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ONTOLOGY REPORT - ANNOTATIONS


Term:CD4-positive, alpha-beta T cell differentiation
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Accession:GO:0043367 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: CD4-positive, alpha-beta T lymphocyte differentiation
 related_synonym: CD4-positive, alpha beta T cell development


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CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BRAF B-Raf proto-oncogene, serine/threonine kinase JBrowse link 16 8,222,909 8,318,179 RGD:13508589
G NKX2-3 NK2 homeobox 3 JBrowse link 28 12,466,319 12,469,467 RGD:13508589
G PAX1 paired box 1 JBrowse link 24 1,742,570 1,752,593 RGD:13508589
G RSAD2 radical S-adenosyl methionine domain containing 2 JBrowse link 17 4,488,202 4,508,705 RGD:13508589
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FUT7 fucosyltransferase 7 JBrowse link 9 48,604,879 48,609,292 RGD:13508589
G PLA2G2D phospholipase A2 group IID JBrowse link 2 78,739,826 78,745,839 RGD:13508589
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G TOX thymocyte selection associated high mobility group box JBrowse link 29 9,542,471 9,841,759 RGD:13508589
negative regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HMGB1 high mobility group box 1 JBrowse link 25 9,431,223 9,558,167 RGD:13508589
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL2 interleukin 2 JBrowse link 19 17,750,780 17,756,394 RGD:13508589
G IL4 interleukin 4 JBrowse link 11 20,972,693 20,981,539 RGD:13508589
G RC3H1 ring finger and CCCH-type domains 1 JBrowse link 7 25,265,836 25,312,417 RGD:13508589
G SMAD7 SMAD family member 7 JBrowse link 7 79,706,485 79,734,673 RGD:13508589
G ZBTB7B zinc finger and BTB domain containing 7B JBrowse link 7 42,468,376 42,482,219 RGD:13508589
G ZC3H12A zinc finger CCCH-type containing 12A JBrowse link 15 4,972,369 4,984,218 RGD:13508589
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G TBX21 T-box transcription factor 21 JBrowse link 9 24,077,752 24,086,560 RGD:13508589
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ANXA1 annexin A1 JBrowse link 1 84,744,159 84,763,011 RGD:13508589
G BCL6 BCL6 transcription repressor JBrowse link 34 20,112,302 20,135,705 RGD:13508589
G HLX H2.0 like homeobox JBrowse link 38 15,538,744 15,543,686 RGD:13508589
G LOC111089966 zinc finger protein 271 JBrowse link 7 54,714,912 54,727,638 RGD:13508589
G SOCS5 suppressor of cytokine signaling 5 JBrowse link 10 48,916,446 48,977,183 RGD:13508589
positive regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G NCKAP1L NCK associated protein 1 like JBrowse link 27 805,274 858,901 RGD:13508589
G SASH3 SAM and SH3 domain containing 3 JBrowse link X 100,989,605 101,003,162 RGD:13508589
G SOCS1 suppressor of cytokine signaling 1 JBrowse link 6 31,511,003 31,511,995 RGD:13508589
G ZBTB7B zinc finger and BTB domain containing 7B JBrowse link 7 42,468,376 42,482,219 RGD:13508589
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IFNG interferon gamma JBrowse link 10 10,406,866 10,411,698 RGD:13508589
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ANXA1 annexin A1 JBrowse link 1 84,744,159 84,763,011 RGD:13508589
G HLX H2.0 like homeobox JBrowse link 38 15,538,744 15,543,686 RGD:13508589
G RIPK2 receptor interacting serine/threonine kinase 2 JBrowse link 29 35,283,209 35,311,608 RGD:13508589
G SOCS5 suppressor of cytokine signaling 5 JBrowse link 10 48,916,446 48,977,183 RGD:13508589
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MALT1 MALT1 paracaspase JBrowse link 1 17,351,458 17,412,591 RGD:13508589
G NFKBID NFKB inhibitor delta JBrowse link 1 116,763,371 116,770,683 RGD:13508589
G NLRP3 NLR family pyrin domain containing 3 JBrowse link 8 251,776 313,290 RGD:13508589
G TYROBP transmembrane immune signaling adaptor TYROBP JBrowse link 1 116,757,271 116,760,453 RGD:13508589
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL23A interleukin 23 subunit alpha JBrowse link 10 635,384 640,715 RGD:13508589
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL18 interleukin 18 JBrowse link 5 20,972,742 20,995,327 RGD:13508589
G NLRP3 NLR family pyrin domain containing 3 JBrowse link 8 251,776 313,290 RGD:13508589
G PRKCZ protein kinase C zeta JBrowse link 5 57,012,020 57,113,346 RGD:13508589
G RARA retinoic acid receptor alpha JBrowse link 9 22,254,803 22,298,614 RGD:13508589
positive regulation of T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SHB SH2 domain containing adaptor protein B JBrowse link 11 54,189,580 54,329,004 RGD:13508589
regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GATA3 GATA binding protein 3 JBrowse link 2 28,068,143 28,098,445 RGD:13508589
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL27 interleukin 27 JBrowse link 6 18,243,988 18,248,369 RGD:13508589
T follicular helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GPR183 G protein-coupled receptor 183 JBrowse link 22 49,332,665 49,347,721 RGD:13508589
G RC3H1 ring finger and CCCH-type domains 1 JBrowse link 7 25,265,836 25,312,417 RGD:13508589
T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HMGB1 high mobility group box 1 JBrowse link 25 9,431,223 9,558,167 RGD:13508589
G IL18R1 interleukin 18 receptor 1 JBrowse link 10 40,614,336 40,653,300 RGD:13508589
G RELB RELB proto-oncogene, NF-kB subunit JBrowse link 1 110,436,677 110,466,709 RGD:13508589
G SEMA4A semaphorin 4A JBrowse link 7 41,670,814 41,695,349 RGD:13508589
G TMEM98 transmembrane protein 98 JBrowse link 9 40,130,421 40,144,120 RGD:13508589
T-helper 1 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MTOR mechanistic target of rapamycin kinase JBrowse link 2 84,818,893 84,939,283 RGD:13508589
T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RORA RAR related orphan receptor A JBrowse link 30 25,315,974 26,026,708 RGD:13508589
T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BATF basic leucine zipper ATF-like transcription factor JBrowse link 8 48,537,036 48,561,154 RGD:13508589
G IL6 interleukin 6 JBrowse link 14 36,474,268 36,478,519 RGD:13508589
G IRF4 interferon regulatory factor 4 JBrowse link 35 760,367 782,314 RGD:13508589
G LY9 lymphocyte antigen 9 JBrowse link 38 21,522,898 21,554,652 RGD:13508589
G STAT3 signal transducer and activator of transcription 3 JBrowse link 9 20,539,660 20,614,631 RGD:13508589
T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BATF basic leucine zipper ATF-like transcription factor JBrowse link 8 48,537,036 48,561,154 RGD:13508589
G GATA3 GATA binding protein 3 JBrowse link 2 28,068,143 28,098,445 RGD:13508589
G IL4 interleukin 4 JBrowse link 11 20,972,693 20,981,539 RGD:13508589
T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL12B interleukin 12B JBrowse link 4 51,178,637 51,194,606 RGD:13508589
G PTGER4 prostaglandin E receptor 4 JBrowse link 4 68,663,362 68,676,241 RGD:13508589

