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ONTOLOGY REPORT - ANNOTATIONS


Term:CD8-positive, alpha-beta T cell differentiation
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Accession:GO:0043374 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: CD8-positive, alpha-beta T lymphocyte differentiation
 related_synonym: CD8-positive, alpha-beta T cell development


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CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IRF1 interferon regulatory factor 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:134,776,122...134,783,646
Ensembl chr 2:134,776,134...134,783,646
JBrowse link
G OTUD5 OTU deubiquitinase 5 ISO (MGI:MGI:5621075|PMID:25470037) MGI PMID:25470037 MGI:MGI:5621075 NCBI chr  X:43,001,491...43,029,471
Ensembl chr  X:43,000,227...43,029,465
JBrowse link
G PAX1 paired box 1 IEA Ensembl GO_REF:0000107 NCBI chr17:29,421,117...29,436,481
Ensembl chr17:29,422,129...29,431,990
JBrowse link
G PSMB11 proteasome subunit beta 11 IEA Ensembl GO_REF:0000107 NCBI chr 7:76,005,609...76,006,728
Ensembl chr 7:76,005,612...76,006,703
JBrowse link
G SATB1 SATB homeobox 1 IEA Ensembl GO_REF:0000107 NCBI chr13:5,315,985...5,410,686
Ensembl chr13:5,314,358...5,417,591
JBrowse link
G TNFSF8 TNF superfamily member 8 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:255,436,206...255,459,020
Ensembl chr 1:255,432,969...255,459,073
JBrowse link
CD8-positive, alpha-beta intraepithelial T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPR18 G protein-coupled receptor 18 IEA Ensembl GO_REF:0000107 NCBI chr11:68,187,402...68,191,622
Ensembl chr11:68,187,327...68,191,269
JBrowse link
CD8-positive, alpha-beta T cell differentiation involved in immune response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EOMES eomesodermin IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:14,209,590...14,216,184
Ensembl chr13:14,210,083...14,215,797
JBrowse link
G IFNG interferon gamma ISO (MGI:MGI:3829555|PMID:17277142) MGI PMID:17277142 MGI:MGI:3829555 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,848...32,482,752
JBrowse link
CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator ISO (MGI:MGI:2156164|PMID:8170972) MGI PMID:8170972 MGI:MGI:2156164 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G TOX thymocyte selection associated high mobility group box IEA Ensembl GO_REF:0000107 NCBI chr 4:73,810,180...74,115,352
Ensembl chr 4:73,810,188...74,134,229
JBrowse link
negative regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SOCS1 suppressor of cytokine signaling 1 IEA Ensembl GO_REF:0000107 NCBI chr 3:31,879,143...31,883,041
Ensembl chr 3:31,881,225...31,884,969
JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B IEA Ensembl GO_REF:0000107 NCBI chr 4:94,780,404...94,796,722
Ensembl chr 4:94,780,401...94,798,588
JBrowse link
positive regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBFB core-binding factor subunit beta IEA Ensembl GO_REF:0000107 NCBI chr 6:27,684,320...27,750,856
Ensembl chr 6:27,684,030...27,776,751
JBrowse link
G NCKAP1L NCK associated protein 1 like IEA Ensembl GO_REF:0000107 NCBI chr 5:19,677,613...19,720,550
Ensembl chr 5:19,677,875...19,723,132
JBrowse link
G RUNX1 RUNX family transcription factor 1 ISO (MGI:MGI:3772948|PMID:18258917) UniProtKB PMID:18258917 MGI:MGI:3772948 NCBI chr13:198,371,835...198,635,648
Ensembl chr13:198,371,835...198,638,189
JBrowse link
G RUNX3 RUNX family transcription factor 3 ISO (MGI:MGI:3772948|PMID:18258917) UniProtKB PMID:18258917 MGI:MGI:3772948 NCBI chr 6:82,531,203...82,595,044
Ensembl chr 6:82,531,215...82,595,026
JBrowse link
regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ZBTB7B zinc finger and BTB domain containing 7B ISO (MGI:MGI:3817343|PMID:18776904) MGI PMID:18776904 MGI:MGI:3817343 NCBI chr 4:94,780,404...94,796,722
Ensembl chr 4:94,780,401...94,798,588
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16524
    immune system process 2296
      leukocyte activation 894
        lymphocyte activation 724
          lymphocyte differentiation 398
            T cell differentiation 284
              alpha-beta T cell differentiation 121
                CD8-positive, alpha-beta T cell differentiation 17
                  CD8-positive, alpha-beta T cell differentiation involved in immune response 2
                  CD8-positive, alpha-beta T cell lineage commitment 2
                  CD8-positive, alpha-beta cytotoxic T cell differentiation 0
                  CD8-positive, alpha-beta intraepithelial T cell differentiation 1
                  CD8-positive, alpha-beta regulatory T cell differentiation 0
                  negative regulation of CD8-positive, alpha-beta T cell differentiation 2
                  positive regulation of CD8-positive, alpha-beta T cell differentiation 4
                  regulation of CD8-positive, alpha-beta T cell differentiation + 6
Path 2
Term Annotations click to browse term
  biological_process 16524
    developmental process 6285
      anatomical structure development 5826
        multicellular organism development 5330
          system development 4955
            immune system development 1027
              hematopoietic or lymphoid organ development 964
                hemopoiesis 916
                  leukocyte differentiation 579
                    lymphocyte differentiation 398
                      T cell differentiation 284
                        alpha-beta T cell differentiation 121
                          CD8-positive, alpha-beta T cell differentiation 17
                            CD8-positive, alpha-beta T cell differentiation involved in immune response 2
                            CD8-positive, alpha-beta T cell lineage commitment 2
                            CD8-positive, alpha-beta cytotoxic T cell differentiation 0
                            CD8-positive, alpha-beta intraepithelial T cell differentiation 1
                            CD8-positive, alpha-beta regulatory T cell differentiation 0
                            negative regulation of CD8-positive, alpha-beta T cell differentiation 2
                            positive regulation of CD8-positive, alpha-beta T cell differentiation 4
                            regulation of CD8-positive, alpha-beta T cell differentiation + 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.