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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of MAP kinase activity
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Accession:GO:0043407 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
Synonyms:exact_synonym: down regulation of MAPK activity;   downregulation of MAPK activity;   negative regulation of mitogen activated protein kinase activity
 narrow_synonym: inhibition of MAPK activity


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negative regulation of MAP kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing ISS
IEA
UniProt
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,684...124,646,648
JBrowse link
G AGT angiotensinogen IEA Ensembl GO_REF:0000107 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428
JBrowse link
G APOE apolipoprotein E IEA Ensembl GO_REF:0000107 NCBI chr 6:51,373,113...51,375,333
Ensembl chr 6:51,372,259...51,377,794
JBrowse link
G BMP4 bone morphogenetic protein 4 IEA Ensembl GO_REF:0000107 NCBI chr 1:183,415,989...183,422,888
Ensembl chr 1:183,416,134...183,792,417
JBrowse link
G BMP7 bone morphogenetic protein 7 IEA Ensembl GO_REF:0000107 NCBI chr17:57,567,770...57,676,516
Ensembl chr17:57,584,091...57,676,944
JBrowse link
G CAV1 caveolin 1 ISO (MGI:3703676|PMID:12388746) MGI PMID:12388746 MGI:3703676 NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465
JBrowse link
G CAV3 caveolin 3 IEA Ensembl GO_REF:0000107 NCBI chr13:65,117,868...65,130,886
Ensembl chr13:65,117,776...65,134,066
JBrowse link
G CBLC Cbl proto-oncogene C IEA Ensembl GO_REF:0000107 NCBI chr 6:51,274,717...51,292,546
Ensembl chr 6:51,276,504...51,296,369
JBrowse link
G CD300A CD300a molecule ISO (PMID:16254138) UniProtKB PMID:16254138 NCBI chr12:6,665,578...6,681,329 JBrowse link
G CDK5RAP3 CDK5 regulatory subunit associated protein 3 IEA Ensembl GO_REF:0000107 NCBI chr12:24,224,262...24,234,468
Ensembl chr12:24,224,256...24,234,467
JBrowse link
G DAB2IP DAB2 interacting protein IEA Ensembl GO_REF:0000107 NCBI chr 1:261,732,280...261,859,833
Ensembl chr 1:261,659,660...261,859,830
JBrowse link
G DEFB114 defensin beta 114 IEA Ensembl GO_REF:0000107 NCBI chr 7:43,982,219...43,993,156
Ensembl chr 7:43,982,233...43,993,156
JBrowse link
G DUSP1 dual specificity phosphatase 1 ISO (PMID:7593328) UniProtKB PMID:7593328 NCBI chr16:51,457,924...51,461,095
Ensembl chr16:51,458,020...51,461,086
JBrowse link
G DUSP7 dual specificity phosphatase 7 ISO (PMID:9788880) UniProtKB PMID:9788880 NCBI chr13:34,199,404...34,210,621 JBrowse link
G FEM1A fem-1 homolog A ISO (MGI:3790904|PMID:18270204) MGI PMID:18270204 MGI:3790904 NCBI chr 2:74,041,391...74,045,123
Ensembl chr 2:74,042,989...74,044,983
JBrowse link
G GBA glucosylceramidase beta IEA Ensembl GO_REF:0000107 NCBI chr 4:94,583,905...94,606,689
Ensembl chr 4:94,584,196...94,609,745
JBrowse link
G GSK3B glycogen synthase kinase 3 beta ISO RGD PMID:17182785 RGD:2301767 NCBI chr13:140,136,109...140,370,197
Ensembl chr13:140,136,158...140,369,574
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase IEA Ensembl GO_REF:0000107 NCBI chr 2:84,380,245...84,401,117
Ensembl chr 2:84,380,225...84,402,956
JBrowse link
G HYAL2 hyaluronidase 2 ISS
IEA
UniProt
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr13:32,805,220...32,813,684
Ensembl chr13:32,805,223...32,815,335
JBrowse link
G INPP5K inositol polyphosphate-5-phosphatase K IEA Ensembl GO_REF:0000107 NCBI chr12:47,717,898...47,738,540
Ensembl chr12:47,717,907...47,738,477
JBrowse link
G INPPL1 inositol polyphosphate phosphatase like 1 ISO RGD PMID:12933696 RGD:1626126 NCBI chr 9:6,793,971...6,807,286
Ensembl chr 9:6,792,884...6,808,028
JBrowse link
G IRAK3 interleukin 1 receptor associated kinase 3 IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr 5:30,524,704...30,601,067
Ensembl chr 5:30,525,948...30,609,922
JBrowse link
