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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of MAP kinase activity
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Accession:GO:0043407 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
Synonyms:exact_synonym: down regulation of MAPK activity;   downregulation of MAPK activity;   negative regulation of mitogen activated protein kinase activity
 narrow_synonym: inhibition of MAPK activity


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negative regulation of MAP kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:1624291
RGD:1600115
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1600115
RGD:1624291
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:1624291
RGD:1600115
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1600115
RGD:1624291
G Bmp7 bone morphogenetic protein 7 JBrowse link 3 170,879,972 170,955,820 RGD:1624291
RGD:1600115
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:1624291
G Cav3 caveolin 3 JBrowse link 4 144,382,945 144,398,919 RGD:1624291
RGD:1600115
G Cblc Cbl proto-oncogene C JBrowse link 1 80,699,321 80,716,146 RGD:1624291
RGD:1600115
G Cd300a Cd300a molecule JBrowse link 10 103,437,978 103,451,170 RGD:1624291
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 JBrowse link 10 84,780,644 84,789,800 RGD:1600115
RGD:1624291
G Dab2ip DAB2 interacting protein JBrowse link 3 14,889,263 15,060,286 RGD:1600115
RGD:1624291
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:1624291
RGD:1600115
G Dusp7 dual specificity phosphatase 7 JBrowse link 8 115,069,095 115,076,130 RGD:1624291
G Fem1a fem-1 homolog A JBrowse link 9 10,798,934 10,801,140 RGD:1624291
G Gba glucosylceramidase beta JBrowse link 2 188,511,781 188,522,602 RGD:1624291
RGD:1600115
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:2301767
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:1624291
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase JBrowse link 2 27,480,224 27,500,654 RGD:1624291
RGD:1600115
G Hyal2 hyaluronidase 2 JBrowse link 8 116,324,062 116,328,978 RGD:1600115
RGD:1624291
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1624291
RGD:1600115
G Inpp5k inositol polyphosphate-5-phosphatase K JBrowse link 10 63,775,639 63,796,879 RGD:1624291
RGD:1600115
G Inppl1 inositol polyphosphate phosphatase-like 1 JBrowse link 1 166,898,177 166,912,524 RGD:1626126
G Irak3 interleukin-1 receptor-associated kinase 3 JBrowse link 7 64,922,830 64,982,224 RGD:1624291
RGD:13792537
G Kng2 kininogen 2 JBrowse link 11 81,509,185 81,516,759 RGD:1600541
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 5 16,526,058 16,642,648 RGD:1624291
RGD:1600115
G Mapk7 mitogen-activated protein kinase 7 JBrowse link 10 47,768,592 47,775,130 RGD:1624291
G Nf1 neurofibromin 1 JBrowse link 10 66,732,460 66,928,706 RGD:1600115
RGD:1624291
G Nup62 nucleoporin 62 JBrowse link 1 100,811,140 100,827,119 RGD:1624291
RGD:1600115
G Paqr3 progestin and adipoQ receptor family member 3 JBrowse link 14 14,107,513 14,129,780 RGD:1624291
RGD:1600115
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:1624291
RGD:1600115
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 3 164,665,462 164,711,936 RGD:1624291
RGD:1600115
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 JBrowse link 1 103,197,918 103,258,309 RGD:10044039
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:1600115
RGD:1624291
G Ptprj protein tyrosine phosphatase, receptor type, J JBrowse link 3 79,233,519 79,390,956 RGD:1624291
RGD:13792537
G Rgs14 regulator of G-protein signaling 14 JBrowse link 17 9,777,925 9,792,007 RGD:1624291
RGD:1600115
G Rgs2 regulator of G-protein signaling 2 JBrowse link 13 60,846,458 60,849,061 RGD:1624291
RGD:1600115
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:1624291
RGD:1600115
G Smpd1 sphingomyelin phosphodiesterase 1 JBrowse link 1 170,383,682 170,387,525 RGD:1624291
RGD:1600115
G Sorl1 sortilin related receptor 1 JBrowse link 8 46,228,077 46,287,171 RGD:1624291
G Spry1 sprouty RTK signaling antagonist 1 JBrowse link 2 124,400,689 124,405,331 RGD:1624291
RGD:13792537
G Spry2 sprouty RTK signaling antagonist 2 JBrowse link 15 90,172,769 90,177,823 RGD:1624291
RGD:13792537
G Spry3 sprouty RTK signaling antagonist 3 JBrowse link 12 18,930,087 18,940,622 RGD:13792537
G Spry4 sprouty RTK signaling antagonist 4 JBrowse link 18 32,593,370 32,609,890 RGD:1624291
RGD:13792537
G Stk38 serine/threonine kinase 38 JBrowse link 20 6,224,300 6,257,613 RGD:1624291
RGD:1600115
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1580517
G Uchl1 ubiquitin C-terminal hydrolase L1 JBrowse link 14 43,133,224 43,143,942 RGD:1624291
RGD:1600115
inactivation of MAPK activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:1624291
RGD:1600115
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:1600115
RGD:13792537
G Dusp10 dual specificity phosphatase 10 JBrowse link 13 104,284,660 104,321,455 RGD:1624291
