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ONTOLOGY REPORT - ANNOTATIONS


Term:CD4-positive, alpha-beta T cell differentiation
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Accession:GO:0043367 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: CD4-positive, alpha-beta T lymphocyte differentiation
 related_synonym: CD4-positive, alpha beta T cell development


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CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Braf Braf transforming gene JBrowse link 6 39,603,231 39,725,658 RGD:2290270
G Nkx2-3 NK2 homeobox 3 JBrowse link 19 43,612,325 43,615,892 RGD:2290270
G Pax1 paired box 1 JBrowse link 2 147,361,930 147,375,049 RGD:2290270
G Rsad2 radical S-adenosyl methionine domain containing 2 JBrowse link 12 26,442,743 26,456,452 RGD:2290270
G Satb1 special AT-rich sequence binding protein 1 JBrowse link 17 51,736,187 51,833,290 RGD:2290270
CD4-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tox thymocyte selection-associated high mobility group box JBrowse link 4 6,686,353 6,991,552 RGD:2290270
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fut7 fucosyltransferase 7 JBrowse link 2 25,422,351 25,426,374 RGD:2290270
G Ncor1 nuclear receptor co-repressor 1 JBrowse link 11 62,315,663 62,457,414 RGD:2290270
G Pla2g2d phospholipase A2, group IID JBrowse link 4 138,775,735 138,782,052 RGD:2290270
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp3 forkhead box P3 JBrowse link X 7,579,676 7,595,243 RGD:2290270
G Tgfb1 transforming growth factor, beta 1 JBrowse link 7 25,687,002 25,705,077 RGD:2290270
G Tox thymocyte selection-associated high mobility group box JBrowse link 4 6,686,353 6,991,552 RGD:2290270
negative regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cbfb core binding factor beta JBrowse link 8 105,170,674 105,217,989 RGD:2290270
G Runx1 runt related transcription factor 1 JBrowse link 16 92,601,466 92,826,074 RGD:2290270
G Runx3 runt related transcription factor 3 JBrowse link 4 135,120,645 135,177,990 RGD:2290270
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il4ra interleukin 4 receptor, alpha JBrowse link 7 125,552,271 125,579,474 RGD:2290270
G Jak3 Janus kinase 3 JBrowse link 8 71,676,383 71,690,577 RGD:2290270
G Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 JBrowse link 1 161,395,438 161,418,206 RGD:2290270
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp3 forkhead box P3 JBrowse link X 7,579,676 7,595,243 RGD:2290270
G Il2 interleukin 2 JBrowse link 3 37,120,713 37,125,954 RGD:2290270
G Il4 interleukin 4 JBrowse link 11 53,612,460 53,618,665 RGD:2290270
G Rc3h1 RING CCCH (C3H) domains 1 JBrowse link 1 160,906,411 160,974,976 RGD:2290270
G Rc3h2 ring finger and CCCH-type zinc finger domains 2 JBrowse link 2 37,368,861 37,424,370 RGD:2290270
G Smad7 SMAD family member 7 JBrowse link 18 75,367,365 75,395,935 RGD:2290270
G Tbx21 T-box 21 JBrowse link 11 97,098,007 97,115,331 RGD:2290270
G Zbtb7b zinc finger and BTB domain containing 7B JBrowse link 3 89,377,644 89,393,673 RGD:2290270
G Zc3h12a zinc finger CCCH type containing 12A JBrowse link 4 125,118,414 125,127,881 RGD:2290270
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Loxl3 lysyl oxidase-like 3 JBrowse link 6 83,034,205 83,052,566 RGD:2290270
G Tbx21 T-box 21 JBrowse link 11 97,098,007 97,115,331 RGD:2290270
G Tnfsf18 tumor necrosis factor (ligand) superfamily, member 18 JBrowse link 1 161,494,657 161,505,290 RGD:2290270
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa1 annexin A1 JBrowse link 19 20,373,434 20,390,671 RGD:2290270
G Bcl6 B cell leukemia/lymphoma 6 JBrowse link 16 23,965,050 23,988,866 RGD:2290270
G Hlx H2.0-like homeobox JBrowse link 1 184,727,143 184,732,493 RGD:2290270
G Irf1 interferon regulatory factor 1 JBrowse link 11 53,769,854 53,778,374 RGD:2290270
G Socs5 suppressor of cytokine signaling 5 JBrowse link 17 87,107,278 87,137,647 RGD:2290270
G Zfp35 zinc finger protein 35 JBrowse link 18 23,989,634 24,005,371 RGD:2290270
negative regulation of T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rc3h1 RING CCCH (C3H) domains 1 JBrowse link 1 160,906,411 160,974,976 RGD:2290270
positive regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd83 CD83 antigen JBrowse link 13 43,785,112 43,803,133 RGD:2290270
G Nckap1l NCK associated protein 1 like JBrowse link 15 103,453,783 103,502,860 RGD:2290270
G Sash3 SAM and SH3 domain containing 3 JBrowse link X 48,146,436 48,161,565 RGD:2290270
G Socs1 suppressor of cytokine signaling 1 JBrowse link 16 10,783,808 10,785,536 RGD:2290270
G Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 JBrowse link 1 161,395,438 161,418,206 RGD:2290270
