ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of DNA-binding transcription factor activity
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Accession:GO:0043433 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
Synonyms:exact_synonym: down regulation of transcription factor activity;   downregulation of transcription factor activity;   negative regulation of sequence-specific DNA binding transcription factor activity
 narrow_synonym: inhibition of transcription factor activity;   negative regulation of androgen receptor activity;   negative regulation of thyroid hormone receptor activity
 broad_synonym: negative regulation of transcription factor activity
 alt_id: GO:1904168;   GO:2000824


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negative regulation of DNA-binding transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BHLHE40 basic helix-loop-helix family member e40 JBrowse link 3 5,028,217 5,033,968 RGD:9068941
G BTRC beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link 10 101,431,318 101,632,496 RGD:9068941
G CEBPG CCAAT enhancer binding protein gamma JBrowse link 19 39,039,837 39,049,671 RGD:9068941
G CTNNBIP1 catenin beta interacting protein 1 JBrowse link 1 9,846,511 9,882,049 RGD:9068941
G DDIT3 DNA damage inducible transcript 3 JBrowse link 12 31,664,766 31,668,699 RGD:9068941
G EGLN1 egl-9 family hypoxia inducible factor 1 JBrowse link 1 211,939,543 211,997,325 RGD:9068941
G EOMES eomesodermin JBrowse link 3 27,923,970 27,930,687 RGD:9068941
G ESR1 estrogen receptor 1 JBrowse link 6 154,200,521 154,635,806 RGD:9068941
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit JBrowse link 7 153,017,590 153,059,726 RGD:9068941
G FLNA filamin A RGD:9068941
G FOXA2 forkhead box A2 JBrowse link 20 22,872,251 22,874,997 RGD:9068941
G FOXH1 forkhead box H1 JBrowse link 8 144,229,228 144,231,829 RGD:9068941
G FOXP3 forkhead box P3 JBrowse link X 49,402,652 49,417,029 RGD:9068941
G FOXS1 forkhead box S1 JBrowse link 20 29,268,112 29,269,423 RGD:9068941
G FZD6 frizzled class receptor 6 JBrowse link 8 102,110,317 102,144,363 RGD:9068941
G GAS6 growth arrest specific 6 JBrowse link 13 113,968,843 114,009,506 RGD:9068941
G GLIS2 GLIS family zinc finger 2 JBrowse link 16 4,418,525 4,425,633 RGD:9068941
G HAND1 heart and neural crest derivatives expressed 1 JBrowse link 5 155,875,100 155,878,374 RGD:9068941
G HAND2 heart and neural crest derivatives expressed 2 JBrowse link 4 177,990,362 177,992,861 RGD:9068941
G HDAC2 histone deacetylase 2 JBrowse link 6 115,802,367 115,833,004 RGD:9068941
G HDAC4 histone deacetylase 4 JBrowse link 2B 245,123,061 245,428,441 RGD:9068941
G HEYL hes related family bHLH transcription factor with YRPW motif like JBrowse link 1 40,240,114 40,256,300 RGD:9068941
G HMOX1 heme oxygenase 1 JBrowse link 22 34,230,825 34,244,063 RGD:9068941
G ID1 inhibitor of DNA binding 1, HLH protein JBrowse link 20 28,535,470 28,536,726 RGD:9068941
G ID2 inhibitor of DNA binding 2 JBrowse link 2A 8,847,776 8,850,720 RGD:9068941
G ID3 inhibitor of DNA binding 3, HLH protein JBrowse link 1 23,734,263 23,736,175 RGD:9068941
G KDM1A lysine demethylase 1A JBrowse link 1 23,153,066 23,217,693 RGD:9068941
G KEAP1 kelch like ECH associated protein 1 JBrowse link 19 10,701,298 10,717,664 RGD:9068941
G LOC100990946 group 10 secretory phospholipase A2 JBrowse link 16 15,021,025 15,043,782 RGD:9068941
G MAD2L2 mitotic arrest deficient 2 like 2 JBrowse link 1 11,654,963 11,671,364 RGD:9068941
G MAP3K10 mitogen-activated protein kinase kinase kinase 10 JBrowse link 19 45,753,227 45,775,421 RGD:9068941
