cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adora3 adenosine A3 receptor JBrowse link 2 208,336,909 208,379,217 RGD:1624291
G Btk Bruton tyrosine kinase JBrowse link X 105,360,922 105,390,580 RGD:1600535
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 5 16,526,058 16,642,648 RGD:1578516
G Snap23 synaptosome associated protein 23 JBrowse link 3 112,333,972 112,362,960 RGD:1624291
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta JBrowse link 7 75,573,553 75,598,295 RGD:1625716
negative regulation of mast cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd300a Cd300a molecule JBrowse link 10 103,437,978 103,451,170 RGD:1624291
G Cd84 CD84 molecule JBrowse link 13 90,241,369 90,283,625 RGD:1624291
RGD:1600115
G Foxf1 forkhead box F1 JBrowse link 19 53,012,306 53,016,100 RGD:1624291
RGD:1600115
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:1601626
G Il13ra2 interleukin 13 receptor subunit alpha 2 JBrowse link X 118,443,955 118,514,716 RGD:1624291
RGD:1600115
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
G Rabgef1 RAB guanine nucleotide exchange factor 1 JBrowse link 12 29,960,132 30,004,727 RGD:1624291
RGD:1600115
positive regulation of histamine secretion by mast cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nppa natriuretic peptide A JBrowse link 5 164,808,407 164,809,716 RGD:13461752
G Snx4 sorting nexin 4 JBrowse link 11 70,693,381 70,753,620 RGD:1624291
RGD:1600115
G Vamp7 vesicle-associated membrane protein 7 JBrowse link 12 18,996,566 19,033,714 RGD:1624291
RGD:1600115
G Vamp8 vesicle-associated membrane protein 8 JBrowse link 4 100,250,301 100,252,756 RGD:1600115
RGD:1624291
positive regulation of mast cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adora2b adenosine A2B receptor JBrowse link 10 48,569,563 48,586,366 RGD:1624291
RGD:1600115
G Adora3 adenosine A3 receptor JBrowse link 2 208,336,909 208,379,217 RGD:1624291
G Crhr1 corticotropin releasing hormone receptor 1 JBrowse link 10 92,191,473 92,233,662 RGD:5130941
G Fcer1a Fc fragment of IgE receptor Ia JBrowse link 13 91,727,253 91,737,106 RGD:1624291
G Fcer1g Fc fragment of IgE receptor Ig JBrowse link 13 89,601,894 89,606,326 RGD:1624291
RGD:1600115
G Fgr FGR proto-oncogene, Src family tyrosine kinase JBrowse link 5 151,172,189 151,199,746 RGD:1624291
RGD:1600115
G Gab2 GRB2-associated binding protein 2 JBrowse link 1 162,082,876 162,283,379 RGD:1624291
RGD:1600115
G Gata1 GATA binding protein 1 JBrowse link X 15,273,937 15,281,759 RGD:9587812
G Gata2 GATA binding protein 2 JBrowse link 4 120,129,028 120,142,490 RGD:9587812
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:1624291
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1624291
G Il4r interleukin 4 receptor JBrowse link 1 196,942,343 196,967,221 RGD:1624291
G Ms4a2 membrane spanning 4-domains A2 JBrowse link 1 227,957,363 227,965,312 RGD:1578516
G Nppc natriuretic peptide C JBrowse link 9 93,731,436 93,735,636 RGD:13461752
G Pld2 phospholipase D2 JBrowse link 10 57,161,921 57,181,148 RGD:2299903
G Sphk2 sphingosine kinase 2 JBrowse link 1 101,692,972 101,700,604 RGD:1600115
RGD:1624291
G Stxbp1 syntaxin binding protein 1 JBrowse link 3 11,823,779 11,885,479 RGD:12904029
G Stxbp2 syntaxin binding protein 2 JBrowse link 12 2,180,101 2,191,863 RGD:12904029
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:2299903
RGD:13792537
RGD:1600115
RGD:1624291
regulation of histamine secretion by mast cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Snx6 sorting nexin 6 JBrowse link 6 75,626,927 75,670,172 RGD:1624291
G Vamp2 vesicle-associated membrane protein 2 JBrowse link 10 55,675,171 55,679,405 RGD:1624291
G Vamp3 vesicle-associated membrane protein 3 JBrowse link 5 168,126,157 168,136,628 RGD:1624291
regulation of mast cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fer FER tyrosine kinase JBrowse link 9 111,557,804 111,868,583 RGD:13792537
G Fes FES proto-oncogene, tyrosine kinase JBrowse link 1 142,174,648 142,183,884 RGD:1624291
RGD:13792537
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 5 16,526,058 16,642,648 RGD:1624291
RGD:13792537
RGD:1600115
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:1624291
RGD:1600115
G Rac2 Rac family small GTPase 2 JBrowse link 7 119,769,708 119,797,111 RGD:1624291
RGD:1600115
G RGD1311164 similar to DNA segment, Chr 6, Wayne State University 163, expressed JBrowse link 4 159,483,089 159,518,387 RGD:10047193
G Stxbp2 syntaxin binding protein 2 JBrowse link 12 2,180,101 2,191,863 RGD:2312429
G Unc13d unc-13 homolog D JBrowse link 10 104,613,907 104,628,664 RGD:1600115
RGD:1624291
serotonin secretion by mast cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd300a Cd300a molecule JBrowse link 10 103,437,978 103,451,170 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18008
    localization 6032
      establishment of localization 4634
        establishment of organelle localization 368
          mast cell degranulation 55
            histamine secretion by mast cell + 12
            negative regulation of mast cell degranulation + 7
            positive regulation of mast cell degranulation + 23
            regulation of mast cell degranulation + 40
            serotonin secretion by mast cell 1
Path 2
Term Annotations click to browse term
  biological_process 18008
    localization 6032
      establishment of localization 4634
        transport 4494
          export from cell 1172
            secretion by cell 1127
              exocytosis 399
                regulated exocytosis 283
                  leukocyte degranulation 79
                    mast cell degranulation 55
                      histamine secretion by mast cell + 12
                      negative regulation of mast cell degranulation + 7
                      positive regulation of mast cell degranulation + 23
                      regulation of mast cell degranulation + 40
                      serotonin secretion by mast cell 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.