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ONTOLOGY REPORT - ANNOTATIONS


Term:CD4-positive, alpha-beta T cell differentiation
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Accession:GO:0043367 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: CD4-positive, alpha-beta T lymphocyte differentiation
 related_synonym: CD4-positive, alpha beta T cell development


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CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BRAF B-Raf proto-oncogene, serine/threonine kinase JBrowse link 18 8,957,963 9,132,558 RGD:14298760
G NKX2-3 NK2 homeobox 3 JBrowse link 14 110,720,384 110,724,002 RGD:14298760
G PAX1 paired box 1 JBrowse link 17 29,421,117 29,436,481 RGD:14298760
G RSAD2 radical S-adenosyl methionine domain containing 2 JBrowse link 3 128,880,853 128,897,809 RGD:14298760
G SATB1 SATB homeobox 1 JBrowse link 13 5,315,985 5,410,686 RGD:14298760
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FUT7 fucosyltransferase 7 RGD:14298760
G PLA2G2D phospholipase A2 group IID JBrowse link 6 78,391,063 78,397,394 RGD:14298760
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G TOX thymocyte selection associated high mobility group box JBrowse link 4 73,810,180 74,115,352 RGD:14298760
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FOXP3 forkhead box P3 JBrowse link X 43,303,777 43,328,164 RGD:14298760
G IL2 interleukin 2 JBrowse link 8 101,640,938 101,645,683 RGD:14298760
G IL4 interleukin 4 JBrowse link 2 134,986,817 134,994,365 RGD:14298760
G RC3H1 ring finger and CCCH-type domains 1 JBrowse link 9 116,204,807 116,292,455 RGD:14298760
G RC3H2 ring finger and CCCH-type domains 2 JBrowse link 1 263,769,403 263,822,101 RGD:14298760
G SMAD7 SMAD family member 7 JBrowse link 1 98,512,800 98,543,924 RGD:14298760
G ZBTB7B zinc finger and BTB domain containing 7B JBrowse link 4 94,780,404 94,796,722 RGD:14298760
G ZC3H12A zinc finger CCCH-type containing 12A JBrowse link 6 93,541,334 93,551,200 RGD:14298760
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LOXL3 lysyl oxidase like 3 JBrowse link 3 68,498,114 68,516,829 RGD:14298760
G TBX21 T-box transcription factor 21 JBrowse link 12 23,996,415 24,009,353 RGD:14298760
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ANXA1 annexin A1 JBrowse link 1 226,414,200 226,431,963 RGD:14298760
G BCL6 BCL6 transcription repressor JBrowse link 13 125,377,247 125,401,328 RGD:14298760
G SOCS5 suppressor of cytokine signaling 5 JBrowse link 3 93,777,402 93,925,859 RGD:14298760
G ZNF397 zinc finger protein 397 JBrowse link 6 119,076,683 119,144,643 RGD:14298760
positive regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SASH3 SAM and SH3 domain containing 3 JBrowse link X 106,373,871 106,389,454 RGD:14298760
G SOCS1 suppressor of cytokine signaling 1 JBrowse link 3 31,879,143 31,883,041 RGD:14298760
G ZBTB7B zinc finger and BTB domain containing 7B JBrowse link 4 94,780,404 94,796,722 RGD:14298760
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FOXP3 forkhead box P3 JBrowse link X 43,303,777 43,328,164 RGD:14298760
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IFNG interferon gamma JBrowse link 5 32,477,906 32,482,670 RGD:14298760
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ANXA1 annexin A1 JBrowse link 1 226,414,200 226,431,963 RGD:14298760
G RIPK2 receptor interacting serine/threonine kinase 2 JBrowse link 4 47,026,558 47,075,133 RGD:14298760
G SOCS5 suppressor of cytokine signaling 5 JBrowse link 3 93,777,402 93,925,859 RGD:14298760
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MALT1 MALT1 paracaspase JBrowse link 1 162,076,933 162,144,915 RGD:14298760
G NFKBIZ NFKB inhibitor zeta JBrowse link 13 157,261,419 157,273,119 RGD:14298760
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL23A interleukin 23 subunit alpha JBrowse link 5 21,732,416 21,733,981 RGD:14298760
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL18 interleukin 18 JBrowse link 9 39,839,959 39,861,258 RGD:14298760
G PRKCZ protein kinase C zeta JBrowse link 6 64,073,343 64,159,187 RGD:14298760
G RARA retinoic acid receptor alpha JBrowse link 12 22,047,449 22,085,759 RGD:14298760
positive regulation of T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SHB SH2 domain containing adaptor protein B JBrowse link 1 238,680,804 238,826,424 RGD:14298760
regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GATA3 GATA binding protein 3 JBrowse link 10 63,367,684 63,397,977 RGD:14298760
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL27 interleukin 27 JBrowse link 3 18,421,962 18,427,916 RGD:14298760
T follicular helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FOXP1 forkhead box P1 JBrowse link 13 52,346,844 52,974,358 RGD:14298760
G GPR183 G protein-coupled receptor 183 JBrowse link 11 68,231,851 68,248,627 RGD:14298760
G RC3H1 ring finger and CCCH-type domains 1 JBrowse link 9 116,204,807 116,292,455 RGD:14298760
G RC3H2 ring finger and CCCH-type domains 2 JBrowse link 1 263,769,403 263,822,101 RGD:14298760
T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL18R1 interleukin 18 receptor 1 JBrowse link 3 51,803,383 51,844,758 RGD:14298760
G LEF1 lymphoid enhancer binding factor 1 JBrowse link 8 113,824,511 113,944,078 RGD:14298760
G RELB RELB proto-oncogene, NF-kB subunit JBrowse link 6 51,444,670 51,480,350 RGD:14298760
G SEMA4A semaphorin 4A JBrowse link 4 93,865,054 93,892,995 RGD:14298760
G TMEM98 transmembrane protein 98 JBrowse link 12 42,087,691 42,101,152 RGD:14298760
T-helper 1 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MTOR mechanistic target of rapamycin kinase JBrowse link 6 71,286,989 71,412,913 RGD:14298760
G STAT6 signal transducer and activator of transcription 6 JBrowse link 5 22,406,356 22,422,412 RGD:14298760
T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RORA RAR related orphan receptor A JBrowse link 1 110,719,004 111,482,807 RGD:14298760
T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL-6 interleukin-6 RGD:14298760
G IL6 interleukin 6 JBrowse link 9 91,506,421 91,510,830 RGD:14298760
G IRF4 interferon regulatory factor 4 JBrowse link 7 133,358 149,609 RGD:14298760
G LY9 lymphocyte antigen 9 JBrowse link 4 89,701,806 89,728,848 RGD:14298760
G SLAMF6 SLAM family member 6 JBrowse link 4 89,980,592 90,004,222 RGD:14298760
G STAT3 signal transducer and activator of transcription 3 JBrowse link 12 20,407,316 20,471,091 RGD:14298760
T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BCL3 BCL3 transcription coactivator JBrowse link 6 51,256,033 51,264,923 RGD:14298760
G GATA3 GATA binding protein 3 JBrowse link 10 63,367,684 63,397,977 RGD:14298760
G IL4 interleukin 4 JBrowse link 2 134,986,817 134,994,365 RGD:14298760
T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL12B interleukin 12B JBrowse link 16 64,143,268 64,158,929 RGD:14298760
G PTGER4 prostaglandin E receptor 4 JBrowse link 16 25,670,832 25,686,556 RGD:14298760

