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ONTOLOGY REPORT - ANNOTATIONS


Term:neutrophil degranulation
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Accession:GO:0043312 term browser browse the term
Definition:The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
Synonyms:exact_synonym: neutrophil granule exocytosis
 related_synonym: heterophil degranulation


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neutrophil degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa3 annexin A3 JBrowse link NW_004955433 2,981,113 3,043,894 RGD:9068941
G Myo1f myosin IF JBrowse link NW_004955563 880,545 916,630 RGD:9068941
G Stx11 syntaxin 11 JBrowse link NW_004955436 16,303,169 16,327,854 RGD:9068941
G Stxbp2 syntaxin binding protein 2 JBrowse link NW_004955563 1,617,621 1,624,441 RGD:9068941
G Stxbp3 syntaxin binding protein 3 JBrowse link NW_004955435 12,215,665 12,270,769 RGD:9068941
G Vamp2 vesicle associated membrane protein 2 JBrowse link NW_004955467 8,793,296 8,796,771 RGD:9068941
G Vamp7 vesicle associated membrane protein 7 JBrowse link NW_004955594 20,496 72,648 RGD:9068941
G Vamp8 vesicle associated membrane protein 8 JBrowse link NW_004955424 1,922,830 1,926,844 RGD:9068941
negative regulation of neutrophil degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abr ABR activator of RhoGEF and GTPase JBrowse link NW_004955481 2,503,309 2,710,667 RGD:9068941
G Bcr BCR activator of RhoGEF and GTPase JBrowse link NW_004955455 7,598,794 7,727,386 RGD:9068941
positive regulation of neutrophil degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd177 CD177 molecule JBrowse link NW_004955555 1,106,722 1,120,756 RGD:9068941
G Itgam integrin subunit alpha M JBrowse link NW_004955493 8,116,886 8,160,806 RGD:9068941
G Itgb2 integrin subunit beta 2 JBrowse link NW_004955407 41,779,849 41,805,637 RGD:9068941
G Ptafr platelet activating factor receptor JBrowse link NW_004955452 7,309,854 7,345,579 RGD:9068941
regulation of neutrophil degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pram1 PML-RARA regulated adaptor molecule 1 JBrowse link NW_004955563 924,365 933,198 RGD:9068941
G Syk spleen associated tyrosine kinase JBrowse link NW_004955515 1,328,793 1,400,206 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11825
    immune system process 1887
      immune effector process 594
        leukocyte degranulation 69
          neutrophil degranulation 16
            negative regulation of neutrophil degranulation 2
            positive regulation of neutrophil degranulation 4
            regulation of neutrophil degranulation + 8
Path 2
Term Annotations click to browse term
  biological_process 11825
    localization 4738
      establishment of localization 3419
        transport 3275
          secretion 1030
            secretion by cell 888
              exocytosis 314
                regulated exocytosis 242
                  leukocyte degranulation 69
                    neutrophil degranulation 16
                      negative regulation of neutrophil degranulation 2
                      positive regulation of neutrophil degranulation 4
                      regulation of neutrophil degranulation + 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.