ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of DNA-binding transcription factor activity
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Accession:GO:0043433 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
Synonyms:exact_synonym: down regulation of transcription factor activity;   downregulation of transcription factor activity;   negative regulation of sequence-specific DNA binding transcription factor activity
 narrow_synonym: inhibition of transcription factor activity;   negative regulation of androgen receptor activity;   negative regulation of thyroid hormone receptor activity
 broad_synonym: negative regulation of transcription factor activity
 alt_id: GO:1904168;   GO:2000824


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negative regulation of DNA-binding transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BHLHE40 basic helix-loop-helix family member e40 JBrowse link 20 12,641,872 12,647,519 RGD:13508589
RGD:9068941
G BTRC beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link 28 13,988,408 14,173,223 RGD:9068941
G CEBPG CCAAT enhancer binding protein gamma JBrowse link 1 118,777,110 118,784,397 RGD:13508589
RGD:9068941
G CENPS centromere protein S JBrowse link 2 85,379,378 85,389,175 RGD:9068941
G DDIT3 DNA damage inducible transcript 3 JBrowse link 10 1,606,693 1,612,410 RGD:9068941
G EGLN1 egl-9 family hypoxia inducible factor 1 JBrowse link 4 8,053,486 8,110,791 RGD:13508589
RGD:9068941
G EOMES eomesodermin JBrowse link 23 16,476,498 16,512,406 RGD:9068941
G ESR1 estrogen receptor 1 JBrowse link 1 42,081,952 42,368,544 RGD:13508589
RGD:9068941
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit JBrowse link 16 1,926,443 1,991,995 RGD:13508589
RGD:9068941
G FLNA filamin A JBrowse link X 122,058,303 122,083,467 RGD:9068941
G FOXA2 forkhead box A2 JBrowse link 24 1,010,370 1,013,791 RGD:9068941
RGD:13508589
G FOXH1 forkhead box H1 JBrowse link 13 37,883,554 37,887,324 RGD:9068941
G FOXP3 forkhead box P3 JBrowse link X 42,331,229 42,362,841 RGD:9068941
G FOXS1 forkhead box S1 JBrowse link 24 21,307,275 21,308,632 RGD:9068941
G FZD6 frizzled class receptor 6 JBrowse link 13 4,732,541 4,771,294 RGD:13508589
RGD:9068941
G GAS6 growth arrest specific 6 JBrowse link 22 60,975,196 61,005,869 RGD:9068941
G GLIS2 GLIS family zinc finger 2 JBrowse link 6 37,048,380 37,069,740 RGD:13508589
RGD:9068941
G HAND1 heart and neural crest derivatives expressed 1 JBrowse link 4 55,231,061 55,234,640 RGD:13508589
RGD:9068941
G HAND2 heart and neural crest derivatives expressed 2 JBrowse link 25 24,140,496 24,143,143 RGD:9068941
G HDAC2 histone deacetylase 2 JBrowse link 12 70,053,822 70,083,491 RGD:9068941
G HDAC4 histone deacetylase 4 JBrowse link 25 49,318,621 49,545,314 RGD:9068941
G HMOX1 heme oxygenase 1 JBrowse link 10 28,744,404 28,751,544 RGD:9068941
G ID1 inhibitor of DNA binding 1, HLH protein JBrowse link 24 21,094,339 21,096,276 RGD:9068941
G ID2 inhibitor of DNA binding 2 JBrowse link 10 54,954,852 54,957,116 RGD:9068941
G ID3 inhibitor of DNA binding 3, HLH protein JBrowse link 2 75,880,659 75,881,786 RGD:9068941
G KDM1A lysine demethylase 1A JBrowse link 2 76,313,742 76,375,716 RGD:9068941
G KEAP1 kelch like ECH associated protein 1 JBrowse link 20 50,651,070 50,661,178 RGD:9068941
