Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:positive T cell selection
go back to main search page
Accession:GO:0043368 term browser browse the term
Definition:The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death.
Synonyms:exact_synonym: positive T lymphocyte selection


show annotations for term's descendants           Sort by:
 
positive T cell selection term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl11b BAF chromatin remodeling complex subunit BCL11B ISO MGI:MGI:3767620 (MGI:MGI:3767367|PMID:17998389) RGD PMID:17998389 MGI:MGI:3767367 NCBI chr 6:131,834,097...131,927,251
Ensembl chr 6:131,834,097...131,926,272
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO MGI:MGI:3711006 (MGI:MGI:5473721|PMID:23334952) RGD PMID:23334952 MGI:MGI:5473721 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356
JBrowse link
G Themis thymocyte selection associated ISO (MGI:MGI:4352756|PMID:19597499), (MGI:MGI:4352757|PMID:19597498), (MGI:MGI:4352758|PMID:19597497), (MGI:MGI:4361774|PMID:19805304) RGD PMID:19597497, PMID:19597498, PMID:19597499, PMID:19805304 MGI:MGI:4352756, MGI:MGI:4352757, MGI:MGI:4352758, MGI:MGI:4361774 NCBI chr 1:17,152,973...17,378,225
Ensembl chr 1:17,171,631...17,378,047
JBrowse link
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO MGI:MGI:1857579 (MGI:MGI:3773982|PMID:18228248) RGD PMID:18228248 MGI:MGI:3773982 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase ISO
IEA
MGI:MGI:3664438 (MGI:MGI:3656194|PMID:16501569)
GO_REF:0000107
RGD
Ensembl
PMID:16501569 GO_REF:0000107, MGI:MGI:3656194 NCBI chr19:19,264,984...19,323,817
Ensembl chr19:19,265,164...19,315,357
JBrowse link
G Shh sonic hedgehog signaling molecule ISO
ISS
IEA
(PMID:17227833)
GO_REF:0000024
GO_REF:0000107
(MGI:MGI:3834308|PMID:17227833)
RGD
UniProt
Ensembl
PMID:17227833 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3834308 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
CD4-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsl cathepsin L ISS
ISO
GO_REF:0000024
(MGI:MGI:2655909|PMID:9545226)
UniProt
RGD
PMID:9545226 GO_REF:0000024, MGI:MGI:2655909 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Tox thymocyte selection-associated high mobility group box ISO (MGI:MGI:3773459|PMID:18195075) RGD PMID:18195075 MGI:MGI:3773459 NCBI chr 5:19,892,698...20,189,721
Ensembl chr 5:19,892,698...20,189,721
JBrowse link
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tox thymocyte selection-associated high mobility group box ISO (MGI:MGI:3773459|PMID:18195075) RGD PMID:18195075 MGI:MGI:3773459 NCBI chr 5:19,892,698...20,189,721
Ensembl chr 5:19,892,698...20,189,721
JBrowse link
CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator ISO
IEA
MGI:MGI:2156165 (MGI:MGI:2156164|PMID:8170972)
GO_REF:0000107
RGD
Ensembl
PMID:8170972 GO_REF:0000107, MGI:MGI:2156164 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Tox thymocyte selection-associated high mobility group box ISO (MGI:MGI:2159528|PMID:11850626), (MGI:MGI:3045816|PMID:15078895) RGD PMID:11850626, PMID:15078895 MGI:MGI:2159528, MGI:MGI:3045816 NCBI chr 5:19,892,698...20,189,721
Ensembl chr 5:19,892,698...20,189,721
JBrowse link
negative regulation of positive thymic T cell selection term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 ISO
ISS
(MGI:MGI:5320871|PMID:22080863)
GO_REF:0000024
RGD
UniProt
PMID:22080863 GO_REF:0000024, MGI:MGI:5320871 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Loxl3 lysyl oxidase-like 3 ISO (MGI:MGI:5825383|PMID:28065600) RGD PMID:28065600 MGI:MGI:5825383 NCBI chr 4:113,866,782...113,883,713
Ensembl chr 4:113,866,804...113,883,477
JBrowse link
G Tbx21 T-box transcription factor 21 ISO (MGI:MGI:4868293|PMID:21151104) RGD PMID:21151104 MGI:MGI:4868293 NCBI chr10:85,032,799...85,049,331
Ensembl chr10:85,032,799...85,049,331
JBrowse link
G Tnfsf18 TNF superfamily member 18 ISO (MGI:MGI:5551556|PMID:24107315) RGD PMID:24107315 MGI:MGI:5551556 NCBI chr13:79,378,412...79,388,687
Ensembl chr13:79,378,733...79,388,498
JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il23a interleukin 23 subunit alpha ISO
IBA
(MGI:MGI:3851279|PMID:19501566)
PMID:21873635
RGD PMID:19501566, PMID:21873635 MGI:MGI:3851279, RGD:13792537 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
positive thymic T cell selection term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd1d1 CD1d1 molecule ISO MGI:MGI:2180711 (MGI:MGI:87097|PMID:9133426) RGD PMID:9133426 MGI:MGI:87097 NCBI chr 2:186,330,298...186,333,805
Ensembl chr 2:186,330,298...186,333,805
JBrowse link
G Cd3d CD3d molecule ISO
IBA
ISS
(MGI:MGI:87267|PMID:9135151)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:9135151, PMID:21873635 GO_REF:0000024, MGI:MGI:87267, RGD:13792537 NCBI chr 8:49,282,502...49,287,095
Ensembl chr 8:49,282,460...49,287,110
JBrowse link
G Cd3e CD3e molecule IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:49,297,604...49,309,370
Ensembl chr 8:49,297,608...49,308,806
JBrowse link
G Cd3g CD3g molecule IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:49,274,553...49,280,943
Ensembl chr 8:49,274,960...49,280,901
JBrowse link
G Cd74 CD74 molecule ISO MGI:MGI:1927205|MGI:MGI:1927530 (MGI:MGI:3033881|PMID:9432982), (MGI:MGI:52620|PMID:7679955), (MGI:MGI:79110|PMID:8598040) RGD PMID:7679955, PMID:8598040, PMID:9432982 MGI:MGI:3033881, MGI:MGI:52620, MGI:MGI:79110 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Dock2 dedicator of cytokinesis 2 ISO MGI:MGI:2152031 (MGI:MGI:2668308|PMID:12871644) RGD PMID:12871644 MGI:MGI:2668308 NCBI chr10:19,181,512...19,603,171 JBrowse link
G Itpkb inositol-trisphosphate 3-kinase B ISO MGI:MGI:3039799 (MGI:MGI:3039326|PMID:15064401) RGD PMID:15064401 MGI:MGI:3039326 NCBI chr13:98,615,287...98,710,426
Ensembl chr13:98,615,287...98,708,149
JBrowse link
G LOC100909593 class II histocompatibility antigen, M alpha chain-like ISO MGI:MGI:1861933|MGI:MGI:2384509|MGI:MGI:2652160 (MGI:MGI:3033881|PMID:9432982), (MGI:MGI:79110|PMID:8598040), (MGI:MGI:79111|PMID:8598041), (MGI:MGI:79272|PMID:8638109) RGD PMID:8598040, PMID:8598041, PMID:8638109, PMID:9432982 MGI:MGI:3033881, MGI:MGI:79110, MGI:MGI:79111, MGI:MGI:79272 NCBI chr20:3,935,501...3,938,915 JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C ISO MGI:MGI:1857277 (MGI:MGI:80946|PMID:8666928) RGD PMID:8666928 MGI:MGI:80946 NCBI chr13:55,061,561...55,174,150
Ensembl chr13:55,061,562...55,173,692
JBrowse link
G RT1-DMa RT1 class II, locus DMa ISO MGI:MGI:1861933|MGI:MGI:2384509|MGI:MGI:2652160 (MGI:MGI:3033881|PMID:9432982), (MGI:MGI:79110|PMID:8598040), (MGI:MGI:79111|PMID:8598041), (MGI:MGI:79272|PMID:8638109) RGD PMID:8598040, PMID:8598041, PMID:8638109, PMID:9432982 MGI:MGI:3033881, MGI:MGI:79110, MGI:MGI:79111, MGI:MGI:79272 NCBI chr20:3,935,512...3,938,915
Ensembl chr20:5,240,975...5,244,386
JBrowse link
G Shh sonic hedgehog signaling molecule ISO
ISS
IEA
(MGI:MGI:3834308|PMID:17227833)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:17227833 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3834308 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
G Srf serum response factor ISO MGI:MGI:2449947|MGI:MGI:3046779 (MGI:MGI:4940955|PMID:21098124) RGD PMID:21098124 MGI:MGI:4940955 NCBI chr 9:16,737,637...16,747,226
Ensembl chr 9:16,737,642...16,747,225
JBrowse link
G Stk11 serine/threonine kinase 11 ISO
IEA
MGI:MGI:2386448|MGI:MGI:2387402|MGI:MGI:3054844 (MGI:MGI:5003385|PMID:21487392)
GO_REF:0000107
RGD
Ensembl
PMID:21487392 GO_REF:0000107, MGI:MGI:5003385 NCBI chr 7:12,440,751...12,457,513
Ensembl chr 7:12,440,751...12,457,513
JBrowse link
G Zap70 zeta chain of T cell receptor associated protein kinase 70 ISO (PMID:7630421)
MGI:MGI:2677447 (MGI:MGI:75253|PMID:7630421)
RGD PMID:7630421 MGI:MGI:75253 NCBI chr 9:43,331,149...43,353,097
Ensembl chr 9:43,331,155...43,353,113
JBrowse link
regulation of positive thymic T cell selection term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxn1 forkhead box N1 ISO (MGI:MGI:5554515|PMID:24184560) RGD PMID:24184560 MGI:MGI:5554515 NCBI chr10:65,621,142...65,634,666