G MED13 mediator complex subunit 13 JBrowse link 17 61,153,835 61,274,555 RGD:9068941
G MEN1 menin 1 JBrowse link 11 63,499,954 63,507,164 RGD:9068941
G NR0B1 nuclear receptor subfamily 0 group B member 1 JBrowse link X 30,459,527 30,464,652 RGD:9068941
G NR0B2 nuclear receptor subfamily 0 group B member 2 JBrowse link 1 27,230,362 27,232,949 RGD:9068941
G NUPR1 nuclear protein 1, transcriptional regulator JBrowse link 16 29,015,155 29,016,987 RGD:9068941
G PAXIP1 PAX interacting protein 1 JBrowse link 7 158,274,193 158,329,139 RGD:9068941
G PBX1 PBX homeobox 1 JBrowse link 1 143,778,426 144,104,493 RGD:9068941
G PEX14 peroxisomal biogenesis factor 14 JBrowse link 1 10,459,863 10,614,187 RGD:9068941
G PHB2 prohibitin 2 JBrowse link 12 7,012,862 7,018,303 RGD:9068941
G PIAS2 protein inhibitor of activated STAT 2 JBrowse link 18 43,622,455 43,728,675 RGD:9068941
G PIM1 Pim-1 proto-oncogene, serine/threonine kinase JBrowse link 6 37,923,556 37,928,841 RGD:9068941
G POU4F2 POU class 4 homeobox 2 JBrowse link 4 150,626,392 150,629,961 RGD:9068941
G PRNP prion protein JBrowse link 20 4,523,141 4,525,522 RGD:9068941
G PROX1 prospero homeobox 1 JBrowse link 1 194,412,980 194,466,170 RGD:9068941
G PTCH1 patched 1 JBrowse link 9 94,668,792 94,741,517 RGD:9068941
G RB1 RB transcriptional corepressor 1 JBrowse link 13 48,155,608 48,326,396 RGD:9068941
G RLIM ring finger protein, LIM domain interacting JBrowse link X 73,952,928 73,982,412 RGD:9068941
G RNF2 ring finger protein 2 JBrowse link 1 164,721,554 164,779,420 RGD:9068941
G SFRP4 secreted frizzled related protein 4 JBrowse link 7 38,764,146 38,774,264 RGD:9068941
G SFRP5 secreted frizzled related protein 5 JBrowse link 10 97,877,790 97,882,846 RGD:9068941
G SIGIRR single Ig and TIR domain containing JBrowse link 11 442,468 448,958 RGD:9068941
G SIRT1 sirtuin 1 JBrowse link 10 66,681,983 66,714,065 RGD:9068941
G SMAD7 SMAD family member 7 JBrowse link 18 45,659,375 45,689,505 RGD:9068941
G SP100 SP100 nuclear antigen JBrowse link 2B 236,474,298 236,601,277 RGD:9068941
G SUFU SUFU negative regulator of hedgehog signaling JBrowse link 10 102,571,886 102,696,472 RGD:9068941
G SUMO1 small ubiquitin like modifier 1 JBrowse link 2B 207,613,649 207,645,590 RGD:9068941
G TAF1 TATA-box binding protein associated factor 1 JBrowse link X 70,684,192 70,784,292 RGD:9068941
G TAF3 TATA-box binding protein associated factor 3 JBrowse link 10 7,831,826 8,026,345 RGD:9068941
G TBX6 T-box 6 JBrowse link 16 30,460,305 30,467,090 RGD:9068941
G TBXT T-box transcription factor T JBrowse link 6 169,095,723 169,106,595 RGD:9068941
G TCF7L2 transcription factor 7 like 2 JBrowse link 10 112,991,588 113,193,992 RGD:9068941
G TNFRSF4 TNF receptor superfamily member 4 JBrowse link 1 1,168,706 1,171,341 RGD:9068941
G TNFSF4 TNF superfamily member 4 JBrowse link 1 152,391,450 152,699,026 RGD:9068941
G TRIB1 tribbles pseudokinase 1 JBrowse link 8 124,867,334 124,874,863 RGD:9068941
G TWIST1 twist family bHLH transcription factor 1 JBrowse link 7 19,086,842 19,088,398 RGD:9068941
G WFS1 wolframin ER transmembrane glycoprotein JBrowse link 4 6,345,960 6,379,094 RGD:9068941
G WWP2 WW domain containing E3 ubiquitin protein ligase 2 JBrowse link 16 69,525,246 69,703,831 RGD:9068941
cytoplasmic sequestering of NF-kappaB term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CCDC22 coiled-coil domain containing 22 JBrowse link X 49,387,980 49,402,742 RGD:9068941
G FAF1 Fas associated factor 1 JBrowse link 1 51,188,540 51,603,694 RGD:9068941
