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ONTOLOGY REPORT - ANNOTATIONS


Term:CD8-positive, alpha-beta T cell differentiation
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Accession:GO:0043374 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: CD8-positive, alpha-beta T lymphocyte differentiation
 related_synonym: CD8-positive, alpha-beta T cell development


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CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Irf1 interferon regulatory factor 1 ISO
IEA
MGI:MGI:1857205 (MGI:MGI:1934722|PMID:11359801)
GO_REF:0000107
RGD
Ensembl
PMID:11359801 GO_REF:0000107, MGI:MGI:1934722 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Otud5 OTU deubiquitinase 5 ISO MGI:MGI:2386448|MGI:MGI:5752247 (MGI:MGI:5621075|PMID:25470037) RGD PMID:25470037 MGI:MGI:5621075 NCBI chr  X:15,471,212...15,504,372
Ensembl chr  X:15,471,211...15,504,165
JBrowse link
G Pax1 paired box 1 ISO MGI:MGI:3603176 (MGI:MGI:3590033|PMID:16093716) RGD PMID:16093716 MGI:MGI:3590033 NCBI chr 3:141,577,124...141,589,849
Ensembl chr 3:141,577,504...141,589,849
JBrowse link
G Psmb11 proteasome subunit beta 11 ISO MGI:MGI:3716870 (MGI:MGI:3712579|PMID:17540904), (MGI:MGI:6392185|PMID:31915251) RGD PMID:17540904, PMID:31915251 MGI:MGI:3712579, MGI:MGI:6392185 NCBI chr15:33,267,413...33,273,587
Ensembl chr15:33,271,015...33,271,920
JBrowse link
G Satb1 SATB homeobox 1 ISO MGI:MGI:2386676 (MGI:MGI:1354431|PMID:10716941), (MGI:MGI:3577552|PMID:15814699) RGD PMID:10716941, PMID:15814699 MGI:MGI:1354431, MGI:MGI:3577552 NCBI chr 9:2,181,135...2,277,949
Ensembl chr 9:2,190,915...2,274,629
JBrowse link
G Tnfsf8 TNF superfamily member 8 ISO
IBA
MGI:MGI:3054968 (MGI:MGI:3700858|PMID:16177108)
PMID:21873635
RGD PMID:16177108, PMID:21873635 MGI:MGI:3700858, RGD:13792537 NCBI chr 5:79,664,779...79,691,547
Ensembl chr 5:79,664,765...79,691,258
JBrowse link
CD8-positive, alpha-beta intraepithelial T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpr18 G protein-coupled receptor 18 ISO MGI:MGI:5708707 (MGI:MGI:5629467|PMID:25348153) RGD PMID:25348153 MGI:MGI:5629467 NCBI chr15:108,323,157...108,326,907
Ensembl chr15:108,323,179...108,326,907
JBrowse link
CD8-positive, alpha-beta T cell differentiation involved in immune response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eomes eomesodermin ISO
IBA
(PMID:17566017)
PMID:21873635
(MGI:MGI:4399030|PMID:14605368)
RGD PMID:14605368, PMID:17566017, PMID:21873635 MGI:MGI:4399030, RGD:13792537 NCBI chr 8:127,144,367...127,152,618
Ensembl chr 8:127,144,903...127,151,493
JBrowse link
G Ifng interferon gamma ISO (MGI:MGI:3829555|PMID:17277142) RGD PMID:17277142 MGI:MGI:3829555 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator ISO
IEA
MGI:MGI:2156165 (MGI:MGI:2156164|PMID:8170972)
GO_REF:0000107
RGD
Ensembl
PMID:8170972 GO_REF:0000107, MGI:MGI:2156164 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Tox thymocyte selection-associated high mobility group box ISO (MGI:MGI:2159528|PMID:11850626), (MGI:MGI:3045816|PMID:15078895) RGD PMID:11850626, PMID:15078895 MGI:MGI:2159528, MGI:MGI:3045816 NCBI chr 5:19,892,698...20,189,721
Ensembl chr 5:19,892,698...20,189,721
JBrowse link
negative regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Socs1 suppressor of cytokine signaling 1 ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:MGI:6140589|PMID:24880459)
UniProt
Ensembl
RGD
PMID:24880459 GO_REF:0000024, GO_REF:0000107, MGI:MGI:6140589 NCBI chr10:4,956,795...4,958,472
Ensembl chr10:4,957,326...4,958,461
JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B ISO (MGI:MGI:5446998|PMID:22730529), (MGI:MGI:6140589|PMID:24880459) RGD PMID:22730529, PMID:24880459 MGI:MGI:5446998, MGI:MGI:6140589 NCBI chr 2:188,704,989...188,719,674
