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ONTOLOGY REPORT - ANNOTATIONS


Term:CD8-positive, alpha-beta T cell differentiation
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Accession:GO:0043374 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: CD8-positive, alpha-beta T lymphocyte differentiation
 related_synonym: CD8-positive, alpha-beta T cell development


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CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Irf1 interferon regulatory factor 1 JBrowse link 10 39,109,530 39,116,532 RGD:1624291
RGD:1600115
G Otud5 OTU deubiquitinase 5 JBrowse link X 15,471,212 15,504,372 RGD:1624291
G Pax1 paired box 1 JBrowse link 3 141,577,124 141,589,849 RGD:1624291
G Psmb11 proteasome subunit beta 11 JBrowse link 15 33,267,413 33,273,587 RGD:1624291
G Satb1 SATB homeobox 1 JBrowse link 9 2,181,135 2,277,949 RGD:1624291
G Tnfsf8 TNF superfamily member 8 JBrowse link 5 79,664,779 79,691,547 RGD:1624291
RGD:13792537
CD8-positive, alpha-beta intraepithelial T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gpr18 G protein-coupled receptor 18 JBrowse link 15 108,323,157 108,326,907 RGD:1624291
CD8-positive, alpha-beta T cell differentiation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eomes eomesodermin JBrowse link 8 127,144,367 127,152,618 RGD:1624291
RGD:1600115
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:1624291
CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:1624291
RGD:1600115
G Tox thymocyte selection-associated high mobility group box JBrowse link 5 19,892,698 20,189,721 RGD:1624291
negative regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Socs1 suppressor of cytokine signaling 1 JBrowse link 10 4,956,795 4,958,472 RGD:1600115
RGD:1624291
G Zbtb7b zinc finger and BTB domain containing 7B JBrowse link 2 188,704,989 188,719,674 RGD:1624291
positive regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cbfb core-binding factor subunit beta JBrowse link 19 37,127,508 37,171,075 RGD:1624291
G Nckap1l NCK associated protein 1 like JBrowse link 7 145,068,239 145,113,507 RGD:1624291
RGD:1600115
G Runx1 RUNX family transcription factor 1 JBrowse link 11 32,765,147 33,003,061 RGD:1600115
RGD:1624291
G Runx3 RUNX family transcription factor 3 JBrowse link 5 153,507,093 153,531,137 RGD:1624291
regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Zbtb7b zinc finger and BTB domain containing 7B JBrowse link 2 188,704,989 188,719,674 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19576
    immune system process 2692
      leukocyte activation 1008
        lymphocyte activation 828
          lymphocyte differentiation 392
            T cell differentiation 279
              alpha-beta T cell differentiation 119
                CD8-positive, alpha-beta T cell differentiation 17
                  CD8-positive, alpha-beta T cell differentiation involved in immune response 2
                  CD8-positive, alpha-beta T cell lineage commitment 2
                  CD8-positive, alpha-beta cytotoxic T cell differentiation 0
                  CD8-positive, alpha-beta intraepithelial T cell differentiation 1
                  CD8-positive, alpha-beta regulatory T cell differentiation 0
                  negative regulation of CD8-positive, alpha-beta T cell differentiation 2
                  positive regulation of CD8-positive, alpha-beta T cell differentiation 4
                  regulation of CD8-positive, alpha-beta T cell differentiation + 6
Path 2
Term Annotations click to browse term
  biological_process 19576
    developmental process 6694
      anatomical structure development 6153
        multicellular organism development 5621
          system development 5156
            immune system development 1046
              hematopoietic or lymphoid organ development 982
                hemopoiesis 930
                  leukocyte differentiation 575
                    lymphocyte differentiation 392
                      T cell differentiation 279
                        alpha-beta T cell differentiation 119
                          CD8-positive, alpha-beta T cell differentiation 17
                            CD8-positive, alpha-beta T cell differentiation involved in immune response 2
                            CD8-positive, alpha-beta T cell lineage commitment 2
                            CD8-positive, alpha-beta cytotoxic T cell differentiation 0
                            CD8-positive, alpha-beta intraepithelial T cell differentiation 1
                            CD8-positive, alpha-beta regulatory T cell differentiation 0
                            negative regulation of CD8-positive, alpha-beta T cell differentiation 2
                            positive regulation of CD8-positive, alpha-beta T cell differentiation 4
                            regulation of CD8-positive, alpha-beta T cell differentiation + 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.