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ONTOLOGY REPORT - ANNOTATIONS


Term:CD4-positive, alpha-beta T cell differentiation
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Accession:GO:0043367 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: CD4-positive, alpha-beta T lymphocyte differentiation
 related_synonym: CD4-positive, alpha beta T cell development


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CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BRAF B-Raf proto-oncogene, serine/threonine kinase JBrowse link 7 145,124,291 145,327,115 RGD:9068941
G NKX2-3 NK2 homeobox 3 JBrowse link 10 99,640,589 99,643,924 RGD:9068941
G PAX1 paired box 1 JBrowse link 20 21,623,771 21,633,468 RGD:9068941
G RSAD2 radical S-adenosyl methionine domain containing 2 JBrowse link 2A 7,010,762 7,042,500 RGD:9068941
G SATB1 SATB homeobox 1 JBrowse link 3 18,602,204 18,700,696 RGD:9068941
CD4-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G TOX thymocyte selection associated high mobility group box JBrowse link 8 56,913,312 57,219,640 RGD:9068941
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FOXP3 forkhead box P3 JBrowse link X 49,402,652 49,417,029 RGD:9068941
G FUT7 fucosyltransferase 7 JBrowse link 9 137,058,831 137,061,607 RGD:9068941
G PLA2G2D phospholipase A2 group IID JBrowse link 1 20,110,664 20,117,583 RGD:9068941
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FOXP3 forkhead box P3 JBrowse link X 49,402,652 49,417,029 RGD:9068941
G TOX thymocyte selection associated high mobility group box JBrowse link 8 56,913,312 57,219,640 RGD:9068941
negative regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HMGB1 high mobility group box 1 JBrowse link 13 30,173,875 30,179,527 RGD:9068941
G RUNX1 RUNX family transcription factor 1 JBrowse link 21 34,526,631 34,788,930 RGD:9068941
G RUNX3 RUNX family transcription factor 3 JBrowse link 1 25,073,135 25,137,343 RGD:9068941
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL4R interleukin 4 receptor JBrowse link 16 27,686,760 27,737,445 RGD:9068941
G JAK3 Janus kinase 3 JBrowse link 19 18,283,157 18,304,641 RGD:9068941
G TNFSF4 TNF superfamily member 4 JBrowse link 1 152,391,450 152,699,026 RGD:9068941
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FOXP3 forkhead box P3 JBrowse link X 49,402,652 49,417,029 RGD:9068941
G IL2 interleukin 2 JBrowse link 4 125,782,563 125,787,819 RGD:9068941
G IL4 interleukin 4 JBrowse link 5 134,253,039 134,261,581 RGD:9068941
G RC3H1 ring finger and CCCH-type domains 1 JBrowse link 1 153,153,048 153,213,402 RGD:9068941
G RC3H2 ring finger and CCCH-type domains 2 JBrowse link 9 122,308,725 122,365,106 RGD:9068941
G SMAD7 SMAD family member 7 JBrowse link 18 45,659,375 45,689,505 RGD:9068941
G TBX21 T-box transcription factor 21 JBrowse link 17 9,973,343 9,988,131 RGD:9068941
G ZBTB7B zinc finger and BTB domain containing 7B JBrowse link 1 133,959,365 133,975,729 RGD:9068941
G ZC3H12A zinc finger CCCH-type containing 12A JBrowse link 1 38,093,036 38,103,556 RGD:9068941
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LOXL3 lysyl oxidase like 3 JBrowse link 2A 76,105,957 76,128,495 RGD:9068941
G TBX21 T-box transcription factor 21 JBrowse link 17 9,973,343 9,988,131 RGD:9068941
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ANXA1 annexin A1 JBrowse link 9 71,930,148 71,948,779 RGD:9068941
G BCL6 BCL6 transcription repressor JBrowse link 3 193,308,296 193,332,452 RGD:9068941
G HLX H2.0 like homeobox JBrowse link 1 201,500,470 201,506,222 RGD:9068941
G SOCS5 suppressor of cytokine signaling 5 JBrowse link 2A 47,745,216 47,808,566 RGD:9068941
negative regulation of T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RC3H1 ring finger and CCCH-type domains 1 JBrowse link 1 153,153,048 153,213,402 RGD:9068941
positive regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CD83 CD83 molecule JBrowse link 6 14,330,752 14,349,946 RGD:9068941
G NCKAP1L NCK associated protein 1 like JBrowse link 12 34,932,470 34,977,881 RGD:9068941
G SASH3 SAM and SH3 domain containing 3 JBrowse link X 129,207,049 129,222,342 RGD:9068941
G TNFSF4 TNF superfamily member 4 JBrowse link 1 152,391,450 152,699,026 RGD:9068941
