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ONTOLOGY REPORT - ANNOTATIONS


Term:CD4-positive, alpha-beta T cell differentiation
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Accession:GO:0043367 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: CD4-positive, alpha-beta T lymphocyte differentiation
 related_synonym: CD4-positive, alpha beta T cell development


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CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link NW_004955494 2,567,238 2,712,708 RGD:9068941
G Nkx2-3 NK2 homeobox 3 JBrowse link NW_004955507 5,454,871 5,457,247 RGD:9068941
G Pax1 paired box 1 JBrowse link NW_004955415 29,413,253 29,420,682 RGD:9068941
G Rsad2 radical S-adenosyl methionine domain containing 2 JBrowse link NW_004955487 1,988,226 2,001,731 RGD:9068941
G Satb1 SATB homeobox 1 JBrowse link NW_004955430 10,587,539 10,683,887 RGD:9068941
CD4-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tox thymocyte selection associated high mobility group box JBrowse link NW_004955444 19,453,789 19,796,419 RGD:9068941
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp3 forkhead box P3 JBrowse link NW_004955543 731,707 742,606 RGD:9068941
G Fut7 fucosyltransferase 7 JBrowse link NW_004955513 5,056,718 5,061,974 RGD:9068941
G Pla2g2d phospholipase A2 group IID JBrowse link NW_004955452 738,133 743,718 RGD:9068941
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp3 forkhead box P3 JBrowse link NW_004955543 731,707 742,606 RGD:9068941
G Tox thymocyte selection associated high mobility group box JBrowse link NW_004955444 19,453,789 19,796,419 RGD:9068941
negative regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cbfb core-binding factor subunit beta JBrowse link NW_004955484 9,503,286 9,557,066 RGD:9068941
G Hmgb1 high mobility group box 1 JBrowse link NW_004955431 15,373,207 15,377,339 RGD:9068941
G Runx1 RUNX family transcription factor 1 JBrowse link NW_004955407 34,108,653 34,342,657 RGD:9068941
G Runx3 RUNX family transcription factor 3 JBrowse link NW_004955452 4,580,444 4,606,820 RGD:9068941
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il4r interleukin 4 receptor JBrowse link NW_004955493 5,546,340 5,580,745 RGD:9068941
G Jak3 Janus kinase 3 JBrowse link NW_004955524 3,399,895 3,412,018 RGD:9068941
G Tnfsf4 TNF superfamily member 4 JBrowse link NW_004955406 13,477,077 13,493,309 RGD:9068941
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp3 forkhead box P3 JBrowse link NW_004955543 731,707 742,606 RGD:9068941
G Il2 interleukin 2 JBrowse link NW_004955428 18,163,010 18,168,157 RGD:9068941
G Il4 interleukin 4 JBrowse link NW_004955408 4,058,052 4,065,999 RGD:9068941
G Rc3h1 ring finger and CCCH-type domains 1 JBrowse link NW_004955406 14,053,122 14,123,023 RGD:9068941
G Rc3h2 ring finger and CCCH-type domains 2 JBrowse link NW_004955419 5,054,288 5,103,926 RGD:9068941
G Smad7 SMAD family member 7 JBrowse link NW_004955402 34,028,184 34,058,949 RGD:9068941
G Tbx21 T-box transcription factor 21 JBrowse link NW_004955451 13,315,237 13,317,888 RGD:9068941
G Zbtb7b zinc finger and BTB domain containing 7B JBrowse link NW_004955545 1,504,656 1,519,954 RGD:9068941
G Zc3h12a zinc finger CCCH-type containing 12A JBrowse link NW_004955452 15,306,398 15,314,959 RGD:9068941
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Loxl3 lysyl oxidase like 3 JBrowse link NW_004955424 11,236,415 11,255,801 RGD:9068941
G Tbx21 T-box transcription factor 21 JBrowse link NW_004955451 13,315,237 13,317,888 RGD:9068941
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa1 annexin A1 JBrowse link NW_004955512 5,686,508 5,703,645 RGD:9068941
G Bcl6 BCL6 transcription repressor JBrowse link NW_004955420 19,998,960 20,021,200 RGD:9068941
G Hlx H2.0 like homeobox JBrowse link NW_004955520 2,937,131 2,941,170 RGD:9068941
G Socs5 suppressor of cytokine signaling 5 JBrowse link NW_004955441 13,593,342 13,657,389 RGD:9068941
negative regulation of T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rc3h1 ring finger and CCCH-type domains 1 JBrowse link NW_004955406 14,053,122 14,123,023 RGD:9068941
positive regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd83 CD83 molecule JBrowse link NW_004955465 676,006 692,770 RGD:9068941
G Nckap1l NCK associated protein 1 like JBrowse link NW_004955458 1,733,799 1,785,591 RGD:9068941
G Sash3 SAM and SH3 domain containing 3 JBrowse link NW_004955473 5,224,635 5,237,066 RGD:9068941
G Socs1 suppressor of cytokine signaling 1 JBrowse link NW_004955442 7,321,337 7,323,109 RGD:9068941