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15166
    immune system process 1627
      leukocyte activation 575
        lymphocyte activation 481
          lymphocyte differentiation 266
            T cell differentiation 186
              alpha-beta T cell differentiation 75
                CD4-positive, alpha-beta T cell differentiation 54
                  CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 5
                  CD4-positive, alpha-beta T cell differentiation involved in immune response + 44
                  CD4-positive, alpha-beta T cell lineage commitment + 12
                  CD4-positive, alpha-beta intraepithelial T cell differentiation 0
                  negative regulation of CD4-positive, alpha-beta T cell differentiation + 14
                  positive regulation of CD4-positive, alpha-beta T cell differentiation + 15
                  regulation of CD4-positive, alpha-beta T cell differentiation + 27
Path 2
Term Annotations click to browse term
  biological_process 15166
    developmental process 4237
      anatomical structure development 3929
        multicellular organism development 3485
          system development 3187
            immune system development 683
              hematopoietic or lymphoid organ development 640
                hemopoiesis 602
                  leukocyte differentiation 389
                    lymphocyte differentiation 266
                      T cell differentiation 186
                        alpha-beta T cell differentiation 75
                          CD4-positive, alpha-beta T cell differentiation 54
                            CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 5
                            CD4-positive, alpha-beta T cell differentiation involved in immune response + 44
                            CD4-positive, alpha-beta T cell lineage commitment + 12
                            CD4-positive, alpha-beta intraepithelial T cell differentiation 0
                            negative regulation of CD4-positive, alpha-beta T cell differentiation + 14
                            positive regulation of CD4-positive, alpha-beta T cell differentiation + 15
                            regulation of CD4-positive, alpha-beta T cell differentiation + 27
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.