G ZBTB7B zinc finger and BTB domain containing 7B JBrowse link 1 133,959,365 133,975,729 RGD:9068941
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FOXP3 forkhead box P3 JBrowse link X 49,402,652 49,417,029 RGD:9068941
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IFNG interferon gamma JBrowse link 12 68,448,861 68,453,829 RGD:9068941
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ANXA1 annexin A1 JBrowse link 9 71,930,148 71,948,779 RGD:9068941
G CCL19 C-C motif chemokine ligand 19 JBrowse link 9 35,334,353 35,336,108 RGD:9068941
G CD80 CD80 molecule JBrowse link 3 123,559,559 123,594,870 RGD:9068941
G HLX H2.0 like homeobox JBrowse link 1 201,500,470 201,506,222 RGD:9068941
G RIPK2 receptor interacting serine/threonine kinase 2 JBrowse link 8 88,397,768 88,431,690 RGD:9068941
G SOCS5 suppressor of cytokine signaling 5 JBrowse link 2A 47,745,216 47,808,566 RGD:9068941
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MALT1 MALT1 paracaspase JBrowse link 18 55,395,462 55,473,574 RGD:9068941
G NFKBID NFKB inhibitor delta JBrowse link 19 41,553,727 41,565,216 RGD:9068941
G NFKBIZ NFKB inhibitor zeta JBrowse link 3 105,616,645 105,628,300 RGD:9068941
G NLRP3 NLR family pyrin domain containing 3 JBrowse link 1 228,505,147 228,537,216 RGD:9068941
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL12B interleukin 12B JBrowse link 5 161,323,402 161,339,051 RGD:9068941
G IL12RB1 interleukin 12 receptor subunit beta 1 JBrowse link 19 18,513,585 18,541,383 RGD:9068941
G IL23A interleukin 23 subunit alpha JBrowse link 12 32,828,902 32,830,621 RGD:9068941
G IL23R interleukin 23 receptor JBrowse link 1 68,293,514 68,386,815 RGD:9068941
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CD86 CD86 molecule JBrowse link 3 126,059,008 126,124,339 RGD:9068941
G IL18 interleukin 18 JBrowse link 11 110,867,586 110,888,371 RGD:9068941
G IL4R interleukin 4 receptor JBrowse link 16 27,686,760 27,737,445 RGD:9068941
G NLRP3 NLR family pyrin domain containing 3 JBrowse link 1 228,505,147 228,537,216 RGD:9068941
G PRKCZ protein kinase C zeta JBrowse link 1 1,918,653 2,046,236 RGD:9068941
G RARA retinoic acid receptor alpha JBrowse link 17 17,156,923 17,205,451 RGD:9068941
G TNFSF4 TNF superfamily member 4 JBrowse link 1 152,391,450 152,699,026 RGD:9068941
positive regulation of T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MYB MYB proto-oncogene, transcription factor JBrowse link 6 136,974,525 137,086,194 RGD:9068941
regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GATA3 GATA binding protein 3 JBrowse link 10 8,055,853 8,086,271 RGD:9068941
G SH3RF1 SH3 domain containing ring finger 1 JBrowse link 4 173,392,485 173,569,072 RGD:9068941
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL27 interleukin 27 JBrowse link 16 28,979,717 28,984,655 RGD:9068941
regulation of T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IRF4 interferon regulatory factor 4 JBrowse link 6 341,637 360,492 RGD:9068941
T follicular helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FOXP1 forkhead box P1 JBrowse link 3 72,255,364 72,878,625 RGD:9068941
G GPR183 G protein-coupled receptor 183 JBrowse link 13 99,600,695 99,613,671 RGD:9068941
G RC3H1 ring finger and CCCH-type domains 1 JBrowse link 1 153,153,048 153,213,402 RGD:9068941
G RC3H2 ring finger and CCCH-type domains 2 JBrowse link 9 122,308,725 122,365,106 RGD:9068941
T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HMGB1 high mobility group box 1 JBrowse link 13 30,173,875 30,179,527 RGD:9068941
G IL18R1 interleukin 18 receptor 1 JBrowse link 2A 103,459,397 103,488,025 RGD:9068941
G LEF1 lymphoid enhancer binding factor 1 JBrowse link 4 111,125,312 111,245,980 RGD:9068941
G RELB RELB proto-oncogene, NF-kB subunit JBrowse link 19 50,563,164 50,590,627 RGD:9068941
G SEMA4A semaphorin 4A JBrowse link 1 135,321,147 135,350,724 RGD:9068941
G TMEM98 transmembrane protein 98 JBrowse link 17 24,136,588 24,146,912 RGD:9068941
T-helper 1 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MTOR mechanistic target of rapamycin kinase JBrowse link 1 11,093,765 11,249,841 RGD:9068941
G SPN sialophorin JBrowse link 16 30,034,739 30,037,033 RGD:9068941
G STAT6 signal transducer and activator of transcription 6 JBrowse link 12 32,068,645 32,085,099 RGD:9068941
