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ONTOLOGY REPORT - ANNOTATIONS


Term:CD8-positive, alpha-beta T cell differentiation
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Accession:GO:0043374 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: CD8-positive, alpha-beta T lymphocyte differentiation
 related_synonym: CD8-positive, alpha-beta T cell development


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CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IRF1 interferon regulatory factor 1 IEA Ensembl GO_REF:0000107 NCBI chr11:20,773,801...20,781,106
Ensembl chr11:20,760,120...20,781,608
JBrowse link
G OTUD5 OTU deubiquitinase 5 ISO (MGI:MGI:5621075|PMID:25470037) MGI PMID:25470037 MGI:MGI:5621075 NCBI chr  X:42,079,396...42,109,129
Ensembl chr  X:42,081,561...42,108,612
JBrowse link
G PAX1 paired box 1 IEA Ensembl GO_REF:0000107 NCBI chr24:1,742,570...1,752,593
Ensembl chr24:1,743,940...1,753,185
JBrowse link
G PSMB11 proteasome subunit beta 11 ISO (MGI:MGI:6392185|PMID:31915251)
(MGI:MGI:3712579|PMID:17540904)
MGI PMID:17540904, PMID:31915251 MGI:MGI:3712579, MGI:MGI:6392185 NCBI chr 8:3,355,239...3,356,505 JBrowse link
G SATB1 SATB homeobox 1 IEA Ensembl GO_REF:0000107 NCBI chr23:24,614,198...24,692,254
Ensembl chr23:24,593,489...24,690,977
JBrowse link
G TNFSF8 TNF superfamily member 8 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr11:68,979,498...69,006,898
Ensembl chr11:68,982,360...69,007,355
JBrowse link
CD8-positive, alpha-beta intraepithelial T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPR18 G protein-coupled receptor 18 IEA Ensembl GO_REF:0000107 NCBI chr22:49,288,226...49,294,567
Ensembl chr22:49,288,343...49,289,338
JBrowse link
CD8-positive, alpha-beta T cell differentiation involved in immune response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EOMES eomesodermin IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr23:16,476,498...16,512,406
Ensembl chr23:16,506,032...16,511,527
JBrowse link
G IFNG interferon gamma ISO (MGI:MGI:3829555|PMID:17277142) MGI PMID:17277142 MGI:MGI:3829555 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698
JBrowse link
CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator IEA Ensembl GO_REF:0000107 NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658
JBrowse link
G TOX thymocyte selection associated high mobility group box IEA Ensembl GO_REF:0000107 NCBI chr29:9,542,471...9,841,759
Ensembl chr29:9,544,561...9,842,034
JBrowse link
negative regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SOCS1 suppressor of cytokine signaling 1 IEA Ensembl GO_REF:0000107 NCBI chr 6:31,511,003...31,511,995
Ensembl chr 6:31,509,268...31,511,557
JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B IEA Ensembl GO_REF:0000107 NCBI chr 7:42,468,376...42,482,219
Ensembl chr 7:42,468,247...42,483,436
JBrowse link
positive regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBFB core-binding factor subunit beta ISO (MGI:MGI:3772948|PMID:18258917) UniProtKB PMID:18258917 MGI:MGI:3772948 NCBI chr 5:82,253,496...82,313,765
Ensembl chr 5:82,255,617...82,313,168
JBrowse link
G NCKAP1L NCK associated protein 1 like IEA Ensembl GO_REF:0000107 NCBI chr27:805,274...858,901
Ensembl chr27:805,310...843,439
JBrowse link
G RUNX1 RUNX family transcription factor 1 ISO (MGI:MGI:3772948|PMID:18258917) UniProtKB PMID:18258917 MGI:MGI:3772948 NCBI chr31:30,170,859...30,420,344
Ensembl chr31:30,170,605...30,420,839
JBrowse link
regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ZBTB7B zinc finger and BTB domain containing 7B ISO (MGI:MGI:3817343|PMID:18776904) MGI PMID:18776904 MGI:MGI:3817343 NCBI chr 7:42,468,376...42,482,219
Ensembl chr 7:42,468,247...42,483,436
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16162
    immune system process 2288
      leukocyte activation 884
        lymphocyte activation 713
          lymphocyte differentiation 386
            T cell differentiation 282
              alpha-beta T cell differentiation 122
                CD8-positive, alpha-beta T cell differentiation 16
                  CD8-positive, alpha-beta T cell differentiation involved in immune response 2
                  CD8-positive, alpha-beta T cell lineage commitment 2
                  CD8-positive, alpha-beta cytotoxic T cell differentiation 0
                  CD8-positive, alpha-beta intraepithelial T cell differentiation 1
                  CD8-positive, alpha-beta regulatory T cell differentiation 0
                  negative regulation of CD8-positive, alpha-beta T cell differentiation 2
                  positive regulation of CD8-positive, alpha-beta T cell differentiation 3
                  regulation of CD8-positive, alpha-beta T cell differentiation + 5
Path 2
Term Annotations click to browse term
  biological_process 16162
    developmental process 6290
      anatomical structure development 5839
        multicellular organism development 5337
          system development 4972
            immune system development 1020
              hematopoietic or lymphoid organ development 957
                hemopoiesis 910
                  leukocyte differentiation 571
                    lymphocyte differentiation 386
                      T cell differentiation 282
                        alpha-beta T cell differentiation 122
                          CD8-positive, alpha-beta T cell differentiation 16
                            CD8-positive, alpha-beta T cell differentiation involved in immune response 2
                            CD8-positive, alpha-beta T cell lineage commitment 2
                            CD8-positive, alpha-beta cytotoxic T cell differentiation 0
                            CD8-positive, alpha-beta intraepithelial T cell differentiation 1
                            CD8-positive, alpha-beta regulatory T cell differentiation 0
                            negative regulation of CD8-positive, alpha-beta T cell differentiation 2
                            positive regulation of CD8-positive, alpha-beta T cell differentiation 3
                            regulation of CD8-positive, alpha-beta T cell differentiation + 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.