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ONTOLOGY REPORT - ANNOTATIONS


Term:CD8-positive, alpha-beta T cell differentiation
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Accession:GO:0043374 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: CD8-positive, alpha-beta T lymphocyte differentiation
 related_synonym: CD8-positive, alpha-beta T cell development


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CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Irf1 interferon regulatory factor 1 IMP (MGI:MGI:1934722|PMID:11359801) MGI PMID:11359801 MGI:MGI:1934722 NCBI chr11:53,770,014...53,778,374
Ensembl chr11:53,770,014...53,778,374
JBrowse link
G Otud5 OTU domain containing 5 IMP (MGI:MGI:5621075|PMID:25470037) MGI PMID:25470037 MGI:MGI:5621075 NCBI chr  X:7,839,613...7,876,626
Ensembl chr  X:7,841,364...7,876,626
JBrowse link
G Pax1 paired box 1 IMP (MGI:MGI:3590033|PMID:16093716) MGI PMID:16093716 MGI:MGI:3590033 NCBI chr 2:147,361,930...147,375,049
Ensembl chr 2:147,361,925...147,393,295
JBrowse link
G Psmb11 proteasome (prosome, macropain) subunit, beta type, 11 IMP (MGI:MGI:3712579|PMID:17540904)
(MGI:MGI:6392185|PMID:31915251)
MGI PMID:17540904, PMID:31915251 MGI:MGI:3712579, MGI:MGI:6392185 NCBI chr14:54,625,310...54,629,556
Ensembl chr14:54,621,433...54,629,556
JBrowse link
G Satb1 special AT-rich sequence binding protein 1 IMP (MGI:MGI:1354431|PMID:10716941), (MGI:MGI:3577552|PMID:15814699) MGI PMID:10716941, PMID:15814699 MGI:MGI:1354431, MGI:MGI:3577552 NCBI chr17:51,736,187...51,833,290
Ensembl chr17:51,736,187...51,833,290
JBrowse link
G Tnfsf8 tumor necrosis factor (ligand) superfamily, member 8 IMP
IBA
(MGI:MGI:3700858|PMID:16177108)
(MGI:MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:16177108, PMID:21873635 MGI:MGI:3700858, MGI:MGI:6201960 NCBI chr 4:63,831,202...63,861,508
Ensembl chr 4:63,831,308...63,861,347
JBrowse link
CD8-positive, alpha-beta intraepithelial T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpr18 G protein-coupled receptor 18 IMP
IDA
(MGI:MGI:5629467|PMID:25348153) MGI PMID:25348153 MGI:MGI:5629467 NCBI chr14:121,911,434...121,915,888
Ensembl chr14:121,911,253...121,915,781
JBrowse link
CD8-positive, alpha-beta T cell differentiation involved in immune response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eomes eomesodermin IDA
IBA
ISO
(MGI:MGI:4399030|PMID:14605368)
(MGI:MGI:6201960|PMID:21873635)
UniProtKB
GO_Central
MGI
PMID:14605368, PMID:21873635 GO_REF:0000096, MGI:MGI:4399030, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr 9:118,478,186...118,486,132
Ensembl chr 9:118,478,212...118,486,132
JBrowse link
G Ifng interferon gamma IDA (MGI:MGI:3829555|PMID:17277142) MGI PMID:17277142 MGI:MGI:3829555 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 B cell leukemia/lymphoma 2 IMP (MGI:MGI:2156164|PMID:8170972) MGI PMID:8170972 MGI:MGI:2156164 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Tox thymocyte selection-associated high mobility group box IMP (MGI:MGI:2159528|PMID:11850626), (MGI:MGI:3045816|PMID:15078895) UniProt PMID:11850626, PMID:15078895 MGI:MGI:2159528, MGI:MGI:3045816 NCBI chr 4:6,686,353...6,991,557
Ensembl chr 4:6,686,353...6,991,557
JBrowse link
negative regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Socs1 suppressor of cytokine signaling 1 IMP (MGI:MGI:6140589|PMID:24880459) UniProtKB PMID:24880459 MGI:MGI:6140589 NCBI chr16:10,783,808...10,785,536
Ensembl chr16:10,782,240...10,785,536
JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B IMP (MGI:MGI:5446998|PMID:22730529), (MGI:MGI:6140589|PMID:24880459) UniProtKB PMID:22730529, PMID:24880459 MGI:MGI:5446998, MGI:MGI:6140589 NCBI chr 3:89,377,644...89,393,673