G G3BP2 G3BP stress granule assembly factor 2 JBrowse link 4 54,368,332 54,399,374 RGD:9068941
G IL10 interleukin 10 JBrowse link 1 186,648,289 186,653,155 RGD:9068941
G NFKBIA NFKB inhibitor alpha JBrowse link 14 34,337,307 34,340,225 RGD:9068941
G PSMD10 proteasome 26S subunit, non-ATPase 10 JBrowse link X 107,552,180 107,559,616 RGD:9068941
G TMSB4X thymosin beta 4 X-linked JBrowse link X 12,874,827 12,878,545 RGD:9068941
cytoplasmic sequestering of transcription factor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CREB3 cAMP responsive element binding protein 3 JBrowse link 9 36,385,867 36,390,540 RGD:9068941
G KEAP1 kelch like ECH associated protein 1 JBrowse link 19 10,701,298 10,717,664 RGD:9068941
G MDFI MyoD family inhibitor JBrowse link 6 42,527,805 42,545,030 RGD:9068941
G MXI1 MAX interactor 1, dimerization protein JBrowse link 10 110,252,184 110,328,782 RGD:9068941
G NFKBIA NFKB inhibitor alpha JBrowse link 14 34,337,307 34,340,225 RGD:9068941
G NFKBIE NFKB inhibitor epsilon JBrowse link 6 45,137,160 45,144,699 RGD:9068941
G NFKBIL1 NFKB inhibitor like 1 JBrowse link 6 32,097,824 32,109,944 RGD:9068941
G PKD1 polycystin 1, transient receptor potential channel interacting JBrowse link 16 2,176,778 2,185,337 RGD:9068941
G PKD2 polycystin 2, transient receptor potential cation channel JBrowse link 4 91,019,739 91,088,858 RGD:9068941
G SRI sorcin JBrowse link 7 93,849,129 93,864,088 RGD:9068941
G SUFU SUFU negative regulator of hedgehog signaling JBrowse link 10 102,571,886 102,696,472 RGD:9068941
G TONSL tonsoku like, DNA repair protein JBrowse link 8 144,185,674 144,200,930 RGD:9068941
negative regulation of CREB transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADGRG3 adhesion G protein-coupled receptor G3 JBrowse link 16 57,077,366 57,098,456 RGD:9068941
G DDIT3 DNA damage inducible transcript 3 JBrowse link 12 31,664,766 31,668,699 RGD:9068941
G EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 JBrowse link 15 37,128,000 37,229,216 RGD:9068941
G FOXP3 forkhead box P3 JBrowse link X 49,402,652 49,417,029 RGD:9068941
G MSX2 msh homeobox 2 JBrowse link 5 176,968,315 176,974,679 RGD:9068941
G SIK1 salt inducible kinase 1 JBrowse link 21 42,975,914 42,987,948 RGD:9068941
negative regulation of NF-kappaB transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACOD1 aconitate decarboxylase 1 JBrowse link 13 77,148,051 77,219,410 RGD:9068941
G AIM2 absent in melanoma 2 JBrowse link 1 138,210,738 138,336,219 RGD:9068941
G ANXA4 annexin A4 JBrowse link 2A 70,804,600 70,986,917 RGD:9068941
G ARRB1 arrestin beta 1 JBrowse link 11 73,624,254 73,670,495 RGD:9068941
G ARRB2 arrestin beta 2 JBrowse link 17 4,757,048 4,767,517 RGD:9068941
G BMP7 bone morphogenetic protein 7 JBrowse link 20 54,788,974 54,885,015 RGD:9068941
G BRMS1 BRMS1 transcriptional repressor and anoikis regulator JBrowse link 11 65,028,407 65,036,163 RGD:9068941
G CACTIN cactin, spliceosome C complex subunit JBrowse link 19 3,585,688 3,602,031 RGD:9068941
G CARD8 caspase recruitment domain family member 8 JBrowse link 19 53,798,913 53,850,328 RGD:9068941
G CAT catalase JBrowse link 11 34,289,603 34,323,160 RGD:9068941
G CD200 CD200 molecule JBrowse link 3 116,404,606 116,434,363 RGD:9068941
G CDK5RAP3 CDK5 regulatory subunit associated protein 3 JBrowse link 17 9,738,144 9,748,989 RGD:9068941
G CDKN2A cyclin dependent kinase inhibitor 2A JBrowse link 9 22,420,748 22,447,243 RGD:9068941
G CHP1 calcineurin like EF-hand protein 1 JBrowse link 15 38,418,815 38,466,925 RGD:9068941