RGD:13792537
G Dusp14 dual specificity phosphatase 14 JBrowse link 10 71,363,688 71,383,602 RGD:1600115
G Dusp14l1 dual specificity phosphatase 14-like 1 JBrowse link 2 140,835,793 140,837,188 RGD:1600115
G Dusp16 dual specificity phosphatase 16 JBrowse link 4 168,470,141 168,551,346 RGD:1624291
RGD:13792537
G Dusp18 dual specificity phosphatase 18 JBrowse link 14 84,150,484 84,169,645 RGD:1600115
G Dusp19 dual specificity phosphatase 19 JBrowse link 3 67,849,966 67,862,475 RGD:1624291
G Dusp2 dual specificity phosphatase 2 JBrowse link 3 119,776,925 119,779,110 RGD:13792537
G Dusp21 dual specificity phosphatase 21 JBrowse link X 4,956,699 4,957,555 RGD:1600115
G Dusp3 dual specificity phosphatase 3 JBrowse link 10 89,904,578 89,918,296 RGD:1624291
RGD:1600115
G Dusp4 dual specificity phosphatase 4 JBrowse link 16 61,080,767 61,090,973 RGD:1600115
RGD:13792537
RGD:1624291
G Dusp5 dual specificity phosphatase 5 JBrowse link 1 274,245,184 274,258,595 RGD:1600115
RGD:13792537
G Dusp6 dual specificity phosphatase 6 JBrowse link 7 41,475,163 41,479,393 RGD:1624291
RGD:1600115
G Dusp7 dual specificity phosphatase 7 JBrowse link 8 115,069,095 115,076,130 RGD:1600115
G Dusp8 dual specificity phosphatase 8 JBrowse link 1 215,030,429 215,043,111 RGD:1624291
RGD:13792537
G Dusp9 dual specificity phosphatase 9 JBrowse link X 157,168,143 157,172,068 RGD:1624291
RGD:1600115
G Lax1 lymphocyte transmembrane adaptor 1 JBrowse link 13 50,164,563 50,175,119 RGD:1624291
G Pp2d1 protein phosphatase 2C-like domain containing 1 JBrowse link 14 72,948,241 72,970,335 RGD:1600115
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:1624291
G Spred1 sprouty-related, EVH1 domain containing 1 JBrowse link 3 108,795,337 108,861,650 RGD:1624291
RGD:13792537
G Spred2 sprouty-related, EVH1 domain containing 2 JBrowse link 14 104,268,362 104,290,206 RGD:1624291
RGD:13792537
RGD:1600115
G Spred3 sprouty-related, EVH1 domain containing 3 JBrowse link 1 88,101,213 88,112,719 RGD:1624291
RGD:13792537
negative regulation of JUN kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aida axin interactor, dorsalization associated JBrowse link 13 101,698,096 101,724,928 RGD:1624291
RGD:1600115
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 JBrowse link 5 57,028,467 57,039,378 RGD:1624291
RGD:1600115
G Dusp10 dual specificity phosphatase 10 JBrowse link 13 104,284,660 104,321,455 RGD:1624291
RGD:13792537
G Dusp19 dual specificity phosphatase 19 JBrowse link 3 67,849,966 67,862,475 RGD:1624291
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:1624291
RGD:1600115
G Hipk3 homeodomain interacting protein kinase 3 JBrowse link 3 94,349,778 94,419,185 RGD:1600115
RGD:1624291
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 JBrowse link 3 81,295,023 81,304,181 RGD:1299562
RGD:13673827
G Nppa natriuretic peptide A JBrowse link 5 164,808,407 164,809,716 RGD:1624291
G Pdcd4 programmed cell death 4 JBrowse link 1 274,616,625 274,648,204 RGD:1600115
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:1624291
G Serpinb3 serpin family B member 3 JBrowse link 13 27,186,701 27,193,211 RGD:1624291
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:1624291
RGD:1600115
G Sfrp2 secreted frizzled-related protein 2 JBrowse link 2 182,723,732 182,731,277 RGD:1624291
RGD:1600115
G Sfrp5 secreted frizzled-related protein 5 JBrowse link 1 261,442,108 261,446,570 RGD:1624291
G Tp73 tumor protein p73 JBrowse link 5 171,355,876 171,415,354 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19317
    cellular process 17226
      signal transduction 6875
        signal transduction by protein phosphorylation 874
          MAPK cascade 854
            negative regulation of MAPK cascade 181
              negative regulation of MAP kinase activity 78
                inactivation of MAPK activity + 23
                negative regulation of JUN kinase activity 15
Path 2
Term Annotations click to browse term
  biological_process 19317
    metabolic process 11540
      organic substance metabolic process 10932
        macromolecule metabolic process 9412
          cellular macromolecule metabolic process 8135
            cellular protein metabolic process 5303
              cellular protein modification process 3864
                regulation of protein modification process 1936
                  regulation of protein phosphorylation 1512
                    regulation of protein kinase activity 758
                      regulation of protein serine/threonine kinase activity 487
                        negative regulation of protein serine/threonine kinase activity 131
                          negative regulation of MAP kinase activity 78
                            inactivation of MAPK activity + 23
                            negative regulation of JUN kinase activity 15
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.