G KNG1 kininogen 1 ISO in ConA- or PHA-stimulated Jurkat cells RGD PMID:16140359 RGD:1600541 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,277...124,557,376
JBrowse link
G LOC100739163 glutathione S-transferase P-like ISO (PMID:11408560) BHF-UCL PMID:11408560 NCBI chr 2:4,978,761...4,982,233 JBrowse link
G LOC110258578 interleukin-1 beta-like ISO (MGI:3828398|PMID:16865359) BHF-UCL PMID:16865359 MGI:3828398
G LYN LYN proto-oncogene, Src family tyrosine kinase IEA Ensembl GO_REF:0000107 NCBI chr 4:75,793,273...75,903,710
Ensembl chr 4:75,786,099...75,868,591
JBrowse link
G MAPK7 mitogen-activated protein kinase 7 ISO (MGI:1933463|PMID:11139578), (MGI:2135469|PMID:11381262) MGI PMID:11139578, PMID:11381262 MGI:1933463, MGI:2135469 NCBI chr12:60,144,138...60,148,743
Ensembl chr12:60,128,686...60,149,270
JBrowse link
G NF1 neurofibromin 1 IEA Ensembl GO_REF:0000107 NCBI chr12:43,487,098...43,754,205
Ensembl chr12:43,489,171...43,754,176
JBrowse link
G NUP62 nucleoporin 62 IEA Ensembl GO_REF:0000107 NCBI chr 6:54,921,627...54,945,705
Ensembl chr 6:54,921,627...54,923,227
JBrowse link
G PAQR3 progestin and adipoQ receptor family member 3 IEA Ensembl GO_REF:0000107 NCBI chr 8:138,646,626...138,670,166
Ensembl chr 8:138,646,625...138,669,126
JBrowse link
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta ISO (MGI:6444553|PMID:30496354) BHF-UCL PMID:30496354 MGI:6444553 NCBI chr13:79,427,033...79,610,840
Ensembl chr13:79,425,812...79,610,840
JBrowse link
G PRKCD protein kinase C delta IEA Ensembl GO_REF:0000107 NCBI chr13:35,290,835...35,323,245
Ensembl chr13:35,290,264...35,323,356
JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 IEA Ensembl GO_REF:0000107 NCBI chr17:52,017,100...52,086,747
Ensembl chr17:52,017,104...52,086,736
JBrowse link
G PTPN5 protein tyrosine phosphatase non-receptor type 5 ISO RGD PMID:9857190 RGD:10044039 NCBI chr 2:40,458,865...40,521,470
Ensembl chr 2:40,458,903...40,523,363
JBrowse link
G PTPN6 protein tyrosine phosphatase non-receptor type 6 IEA Ensembl GO_REF:0000107 NCBI chr 5:63,762,109...63,779,086
Ensembl chr 5:63,762,112...63,808,350
JBrowse link
G PTPRJ protein tyrosine phosphatase receptor type J IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr 2:14,548,489...14,724,823
Ensembl chr 2:14,548,425...14,726,715
JBrowse link
G RGS14 regulator of G protein signaling 14 IEA Ensembl GO_REF:0000107 NCBI chr 2:80,574,411...80,589,998
Ensembl chr 2:80,574,411...80,590,003
JBrowse link
G RGS2 regulator of G protein signaling 2 IEA Ensembl GO_REF:0000107 NCBI chr10:936,836...940,083
Ensembl chr10:936,789...940,098
JBrowse link
G SH2B3 SH2B adaptor protein 3 IEA Ensembl GO_REF:0000107 NCBI chr14:32,623,286...32,664,606
Ensembl chr14:32,623,308...32,664,598
JBrowse link
G SMPD1 sphingomyelin phosphodiesterase 1 IEA Ensembl GO_REF:0000107 NCBI chr 9:3,324,091...3,328,493
Ensembl chr 9:3,324,091...3,328,373
JBrowse link
G SORL1 sortilin related receptor 1 IEA Ensembl GO_REF:0000107 NCBI chr 9:48,435,350...48,653,670
Ensembl chr 9:48,435,016...48,653,655
JBrowse link
G SPRY1 sprouty RTK signaling antagonist 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:100,449,476...100,863,780
Ensembl chr 8:100,450,247...100,863,446
JBrowse link
G SPRY2 sprouty RTK signaling antagonist 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr11:52,153,695...52,158,766
Ensembl chr11:52,153,704...52,160,497
JBrowse link
G SPRY3 sprouty RTK signaling antagonist 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:125,744,643...125,764,342
Ensembl chr  X:125,754,671...125,763,639
JBrowse link
G SPRY4 sprouty RTK signaling antagonist 4 IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr 2:143,877,334...143,891,280
Ensembl chr 2:143,875,353...143,892,292
JBrowse link
G STK38 serine/threonine kinase 38 IEA Ensembl GO_REF:0000107 NCBI chr 7:32,206,532...32,253,673
Ensembl chr 7:32,206,541...32,253,636
JBrowse link