G Zbtb7b zinc finger and BTB domain containing 7B JBrowse link 3 89,377,644 89,393,673 RGD:2290270
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp3 forkhead box P3 JBrowse link X 7,579,676 7,595,243 RGD:2290270
G Il2rg interleukin 2 receptor, gamma chain JBrowse link X 101,264,385 101,268,255 RGD:2290270
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ifng interferon gamma JBrowse link 10 118,441,046 118,445,894 RGD:2290270
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa1 annexin A1 JBrowse link 19 20,373,434 20,390,671 RGD:2290270
G Ccl19 chemokine (C-C motif) ligand 19 JBrowse link 4 42,754,525 42,756,518 RGD:2290270
G Ccr2 chemokine (C-C motif) receptor 2 JBrowse link 9 124,101,918 124,109,140 RGD:2290270
G Ccr7 chemokine (C-C motif) receptor 7 JBrowse link 11 99,144,199 99,155,077 RGD:2290270
G Hlx H2.0-like homeobox JBrowse link 1 184,727,143 184,732,493 RGD:2290270
G Irf1 interferon regulatory factor 1 JBrowse link 11 53,769,854 53,778,374 RGD:2290270
G Ripk2 receptor (TNFRSF)-interacting serine-threonine kinase 2 JBrowse link 4 16,122,732 16,163,678 RGD:2290270
G Socs5 suppressor of cytokine signaling 5 JBrowse link 17 87,107,278 87,137,647 RGD:2290270
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Malt1 MALT1 paracaspase JBrowse link 18 65,430,939 65,478,888 RGD:2290270
G Mir326 microRNA 326 JBrowse link 7 99,552,269 99,552,363 RGD:2290270
G Nfkbid nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta JBrowse link 7 30,421,731 30,428,749 RGD:2290270
G Nfkbiz nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta JBrowse link 16 55,811,375 55,838,954 RGD:2290270
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 11 59,541,569 59,566,955 RGD:2290270
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il23a interleukin 23, alpha subunit p19 JBrowse link 10 128,296,140 128,298,084 RGD:2290270
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il18 interleukin 18 JBrowse link 9 50,554,700 50,581,841 RGD:2290270
G Il4ra interleukin 4 receptor, alpha JBrowse link 7 125,552,271 125,579,474 RGD:2290270
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:2290270
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 11 59,541,569 59,566,955 RGD:2290270
G Prkcz protein kinase C, zeta JBrowse link 4 155,260,118 155,361,428 RGD:2290270
G Rara retinoic acid receptor, alpha JBrowse link 11 98,927,800 98,974,942 RGD:2290270
G Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 JBrowse link 1 161,395,438 161,418,206 RGD:2290270
positive regulation of T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Myb myeloblastosis oncogene JBrowse link 10 21,124,930 21,160,984 RGD:2290270
G Shb src homology 2 domain-containing transforming protein B JBrowse link 4 45,423,276 45,530,828 RGD:2290270
regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gata3 GATA binding protein 3 JBrowse link 2 9,857,078 9,887,953 RGD:2290270
G Sh3rf1 SH3 domain containing ring finger 1 JBrowse link 8 61,224,083 61,465,293 RGD:2290270
G Zbtb7b zinc finger and BTB domain containing 7B JBrowse link 3 89,377,644 89,393,673 RGD:2290270
regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tgfb1 transforming growth factor, beta 1 JBrowse link 7 25,687,002 25,705,077 RGD:2290270
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il27 interleukin 27 JBrowse link 7 126,589,009 126,595,035 RGD:2290270
regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl20 chemokine (C-C motif) ligand 20 JBrowse link 1 83,116,766 83,119,167 RGD:2290270
G Ccr6 chemokine (C-C motif) receptor 6 JBrowse link 17 8,236,041 8,258,519 RGD:2290270
G Mir301 microRNA 301 JBrowse link 11 87,113,004 87,113,089 RGD:2290270
T follicular helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp1 forkhead box P1 JBrowse link 6 98,925,342 99,522,746 RGD:2290270
G Gpr183 G protein-coupled receptor 183 JBrowse link 14 121,952,331 121,965,193 RGD:2290270
G Rc3h1 RING CCCH (C3H) domains 1 JBrowse link 1 160,906,411 160,974,976 RGD:2290270
G Rc3h2 ring finger and CCCH-type zinc finger domains 2 JBrowse link 2 37,368,861 37,424,370 RGD:2290270
T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gadd45g growth arrest and DNA-damage-inducible 45 gamma JBrowse link 13 51,846,675 51,848,475 RGD:2290270
G Il18r1 interleukin 18 receptor 1 JBrowse link 1 40,465,552 40,500,854 RGD:2290270
G Lef1 lymphoid enhancer binding factor 1 JBrowse link 3 131,110,277 131,224,357 RGD:2290270
G Relb avian reticuloendotheliosis viral (v-rel) oncogene related B JBrowse link 7 19,606,217 19,629,438 RGD:2290270
G Sema4a sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A JBrowse link 3 88,435,959 88,461,240 RGD:2290270
G Tmem98 transmembrane protein 98 JBrowse link 11 80,810,366 80,822,033 RGD:2290270