G LOC479600 beta-catenin-interacting protein 1 JBrowse link 5 62,937,154 63,093,083 RGD:13508589
G LOC490356 cytokine SCM-1 beta JBrowse link 7 29,986,433 29,991,096 RGD:9068941
G MAD2L2 mitotic arrest deficient 2 like 2 JBrowse link 2 84,539,724 84,549,402 RGD:9068941
G MAP3K10 mitogen-activated protein kinase kinase kinase 10 JBrowse link 1 113,422,239 113,435,979 RGD:9068941
G MED13 mediator complex subunit 13 JBrowse link 9 34,638,892 34,742,235 RGD:9068941
G MEN1 menin 1 JBrowse link 18 52,346,747 52,352,884 RGD:13508589
RGD:9068941
G NR0B1 nuclear receptor subfamily 0 group B member 1 JBrowse link X 25,396,527 25,401,587 RGD:9068941
G NR0B2 nuclear receptor subfamily 0 group B member 2 JBrowse link 2 73,234,482 73,236,548 RGD:9068941
G NUPR1 nuclear protein 1, transcriptional regulator JBrowse link 6 18,222,367 18,224,015 RGD:9068941
G PAXIP1 PAX interacting protein 1 JBrowse link 16 18,066,289 18,116,007 RGD:9068941
G PBX1 PBX homeobox 1 JBrowse link 38 18,378,997 18,703,694 RGD:9068941
G PHB2 prohibitin 2 JBrowse link 27 38,075,769 38,080,440 RGD:9068941
G PIAS2 protein inhibitor of activated STAT 2 JBrowse link 7 44,436,100 44,583,657 RGD:9068941
G PIM1 Pim-1 proto-oncogene, serine/threonine kinase JBrowse link 12 6,213,504 6,217,933 RGD:9068941
G PLA2G10 phospholipase A2 group X JBrowse link 6 28,573,239 28,591,714 RGD:9068941
G POU4F2 POU class 4 homeobox 2 JBrowse link 15 45,030,818 45,034,446 RGD:9068941
G PRNP prion protein JBrowse link 24 16,845,224 16,862,319 RGD:13508589
RGD:9068941
G PROX1 prospero homeobox 1 JBrowse link 7 11,996,282 12,047,693 RGD:13508589
RGD:9068941
G PTCH1 patched 1 JBrowse link 1 71,246,750 71,309,036 RGD:9068941
G RB1 RB transcriptional corepressor 1 JBrowse link 22 3,061,621 3,204,625 RGD:9068941
G RLIM ring finger protein, LIM domain interacting JBrowse link X 57,879,749 57,905,805 RGD:13508589
RGD:9068941
G RNF2 ring finger protein 2 JBrowse link 7 18,240,672 18,283,091 RGD:9068941
G SFRP4 secreted frizzled related protein 4 JBrowse link 18 12,018,049 12,028,123 RGD:13508589
RGD:9068941
G SFRP5 secreted frizzled related protein 5 JBrowse link 28 10,994,180 10,999,552 RGD:9068941
G SIGIRR single Ig and TIR domain containing JBrowse link 18 25,548,484 25,553,720 RGD:9068941
G SIRT1 sirtuin 1 JBrowse link 4 19,188,616 19,220,031 RGD:9068941
G SMAD7 SMAD family member 7 JBrowse link 7 79,706,485 79,734,673 RGD:9068941
G SP100 SP100 nuclear antigen JBrowse link 25 42,538,428 42,635,825 RGD:9068941
G SUFU SUFU negative regulator of hedgehog signaling JBrowse link 28 14,992,989 15,115,499 RGD:9068941
G SUMO1 small ubiquitin like modifier 1 JBrowse link 37 11,199,937 11,229,743 RGD:9068941
G TAF1 TATA-box binding protein associated factor 1 JBrowse link X 55,693,091 55,764,268 RGD:9068941
G TAF3 TATA-box binding protein associated factor 3 JBrowse link 2 28,121,719 28,298,961 RGD:13508589
RGD:9068941
G TBX6 T-box 6 JBrowse link 6 18,093,201 18,098,592 RGD:9068941
G TBXT T-box transcription factor T JBrowse link 1 54,183,495 54,192,331 RGD:13508589
RGD:9068941
G TCF7L2 transcription factor 7 like 2 JBrowse link 28 23,966,079 24,162,775 RGD:9068941
G TNFRSF4 TNF receptor superfamily member 4 JBrowse link 5 56,401,410 56,404,410 RGD:9068941