Ensembl chr 2:188,704,687...188,718,704
JBrowse link
positive regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbfb core-binding factor subunit beta ISO (MGI:MGI:3772948|PMID:18258917) RGD PMID:18258917 MGI:MGI:3772948 NCBI chr19:37,127,508...37,171,075
Ensembl chr19:37,127,508...37,171,069
JBrowse link
G Nckap1l NCK associated protein 1 like ISO
ISS
(MGI:MGI:3818191|PMID:19015308)
GO_REF:0000024
RGD
UniProt
PMID:19015308 GO_REF:0000024, MGI:MGI:3818191 NCBI chr 7:145,068,239...145,113,507
Ensembl chr 7:145,068,286...145,113,507
JBrowse link
G Runx1 RUNX family transcription factor 1 ISS
ISO
GO_REF:0000024
(MGI:MGI:3772948|PMID:18258917)
UniProt
RGD
PMID:18258917 GO_REF:0000024, MGI:MGI:3772948 NCBI chr11:32,765,147...33,003,061
Ensembl chr11:32,769,165...33,003,021
JBrowse link
G Runx3 RUNX family transcription factor 3 ISO (MGI:MGI:3772948|PMID:18258917) RGD PMID:18258917 MGI:MGI:3772948 NCBI chr 5:153,507,093...153,531,137
Ensembl chr 5:153,507,093...153,531,137
JBrowse link
regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zbtb7b zinc finger and BTB domain containing 7B ISO MGI:MGI:3817628 (MGI:MGI:3817343|PMID:18776904) RGD PMID:18776904 MGI:MGI:3817343 NCBI chr 2:188,704,989...188,719,674
Ensembl chr 2:188,704,687...188,718,704
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    immune system process 2837
      leukocyte activation 1057
        lymphocyte activation 870
          lymphocyte differentiation 407
            T cell differentiation 289
              alpha-beta T cell differentiation 122
                CD8-positive, alpha-beta T cell differentiation 17
                  CD8-positive, alpha-beta T cell differentiation involved in immune response 2
                  CD8-positive, alpha-beta T cell lineage commitment 2
                  CD8-positive, alpha-beta cytotoxic T cell differentiation 0
                  CD8-positive, alpha-beta intraepithelial T cell differentiation 1
                  CD8-positive, alpha-beta regulatory T cell differentiation 0
                  negative regulation of CD8-positive, alpha-beta T cell differentiation 2
                  positive regulation of CD8-positive, alpha-beta T cell differentiation 4
                  regulation of CD8-positive, alpha-beta T cell differentiation + 6
Path 2
Term Annotations click to browse term
  biological_process 20014
    developmental process 6812
      anatomical structure development 6256
        multicellular organism development 5735
          system development 5272
            immune system development 1073
              hematopoietic or lymphoid organ development 1008
                hemopoiesis 956
                  leukocyte differentiation 595
                    lymphocyte differentiation 407
                      T cell differentiation 289
                        alpha-beta T cell differentiation 122
                          CD8-positive, alpha-beta T cell differentiation 17
                            CD8-positive, alpha-beta T cell differentiation involved in immune response 2
                            CD8-positive, alpha-beta T cell lineage commitment 2
                            CD8-positive, alpha-beta cytotoxic T cell differentiation 0
                            CD8-positive, alpha-beta intraepithelial T cell differentiation 1
                            CD8-positive, alpha-beta regulatory T cell differentiation 0
                            negative regulation of CD8-positive, alpha-beta T cell differentiation 2
                            positive regulation of CD8-positive, alpha-beta T cell differentiation 4
                            regulation of CD8-positive, alpha-beta T cell differentiation + 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.