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ONTOLOGY REPORT - ANNOTATIONS


Term:CD8-positive, alpha-beta T cell differentiation
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Accession:GO:0043374 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: CD8-positive, alpha-beta T lymphocyte differentiation
 related_synonym: CD8-positive, alpha-beta T cell development


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CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IRF1 interferon regulatory factor 1 IEA Ensembl GO_REF:0000107 NCBI chr 5:132,481,609...132,490,789
Ensembl chr 5:132,481,609...132,490,777
JBrowse link
G OTUD5 OTU deubiquitinase 5 ISO (MGI:MGI:5621075|PMID:25470037) MGI PMID:25470037 MGI:MGI:5621075 NCBI chr  X:48,922,024...48,960,783
Ensembl chr  X:48,922,028...48,958,386
JBrowse link
G PAX1 paired box 1 IEA Ensembl GO_REF:0000107 NCBI chr20:21,705,664...21,718,481
Ensembl chr20:21,705,659...21,718,486
JBrowse link
G PSMB11 proteasome subunit beta 11 IEA Ensembl GO_REF:0000107 NCBI chr14:23,042,212...23,044,060
Ensembl chr14:23,042,212...23,044,060
JBrowse link
G SATB1 SATB homeobox 1 IEA Ensembl GO_REF:0000107 NCBI chr 3:18,345,377...18,445,592
Ensembl chr 3:18,345,377...18,445,588
JBrowse link
G TNFSF8 TNF superfamily member 8 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:114,893,343...114,930,674
Ensembl chr 9:114,893,343...114,930,595
JBrowse link
CD8-positive, alpha-beta intraepithelial T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPR18 G protein-coupled receptor 18 IEA Ensembl GO_REF:0000107 NCBI chr13:99,254,713...99,262,498
Ensembl chr13:99,254,714...99,261,744
JBrowse link
CD8-positive, alpha-beta T cell differentiation involved in immune response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EOMES eomesodermin IMP
IBA
(PMID:17566017)
(PMID:21873635)
UniProtKB
GO_Central
PMID:17566017, PMID:21873635 NCBI chr 3:27,715,953...27,722,713
Ensembl chr 3:27,715,949...27,722,711
JBrowse link
G IFNG interferon gamma ISO (MGI:MGI:3829555|PMID:17277142) MGI PMID:17277142 MGI:MGI:3829555 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator IEA Ensembl GO_REF:0000107 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G TOX thymocyte selection associated high mobility group box ISS UniProt GO_REF:0000024 NCBI chr 8:58,805,412...59,119,293
Ensembl chr 8:58,805,412...59,119,147
JBrowse link
negative regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SOCS1 suppressor of cytokine signaling 1 ISS UniProtKB GO_REF:0000024 NCBI chr16:11,254,417...11,256,182
Ensembl chr16:11,254,408...11,256,204
Ensembl chr16:11,254,408...11,256,204
JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B ISS UniProtKB GO_REF:0000024 NCBI chr 1:155,002,628...155,018,523
Ensembl chr 1:155,002,630...155,018,522
JBrowse link
positive regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBFB core-binding factor subunit beta ISS UniProtKB GO_REF:0000024 NCBI chr16:67,029,149...67,101,058
Ensembl chr16:67,028,984...67,101,058
JBrowse link
G NCKAP1L NCK associated protein 1 like ISS UniProtKB GO_REF:0000024 NCBI chr12:54,497,752...54,548,243
Ensembl chr12:54,497,752...54,548,243
JBrowse link
G RUNX1 RUNX family transcription factor 1 ISS UniProt GO_REF:0000024 NCBI chr21:34,787,801...35,049,334
Ensembl chr21:34,787,801...36,004,667
JBrowse link
G RUNX3 RUNX family transcription factor 3 ISS UniProtKB GO_REF:0000024 NCBI chr 1:24,899,511...24,965,158
Ensembl chr 1:24,899,511...24,965,121
JBrowse link
regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ZBTB7B zinc finger and BTB domain containing 7B ISO (MGI:MGI:3817343|PMID:18776904) MGI PMID:18776904 MGI:MGI:3817343 NCBI chr 1:155,002,628...155,018,523
Ensembl chr 1:155,002,630...155,018,522
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18626
    immune system process 3565
      leukocyte activation 1471
        lymphocyte activation 885
          lymphocyte differentiation 431
            T cell differentiation 299
              alpha-beta T cell differentiation 126
                CD8-positive, alpha-beta T cell differentiation 17
                  CD8-positive, alpha-beta T cell differentiation involved in immune response 2
                  CD8-positive, alpha-beta T cell lineage commitment 2
                  CD8-positive, alpha-beta cytotoxic T cell differentiation 0
                  CD8-positive, alpha-beta intraepithelial T cell differentiation 1
                  CD8-positive, alpha-beta regulatory T cell differentiation 0
                  negative regulation of CD8-positive, alpha-beta T cell differentiation 2
                  positive regulation of CD8-positive, alpha-beta T cell differentiation 4
                  regulation of CD8-positive, alpha-beta T cell differentiation + 6
Path 2
Term Annotations click to browse term
  biological_process 18626
    developmental process 7445
      anatomical structure development 6849
        multicellular organism development 6327
          system development 5732
            immune system development 1215
              hematopoietic or lymphoid organ development 1146
                hemopoiesis 1098
                  leukocyte differentiation 631
                    lymphocyte differentiation 431
                      T cell differentiation 299
                        alpha-beta T cell differentiation 126
                          CD8-positive, alpha-beta T cell differentiation 17
                            CD8-positive, alpha-beta T cell differentiation involved in immune response 2
                            CD8-positive, alpha-beta T cell lineage commitment 2
                            CD8-positive, alpha-beta cytotoxic T cell differentiation 0
                            CD8-positive, alpha-beta intraepithelial T cell differentiation 1
                            CD8-positive, alpha-beta regulatory T cell differentiation 0
                            negative regulation of CD8-positive, alpha-beta T cell differentiation 2
                            positive regulation of CD8-positive, alpha-beta T cell differentiation 4
                            regulation of CD8-positive, alpha-beta T cell differentiation + 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.