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ONTOLOGY REPORT - ANNOTATIONS


Term:CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
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Accession:GO:0043369 term browser browse the term
Definition:The process in which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells.
Synonyms:exact_synonym: CD4-positive or CD8-positive, alpha-beta T lymphocyte lineage commitment;   CD4-positive/CD8-positive, alpha-beta T cell lineage commitment


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CD4-positive or CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO MGI:MGI:1857579 (MGI:MGI:3773982|PMID:18228248) RGD PMID:18228248 MGI:MGI:3773982 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase ISO
IEA
MGI:MGI:3664438 (MGI:MGI:3656194|PMID:16501569)
GO_REF:0000107
RGD
Ensembl
PMID:16501569 GO_REF:0000107, MGI:MGI:3656194 NCBI chr19:19,264,984...19,323,817
Ensembl chr19:19,265,164...19,315,357
JBrowse link
G Shh sonic hedgehog signaling molecule ISO
ISS
IEA
(PMID:17227833)
GO_REF:0000024
GO_REF:0000107
(MGI:MGI:3834308|PMID:17227833)
RGD
UniProt
Ensembl
PMID:17227833 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3834308 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
CD4-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsl cathepsin L ISS
ISO
GO_REF:0000024
(MGI:MGI:2655909|PMID:9545226)
UniProt
RGD
PMID:9545226 GO_REF:0000024, MGI:MGI:2655909 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Tox thymocyte selection-associated high mobility group box ISO (MGI:MGI:3773459|PMID:18195075) RGD PMID:18195075 MGI:MGI:3773459 NCBI chr 5:19,892,698...20,189,721
Ensembl chr 5:19,892,698...20,189,721
JBrowse link
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tox thymocyte selection-associated high mobility group box ISO (MGI:MGI:3773459|PMID:18195075) RGD PMID:18195075 MGI:MGI:3773459 NCBI chr 5:19,892,698...20,189,721
Ensembl chr 5:19,892,698...20,189,721
JBrowse link
CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator ISO
IEA
MGI:MGI:2156165 (MGI:MGI:2156164|PMID:8170972)
GO_REF:0000107
RGD
Ensembl
PMID:8170972 GO_REF:0000107, MGI:MGI:2156164 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Tox thymocyte selection-associated high mobility group box ISO (MGI:MGI:2159528|PMID:11850626), (MGI:MGI:3045816|PMID:15078895) RGD PMID:11850626, PMID:15078895 MGI:MGI:2159528, MGI:MGI:3045816 NCBI chr 5:19,892,698...20,189,721
Ensembl chr 5:19,892,698...20,189,721
JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Loxl3 lysyl oxidase-like 3 ISO (MGI:MGI:5825383|PMID:28065600) RGD PMID:28065600 MGI:MGI:5825383 NCBI chr 4:113,866,782...113,883,713
Ensembl chr 4:113,866,804...113,883,477
JBrowse link
G Tbx21 T-box transcription factor 21 ISO (MGI:MGI:4868293|PMID:21151104) RGD PMID:21151104 MGI:MGI:4868293 NCBI chr10:85,032,799...85,049,331
Ensembl chr10:85,032,799...85,049,331
JBrowse link
G Tnfsf18 TNF superfamily member 18 ISO (MGI:MGI:5551556|PMID:24107315) RGD PMID:24107315 MGI:MGI:5551556 NCBI chr13:79,378,412...79,388,687
Ensembl chr13:79,378,733...79,388,498
JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il23a interleukin 23 subunit alpha ISO
IBA
(MGI:MGI:3851279|PMID:19501566)
PMID:21873635
RGD PMID:19501566, PMID:21873635 MGI:MGI:3851279, RGD:13792537 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
T-helper 1 cell lineage commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4 interleukin 4 ISO MGI:MGI:103034 (MGI:MGI:4838368|PMID:20706986) RGD PMID:20706986 MGI:MGI:4838368 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO (MGI:MGI:5788050|PMID:26410627) RGD PMID:26410627 MGI:MGI:5788050 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Spn sialophorin ISS