Ensembl chr10:65,621,257...65,634,666
JBrowse link
G Tox thymocyte selection-associated high mobility group box ISO (MGI:MGI:3773459|PMID:18195075) RGD PMID:18195075 MGI:MGI:3773459 NCBI chr 5:19,892,698...20,189,721
Ensembl chr 5:19,892,698...20,189,721
JBrowse link
T-helper 1 cell lineage commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4 interleukin 4 ISO MGI:MGI:103034 (MGI:MGI:4838368|PMID:20706986) RGD PMID:20706986 MGI:MGI:4838368 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO (MGI:MGI:5788050|PMID:26410627) RGD PMID:26410627 MGI:MGI:5788050 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Spn sialophorin ISS
ISO
GO_REF:0000024
(PMID:18036228)
UniProt
RGD
PMID:18036228 GO_REF:0000024 NCBI chr 1:198,572,999...198,585,664
Ensembl chr 1:198,572,999...198,577,226
JBrowse link
G Stat6 signal transducer and activator of transcription 6 ISO MGI:MGI:96556 (MGI:MGI:4838368|PMID:20706986) RGD PMID:20706986 MGI:MGI:4838368 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
T-helper 17 cell lineage commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor ISS
ISO
GO_REF:0000024
(MGI:MGI:3851267|PMID:19578362), (MGI:MGI:5448096|PMID:22983707)
UniProt
RGD
PMID:19578362, PMID:22983707 GO_REF:0000024, MGI:MGI:3851267, MGI:MGI:5448096 NCBI chr 6:109,562,415...109,584,541
Ensembl chr 6:109,562,587...109,584,545
JBrowse link
G Il6 interleukin 6 ISS
ISO
GO_REF:0000024
(MGI:MGI:3692468|PMID:16990136), (MGI:MGI:6142555|PMID:27893700)
UniProt
RGD
PMID:16990136, PMID:27893700 GO_REF:0000024, MGI:MGI:3692468, MGI:MGI:6142555 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6r interleukin 6 receptor ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:MGI:6142555|PMID:27893700)
UniProt
Ensembl
RGD
PMID:27893700 GO_REF:0000024, GO_REF:0000107, MGI:MGI:6142555 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Irf4 interferon regulatory factor 4 ISO (MGI:MGI:5448096|PMID:22983707) RGD PMID:22983707 MGI:MGI:5448096 NCBI chr17:34,886,746...34,905,191
Ensembl chr17:34,886,739...34,905,117
JBrowse link
G Ly9 lymphocyte antigen 9 ISO (PMID:22184727) RGD PMID:22184727 NCBI chr13:90,002,779...90,022,346
Ensembl chr13:90,002,783...90,022,269
JBrowse link
G Otud5 OTU deubiquitinase 5 ISO MGI:MGI:2386448|MGI:MGI:5752247 (MGI:MGI:5621075|PMID:25470037) RGD PMID:25470037 MGI:MGI:5621075 NCBI chr  X:15,471,212...15,504,372
Ensembl chr  X:15,471,211...15,504,165
JBrowse link
G Slamf6 SLAM family member 6 ISO (PMID:22184727) RGD PMID:22184727 NCBI chr13:90,300,160...90,321,781
Ensembl chr13:90,301,006...90,322,457
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO
ISS
(MGI:MGI:5825383|PMID:28065600)
GO_REF:0000024
RGD
UniProt
PMID:28065600 GO_REF:0000024, MGI:MGI:5825383 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20015
    immune system process 2838
      T cell selection 53
        positive T cell selection 39
          CD4-positive or CD8-positive, alpha-beta T cell lineage commitment + 22
          positive extrathymic T cell selection 0
          positive thymic T cell selection + 17
Path 2
Term Annotations click to browse term
  biological_process 20015
    developmental process 6813
      anatomical structure development 6257
        multicellular organism development 5736
          system development 5273
            immune system development 1073
              hematopoietic or lymphoid organ development 1008
                hemopoiesis 956
                  leukocyte differentiation 595
                    lymphocyte differentiation 407
                      T cell differentiation 289
                        T cell selection 53
                          positive T cell selection 39
                            CD4-positive or CD8-positive, alpha-beta T cell lineage commitment + 22
                            positive extrathymic T cell selection 0
                            positive thymic T cell selection + 17
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.