ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of DNA-binding transcription factor activity
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Accession:GO:0043433 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
Synonyms:exact_synonym: down regulation of transcription factor activity;   downregulation of transcription factor activity;   negative regulation of sequence-specific DNA binding transcription factor activity
 narrow_synonym: inhibition of transcription factor activity;   negative regulation of androgen receptor activity;   negative regulation of thyroid hormone receptor activity
 broad_synonym: negative regulation of transcription factor activity
 alt_id: GO:1904168;   GO:2000824


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negative regulation of DNA-binding transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bhlhe40 basic helix-loop-helix family member e40 JBrowse link NW_004955421 8,463,337 8,468,877 RGD:9068941
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link NW_004955485 8,724,375 8,846,647 RGD:9068941
G Cebpg CCAAT enhancer binding protein gamma JBrowse link NW_004955468 3,137,106 3,141,733 RGD:9068941
G Ddit3 DNA damage inducible transcript 3 JBrowse link NW_004955458 5,232,979 5,238,513 RGD:9068941
G Egln1 egl-9 family hypoxia inducible factor 1 JBrowse link NW_004955492 7,407,800 7,454,851 RGD:9068941
G Eomes eomesodermin JBrowse link NW_004955430 19,280,460 19,287,060 RGD:9068941
G Esr1 estrogen receptor 1 JBrowse link NW_004955439 9,588,631 9,953,606 RGD:9068941
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit JBrowse link NW_004955491 4,215,353 4,292,229 RGD:9068941
G Flna filamin A JBrowse link NW_004955580 874,233 895,172 RGD:9068941
G Foxa2 forkhead box A2 JBrowse link NW_004955415 29,982,940 29,987,093 RGD:9068941
G Foxh1 forkhead box H1 JBrowse link NW_004955454 3,094,015 3,096,060 RGD:9068941
G Foxp3 forkhead box P3 JBrowse link NW_004955543 731,707 742,606 RGD:9068941
G Foxs1 forkhead box S1 JBrowse link NW_004955422 29,132,325 29,133,641 RGD:9068941
G Fzd6 frizzled class receptor 6 JBrowse link NW_004955417 27,465,730 27,493,752 RGD:9068941
G Gas6 growth arrest specific 6 JBrowse link NW_004955404 276,397 303,864 RGD:9068941
G Glis2 GLIS family zinc finger 2 JBrowse link NW_004955442 13,097,636 13,113,514 RGD:9068941
G Hand1 heart and neural crest derivatives expressed 1 JBrowse link NW_004955408 8,848,723 8,851,804 RGD:9068941
G Hand2 heart and neural crest derivatives expressed 2 JBrowse link NW_004955403 33,478,034 33,481,613 RGD:9068941
G Hdac2 histone deacetylase 2 JBrowse link NW_004955526 2,739,099 2,759,640 RGD:9068941
G Hdac4 histone deacetylase 4 JBrowse link NW_004955542 1,629,691 1,886,160 RGD:9068941
G Heyl hes related family bHLH transcription factor with YRPW motif like JBrowse link NW_004955452 17,137,066 17,152,714 RGD:9068941
G Hmox1 heme oxygenase 1 JBrowse link NW_004955405 43,124,447 43,128,873 RGD:9068941
G Id1 inhibitor of DNA binding 1, HLH protein JBrowse link NW_004955422 29,337,969 29,339,178 RGD:9068941
G Id2 inhibitor of DNA binding 2 JBrowse link NW_004955487 878,326 880,783 RGD:9068941
G Id3 inhibitor of DNA binding 3, HLH protein JBrowse link NW_004955452 3,537,352 3,538,921 RGD:9068941
G Kdm1a lysine demethylase 1A JBrowse link NW_004955452 3,044,042 3,104,650 RGD:9068941
G Keap1 kelch like ECH associated protein 1 JBrowse link NW_004955495 1,704,695 1,711,339 RGD:9068941
G Mad2l2 mitotic arrest deficient 2 like 2 JBrowse link NW_004955486 2,191,903 2,197,193 RGD:9068941
G Map3k10 mitogen-activated protein kinase kinase kinase 10 JBrowse link NW_004955578 1,018,280 1,037,553 RGD:9068941
