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ONTOLOGY REPORT - ANNOTATIONS


Term:CD4-positive, alpha-beta T cell differentiation
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Accession:GO:0043367 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: CD4-positive, alpha-beta T lymphocyte differentiation
 related_synonym: CD4-positive, alpha beta T cell development


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CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link NW_004936592 4,728,371 4,833,830 RGD:9068941
G Nkx2-3 NK2 homeobox 3 JBrowse link NW_004936636 529,669 532,237 RGD:9068941
G Pax1 paired box 1 JBrowse link NW_004936620 3,765,481 3,773,779 RGD:9068941
G Rsad2 radical S-adenosyl methionine domain containing 2 JBrowse link NW_004936532 3,921,824 3,936,027 RGD:9068941
G Satb1 SATB homeobox 1 JBrowse link NW_004936473 10,906,059 11,001,007 RGD:9068941
CD4-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tox thymocyte selection associated high mobility group box JBrowse link NW_004936496 13,847,210 14,146,110 RGD:9068941
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp3 forkhead box P3 JBrowse link NW_004936721 1,118,376 1,125,282 RGD:9068941
G Fut7 fucosyltransferase 7 JBrowse link NW_004936669 914,520 920,481 RGD:9068941
G Pla2g2d phospholipase A2 group IID JBrowse link NW_004936474 6,167,507 6,172,750 RGD:9068941
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp3 forkhead box P3 JBrowse link NW_004936721 1,118,376 1,125,282 RGD:9068941
G Tox thymocyte selection associated high mobility group box JBrowse link NW_004936496 13,847,210 14,146,110 RGD:9068941
negative regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cbfb core-binding factor subunit beta JBrowse link NW_004936475 17,537,273 17,589,383 RGD:9068941
G Hmgb1 high mobility group box 1 JBrowse link NW_004936472 25,236,728 25,246,585 RGD:9068941
G Runx1 RUNX family transcription factor 1 JBrowse link NW_004936500 7,621,328 7,710,909 RGD:9068941
G Runx3 RUNX family transcription factor 3 JBrowse link NW_004936474 9,751,946 9,802,910 RGD:9068941
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il4r interleukin 4 receptor JBrowse link NW_004936501 11,025,590 11,058,807 RGD:9068941
G Jak3 Janus kinase 3 JBrowse link NW_004936596 3,212,593 3,224,426 RGD:9068941
G Tnfsf4 TNF superfamily member 4 JBrowse link NW_004936481 14,391,359 14,409,514 RGD:9068941
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp3 forkhead box P3 JBrowse link NW_004936721 1,118,376 1,125,282 RGD:9068941
G Il2 interleukin 2 JBrowse link NW_004936662 1,594,953 1,599,625 RGD:9068941
G Il4 interleukin 4 JBrowse link NW_004936647 2,510,457 2,518,576 RGD:9068941
G Rc3h1 ring finger and CCCH-type domains 1 JBrowse link NW_004936481 13,919,006 13,973,868 RGD:9068941
G Rc3h2 ring finger and CCCH-type domains 2 JBrowse link NW_004936487 11,341,663 11,393,275 RGD:9068941
G Smad7 SMAD family member 7 JBrowse link NW_004936497 13,894,586 13,921,978 RGD:9068941
G Tbx21 T-box transcription factor 21 JBrowse link NW_004936490 13,546,405 13,558,635 RGD:9068941
G Zbtb7b zinc finger and BTB domain containing 7B JBrowse link NW_004936580 4,546,139 4,560,157 RGD:9068941
G Zc3h12a zinc finger CCCH-type containing 12A JBrowse link NW_004936474 19,714,145 19,722,512 RGD:9068941
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Loxl3 lysyl oxidase like 3 JBrowse link NW_004936556 745,798 765,926 RGD:9068941
G Tbx21 T-box transcription factor 21 JBrowse link NW_004936490 13,546,405 13,558,635 RGD:9068941
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa1 annexin A1 JBrowse link NW_004936503 9,124,314 9,142,372 RGD:9068941
G Bcl6 BCL6 transcription repressor JBrowse link NW_004936578 2,371,976 2,395,034 RGD:9068941
G Hlx H2.0 like homeobox JBrowse link NW_004936650 1,416,825 1,422,595 RGD:9068941
G Socs5 suppressor of cytokine signaling 5 JBrowse link NW_004936508 5,531,002 5,588,022 RGD:9068941
negative regulation of T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rc3h1 ring finger and CCCH-type domains 1 JBrowse link NW_004936481 13,919,006 13,973,868 RGD:9068941
positive regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd83 CD83 molecule JBrowse link NW_004936552 637,471 654,422 RGD:9068941
G Nckap1l NCK associated protein 1 like JBrowse link NW_004936512 11,683,330 11,734,423 RGD:9068941
G Sash3 SAM and SH3 domain containing 3 JBrowse link NW_004936479 1,752,180 1,765,330 RGD:9068941