G Tnfsf4 TNF superfamily member 4 JBrowse link NW_004955406 13,477,077 13,493,309 RGD:9068941
G Zbtb7b zinc finger and BTB domain containing 7B JBrowse link NW_004955545 1,504,656 1,519,954 RGD:9068941
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp3 forkhead box P3 JBrowse link NW_004955543 731,707 742,606 RGD:9068941
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ifng interferon gamma JBrowse link NW_004955458 14,643,333 14,648,020 RGD:9068941
G Lgals9 galectin 9 JBrowse link NW_004955481 5,234,125 5,249,564 RGD:9068941
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa1 annexin A1 JBrowse link NW_004955512 5,686,508 5,703,645 RGD:9068941
G Ccl19 C-C motif chemokine ligand 19 JBrowse link NW_004955472 1,444,598 1,446,488 RGD:9068941
G Cd80 CD80 molecule JBrowse link NW_004955427 19,237,251 19,274,001 RGD:9068941
G Hlx H2.0 like homeobox JBrowse link NW_004955520 2,937,131 2,941,170 RGD:9068941
G Ripk2 receptor interacting serine/threonine kinase 2 JBrowse link NW_004955417 6,669,675 6,698,142 RGD:9068941
G Socs5 suppressor of cytokine signaling 5 JBrowse link NW_004955441 13,593,342 13,657,389 RGD:9068941
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Malt1 MALT1 paracaspase JBrowse link NW_004955402 42,919,480 42,968,873 RGD:9068941
G Nfkbid NFKB inhibitor delta JBrowse link NW_004955468 2,680,934 2,688,797 RGD:9068941
G Nfkbiz NFKB inhibitor zeta JBrowse link NW_004955427 3,350,174 3,358,609 RGD:9068941
G Nlrp3 NLR family pyrin domain containing 3 JBrowse link NW_004955581 597,952 616,903 RGD:9068941
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il12b interleukin 12B JBrowse link NW_004955408 13,302,506 13,316,300 RGD:9068941
G Il12rb1 interleukin 12 receptor subunit beta 1 JBrowse link NW_004955524 3,276,932 3,299,617 RGD:9068941
G Il23a interleukin 23 subunit alpha JBrowse link NW_004955458 3,946,964 3,949,180 RGD:9068941
G Il23r interleukin 23 receptor JBrowse link NW_004955423 23,841,342 23,885,191 RGD:9068941
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd86 CD86 molecule JBrowse link NW_004955427 21,375,820 21,436,767 RGD:9068941
G Il18 interleukin 18 JBrowse link NW_004955412 13,807,361 13,826,007 RGD:9068941
G Il4r interleukin 4 receptor JBrowse link NW_004955493 5,546,340 5,580,745 RGD:9068941
G Nlrp3 NLR family pyrin domain containing 3 JBrowse link NW_004955581 597,952 616,903 RGD:9068941
G Prkcz protein kinase C zeta JBrowse link NW_004955486 8,947,579 9,021,702 RGD:9068941
G Rara retinoic acid receptor alpha JBrowse link NW_004955451 14,876,663 14,917,134 RGD:9068941
G Tnfsf4 TNF superfamily member 4 JBrowse link NW_004955406 13,477,077 13,493,309 RGD:9068941
positive regulation of T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Myb MYB proto-oncogene, transcription factor JBrowse link NW_004955439 1,523,516 1,560,185 RGD:9068941
regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gata3 GATA binding protein 3 JBrowse link NW_004955421 24,448,446 24,477,885 RGD:9068941
G Sh3rf1 SH3 domain containing ring finger 1 JBrowse link NW_004955403 36,989,509 37,141,188 RGD:9068941
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il27 interleukin 27 JBrowse link NW_004955493 6,712,005 6,717,417 RGD:9068941
regulation of T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Irf4 interferon regulatory factor 4 JBrowse link NW_004955465 12,497,534 12,512,529 RGD:9068941
T follicular helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp1 forkhead box P1 JBrowse link NW_004955421 16,595,445 17,075,923 RGD:9068941
G Gpr183 G protein-coupled receptor 183 JBrowse link NW_004955404 11,264,954 11,277,531 RGD:9068941
G Rc3h1 ring finger and CCCH-type domains 1 JBrowse link NW_004955406 14,053,122 14,123,023 RGD:9068941
G Rc3h2 ring finger and CCCH-type domains 2 JBrowse link NW_004955419 5,054,288 5,103,926 RGD:9068941
T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hmgb1 high mobility group box 1 JBrowse link NW_004955431 15,373,207 15,377,339 RGD:9068941
G Il18r1 interleukin 18 receptor 1 JBrowse link NW_004955470 7,854,995 7,887,810 RGD:9068941
G Lef1 lymphoid enhancer binding factor 1 JBrowse link NW_004955496 1,728,840 1,827,749 RGD:9068941
G Relb RELB proto-oncogene, NF-kB subunit JBrowse link NW_004955555 2,060,533 2,086,229 RGD:9068941
G Sema4a semaphorin 4A JBrowse link NW_004955545 2,316,402 2,341,873 RGD:9068941
G Tmem98 transmembrane protein 98 JBrowse link NW_004955481 7,788,066 7,797,433 RGD:9068941