G Med13 mediator complex subunit 13 JBrowse link NW_004955451 2,891,583 3,008,230 RGD:9068941
G Men1 menin 1 JBrowse link NW_004955422 20,356,491 20,363,374 RGD:9068941
G Nr0b1 nuclear receptor subfamily 0 group B member 1 JBrowse link NW_004955531 567,491 572,329 RGD:9068941
G Nr0b2 nuclear receptor subfamily 0 group B member 2 JBrowse link NW_004955452 6,251,047 6,253,541 RGD:9068941
G Nupr1 nuclear protein 1, transcriptional regulator JBrowse link NW_004955493 6,746,380 6,747,763 RGD:9068941
G Paxip1 PAX interacting protein 1 JBrowse link NW_004955491 8,177,422 8,219,764 RGD:9068941
G Pbx1 PBX homeobox 1 JBrowse link NW_004955462 11,777,168 12,083,068 RGD:9068941
G Pex14 peroxisomal biogenesis factor 14 JBrowse link NW_004955486 2,981,026 3,129,721 RGD:9068941
G Phb2 prohibitin 2 JBrowse link NW_004955413 4,557,969 4,563,697 RGD:9068941
G Pias2 protein inhibitor of activated STAT 2 JBrowse link NW_004955402 32,263,616 32,358,532 RGD:9068941
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase JBrowse link NW_004955437 5,940,825 5,945,367 RGD:9068941
G Pla2g10 phospholipase A2 group X JBrowse link NW_004955442 4,208,497 4,225,893 RGD:9068941
G Pou4f2 POU class 4 homeobox 2 JBrowse link NW_004955428 2,325,775 2,329,122 RGD:9068941
G Prnp prion protein JBrowse link NW_004955415 15,442,313 15,454,644 RGD:9068941
G Prox1 prospero homeobox 1 JBrowse link NW_004955406 3,715,140 3,770,019 RGD:9068941
G Ptch1 patched 1 JBrowse link NW_004955422 22,362,330 22,418,062 RGD:9068941
G Rb1 RB transcriptional corepressor 1 JBrowse link NW_004955431 1,960,765 2,124,576 RGD:9068941
G Rlim ring finger protein, LIM domain interacting JBrowse link NW_004955562 508,723 531,699 RGD:9068941
G Rnf2 ring finger protein 2 JBrowse link NW_004955406 23,672,947 23,725,253 RGD:9068941
G Sfrp4 secreted frizzled related protein 4 JBrowse link NW_004955460 5,654,187 5,666,475 RGD:9068941
G Sfrp5 secreted frizzled related protein 5 JBrowse link NW_004955507 3,836,607 3,841,910 RGD:9068941
G Sigirr single Ig and TIR domain containing JBrowse link NW_004955476 11,603,375 11,610,606 RGD:9068941
G Sirt1 sirtuin 1 JBrowse link NW_004955425 20,280,725 20,307,663 RGD:9068941
G Smad7 SMAD family member 7 JBrowse link NW_004955402 34,028,184 34,058,949 RGD:9068941
G Sp100 SP100 nuclear antigen JBrowse link NW_004955453 4,774,739 4,856,238 RGD:9068941
G Sufu SUFU negative regulator of hedgehog signaling JBrowse link NW_004955485 7,805,244 7,925,414 RGD:9068941
G Sumo1 small ubiquitin like modifier 1 JBrowse link NW_004955457 12,538,974 12,565,803 RGD:9068941
G Taf1 TATA-box binding protein associated factor 1 JBrowse link NW_004955475 10,930,175 11,006,876 RGD:9068941
G Taf3 TATA-box binding protein associated factor 3 JBrowse link NW_004955421 24,263,395 24,414,472 RGD:9068941
G Tbx6 T-box 6 JBrowse link NW_004955493 6,888,832 6,894,840 RGD:9068941
G Tbxt T-box transcription factor T JBrowse link NW_004955439 15,675,680 15,683,542 RGD:9068941
G Tcf7l2 transcription factor 7 like 2 JBrowse link NW_004955431 18,020,309 18,207,926 RGD:9068941
G Tnfrsf4 TNF receptor superfamily member 4 JBrowse link NW_004955486 9,565,424 9,569,836 RGD:9068941
G Tnfsf4 TNF superfamily member 4 JBrowse link NW_004955406 13,477,077 13,493,309 RGD:9068941
G Trib1 tribbles pseudokinase 1 JBrowse link NW_004955461 494,003 501,928 RGD:9068941
G Twist1 twist family bHLH transcription factor 1 JBrowse link NW_004955410 22,003,981 22,005,483 RGD:9068941
G Wfs1 wolframin ER transmembrane glycoprotein JBrowse link NW_004955514 3,902,508 3,924,281 RGD:9068941
G Wwp2 WW domain containing E3 ubiquitin protein ligase 2 JBrowse link NW_004955484 6,853,820 6,967,261 RGD:9068941
G Xcl1 X-C motif chemokine ligand 1 JBrowse link NW_004955462 8,594,416 8,598,101 RGD:9068941
