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ONTOLOGY REPORT - ANNOTATIONS


Term:CD4-positive, alpha-beta T cell differentiation
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Accession:GO:0043367 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: CD4-positive, alpha-beta T lymphocyte differentiation
 related_synonym: CD4-positive, alpha beta T cell development


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CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BRAF B-Raf proto-oncogene, serine/threonine kinase JBrowse link 7 140,713,328 140,924,929 RGD:2290271
G NKX2-3 NK2 homeobox 3 JBrowse link 10 99,532,942 99,536,524 RGD:2290271
G PAX1 paired box 1 JBrowse link 20 21,705,659 21,718,486 RGD:2290271
G RSAD2 radical S-adenosyl methionine domain containing 2 JBrowse link 2 6,865,733 6,898,239 RGD:2290271
G SATB1 SATB homeobox 1 JBrowse link 3 18,345,377 18,445,592 RGD:2290271
CD4-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G TOX thymocyte selection associated high mobility group box JBrowse link 8 58,805,412 59,119,293 RGD:2290271
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FOXP3 forkhead box P3 JBrowse link X 49,250,436 49,264,932 RGD:2290271
G FUT7 fucosyltransferase 7 JBrowse link 9 137,030,174 137,032,088 RGD:2290271
G PLA2G2D phospholipase A2 group IID JBrowse link 1 20,111,939 20,119,566 RGD:2290271
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FOXP3 forkhead box P3 JBrowse link X 49,250,436 49,264,932 RGD:2290271
G TOX thymocyte selection associated high mobility group box JBrowse link 8 58,805,412 59,119,293 RGD:2290271
negative regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CBFB core-binding factor subunit beta JBrowse link 16 67,029,149 67,101,058 RGD:2290271
G HMGB1 high mobility group box 1 JBrowse link 13 30,456,704 30,617,597 RGD:2290271
G RUNX1 RUNX family transcription factor 1 JBrowse link 21 34,787,801 35,049,334 RGD:2290271
G RUNX3 RUNX family transcription factor 3 JBrowse link 1 24,899,511 24,965,158 RGD:2290271
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL4R interleukin 4 receptor JBrowse link 16 27,313,668 27,364,778 RGD:2290271
G JAK3 Janus kinase 3 JBrowse link 19 17,824,782 17,848,071 RGD:2290271
G TNFSF4 TNF superfamily member 4 JBrowse link 1 173,183,729 173,462,208 RGD:2290271
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FOXP3 forkhead box P3 JBrowse link X 49,250,436 49,264,932 RGD:2290271
G IL2 interleukin 2 JBrowse link 4 122,449,479 122,456,725 RGD:2290271
G IL4 interleukin 4 JBrowse link 5 132,673,986 132,682,678 RGD:2290271
G RC3H1 ring finger and CCCH-type domains 1 JBrowse link 1 173,931,084 174,022,357 RGD:2290271
G RC3H2 ring finger and CCCH-type domains 2 JBrowse link 9 122,844,556 122,905,359 RGD:2290271
G SMAD7 SMAD family member 7 JBrowse link 18 48,919,853 48,950,711 RGD:2290271
G TBX21 T-box transcription factor 21 JBrowse link 17 47,733,236 47,746,122 RGD:2290271
G ZBTB7B zinc finger and BTB domain containing 7B JBrowse link 1 155,002,628 155,018,523 RGD:2290271
G ZC3H12A zinc finger CCCH-type containing 12A JBrowse link 1 37,474,518 37,484,377 RGD:2290271
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LOXL3 lysyl oxidase like 3 JBrowse link 2 74,532,258 74,555,719 RGD:2290271
G TBX21 T-box transcription factor 21 JBrowse link 17 47,733,236 47,746,122 RGD:2290271
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ANXA1 annexin A1 JBrowse link 9 73,151,865 73,170,393 RGD:2290271
G BCL6 BCL6 transcription repressor JBrowse link 3 187,721,377 187,745,472 RGD:2290271
G HLX H2.0 like homeobox JBrowse link 1 220,879,443 220,885,059 RGD:2290271
G SOCS5 suppressor of cytokine signaling 5 JBrowse link 2 46,698,960 46,763,129 RGD:2290271
negative regulation of T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RC3H1 ring finger and CCCH-type domains 1 JBrowse link 1 173,931,084 174,022,357 RGD:2290271
positive regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CD83 CD83 molecule JBrowse link 6 14,117,256 14,136,918 RGD:2290271
G NCKAP1L NCK associated protein 1 like JBrowse link 12 54,497,752 54,548,243 RGD:2290271
G SASH3 SAM and SH3 domain containing 3 JBrowse link X 129,779,949 129,795,201 RGD:2290271
G SOCS1 suppressor of cytokine signaling 1 JBrowse link 16 11,254,417 11,256,182 RGD:2290271