G TNFSF4 TNF superfamily member 4 JBrowse link 7 25,883,297 25,909,608 RGD:9068941
G TRIB1 tribbles pseudokinase 1 JBrowse link 13 23,337,788 23,346,304 RGD:13508589
RGD:9068941
G WFS1 wolframin ER transmembrane glycoprotein JBrowse link 13 38,451,722 38,466,481 RGD:13508589
RGD:9068941
G WWP2 WW domain containing E3 ubiquitin protein ligase 2 JBrowse link 5 79,806,424 79,926,846 RGD:9068941
cytoplasmic sequestering of NF-kappaB term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CCDC22 coiled-coil domain containing 22 JBrowse link X 42,329,320 42,343,270 RGD:13508589
RGD:9068941
G FAF1 Fas associated factor 1 JBrowse link 15 10,232,520 10,691,106 RGD:9068941
G G3BP2 G3BP stress granule assembly factor 2 JBrowse link 32 218,783 305,734 RGD:9068941
G IL10 interleukin 10 JBrowse link 7 5,933,285 5,937,057 RGD:9068941
G LOC100683370 thymosin beta-4 JBrowse link 1 21,127,694 21,128,346 RGD:9068941
G NFKBIA NFKB inhibitor alpha JBrowse link 8 14,100,203 14,103,453 RGD:13508589
RGD:9068941
G PSMD10 proteasome 26S subunit, non-ATPase 10 JBrowse link X 81,625,288 81,632,175 RGD:9068941
RGD:13508589
cytoplasmic sequestering of transcription factor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CREB3 cAMP responsive element binding protein 3 JBrowse link 11 52,260,340 52,265,085 RGD:9068941
G KEAP1 kelch like ECH associated protein 1 JBrowse link 20 50,651,070 50,661,178 RGD:9068941
G MDFI MyoD family inhibitor JBrowse link 12 10,324,499 10,339,699 RGD:9068941
G MXI1 MAX interactor 1, dimerization protein JBrowse link 28 21,584,856 21,655,233 RGD:9068941
G NFKBIA NFKB inhibitor alpha JBrowse link 8 14,100,203 14,103,453 RGD:9068941
G NFKBIE NFKB inhibitor epsilon JBrowse link 12 12,668,664 12,674,146 RGD:9068941
G NFKBIL1 NFKB inhibitor like 1 JBrowse link 12 1,048,393 1,057,458 RGD:9068941
G PKD1 polycystin 1, transient receptor potential channel interacting JBrowse link 6 38,811,051 38,865,503 RGD:9068941
G PKD2 polycystin 2, transient receptor potential cation channel JBrowse link 32 11,383,441 11,437,603 RGD:9068941
G SRI sorcin JBrowse link 14 14,257,375 14,274,816 RGD:9068941
G SUFU SUFU negative regulator of hedgehog signaling JBrowse link 28 14,992,989 15,115,499 RGD:9068941
G TONSL tonsoku like, DNA repair protein JBrowse link 13 37,846,010 37,857,633 RGD:9068941
negative regulation of CREB transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADGRG3 adhesion G protein-coupled receptor G3 JBrowse link 2 58,780,800 58,805,593 RGD:13508589
RGD:9068941
G DDIT3 DNA damage inducible transcript 3 JBrowse link 10 1,606,693 1,612,410 RGD:13508589
RGD:9068941
G EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 JBrowse link 30 7,144,727 7,248,014 RGD:9068941
G FOXP3 forkhead box P3 JBrowse link X 42,331,229 42,362,841 RGD:13508589
RGD:9068941
G MSX2 msh homeobox 2 JBrowse link 4 38,002,724 38,007,407 RGD:13508589
RGD:9068941
G SIK1 salt inducible kinase 1 JBrowse link 31 37,455,130 37,466,829 RGD:13508589
RGD:9068941
negative regulation of NF-kappaB transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACOD1 aconitate decarboxylase 1 JBrowse link 22 30,545,991 30,557,199 RGD:9068941
G ADORA3 adenosine A3 receptor JBrowse link 17 63,895,408 63,898,666 RGD:13508589
RGD:9068941
G ANXA4 annexin A4 JBrowse link 10 68,418,678 68,466,181 RGD:13508589