T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BATF basic leucine zipper ATF-like transcription factor JBrowse link 14 74,919,115 74,943,652 RGD:9068941
G RORA RAR related orphan receptor A JBrowse link 15 57,763,345 57,901,854 RGD:9068941
G RORC RAR related orphan receptor C JBrowse link 1 130,808,705 130,834,490 RGD:9068941
T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BATF basic leucine zipper ATF-like transcription factor JBrowse link 14 74,919,115 74,943,652 RGD:9068941
G IL6 interleukin 6 JBrowse link 7 23,027,560 23,032,419 RGD:9068941
G IRF4 interferon regulatory factor 4 JBrowse link 6 341,637 360,492 RGD:9068941
G LY9 lymphocyte antigen 9 JBrowse link 1 140,075,646 140,107,790 RGD:9068941
G SLAMF6 SLAM family member 6 JBrowse link 1 139,761,121 139,799,348 RGD:9068941
G STAT3 signal transducer and activator of transcription 3 JBrowse link 17 15,152,358 15,227,084 RGD:9068941
T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BATF basic leucine zipper ATF-like transcription factor JBrowse link 14 74,919,115 74,943,652 RGD:9068941
G BCL3 BCL3 transcription coactivator JBrowse link 19 50,300,536 50,313,005 RGD:9068941
G GATA3 GATA binding protein 3 JBrowse link 10 8,055,853 8,086,271 RGD:9068941
G IL4 interleukin 4 JBrowse link 5 134,253,039 134,261,581 RGD:9068941
T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ATP7A ATPase copper transporting alpha JBrowse link X 77,205,579 77,342,762 RGD:9068941
G IL12B interleukin 12B JBrowse link 5 161,323,402 161,339,051 RGD:9068941
G PTGER4 prostaglandin E receptor 4 JBrowse link 5 74,731,470 74,745,121 RGD:9068941
G RORC RAR related orphan receptor C JBrowse link 1 130,808,705 130,834,490 RGD:9068941
T-helper cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ZFPM1 zinc finger protein, FOG family member 1 JBrowse link 16 88,822,837 88,907,872 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15758
    immune system process 2763
      leukocyte activation 1166
        lymphocyte activation 645
          lymphocyte differentiation 343
            T cell differentiation 240
              alpha-beta T cell differentiation 101
                CD4-positive, alpha-beta T cell differentiation 73
                  CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 5
                  CD4-positive, alpha-beta T cell differentiation involved in immune response + 59
                  CD4-positive, alpha-beta T cell lineage commitment + 18
                  CD4-positive, alpha-beta intraepithelial T cell differentiation 0
                  negative regulation of CD4-positive, alpha-beta T cell differentiation + 20
                  positive regulation of CD4-positive, alpha-beta T cell differentiation + 27
                  regulation of CD4-positive, alpha-beta T cell differentiation + 44
Path 2
Term Annotations click to browse term
  biological_process 15758
    developmental process 6130
      anatomical structure development 5679
        multicellular organism development 5210
          system development 4662
            immune system development 959
              hematopoietic or lymphoid organ development 907
                hemopoiesis 867
                  leukocyte differentiation 506
                    lymphocyte differentiation 343
                      T cell differentiation 240
                        alpha-beta T cell differentiation 101
                          CD4-positive, alpha-beta T cell differentiation 73
                            CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 5
                            CD4-positive, alpha-beta T cell differentiation involved in immune response + 59
                            CD4-positive, alpha-beta T cell lineage commitment + 18
                            CD4-positive, alpha-beta intraepithelial T cell differentiation 0
                            negative regulation of CD4-positive, alpha-beta T cell differentiation + 20
                            positive regulation of CD4-positive, alpha-beta T cell differentiation + 27
                            regulation of CD4-positive, alpha-beta T cell differentiation + 44
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.