G CHUK component of inhibitor of nuclear factor kappa B kinase complex JBrowse link 10 100,276,290 100,317,082 RGD:9068941
G CMKLR1 chemerin chemokine-like receptor 1 JBrowse link 12 109,256,329 109,307,526 RGD:9068941
G COMMD1 copper metabolism domain containing 1 JBrowse link 2A 63,121,490 63,349,256 RGD:9068941
G COMMD6 COMM domain containing 6 JBrowse link 13 75,525,977 75,537,608 RGD:9068941
G COMMD7 COMM domain containing 7 JBrowse link 20 30,112,233 30,134,007 RGD:9068941
G CYLD CYLD lysine 63 deubiquitinase JBrowse link 16 49,882,751 49,942,629 RGD:9068941
G DAP death associated protein JBrowse link 5 10,846,394 10,927,869 RGD:9068941
G DNAJA3 DnaJ heat shock protein family (Hsp40) member A3 JBrowse link 16 4,519,965 4,550,786 RGD:9068941
G ERBIN erbb2 interacting protein JBrowse link 5 49,589,418 49,739,091 RGD:9068941
G FOXJ1 forkhead box J1 JBrowse link 17 75,637,615 75,642,571 RGD:9068941
G FOXP3 forkhead box P3 JBrowse link X 49,402,652 49,417,029 RGD:9068941
G GFI1 growth factor independent 1 transcriptional repressor JBrowse link 1 93,875,880 93,883,558 RGD:9068941
G HAVCR2 hepatitis A virus cellular receptor 2 JBrowse link 5 159,107,938 159,134,973 RGD:9068941
G IRAK1 interleukin 1 receptor associated kinase 1 JBrowse link X 153,446,827 153,458,189 RGD:9068941
G IRAK2 interleukin 1 receptor associated kinase 2 JBrowse link 3 10,453,329 10,532,629 RGD:9068941
G IRAK3 interleukin 1 receptor associated kinase 3 JBrowse link 12 23,168,346 23,282,903 RGD:9068941
G ITCH itchy E3 ubiquitin protein ligase JBrowse link 20 31,822,496 31,971,945 RGD:9068941
G KLF4 Kruppel like factor 4 JBrowse link 9 106,820,954 106,825,751 RGD:9068941
G LOC100989599 cytochrome P450 1B1 JBrowse link 2A 38,851,000 38,859,883 RGD:9068941
G LRRC14 leucine rich repeat containing 14 JBrowse link 8 144,274,773 144,277,963 RGD:9068941
G MAP2K5 mitogen-activated protein kinase kinase 5 JBrowse link 15 64,761,465 65,029,655 RGD:9068941
G NFKBIA NFKB inhibitor alpha JBrowse link 14 34,337,307 34,340,225 RGD:9068941
G NFKBID NFKB inhibitor delta JBrowse link 19 41,553,727 41,565,216 RGD:9068941
G NFKBIL1 NFKB inhibitor like 1 JBrowse link 6 32,097,824 32,109,944 RGD:9068941
G NLRC3 NLR family CARD domain containing 3 JBrowse link 16 3,637,607 3,674,210 RGD:9068941
G NLRC5 NLR family CARD domain containing 5 JBrowse link 16 56,401,941 56,495,022 RGD:9068941
G NLRP12 NLR family pyrin domain containing 12 JBrowse link 19 59,581,547 59,614,665 RGD:9068941
G NLRP2 NLR family pyrin domain containing 2 JBrowse link 19 60,700,166 60,723,730 RGD:9068941
G NLRP2B NLR family pyrin domain containing 2B JBrowse link X 58,158,901 58,162,077 RGD:9068941
G NLRP3 NLR family pyrin domain containing 3 JBrowse link 1 228,505,147 228,537,216 RGD:9068941
G NR1H4 nuclear receptor subfamily 1 group H member 4 JBrowse link 12 101,457,885 101,548,058 RGD:9068941
G NWD1 NACHT and WD repeat domain containing 1 JBrowse link 19 17,189,728 17,283,045 RGD:9068941
G OTULIN OTU deubiquitinase with linear linkage specificity JBrowse link 5 14,810,187 14,857,597 RGD:9068941
G PARP10 poly(ADP-ribose) polymerase family member 10 JBrowse link 8 143,735,487 143,744,050 RGD:9068941
G PELI1 pellino E3 ubiquitin protein ligase 1 JBrowse link 2A 65,284,472 65,336,335 RGD:9068941
G PIAS4 protein inhibitor of activated STAT 4 JBrowse link 19 3,983,200 4,012,686 RGD:9068941
G PKHD1 PKHD1 ciliary IPT domain containing fibrocystin/polyductin JBrowse link 6 52,435,455 52,903,309 RGD:9068941
G PRDX2 peroxiredoxin 2 JBrowse link 19 13,103,422 13,107,369 RGD:9068941