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14453
    immune system process 1450
      leukocyte activation 495
        lymphocyte activation 417
          lymphocyte differentiation 231
            T cell differentiation 169
              alpha-beta T cell differentiation 70
                CD4-positive, alpha-beta T cell differentiation 50
                  CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 4
                  CD4-positive, alpha-beta T cell differentiation involved in immune response + 40
                  CD4-positive, alpha-beta T cell lineage commitment + 9
                  CD4-positive, alpha-beta intraepithelial T cell differentiation 0
                  negative regulation of CD4-positive, alpha-beta T cell differentiation + 13
                  positive regulation of CD4-positive, alpha-beta T cell differentiation + 18
                  regulation of CD4-positive, alpha-beta T cell differentiation + 29
Path 2
Term Annotations click to browse term
  biological_process 14453
    developmental process 3809
      anatomical structure development 3519
        multicellular organism development 3130
          system development 2864
            immune system development 588
              hematopoietic or lymphoid organ development 542
                hemopoiesis 511
                  leukocyte differentiation 334
                    lymphocyte differentiation 231
                      T cell differentiation 169
                        alpha-beta T cell differentiation 70
                          CD4-positive, alpha-beta T cell differentiation 50
                            CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 4
                            CD4-positive, alpha-beta T cell differentiation involved in immune response + 40
                            CD4-positive, alpha-beta T cell lineage commitment + 9
                            CD4-positive, alpha-beta intraepithelial T cell differentiation 0
                            negative regulation of CD4-positive, alpha-beta T cell differentiation + 13
                            positive regulation of CD4-positive, alpha-beta T cell differentiation + 18
                            regulation of CD4-positive, alpha-beta T cell differentiation + 29
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.