T-helper 1 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mtor mechanistic target of rapamycin kinase JBrowse link NW_004955486 2,487,642 2,599,694 RGD:9068941
G Spn sialophorin JBrowse link NW_004955493 7,256,505 7,258,607 RGD:9068941
G Stat6 signal transducer and activator of transcription 6 JBrowse link NW_004955458 4,833,417 4,847,956 RGD:9068941
T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Batf basic leucine zipper ATF-like transcription factor JBrowse link NW_004955523 42,365 66,103 RGD:9068941
G Rora RAR related orphan receptor A JBrowse link NW_004955450 14,262,199 14,434,611 RGD:9068941
G Rorc RAR related orphan receptor C JBrowse link NW_004955589 590,653 616,784 RGD:9068941
T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Batf basic leucine zipper ATF-like transcription factor JBrowse link NW_004955523 42,365 66,103 RGD:9068941
G Il6 interleukin 6 JBrowse link NW_004955410 25,079,835 25,084,390 RGD:9068941
G Irf4 interferon regulatory factor 4 JBrowse link NW_004955465 12,497,534 12,512,529 RGD:9068941
G Slamf6 SLAM family member 6 JBrowse link NW_004955468 12,233,629 12,264,502 RGD:9068941
G Stat3 signal transducer and activator of transcription 3 JBrowse link NW_004955451 16,320,326 16,348,505 RGD:9068941
T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Batf basic leucine zipper ATF-like transcription factor JBrowse link NW_004955523 42,365 66,103 RGD:9068941
G Bcl3 BCL3 transcription coactivator JBrowse link NW_004955555 1,898,280 1,911,466 RGD:9068941
G Gata3 GATA binding protein 3 JBrowse link NW_004955421 24,448,446 24,477,885 RGD:9068941
G Il4 interleukin 4 JBrowse link NW_004955408 4,058,052 4,065,999 RGD:9068941
T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp7a ATPase copper transporting alpha JBrowse link NW_004955557 1,355,471 1,515,725 RGD:9068941
G Il12b interleukin 12B JBrowse link NW_004955408 13,302,506 13,316,300 RGD:9068941
G Ptger4 prostaglandin E receptor 4 JBrowse link NW_004955426 24,997,811 25,010,822 RGD:9068941
G Rorc RAR related orphan receptor C JBrowse link NW_004955589 590,653 616,784 RGD:9068941
T-helper cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Zfpm1 zinc finger protein, FOG family member 1 JBrowse link NW_004955541 2,461,690 2,495,614 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14616
    immune system process 2526
      leukocyte activation 1097
        lymphocyte activation 621
          lymphocyte differentiation 333
            T cell differentiation 236
              alpha-beta T cell differentiation 103
                CD4-positive, alpha-beta T cell differentiation 75
                  CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 6
                  CD4-positive, alpha-beta T cell differentiation involved in immune response + 59
                  CD4-positive, alpha-beta T cell lineage commitment + 17
                  CD4-positive, alpha-beta intraepithelial T cell differentiation 0
                  negative regulation of CD4-positive, alpha-beta T cell differentiation + 21
                  positive regulation of CD4-positive, alpha-beta T cell differentiation + 29
                  regulation of CD4-positive, alpha-beta T cell differentiation + 47
Path 2
Term Annotations click to browse term
  biological_process 14616
    developmental process 5921
      anatomical structure development 5490
        multicellular organism development 5040
          system development 4518
            immune system development 928
              hematopoietic or lymphoid organ development 876
                hemopoiesis 838
                  leukocyte differentiation 487
                    lymphocyte differentiation 333
                      T cell differentiation 236
                        alpha-beta T cell differentiation 103
                          CD4-positive, alpha-beta T cell differentiation 75
                            CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 6
                            CD4-positive, alpha-beta T cell differentiation involved in immune response + 59
                            CD4-positive, alpha-beta T cell lineage commitment + 17
                            CD4-positive, alpha-beta intraepithelial T cell differentiation 0
                            negative regulation of CD4-positive, alpha-beta T cell differentiation + 21
                            positive regulation of CD4-positive, alpha-beta T cell differentiation + 29
                            regulation of CD4-positive, alpha-beta T cell differentiation + 47
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.