G PRMT2 protein arginine methyltransferase 2 JBrowse link 21 46,233,951 46,263,570 RGD:9068941
G PSMD10 proteasome 26S subunit, non-ATPase 10 JBrowse link X 107,552,180 107,559,616 RGD:9068941
G PTGIS prostaglandin I2 synthase JBrowse link 20 46,909,010 46,952,850 RGD:9068941
G PYCARD PYD and CARD domain containing JBrowse link 16 31,572,332 31,573,828 RGD:9068941
G PYDC1 pyrin domain containing 1 JBrowse link 16 31,587,341 31,588,723 RGD:9068941
G PYDC2 pyrin domain containing 2 JBrowse link 3 197,101,125 197,101,418 RGD:9068941
G RBCK1 RANBP2-type and C3HC4-type zinc finger containing 1 JBrowse link 20 386,569 409,587 RGD:9068941
G RWDD3 RWD domain containing 3 JBrowse link 1 96,622,134 96,634,902 RGD:9068941
G SETD6 SET domain containing 6, protein lysine methyltransferase JBrowse link 16 57,905,846 57,919,851 RGD:9068941
G SIRT1 sirtuin 1 JBrowse link 10 66,681,983 66,714,065 RGD:9068941
G SIVA1 SIVA1 apoptosis inducing factor JBrowse link 14 105,196,118 105,202,678 RGD:9068941
G TAX1BP1 Tax1 binding protein 1 JBrowse link 7 27,975,026 28,071,519 RGD:9068941
G TCEAL7 transcription elongation factor A like 7 JBrowse link X 102,938,570 102,940,708 RGD:9068941
G TMSB4X thymosin beta 4 X-linked JBrowse link X 12,874,827 12,878,545 RGD:9068941
G TNFAIP3 TNF alpha induced protein 3 JBrowse link 6 139,705,255 139,721,264 RGD:9068941
G TRAF3 TNF receptor associated factor 3 JBrowse link 14 103,263,222 103,346,383 RGD:9068941
G TRAIP TRAF interacting protein JBrowse link 3 50,996,647 51,025,243 RGD:9068941
G TRIM21 tripartite motif containing 21 JBrowse link 11 4,254,152 4,262,981 RGD:9068941
G TRIM37 tripartite motif containing 37 JBrowse link 17 57,904,813 58,027,160 RGD:9068941
G TRIM40 tripartite motif containing 40 JBrowse link 6 30,583,968 30,596,583 RGD:9068941
G TUT4 terminal uridylyl transferase 4 JBrowse link 1 53,292,477 53,422,893 RGD:9068941
G UFL1 UFM1 specific ligase 1 JBrowse link 6 98,242,689 98,276,146 RGD:9068941
G USP7 ubiquitin specific peptidase 7 JBrowse link 16 9,065,366 9,106,406 RGD:9068941
G ZC3H12A zinc finger CCCH-type containing 12A JBrowse link 1 38,093,036 38,103,556 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15692
    negative regulation of biological process 5083
      negative regulation of DNA-binding transcription factor activity 158
        cytoplasmic sequestering of transcription factor + 18
        negative regulation of CREB transcription factor activity 6
        negative regulation of NF-kappaB transcription factor activity + 80
Path 2
Term Annotations click to browse term
  biological_process 15692
    metabolic process 10517
      cellular metabolic process 9895
        cellular aromatic compound metabolic process 5449
          nucleobase-containing compound metabolic process 5257
            nucleic acid metabolic process 4752
              RNA metabolic process 4276
                RNA biosynthetic process 3406
                  nucleic acid-templated transcription 3391
                    transcription, DNA-templated 3352
                      regulation of transcription, DNA-templated 3198
                        regulation of DNA-binding transcription factor activity 413
                          negative regulation of DNA-binding transcription factor activity 158
                            cytoplasmic sequestering of transcription factor + 18
                            negative regulation of CREB transcription factor activity 6
                            negative regulation of NF-kappaB transcription factor activity + 80
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.