G Socs1 suppressor of cytokine signaling 1 JBrowse link NW_004936530 9,312,965 9,315,593 RGD:9068941
G Tnfsf4 TNF superfamily member 4 JBrowse link NW_004936481 14,391,359 14,409,514 RGD:9068941
G Zbtb7b zinc finger and BTB domain containing 7B JBrowse link NW_004936580 4,546,139 4,560,157 RGD:9068941
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp3 forkhead box P3 JBrowse link NW_004936721 1,118,376 1,125,282 RGD:9068941
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ifng interferon gamma JBrowse link NW_004936545 6,139,130 6,144,543 RGD:9068941
G Lgals9 galectin 9 JBrowse link NW_004936538 4,034,467 4,050,240 RGD:9068941
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa1 annexin A1 JBrowse link NW_004936503 9,124,314 9,142,372 RGD:9068941
G Ccl19 C-C motif chemokine ligand 19 JBrowse link NW_004936524 2,765,271 2,767,259 RGD:9068941
G Cd80 CD80 molecule JBrowse link NW_004936536 6,462,080 6,483,450 RGD:9068941
G Hlx H2.0 like homeobox JBrowse link NW_004936650 1,416,825 1,422,595 RGD:9068941
G Ripk2 receptor interacting serine/threonine kinase 2 JBrowse link NW_004936544 3,606,925 3,653,248 RGD:9068941
G Socs5 suppressor of cytokine signaling 5 JBrowse link NW_004936508 5,531,002 5,588,022 RGD:9068941
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Malt1 MALT1 paracaspase JBrowse link NW_004936497 5,854,361 5,910,719 RGD:9068941
G Nfkbid NFKB inhibitor delta JBrowse link NW_004936570 464,513 471,333 RGD:9068941
G Nfkbiz NFKB inhibitor zeta JBrowse link NW_004936630 1,601,006 1,633,844 RGD:9068941
G Nlrp3 NLR family pyrin domain containing 3 JBrowse link NW_004936864 709,693 732,119 RGD:9068941
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il12b interleukin 12B JBrowse link NW_004936515 4,056,214 4,066,121 RGD:9068941
G Il12rb1 interleukin 12 receptor subunit beta 1 JBrowse link NW_004936596 3,062,620 3,076,349 RGD:9068941
G Il23a interleukin 23 subunit alpha JBrowse link NW_004936646 743,630 745,998 RGD:9068941
G Il23r interleukin 23 receptor JBrowse link NW_004936591 4,365,598 4,425,053 RGD:9068941
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd86 CD86 molecule JBrowse link NW_004936536 8,414,491 8,481,712 RGD:9068941
G Il18 interleukin 18 JBrowse link NW_004936612 2,306,963 2,325,086 RGD:9068941
G Il4r interleukin 4 receptor JBrowse link NW_004936501 11,025,590 11,058,807 RGD:9068941
G Nlrp3 NLR family pyrin domain containing 3 JBrowse link NW_004936864 709,693 732,119 RGD:9068941
G Prkcz protein kinase C zeta JBrowse link NW_004936737 1,303,502 1,383,135 RGD:9068941
G Rara retinoic acid receptor alpha JBrowse link NW_004936490 15,376,217 15,420,638 RGD:9068941
G Tnfsf4 TNF superfamily member 4 JBrowse link NW_004936481 14,391,359 14,409,514 RGD:9068941
positive regulation of T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Myb MYB proto-oncogene, transcription factor JBrowse link NW_004936560 2,797,943 2,828,813 RGD:9068941
regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gata3 GATA binding protein 3 JBrowse link NW_004936484 6,780,692 6,800,883 RGD:9068941
G Sh3rf1 SH3 domain containing ring finger 1 JBrowse link NW_004936516 1,267,128 1,429,040 RGD:9068941
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il27 interleukin 27 JBrowse link NW_004936501 11,972,715 11,978,152 RGD:9068941
regulation of T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Irf4 interferon regulatory factor 4 JBrowse link NW_004936633 1,565,293 1,580,859 RGD:9068941
T follicular helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp1 forkhead box P1 JBrowse link NW_004936603 2,631,781 3,146,104 RGD:9068941
G Rc3h1 ring finger and CCCH-type domains 1 JBrowse link NW_004936481 13,919,006 13,973,868 RGD:9068941
G Rc3h2 ring finger and CCCH-type domains 2 JBrowse link NW_004936487 11,341,663 11,393,275 RGD:9068941
T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hmgb1 high mobility group box 1 JBrowse link NW_004936472 25,236,728 25,246,585 RGD:9068941
G Il18r1 interleukin 18 receptor 1 JBrowse link NW_004936713 1,038,985 1,075,770 RGD:9068941
G Lef1 lymphoid enhancer binding factor 1 JBrowse link NW_004936818 453,635 569,194 RGD:9068941
G Relb RELB proto-oncogene, NF-kB subunit JBrowse link NW_004936706 1,569,603 1,596,831 RGD:9068941
G Sema4a semaphorin 4A JBrowse link NW_004936580 5,404,380 5,431,183 RGD:9068941
G Tmem98 transmembrane protein 98 JBrowse link NW_004936538 2,065,663 2,074,678 RGD:9068941