G TSC2 TSC complex subunit 2 ISO RGD PMID:14612383 RGD:1580517 NCBI chr 3:39,898,924...39,935,579
Ensembl chr 3:39,898,922...39,937,371
JBrowse link
G UCHL1 ubiquitin C-terminal hydrolase L1 IEA Ensembl GO_REF:0000107 NCBI chr 8:32,353,766...32,367,288
Ensembl chr 8:32,353,246...32,367,323
JBrowse link
inactivation of MAPK activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV1 caveolin 1 IEA Ensembl GO_REF:0000107 NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465
JBrowse link
G DUSP1 dual specificity phosphatase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr16:51,457,924...51,461,095
Ensembl chr16:51,458,020...51,461,086
JBrowse link
G DUSP10 dual specificity phosphatase 10 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:10,866,446...10,905,852
Ensembl chr10:10,866,448...10,905,857
JBrowse link
G DUSP14 dual specificity phosphatase 14 IEA GOC GO_REF:0000108 NCBI chr12:38,941,052...38,978,568
Ensembl chr12:38,941,089...38,978,448
JBrowse link
G DUSP16 dual specificity phosphatase 16 IEA Ensembl
GOC
GO_REF:0000107, GO_REF:0000108 NCBI chr 5:59,869,902...59,961,839
Ensembl chr 5:59,753,048...59,961,844
JBrowse link
G DUSP18 dual specificity phosphatase 18 IEA GOC GO_REF:0000108 NCBI chr14:47,534,152...47,550,953
Ensembl chr14:47,536,198...47,550,495
JBrowse link
G DUSP19 dual specificity phosphatase 19 ISO (MGI:2181737|PMID:11959861) MGI PMID:11959861 MGI:2181737 NCBI chr15:88,549,250...88,574,978
Ensembl chr15:88,549,275...88,574,243
JBrowse link
G DUSP2 dual specificity phosphatase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:47,052,443...47,054,816
Ensembl chr 3:47,052,457...47,054,816
JBrowse link
G DUSP21 dual specificity phosphatase 21 IEA GOC GO_REF:0000108 NCBI chr  X:39,929,707...39,930,539 JBrowse link
G DUSP29 dual specificity phosphatase 29 IEA GOC GO_REF:0000108 NCBI chr14:77,602,871...77,643,109
Ensembl chr14:77,602,870...77,643,114
JBrowse link
G DUSP3 dual specificity phosphatase 3 IEA Ensembl GO_REF:0000107 NCBI chr12:19,336,308...19,349,739
Ensembl chr12:19,336,354...19,349,734
JBrowse link
G DUSP4 dual specificity phosphatase 4 IEA
IBA
(PMID:21873635) GOC
GO_Central
PMID:21873635 GO_REF:0000108 NCBI chr15:55,491,084...55,508,460
Ensembl chr15:55,490,468...55,509,459
JBrowse link
G DUSP5 dual specificity phosphatase 5 IEA
IBA
(PMID:21873635) GOC
GO_Central
PMID:21873635 GO_REF:0000108 NCBI chr14:120,906,340...120,919,398
Ensembl chr14:120,906,343...120,919,395
JBrowse link
G DUSP6 dual specificity phosphatase 6 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:93,303,058...93,307,510
Ensembl chr 5:93,302,975...93,307,504
JBrowse link
G DUSP8 dual specificity phosphatase 8 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:1,006,589...1,022,444
Ensembl chr 2:1,008,761...1,022,445
JBrowse link
G DUSP9 dual specificity phosphatase 9 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:124,404,852...124,414,246
Ensembl chr  X:124,408,417...124,500,620
JBrowse link
G LAX1 lymphocyte transmembrane adaptor 1 IEA Ensembl GO_REF:0000107 NCBI chr 9:64,460,548...64,473,232
Ensembl chr 9:64,460,652...64,475,179
JBrowse link
G POC1A POC1 centriolar protein A IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:34,227,884...34,308,099
Ensembl chr13:34,199,409...34,313,073
JBrowse link
G PRKCA protein kinase C alpha ISO (MGI:2677557|PMID:11923480) MGI PMID:11923480 MGI:2677557 NCBI chr12:12,882,287...13,268,647
Ensembl chr12:12,882,064...13,263,554
JBrowse link
G SPRED1 sprouty related EVH1 domain containing 1 IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr 1:132,903,103...133,016,725
Ensembl chr 1:132,902,304...133,016,467
JBrowse link
G SPRED2 sprouty related EVH1 domain containing 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:76,527,646...76,649,652
Ensembl chr 3:76,523,589...76,649,650
JBrowse link
G SPRED3 sprouty related EVH1 domain containing 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:47,302,211...47,312,034