cytoplasmic sequestering of NF-kappaB term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccdc22 coiled-coil domain containing 22 JBrowse link NW_004955543 719,185 731,788 RGD:9068941
G Faf1 Fas associated factor 1 JBrowse link NW_004955464 8,037,344 8,477,798 RGD:9068941
G G3bp2 G3BP stress granule assembly factor 2 JBrowse link NW_004955474 1,565,048 1,632,427 RGD:9068941
G Il10 interleukin 10 JBrowse link NW_004955406 42,307,789 42,312,255 RGD:9068941
G Nfkbia NFKB inhibitor alpha JBrowse link NW_004955409 25,691,673 25,695,151 RGD:9068941
G Psmd10 proteasome 26S subunit, non-ATPase 10 JBrowse link NW_004955490 7,825,202 7,832,347 RGD:9068941
G Tmsb4x thymosin beta 4 X-linked JBrowse link NW_004955544 266,397 268,447 RGD:9068941
cytoplasmic sequestering of transcription factor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Creb3 cAMP responsive element binding protein 3 JBrowse link NW_004955472 564,227 568,708 RGD:9068941
G Keap1 kelch like ECH associated protein 1 JBrowse link NW_004955495 1,704,695 1,711,339 RGD:9068941
G Mdfi MyoD family inhibitor JBrowse link NW_004955437 8,071,054 8,081,811 RGD:9068941
G Mxi1 MAX interactor 1, dimerization protein JBrowse link NW_004955485 1,088,175 1,156,521 RGD:9068941
G Nfkbia NFKB inhibitor alpha JBrowse link NW_004955409 25,691,673 25,695,151 RGD:9068941
G Nfkbie NFKB inhibitor epsilon JBrowse link NW_004955437 9,882,460 9,888,848 RGD:9068941
G Nfkbil1 NFKB inhibitor like 1 JBrowse link NW_004955437 90,623 100,918 RGD:9068941
G Pkd1 polycystin 1, transient receptor potential channel interacting JBrowse link NW_004955442 15,132,555 15,178,377 RGD:9068941
G Pkd2 polycystin 2, transient receptor potential cation channel JBrowse link NW_004955474 1,831,221 1,868,170 RGD:9068941
G Sri sorcin JBrowse link NW_004955432 5,541,311 5,559,781 RGD:9068941
G Sufu SUFU negative regulator of hedgehog signaling JBrowse link NW_004955485 7,805,244 7,925,414 RGD:9068941
G Tonsl tonsoku like, DNA repair protein JBrowse link NW_004955454 3,054,727 3,067,785 RGD:9068941
negative regulation of CREB transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adgrg3 adhesion G protein-coupled receptor G3 JBrowse link NW_004955433 15,290,538 15,317,020 RGD:9068941
G Ddit3 DNA damage inducible transcript 3 JBrowse link NW_004955458 5,232,979 5,238,513 RGD:9068941
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 JBrowse link NW_004955416 6,897,897 7,005,602 RGD:9068941
G Foxp3 forkhead box P3 JBrowse link NW_004955543 731,707 742,606 RGD:9068941
G Msx2 msh homeobox 2 JBrowse link NW_004955408 27,323,405 27,329,484 RGD:9068941
G Sik1 salt inducible kinase 1 JBrowse link NW_004955407 38,739,062 38,749,293 RGD:9068941
negative regulation of NF-kappaB transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acod1 aconitate decarboxylase 1 JBrowse link NW_004955404 30,254,934 30,266,898 RGD:9068941
G Anxa4 annexin A4 JBrowse link NW_004955424 15,323,604 15,389,136 RGD:9068941
G Arrb1 arrestin beta 1 JBrowse link NW_004955414 16,478,843 16,568,050 RGD:9068941
G Arrb2 arrestin beta 2 JBrowse link NW_004955467 10,109,985 10,118,687 RGD:9068941
G Bmp7 bone morphogenetic protein 7 JBrowse link NW_004955445 2,154,057 2,235,594 RGD:9068941
G Brms1 BRMS1 transcriptional repressor and anoikis regulator JBrowse link NW_004955422 18,981,984 18,989,730 RGD:9068941
G Cactin cactin, spliceosome C complex subunit JBrowse link NW_004955495 5,561,359 5,571,945 RGD:9068941
G Cat catalase JBrowse link NW_004955422 11,783,973 11,826,970 RGD:9068941
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 JBrowse link NW_004955451 13,160,811 13,170,012 RGD:9068941