RGD:9068941
G ARRB1 arrestin beta 1 JBrowse link 21 23,261,020 23,304,448 RGD:9068941
G ARRB2 arrestin beta 2 JBrowse link 5 31,831,208 31,838,875 RGD:9068941
G BMP7 bone morphogenetic protein 7 JBrowse link 24 42,203,183 42,294,105 RGD:9068941
G BRMS1 BRMS1 transcriptional repressor and anoikis regulator JBrowse link 18 50,967,175 50,974,816 RGD:9068941
G CACTIN cactin, spliceosome C complex subunit JBrowse link 20 55,803,494 55,817,467 RGD:13508589
RGD:9068941
G CAT catalase JBrowse link 18 33,383,005 33,422,447 RGD:9068941
G CD200 CD200 molecule JBrowse link 33 16,872,849 16,892,161 RGD:13508589
RGD:9068941
G CDK5RAP3 CDK5 regulatory subunit associated protein 3 JBrowse link 9 24,276,660 24,286,273 RGD:9068941
G CDKN2A cyclin dependent kinase inhibitor 2A JBrowse link 11 41,223,316 41,226,056 RGD:9068941
G CHP1 calcineurin like EF-hand protein 1 JBrowse link 30 8,304,939 8,352,833 RGD:13508589
RGD:9068941
G CHUK component of inhibitor of nuclear factor kappa B kinase complex JBrowse link 28 12,964,670 13,001,557 RGD:13508589
RGD:9068941
G CMKLR1 chemerin chemokine-like receptor 1 JBrowse link 26 18,487,700 18,539,678 RGD:9068941
RGD:13508589
G COMMD1 copper metabolism domain containing 1 JBrowse link 10 61,886,281 62,059,610 RGD:13508589
RGD:9068941
G COMMD6 COMM domain containing 6 JBrowse link 22 29,318,216 29,336,032 RGD:9068941
G COMMD7 COMM domain containing 7 JBrowse link 24 22,035,590 22,057,799 RGD:9068941
G CYLD CYLD lysine 63 deubiquitinase JBrowse link 2 64,561,684 64,628,829 RGD:9068941
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 JBrowse link 17 30,273,281 30,278,554 RGD:9068941
G DAB2IP DAB2 interacting protein JBrowse link 9 60,725,887 60,918,242 RGD:9068941
G DAP death associated protein JBrowse link 34 3,616,960 3,682,424 RGD:9068941
G DNAJA3 DnaJ heat shock protein family (Hsp40) member A3 JBrowse link 6 36,921,941 36,967,718 RGD:9068941
G ERBIN erbb2 interacting protein JBrowse link 2 51,613,344 51,730,868 RGD:9068941
G FOXJ1 forkhead box J1 JBrowse link 9 4,512,898 4,517,764 RGD:13508589
RGD:9068941
G FOXP3 forkhead box P3 JBrowse link X 42,331,229 42,362,841 RGD:13508589
RGD:9068941
G GFI1 growth factor independent 1 transcriptional repressor JBrowse link 6 56,473,032 56,484,422 RGD:9068941
G HAVCR2 hepatitis A virus cellular receptor 2 JBrowse link 4 53,018,990 53,032,035 RGD:13508589
RGD:9068941
G IRAK1 interleukin 1 receptor associated kinase 1 JBrowse link X 121,853,340 121,862,582 RGD:13508589
RGD:9068941
G IRAK3 interleukin 1 receptor associated kinase 3 JBrowse link 10 8,683,541 8,730,757 RGD:9068941
G ITCH itchy E3 ubiquitin protein ligase JBrowse link 24 23,476,619 23,630,574 RGD:9068941
G KLF4 Kruppel like factor 4 JBrowse link 11 62,881,840 62,886,676 RGD:9068941
G LOC100683370 thymosin beta-4 JBrowse link 1 21,127,694 21,128,346 RGD:9068941
G LOC100855742 NACHT, LRR and PYD domains-containing protein 12-like JBrowse link 1 103,571,756 103,605,692 RGD:9068941
G LOC484411 caspase recruitment domain-containing protein 8-like JBrowse link 1 108,026,553 108,058,664 RGD:9068941
G LRRC14 leucine rich repeat containing 14 JBrowse link 13 37,937,437 37,941,202 RGD:9068941
G MAP2K5 mitogen-activated protein kinase kinase 5 JBrowse link 30 31,665,032 31,920,792 RGD:9068941