Ensembl chr 6:47,302,055...47,309,180
JBrowse link
negative regulation of JUN kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIDA axin interactor, dorsalization associated IEA Ensembl GO_REF:0000107 NCBI chr10:11,430,758...11,466,849
Ensembl chr10:11,428,396...11,466,645
JBrowse link
G DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 IEA Ensembl GO_REF:0000107 NCBI chr10:33,432,529...33,445,556
Ensembl chr10:33,432,844...33,445,532
JBrowse link
G DUSP10 dual specificity phosphatase 10 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:10,866,446...10,905,852
Ensembl chr10:10,866,448...10,905,857
JBrowse link
G DUSP19 dual specificity phosphatase 19 ISO (MGI:2182169|PMID:11959862) BHF-UCL PMID:11959862 MGI:2182169 NCBI chr15:88,549,250...88,574,978
Ensembl chr15:88,549,275...88,574,243
JBrowse link
G HIPK3 homeodomain interacting protein kinase 3 IEA Ensembl GO_REF:0000107 NCBI chr 2:27,580,125...27,685,926
Ensembl chr 2:27,580,129...27,685,846
JBrowse link
G LOC100739163 glutathione S-transferase P-like ISO (PMID:16636664)
(MGI:5009198|PMID:10945608), (MGI:5009411|PMID:16023107)
(MGI:3721484|PMID:12646564)
BHF-UCL PMID:10945608, PMID:12646564, PMID:16023107, PMID:16636664 MGI:3721484, MGI:5009198, MGI:5009411 NCBI chr 2:4,978,761...4,982,233 JBrowse link
G MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 ISO PMID:21076496 RGD
UniProt
PMID:12064607, PMID:21076496 RGD:1299562, RGD:13673827 NCBI chr 2:16,562,687...16,584,763
Ensembl chr 2:16,564,255...16,584,768
JBrowse link
G NPPA natriuretic peptide A IEA Ensembl GO_REF:0000107 NCBI chr 6:71,919,557...71,921,345
Ensembl chr 6:71,919,495...71,932,254
JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 ISO (PMID:23991106) UniProtKB PMID:23991106 NCBI chr 4:106,692,102...106,758,101
Ensembl chr 4:106,686,604...106,758,099
JBrowse link
G SFRP1 secreted frizzled related protein 1 IEA Ensembl GO_REF:0000107 NCBI chr17:10,436,414...10,489,773
Ensembl chr17:10,436,426...10,489,748
JBrowse link
G SFRP2 secreted frizzled related protein 2 IEA Ensembl GO_REF:0000107 NCBI chr 8:75,337,311...75,345,926
Ensembl chr 8:75,337,133...75,345,926
JBrowse link
G SFRP5 secreted frizzled related protein 5 ISO (MGI:3839161|PMID:19300477) MGI PMID:19300477 MGI:3839161 NCBI chr14:109,120,382...109,125,655
Ensembl chr14:109,119,822...109,125,686
JBrowse link
G TP73 tumor protein p73 ISO (MGI:3574697|PMID:15483136) MGI PMID:15483136 MGI:3574697 NCBI chr 6:65,169,770...65,228,997
Ensembl chr 6:65,177,682...65,228,992
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16548
    cellular process 15780
      signal transduction 5926
        intracellular signal transduction 2465
          MAPK cascade 793
            negative regulation of MAPK cascade 182
              negative regulation of MAP kinase activity 78
                inactivation of MAPK activity + 22
                negative regulation of JUN kinase activity 13
Path 2
Term Annotations click to browse term
  biological_process 16548
    biological regulation 12014
      regulation of biological process 11423
        regulation of metabolic process 6436
          regulation of cellular metabolic process 5759
            regulation of phosphorus metabolic process 1811
              regulation of phosphate metabolic process 1810
                regulation of phosphorylation 1617
                  regulation of kinase activity 837
                    negative regulation of kinase activity 248
                      negative regulation of protein kinase activity 228
                        negative regulation of protein serine/threonine kinase activity 132
                          negative regulation of MAP kinase activity 78
                            inactivation of MAPK activity + 22
                            negative regulation of JUN kinase activity 13
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.