ISO
GO_REF:0000024
(PMID:18036228)
UniProt
RGD
PMID:18036228 GO_REF:0000024 NCBI chr 1:198,572,999...198,585,664
Ensembl chr 1:198,572,999...198,577,226
JBrowse link
G Stat6 signal transducer and activator of transcription 6 ISO MGI:MGI:96556 (MGI:MGI:4838368|PMID:20706986) RGD PMID:20706986 MGI:MGI:4838368 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
T-helper 17 cell lineage commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor ISS
ISO
GO_REF:0000024
(MGI:MGI:3851267|PMID:19578362), (MGI:MGI:5448096|PMID:22983707)
UniProt
RGD
PMID:19578362, PMID:22983707 GO_REF:0000024, MGI:MGI:3851267, MGI:MGI:5448096 NCBI chr 6:109,562,415...109,584,541
Ensembl chr 6:109,562,587...109,584,545
JBrowse link
G Il6 interleukin 6 ISS
ISO
GO_REF:0000024
(MGI:MGI:3692468|PMID:16990136), (MGI:MGI:6142555|PMID:27893700)
UniProt
RGD
PMID:16990136, PMID:27893700 GO_REF:0000024, MGI:MGI:3692468, MGI:MGI:6142555 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6r interleukin 6 receptor ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:MGI:6142555|PMID:27893700)
UniProt
Ensembl
RGD
PMID:27893700 GO_REF:0000024, GO_REF:0000107, MGI:MGI:6142555 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Irf4 interferon regulatory factor 4 ISO (MGI:MGI:5448096|PMID:22983707) RGD PMID:22983707 MGI:MGI:5448096 NCBI chr17:34,886,746...34,905,191
Ensembl chr17:34,886,739...34,905,117
JBrowse link
G Ly9 lymphocyte antigen 9 ISO (PMID:22184727) RGD PMID:22184727 NCBI chr13:90,002,779...90,022,346
Ensembl chr13:90,002,783...90,022,269
JBrowse link
G Otud5 OTU deubiquitinase 5 ISO MGI:MGI:2386448|MGI:MGI:5752247 (MGI:MGI:5621075|PMID:25470037) RGD PMID:25470037 MGI:MGI:5621075 NCBI chr  X:15,471,212...15,504,372
Ensembl chr  X:15,471,211...15,504,165
JBrowse link
G Slamf6 SLAM family member 6 ISO (PMID:22184727) RGD PMID:22184727 NCBI chr13:90,300,160...90,321,781
Ensembl chr13:90,301,006...90,322,457
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO
ISS
(MGI:MGI:5825383|PMID:28065600)
GO_REF:0000024
RGD
UniProt
PMID:28065600 GO_REF:0000024, MGI:MGI:5825383 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20015
    immune system process 2838
      T cell selection 53
        positive T cell selection 39
          CD4-positive or CD8-positive, alpha-beta T cell lineage commitment 22
            CD4-positive, alpha-beta T cell lineage commitment + 18
            CD8-positive, alpha-beta T cell lineage commitment 2
Path 2
Term Annotations click to browse term
  biological_process 20015
    developmental process 6813
      anatomical structure development 6257
        multicellular organism development 5736
          system development 5273
            animal organ development 4027
              hematopoietic or lymphoid organ development 1008
                hemopoiesis 956
                  leukocyte differentiation 595
                    lymphocyte differentiation 407
                      T cell differentiation 289
                        T cell selection 53
                          positive T cell selection 39
                            CD4-positive or CD8-positive, alpha-beta T cell lineage commitment 22
                              CD4-positive, alpha-beta T cell lineage commitment + 18
                              CD8-positive, alpha-beta T cell lineage commitment 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.