G TNFSF4 TNF superfamily member 4 JBrowse link 1 173,183,729 173,462,208 RGD:2290271
G ZBTB7B zinc finger and BTB domain containing 7B JBrowse link 1 155,002,628 155,018,523 RGD:2290271
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FOXP3 forkhead box P3 JBrowse link X 49,250,436 49,264,932 RGD:2290271
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IFNG interferon gamma JBrowse link 12 68,154,768 68,159,740 RGD:2290271
G LGALS9 galectin 9 JBrowse link 17 27,631,172 27,649,560 RGD:2290271
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ANXA1 annexin A1 JBrowse link 9 73,151,865 73,170,393 RGD:2290271
G CCL19 C-C motif chemokine ligand 19 JBrowse link 9 34,689,570 34,691,276 RGD:2290271
G CD80 CD80 molecule JBrowse link 3 119,524,293 119,559,614 RGD:2290271
G HLX H2.0 like homeobox JBrowse link 1 220,879,443 220,885,059 RGD:2290271
G RIPK2 receptor interacting serine/threonine kinase 2 JBrowse link 8 89,757,816 89,791,064 RGD:2290271
G SOCS5 suppressor of cytokine signaling 5 JBrowse link 2 46,698,960 46,763,129 RGD:2290271
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MALT1 MALT1 paracaspase JBrowse link 18 58,671,420 58,754,477 RGD:2290271
G NFKBID NFKB inhibitor delta JBrowse link 19 35,887,630 35,902,303 RGD:2290271
G NFKBIZ NFKB inhibitor zeta JBrowse link 3 101,827,990 101,861,022 RGD:2290271
G NLRP3 NLR family pyrin domain containing 3 JBrowse link 1 247,416,163 247,448,823 RGD:2290271
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL12B interleukin 12B JBrowse link 5 159,314,780 159,330,487 RGD:2290271
G IL12RB1 interleukin 12 receptor subunit beta 1 JBrowse link 19 18,058,994 18,099,027 RGD:2290271
G IL23A interleukin 23 subunit alpha JBrowse link 12 56,334,159 56,340,410 RGD:2290271
G IL23R interleukin 23 receptor JBrowse link 1 67,138,639 67,259,979 RGD:2290271
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CD86 CD86 molecule JBrowse link 3 122,055,362 122,121,143 RGD:2290271
G IL18 interleukin 18 JBrowse link 11 112,143,251 112,164,104 RGD:2290271
G IL4R interleukin 4 receptor JBrowse link 16 27,313,668 27,364,778 RGD:2290271
G NLRP3 NLR family pyrin domain containing 3 JBrowse link 1 247,416,163 247,448,823 RGD:2290271
G PRKCZ protein kinase C zeta JBrowse link 1 2,050,411 2,185,399 RGD:2290271
G RARA retinoic acid receptor alpha JBrowse link 17 40,309,180 40,357,643 RGD:2290271
G TNFSF4 TNF superfamily member 4 JBrowse link 1 173,183,729 173,462,208 RGD:2290271
positive regulation of T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MYB MYB proto-oncogene, transcription factor JBrowse link 6 135,181,308 135,219,172 RGD:2290271
regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GATA3 GATA binding protein 3 JBrowse link 10 8,045,420 8,075,198 RGD:2290271
G SH3RF1 SH3 domain containing ring finger 1 JBrowse link 4 169,094,259 169,270,956 RGD:2290271
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL27 interleukin 27 JBrowse link 16 28,499,362 28,526,730 RGD:2290271
regulation of T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IRF4 interferon regulatory factor 4 JBrowse link 6 391,752 411,443 RGD:2290271
T follicular helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FOXP1 forkhead box P1 JBrowse link 3 70,952,817 71,583,989 RGD:2290271
G GPR183 G protein-coupled receptor 183 JBrowse link 13 99,294,273 99,307,399 RGD:2290271
G RC3H1 ring finger and CCCH-type domains 1 JBrowse link 1 173,931,084 174,022,357 RGD:2290271
G RC3H2 ring finger and CCCH-type domains 2 JBrowse link 9 122,844,556 122,905,359 RGD:2290271
T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HMGB1 high mobility group box 1 JBrowse link 13 30,456,704 30,617,597 RGD:2290271
G IL18R1 interleukin 18 receptor 1 JBrowse link 2 102,355,796 102,398,777 RGD:2290271
G LEF1 lymphoid enhancer binding factor 1 JBrowse link 4 108,047,545 108,168,956 RGD:2290271
G RELB RELB proto-oncogene, NF-kB subunit JBrowse link 19 45,001,449 45,038,194 RGD:2290271
G SEMA4A semaphorin 4A JBrowse link 1 156,149,672 156,177,751 RGD:2290271
G TMEM98 transmembrane protein 98 JBrowse link 17 32,927,910 32,944,315 RGD:2290271
T-helper 1 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MTOR mechanistic target of rapamycin kinase JBrowse link 1 11,106,535 11,273,497 RGD:2290271
G SPN sialophorin JBrowse link 16 29,662,950 29,670,876 RGD:2290271