G Chp1 calcineurin like EF-hand protein 1 JBrowse link NW_004955416 8,090,034 8,131,605 RGD:9068941
G Chuk component of inhibitor of nuclear factor kappa B kinase complex JBrowse link NW_004955507 6,066,026 6,102,066 RGD:9068941
G Cmklr1 chemerin chemokine-like receptor 1 JBrowse link NW_004955455 9,587,421 9,638,602 RGD:9068941
G Commd1 copper metabolism domain containing 1 JBrowse link NW_004955424 21,962,837 22,067,745 RGD:9068941
G Commd6 COMM domain containing 6 JBrowse link NW_004955404 31,473,054 31,487,169 RGD:9068941
G Commd7 COMM domain containing 7 JBrowse link NW_004955422 28,454,984 28,464,885 RGD:9068941
G Cyld CYLD lysine 63 deubiquitinase JBrowse link NW_004955433 8,788,867 8,845,925 RGD:9068941
G Dab2ip DAB2 interacting protein JBrowse link NW_004955419 6,229,437 6,416,619 RGD:9068941
G Dap death associated protein JBrowse link NW_004955426 398,593 452,004 RGD:9068941
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 JBrowse link NW_004955442 12,971,031 13,002,605 RGD:9068941
G Erbin erbb2 interacting protein JBrowse link NW_004955446 3,046,268 3,151,796 RGD:9068941
G Foxj1 forkhead box J1 JBrowse link NW_004955506 6,127,551 6,132,302 RGD:9068941
G Foxp3 forkhead box P3 JBrowse link NW_004955543 731,707 742,606 RGD:9068941
G Gfi1 growth factor independent 1 transcriptional repressor JBrowse link NW_004955423 2,024,084 2,032,530 RGD:9068941
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link NW_004955408 11,289,920 11,311,216 RGD:9068941
G Irak1 interleukin 1 receptor associated kinase 1 JBrowse link NW_004955580 663,651 668,622 RGD:9068941
G Irak2 interleukin 1 receptor associated kinase 2 JBrowse link NW_004955561 1,585,842 1,650,268 RGD:9068941
G Irak3 interleukin 1 receptor associated kinase 3 JBrowse link NW_004955458 12,839,995 12,880,285 RGD:9068941
G Itch itchy E3 ubiquitin protein ligase JBrowse link NW_004955422 26,810,829 26,918,517 RGD:9068941
G Klf4 Kruppel like factor 4 JBrowse link NW_004955419 19,280,311 19,284,097 RGD:9068941
G LOC102009223 cytochrome P450 1B1 JBrowse link NW_004955441 5,803,397 5,812,131 RGD:9068941
G Lrrc14 leucine rich repeat containing 14 JBrowse link NW_004955454 3,142,621 3,146,470 RGD:9068941
G Map2k5 mitogen-activated protein kinase kinase 5 JBrowse link NW_004955450 8,207,577 8,458,258 RGD:9068941
G Nfkbia NFKB inhibitor alpha JBrowse link NW_004955409 25,691,673 25,695,151 RGD:9068941
G Nfkbid NFKB inhibitor delta JBrowse link NW_004955468 2,680,934 2,688,797 RGD:9068941
G Nfkbil1 NFKB inhibitor like 1 JBrowse link NW_004955437 90,623 100,918 RGD:9068941
G Nlrc3 NLR family CARD domain containing 3 JBrowse link NW_004955442 13,795,322 13,834,362 RGD:9068941
G Nlrc5 NLR family CARD domain containing 5 JBrowse link NW_004955433 14,670,273 14,752,739 RGD:9068941
G Nlrp12 NLR family pyrin domain containing 12 JBrowse link NW_004955604 317,987 331,051 RGD:9068941
G Nlrp3 NLR family pyrin domain containing 3 JBrowse link NW_004955581 597,952 616,903 RGD:9068941
G Nr1h4 nuclear receptor subfamily 1 group H member 4 JBrowse link NW_004955405 36,160,360 36,236,258 RGD:9068941
G Nwd1 NACHT and WD repeat domain containing 1 JBrowse link NW_004955524 1,083,237 1,122,615 RGD:9068941
G Otulin OTU deubiquitinase with linear linkage specificity JBrowse link NW_004955426 3,953,852 3,982,532 RGD:9068941
G Parp10 poly(ADP-ribose) polymerase family member 10 JBrowse link NW_004955454 2,644,718 2,651,962 RGD:9068941
G Peli1 pellino E3 ubiquitin protein ligase 1 JBrowse link NW_004955424 20,212,077 20,263,761 RGD:9068941
G Pias4 protein inhibitor of activated STAT 4 JBrowse link NW_004955495 4,760,576 4,791,422 RGD:9068941
G Pkhd1 PKHD1 ciliary IPT domain containing fibrocystin/polyductin JBrowse link NW_004955411 5,988,100 6,434,369 RGD:9068941