Ensembl chr 3:89,377,644...89,394,776
JBrowse link
positive regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbfb core binding factor beta IMP (MGI:MGI:3772948|PMID:18258917) UniProtKB PMID:18258917 MGI:MGI:3772948 NCBI chr 8:105,170,674...105,217,989
Ensembl chr 8:105,170,674...105,217,989
JBrowse link
G Nckap1l NCK associated protein 1 like IMP (MGI:MGI:3818191|PMID:19015308) UniProtKB PMID:19015308 MGI:MGI:3818191 NCBI chr15:103,453,783...103,502,860
Ensembl chr15:103,453,794...103,498,810
JBrowse link
G Runx1 runt related transcription factor 1 IDA (MGI:MGI:3772948|PMID:18258917) UniProtKB PMID:18258917 MGI:MGI:3772948 NCBI chr16:92,601,466...92,826,074
Ensembl chr16:92,601,466...92,826,149
JBrowse link
G Runx3 runt related transcription factor 3 IMP (MGI:MGI:3772948|PMID:18258917) UniProtKB PMID:18258917 MGI:MGI:3772948 NCBI chr 4:135,120,645...135,177,990
Ensembl chr 4:135,120,652...135,177,990
JBrowse link
regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zbtb7b zinc finger and BTB domain containing 7B IMP (MGI:MGI:3817343|PMID:18776904) MGI PMID:18776904 MGI:MGI:3817343 NCBI chr 3:89,377,644...89,393,673
Ensembl chr 3:89,377,644...89,394,776
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23369
    immune system process 2925
      leukocyte activation 1084
        lymphocyte activation 900
          lymphocyte differentiation 426
            T cell differentiation 295
              alpha-beta T cell differentiation 127
                CD8-positive, alpha-beta T cell differentiation 17
                  CD8-positive, alpha-beta T cell differentiation involved in immune response 2
                  CD8-positive, alpha-beta T cell lineage commitment 2
                  CD8-positive, alpha-beta cytotoxic T cell differentiation 0
                  CD8-positive, alpha-beta intraepithelial T cell differentiation 1
                  CD8-positive, alpha-beta regulatory T cell differentiation 0
                  negative regulation of CD8-positive, alpha-beta T cell differentiation 2
                  positive regulation of CD8-positive, alpha-beta T cell differentiation 4
                  regulation of CD8-positive, alpha-beta T cell differentiation + 6
Path 2
Term Annotations click to browse term
  biological_process 23369
    developmental process 7016
      anatomical structure development 6488
        multicellular organism development 5954
          system development 5368
            immune system development 1118
              hematopoietic or lymphoid organ development 1052
                hemopoiesis 1002
                  leukocyte differentiation 624
                    lymphocyte differentiation 426
                      T cell differentiation 295
                        alpha-beta T cell differentiation 127
                          CD8-positive, alpha-beta T cell differentiation 17
                            CD8-positive, alpha-beta T cell differentiation involved in immune response 2
                            CD8-positive, alpha-beta T cell lineage commitment 2
                            CD8-positive, alpha-beta cytotoxic T cell differentiation 0
                            CD8-positive, alpha-beta intraepithelial T cell differentiation 1
                            CD8-positive, alpha-beta regulatory T cell differentiation 0
                            negative regulation of CD8-positive, alpha-beta T cell differentiation 2
                            positive regulation of CD8-positive, alpha-beta T cell differentiation 4
                            regulation of CD8-positive, alpha-beta T cell differentiation + 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.