G STAT6 signal transducer and activator of transcription 6 JBrowse link 12 57,095,408 57,111,413 RGD:2290271
T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BATF basic leucine zipper ATF-like transcription factor JBrowse link 14 75,522,469 75,546,992 RGD:2290271
G RORA RAR related orphan receptor A JBrowse link 15 60,488,284 61,229,302 RGD:2290271
G RORC RAR related orphan receptor C JBrowse link 1 151,806,071 151,832,451 RGD:2290271
T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BATF basic leucine zipper ATF-like transcription factor JBrowse link 14 75,522,469 75,546,992 RGD:2290271
G IL6 interleukin 6 JBrowse link 7 22,725,889 22,732,002 RGD:2290271
G IRF4 interferon regulatory factor 4 JBrowse link 6 391,752 411,443 RGD:2290271
G LY9 lymphocyte antigen 9 JBrowse link 1 160,796,112 160,828,256 RGD:2290271
G SLAMF6 SLAM family member 6 JBrowse link 1 160,485,030 160,523,263 RGD:2290271
G STAT3 signal transducer and activator of transcription 3 JBrowse link 17 42,313,324 42,388,502 RGD:2290271
T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BATF basic leucine zipper ATF-like transcription factor JBrowse link 14 75,522,469 75,546,992 RGD:2290271
G BCL3 BCL3 transcription coactivator JBrowse link 19 44,742,620 44,760,044 RGD:2290271
G GATA3 GATA binding protein 3 JBrowse link 10 8,045,420 8,075,198 RGD:2290271
G IL4 interleukin 4 JBrowse link 5 132,673,986 132,682,678 RGD:2290271
T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ATP7A ATPase copper transporting alpha JBrowse link X 77,910,656 78,050,395 RGD:2290271
G IL12B interleukin 12B JBrowse link 5 159,314,780 159,330,487 RGD:2290271
G PTGER4 prostaglandin E receptor 4 JBrowse link 5 40,679,915 40,740,936 RGD:2290271
G RORC RAR related orphan receptor C JBrowse link 1 151,806,071 151,832,451 RGD:2290271
T-helper cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ZFPM1 zinc finger protein, FOG family member 1 JBrowse link 16 88,451,782 88,537,031 RGD:2290271

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18105
    immune system process 3316
      leukocyte activation 1330
        lymphocyte activation 776
          lymphocyte differentiation 362
            T cell differentiation 248
              alpha-beta T cell differentiation 104
                CD4-positive, alpha-beta T cell differentiation 76
                  CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 6
                  CD4-positive, alpha-beta T cell differentiation involved in immune response + 60
                  CD4-positive, alpha-beta T cell lineage commitment + 18
                  CD4-positive, alpha-beta intraepithelial T cell differentiation 0
                  negative regulation of CD4-positive, alpha-beta T cell differentiation + 21
                  positive regulation of CD4-positive, alpha-beta T cell differentiation + 29
                  regulation of CD4-positive, alpha-beta T cell differentiation + 47
Path 2
Term Annotations click to browse term
  biological_process 18105
    developmental process 6593
      anatomical structure development 6069
        multicellular organism development 5566
          system development 4986
            immune system development 1030
              hematopoietic or lymphoid organ development 968
                hemopoiesis 928
                  leukocyte differentiation 535
                    lymphocyte differentiation 362
                      T cell differentiation 248
                        alpha-beta T cell differentiation 104
                          CD4-positive, alpha-beta T cell differentiation 76
                            CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 6
                            CD4-positive, alpha-beta T cell differentiation involved in immune response + 60
                            CD4-positive, alpha-beta T cell lineage commitment + 18
                            CD4-positive, alpha-beta intraepithelial T cell differentiation 0
                            negative regulation of CD4-positive, alpha-beta T cell differentiation + 21
                            positive regulation of CD4-positive, alpha-beta T cell differentiation + 29
                            regulation of CD4-positive, alpha-beta T cell differentiation + 47
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.