G Prdx2 peroxiredoxin 2 JBrowse link NW_004955415 31,880,801 31,884,453 RGD:9068941
G Prmt2 protein arginine methyltransferase 2 JBrowse link NW_004955407 42,991,305 43,019,332 RGD:9068941
G Psmd10 proteasome 26S subunit, non-ATPase 10 JBrowse link NW_004955490 7,825,202 7,832,347 RGD:9068941
G Ptgis prostaglandin I2 synthase JBrowse link NW_004955445 8,624,228 8,663,385 RGD:9068941
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 JBrowse link NW_004955597 272,352 289,348 RGD:9068941
G Rwdd3 RWD domain containing 3 JBrowse link NW_004955435 398,707 412,476 RGD:9068941
G Setd6 SET domain containing 6, protein lysine methyltransferase JBrowse link NW_004955433 15,934,091 15,937,738 RGD:9068941
G Sirt1 sirtuin 1 JBrowse link NW_004955425 20,280,725 20,307,663 RGD:9068941
G Siva1 SIVA1 apoptosis inducing factor JBrowse link NW_004955538 3,197,983 3,202,782 RGD:9068941
G Tax1bp1 Tax1 binding protein 1 JBrowse link NW_004955410 29,366,295 29,445,205 RGD:9068941
G Tceal7 transcription elongation factor A like 7 JBrowse link NW_004955548 467,664 470,196 RGD:9068941
G Tlr9 toll like receptor 9 JBrowse link NW_004955532 3,828,645 3,832,699 RGD:9068941
G Tmsb4x thymosin beta 4 X-linked JBrowse link NW_004955544 266,397 268,447 RGD:9068941
G Tnfaip3 TNF alpha induced protein 3 JBrowse link NW_004955436 21,566,591 21,581,551 RGD:9068941
G Traf3 TNF receptor associated factor 3 JBrowse link NW_004955538 1,954,152 2,013,367 RGD:9068941
G Traip TRAF interacting protein JBrowse link NW_004955532 1,725,608 1,746,690 RGD:9068941
G Trim21 tripartite motif containing 21 JBrowse link NW_004955414 20,066,109 20,077,331 RGD:9068941
G Trim37 tripartite motif containing 37 JBrowse link NW_004955451 3,839,757 4,014,178 RGD:9068941
G Trim40 tripartite motif containing 40 JBrowse link NW_004955583 242,054 260,565 RGD:9068941
G Tut4 terminal uridylyl transferase 4 JBrowse link NW_004955464 6,610,350 6,734,606 RGD:9068941
G Ufl1 UFM1 specific ligase 1 JBrowse link NW_004955411 22,548,139 22,577,287 RGD:9068941
G Usp7 ubiquitin specific peptidase 7 JBrowse link NW_004955442 9,316,022 9,355,751 RGD:9068941
G Zc3h12a zinc finger CCCH-type containing 12A JBrowse link NW_004955452 15,306,398 15,314,959 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14516
    negative regulation of biological process 4878
      negative regulation of DNA-binding transcription factor activity 151
        cytoplasmic sequestering of transcription factor + 18
        negative regulation of CREB transcription factor activity 6
        negative regulation of NF-kappaB transcription factor activity + 73
Path 2
Term Annotations click to browse term
  biological_process 14516
    metabolic process 9918
      cellular metabolic process 9355
        cellular aromatic compound metabolic process 5128
          nucleobase-containing compound metabolic process 4945
            nucleic acid metabolic process 4460
              RNA metabolic process 3990
                RNA biosynthetic process 3147
                  nucleic acid-templated transcription 3132
                    transcription, DNA-templated 3094
                      regulation of transcription, DNA-templated 2937
                        regulation of DNA-binding transcription factor activity 396
                          negative regulation of DNA-binding transcription factor activity 151
                            cytoplasmic sequestering of transcription factor + 18
                            negative regulation of CREB transcription factor activity 6
                            negative regulation of NF-kappaB transcription factor activity + 73
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.