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ONTOLOGY REPORT - ANNOTATIONS


Term:CD8-positive, alpha-beta T cell differentiation
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Accession:GO:0043374 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: CD8-positive, alpha-beta T lymphocyte differentiation
 related_synonym: CD8-positive, alpha-beta T cell development


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CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Irf1 interferon regulatory factor 1 ISO (MGI:MGI:1934722|PMID:11359801) MGI PMID:11359801 MGI:MGI:1934722 NCBI chrNW_004936647:2,686,247...2,693,633 JBrowse link
G Otud5 OTU deubiquitinase 5 ISO (MGI:MGI:5621075|PMID:25470037) MGI PMID:25470037 MGI:MGI:5621075 NCBI chrNW_004936721:847,360...876,912 JBrowse link
G Pax1 paired box 1 ISO (MGI:MGI:3590033|PMID:16093716) MGI PMID:16093716 MGI:MGI:3590033 NCBI chrNW_004936620:3,765,481...3,773,779 JBrowse link
G Psmb11 proteasome subunit beta 11 ISO (MGI:MGI:6392185|PMID:31915251)
(MGI:MGI:3712579|PMID:17540904)
MGI PMID:17540904, PMID:31915251 MGI:MGI:3712579, MGI:MGI:6392185 NCBI chrNW_004936722:1,279,867...1,281,232 JBrowse link
G Satb1 SATB homeobox 1 ISO (MGI:MGI:1354431|PMID:10716941), (MGI:MGI:3577552|PMID:15814699) MGI PMID:10716941, PMID:15814699 MGI:MGI:1354431, MGI:MGI:3577552 NCBI chrNW_004936473:10,906,059...11,001,007 JBrowse link
G Tnfsf8 TNF superfamily member 8 ISO (MGI:MGI:3700858|PMID:16177108) MGI PMID:16177108 MGI:MGI:3700858 NCBI chrNW_004936487:4,057,637...4,081,207 JBrowse link
CD8-positive, alpha-beta intraepithelial T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpr18 G protein-coupled receptor 18 ISO (MGI:MGI:5629467|PMID:25348153) MGI PMID:25348153 MGI:MGI:5629467 NCBI chrNW_004936472:11,240,287...11,242,157 JBrowse link
CD8-positive, alpha-beta T cell differentiation involved in immune response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eomes eomesodermin ISO (MGI:MGI:4399030|PMID:14605368)
(PMID:17566017)
UniProtKB PMID:14605368, PMID:17566017 MGI:MGI:4399030 NCBI chrNW_004936473:18,825,969...18,833,179 JBrowse link
G Ifng interferon gamma ISO (MGI:MGI:3829555|PMID:17277142) MGI PMID:17277142 MGI:MGI:3829555 NCBI chrNW_004936545:6,139,130...6,144,543 JBrowse link
CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2 apoptosis regulator ISO (MGI:MGI:2156164|PMID:8170972) MGI PMID:8170972 MGI:MGI:2156164 NCBI chrNW_004936497:2,209,136...2,373,580 JBrowse link
G Tox thymocyte selection associated high mobility group box ISO (MGI:MGI:2159528|PMID:11850626), (MGI:MGI:3045816|PMID:15078895) UniProt PMID:11850626, PMID:15078895 MGI:MGI:2159528, MGI:MGI:3045816 NCBI chrNW_004936496:13,847,210...14,146,110 JBrowse link
negative regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Socs1 suppressor of cytokine signaling 1 ISO (MGI:MGI:6140589|PMID:24880459) UniProtKB PMID:24880459 MGI:MGI:6140589 NCBI chrNW_004936530:9,312,965...9,315,593 JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B ISO (MGI:MGI:5446998|PMID:22730529), (MGI:MGI:6140589|PMID:24880459) UniProtKB PMID:22730529, PMID:24880459 MGI:MGI:5446998, MGI:MGI:6140589 NCBI chrNW_004936580:4,546,139...4,560,157 JBrowse link
positive regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbfb core-binding factor subunit beta ISO (MGI:MGI:3772948|PMID:18258917) UniProtKB PMID:18258917 MGI:MGI:3772948 NCBI chrNW_004936475:17,537,273...17,589,383 JBrowse link
G Nckap1l NCK associated protein 1 like ISO (MGI:MGI:3818191|PMID:19015308) UniProtKB PMID:19015308 MGI:MGI:3818191 NCBI chrNW_004936512:11,683,330...11,734,423 JBrowse link
G Runx3 RUNX family transcription factor 3 ISO (MGI:MGI:3772948|PMID:18258917) UniProtKB PMID:18258917 MGI:MGI:3772948 NCBI chrNW_004936474:9,751,946...9,802,910 JBrowse link
regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zbtb7b zinc finger and BTB domain containing 7B ISO (MGI:MGI:3817343|PMID:18776904) MGI PMID:18776904 MGI:MGI:3817343 NCBI chrNW_004936580:4,546,139...4,560,157 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11962
    immune system process 1913
      leukocyte activation 787
        lymphocyte activation 635
          lymphocyte differentiation 339
            T cell differentiation 254
              alpha-beta T cell differentiation 111
                CD8-positive, alpha-beta T cell differentiation 16
                  CD8-positive, alpha-beta T cell differentiation involved in immune response 2
                  CD8-positive, alpha-beta T cell lineage commitment 2
                  CD8-positive, alpha-beta cytotoxic T cell differentiation 0
                  CD8-positive, alpha-beta intraepithelial T cell differentiation 1
                  CD8-positive, alpha-beta regulatory T cell differentiation 0
                  negative regulation of CD8-positive, alpha-beta T cell differentiation 2
                  positive regulation of CD8-positive, alpha-beta T cell differentiation 3
                  regulation of CD8-positive, alpha-beta T cell differentiation + 5
Path 2
Term Annotations click to browse term
  biological_process 11962
    developmental process 5628
      anatomical structure development 5266
        multicellular organism development 4832
          system development 4554
            immune system development 929
              hematopoietic or lymphoid organ development 869
                hemopoiesis 822
                  leukocyte differentiation 509
                    lymphocyte differentiation 339
                      T cell differentiation 254
                        alpha-beta T cell differentiation 111
                          CD8-positive, alpha-beta T cell differentiation 16
                            CD8-positive, alpha-beta T cell differentiation involved in immune response 2
                            CD8-positive, alpha-beta T cell lineage commitment 2
                            CD8-positive, alpha-beta cytotoxic T cell differentiation 0
                            CD8-positive, alpha-beta intraepithelial T cell differentiation 1
                            CD8-positive, alpha-beta regulatory T cell differentiation 0
                            negative regulation of CD8-positive, alpha-beta T cell differentiation 2
                            positive regulation of CD8-positive, alpha-beta T cell differentiation 3
                            regulation of CD8-positive, alpha-beta T cell differentiation + 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.