T-helper 1 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mtor mechanistic target of rapamycin kinase JBrowse link NW_004936474 158,376 282,310 RGD:9068941
G Spn sialophorin JBrowse link NW_004936501 12,773,967 12,776,642 RGD:9068941
G Stat6 signal transducer and activator of transcription 6 JBrowse link NW_004936646 1,297,530 1,312,508 RGD:9068941
T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Batf basic leucine zipper ATF-like transcription factor JBrowse link NW_004936488 4,607,716 4,631,237 RGD:9068941
G Rora RAR related orphan receptor A JBrowse link NW_004936471 21,402,056 21,567,908 RGD:9068941
G Rorc RAR related orphan receptor C JBrowse link NW_004936580 1,997,640 2,020,649 RGD:9068941
T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Batf basic leucine zipper ATF-like transcription factor JBrowse link NW_004936488 4,607,716 4,631,237 RGD:9068941
G Irf4 interferon regulatory factor 4 JBrowse link NW_004936633 1,565,293 1,580,859 RGD:9068941
G Slamf6 SLAM family member 6 JBrowse link NW_004936740 155,268 165,536 RGD:9068941
G Stat3 signal transducer and activator of transcription 3 JBrowse link NW_004936490 17,119,189 17,178,402 RGD:9068941
T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Batf basic leucine zipper ATF-like transcription factor JBrowse link NW_004936488 4,607,716 4,631,237 RGD:9068941
G Bcl3 BCL3 transcription coactivator JBrowse link NW_004936706 1,410,848 1,427,822 RGD:9068941
G Gata3 GATA binding protein 3 JBrowse link NW_004936484 6,780,692 6,800,883 RGD:9068941
G Il4 interleukin 4 JBrowse link NW_004936647 2,510,457 2,518,576 RGD:9068941
T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp7a ATPase copper transporting alpha JBrowse link NW_004936683 2,874,022 2,936,214 RGD:9068941
G Il12b interleukin 12B JBrowse link NW_004936515 4,056,214 4,066,121 RGD:9068941
G Ptger4 prostaglandin E receptor 4 JBrowse link NW_004936518 1,903,636 1,916,746 RGD:9068941
G Rorc RAR related orphan receptor C JBrowse link NW_004936580 1,997,640 2,020,649 RGD:9068941
T-helper cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Zfpm1 zinc finger protein, FOG family member 1 JBrowse link NW_004936641 1,130,073 1,162,022 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14835
    immune system process 2565
      leukocyte activation 1103
        lymphocyte activation 615
          lymphocyte differentiation 328
            T cell differentiation 233
              alpha-beta T cell differentiation 100
                CD4-positive, alpha-beta T cell differentiation 73
                  CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 6
                  CD4-positive, alpha-beta T cell differentiation involved in immune response + 57
                  CD4-positive, alpha-beta T cell lineage commitment + 16
                  CD4-positive, alpha-beta intraepithelial T cell differentiation 0
                  negative regulation of CD4-positive, alpha-beta T cell differentiation + 21
                  positive regulation of CD4-positive, alpha-beta T cell differentiation + 29
                  regulation of CD4-positive, alpha-beta T cell differentiation + 47
Path 2
Term Annotations click to browse term
  biological_process 14835
    developmental process 5955
      anatomical structure development 5521
        multicellular organism development 5074
          system development 4548
            immune system development 939
              hematopoietic or lymphoid organ development 886
                hemopoiesis 847
                  leukocyte differentiation 486
                    lymphocyte differentiation 328
                      T cell differentiation 233
                        alpha-beta T cell differentiation 100
                          CD4-positive, alpha-beta T cell differentiation 73
                            CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 6
                            CD4-positive, alpha-beta T cell differentiation involved in immune response + 57
                            CD4-positive, alpha-beta T cell lineage commitment + 16
                            CD4-positive, alpha-beta intraepithelial T cell differentiation 0
                            negative regulation of CD4-positive, alpha-beta T cell differentiation + 21
                            positive regulation of CD4-positive, alpha-beta T cell differentiation + 29
                            regulation of CD4-positive, alpha-beta T cell differentiation + 47
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.