T-helper 1 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il4 interleukin 4 JBrowse link 11 53,612,460 53,618,665 RGD:2290270
G Mtor mechanistic target of rapamycin kinase JBrowse link 4 148,448,582 148,557,685 RGD:2290270
G Spn sialophorin JBrowse link 7 127,123,637 127,145,552 RGD:2290270
G Stat6 signal transducer and activator of transcription 6 JBrowse link 10 127,642,955 127,660,987 RGD:2290270
T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Batf basic leucine zipper transcription factor, ATF-like JBrowse link 12 85,686,720 85,709,087 RGD:2290270
G Mir873a microRNA 873a JBrowse link 4 36,668,510 36,668,586 RGD:2290270
G Rora RAR-related orphan receptor alpha JBrowse link 9 68,653,404 69,388,246 RGD:2290270
G Rorc RAR-related orphan receptor gamma JBrowse link 3 94,372,794 94,398,276 RGD:2290270
T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Batf basic leucine zipper transcription factor, ATF-like JBrowse link 12 85,686,720 85,709,087 RGD:2290270
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:2290270
G Irf4 interferon regulatory factor 4 JBrowse link 13 30,749,233 30,766,981 RGD:2290270
G Ly9 lymphocyte antigen 9 JBrowse link 1 171,588,613 171,607,410 RGD:2290270
G Otud5 OTU domain containing 5 JBrowse link X 7,839,613 7,876,626 RGD:2290270
G Slamf6 SLAM family member 6 JBrowse link 1 171,917,458 171,948,958 RGD:2290270
G Stat3 signal transducer and activator of transcription 3 JBrowse link 11 100,886,806 100,939,594 RGD:2290270
G Tgfb1 transforming growth factor, beta 1 JBrowse link 7 25,687,002 25,705,077 RGD:2290270
T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Batf basic leucine zipper transcription factor, ATF-like JBrowse link 12 85,686,720 85,709,087 RGD:2290270
G Bcl3 B cell leukemia/lymphoma 3 JBrowse link 7 19,808,462 19,822,824 RGD:2290270
G Gata3 GATA binding protein 3 JBrowse link 2 9,857,078 9,887,953 RGD:2290270
G Il4 interleukin 4 JBrowse link 11 53,612,460 53,618,665 RGD:2290270
T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp7a ATPase, Cu++ transporting, alpha polypeptide JBrowse link X 106,027,224 106,128,161 RGD:2290270
G Il12b interleukin 12b JBrowse link 11 44,400,063 44,414,677 RGD:2290270
G Ptger4 prostaglandin E receptor 4 (subtype EP4) JBrowse link 15 5,233,399 5,244,187 RGD:2290270
G Rorc RAR-related orphan receptor gamma JBrowse link 3 94,372,794 94,398,276 RGD:2290270

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23162
    immune system process 2759
      leukocyte activation 1023
        lymphocyte activation 858
          lymphocyte differentiation 408
            T cell differentiation 281
              alpha-beta T cell differentiation 120
                CD4-positive, alpha-beta T cell differentiation 85
                  CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 8
                  CD4-positive, alpha-beta T cell differentiation involved in immune response + 67
                  CD4-positive, alpha-beta T cell lineage commitment + 18
                  CD4-positive, alpha-beta intraepithelial T cell differentiation 0
                  negative regulation of CD4-positive, alpha-beta T cell differentiation + 23
                  positive regulation of CD4-positive, alpha-beta T cell differentiation + 30
                  regulation of CD4-positive, alpha-beta T cell differentiation + 52
Path 2
Term Annotations click to browse term
  biological_process 23162
    developmental process 6415
      anatomical structure development 5942
        multicellular organism development 5433
          system development 4828
            immune system development 1062
              hematopoietic or lymphoid organ development 1000
                hemopoiesis 952
                  leukocyte differentiation 585
                    lymphocyte differentiation 408
                      T cell differentiation 281
                        alpha-beta T cell differentiation 120
                          CD4-positive, alpha-beta T cell differentiation 85
                            CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 8
                            CD4-positive, alpha-beta T cell differentiation involved in immune response + 67
                            CD4-positive, alpha-beta T cell lineage commitment + 18
                            CD4-positive, alpha-beta intraepithelial T cell differentiation 0
                            negative regulation of CD4-positive, alpha-beta T cell differentiation + 23
                            positive regulation of CD4-positive, alpha-beta T cell differentiation + 30
                            regulation of CD4-positive, alpha-beta T cell differentiation + 52
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.