G NFKBIA NFKB inhibitor alpha JBrowse link 8 14,100,203 14,103,453 RGD:9068941
G NFKBID NFKB inhibitor delta JBrowse link 1 116,763,371 116,770,683 RGD:9068941
G NFKBIL1 NFKB inhibitor like 1 JBrowse link 12 1,048,393 1,057,458 RGD:13508589
RGD:9068941
G NLRC3 NLR family CARD domain containing 3 JBrowse link 6 37,668,654 37,707,387 RGD:9068941
G NLRC5 NLR family CARD domain containing 5 JBrowse link 2 59,279,535 59,359,327 RGD:13508589
RGD:9068941
G NLRP2 NLR family pyrin domain containing 2 JBrowse link 1 102,613,871 102,637,379 RGD:9068941
G NLRP3 NLR family pyrin domain containing 3 JBrowse link 8 251,776 313,290 RGD:13508589
RGD:9068941
G NR1H4 nuclear receptor subfamily 1 group H member 4 JBrowse link 15 39,497,313 39,608,120 RGD:13508589
RGD:9068941
G NWD1 NACHT and WD repeat domain containing 1 JBrowse link 20 45,792,745 45,854,889 RGD:9068941
G OTULIN OTU deubiquitinase with linear linkage specificity JBrowse link 34 119,307 159,419 RGD:9068941
G PELI1 pellino E3 ubiquitin protein ligase 1 JBrowse link 10 63,727,905 63,863,599 RGD:13508589
RGD:9068941
G PIAS4 protein inhibitor of activated STAT 4 JBrowse link 20 55,529,841 55,553,604 RGD:13508589
RGD:9068941
G PKHD1 PKHD1, fibrocystin/polyductin JBrowse link 12 19,280,866 19,744,669 RGD:13508589
RGD:9068941
G PRDX2 peroxiredoxin 2 JBrowse link 20 49,352,271 49,356,755 RGD:13508589
RGD:9068941
G PRMT2 protein arginine methyltransferase 2 JBrowse link 31 39,806,086 39,838,959 RGD:13508589
RGD:9068941
G PSMD10 proteasome 26S subunit, non-ATPase 10 JBrowse link X 81,625,288 81,632,175 RGD:9068941
G PTGIS prostaglandin I2 synthase JBrowse link 24 36,129,091 36,162,525 RGD:9068941
G PYCARD PYD and CARD domain containing JBrowse link 6 17,049,352 17,051,348 RGD:9068941
G RBCK1 RANBP2-type and C3HC4-type zinc finger containing 1 JBrowse link 24 20,423,378 20,440,985 RGD:13508589
RGD:9068941
G RWDD3 RWD domain containing 3 JBrowse link 6 54,082,061 54,094,218 RGD:9068941
G SETD6 SET domain containing 6, protein lysine methyltransferase JBrowse link 2 58,138,739 58,142,909 RGD:9068941
G SIRT1 sirtuin 1 JBrowse link 4 19,188,616 19,220,031 RGD:9068941
G SIVA1 SIVA1 apoptosis inducing factor JBrowse link 8 72,309,400 72,313,726 RGD:9068941
G TAX1BP1 Tax1 binding protein 1 JBrowse link 14 40,845,532 40,939,172 RGD:9068941
G TCEAL7 transcription elongation factor A like 7 JBrowse link X 76,372,804 76,374,938 RGD:13508589
RGD:9068941
G TLR9 toll like receptor 9 JBrowse link 20 37,529,322 37,547,117 RGD:9068941
G TMIGD3 transmembrane and immunoglobulin domain containing 3 JBrowse link 17 63,904,582 63,907,044 RGD:9068941
G TNFAIP3 TNF alpha induced protein 3 JBrowse link 1 30,247,432 30,262,992 RGD:13508589
RGD:9068941
G TRAF3 TNF receptor associated factor 3 JBrowse link 8 70,739,389 70,794,448 RGD:9068941
G TRAIP TRAF interacting protein JBrowse link 20 39,430,109 39,454,437 RGD:13508589
RGD:9068941
G TRIM21 tripartite motif containing 21 JBrowse link 21 26,775,227 26,783,180 RGD:9068941
G TRIM37 tripartite motif containing 37 JBrowse link 9 33,446,903 33,687,650 RGD:13508589
RGD:9068941
G TUT4 terminal uridylyl transferase 4 JBrowse link 15 8,832,208 8,958,136 RGD:9068941
G UFL1 UFM1 specific ligase 1 JBrowse link 12 54,988,200 55,023,414 RGD:13508589
RGD:9068941
G USP7 ubiquitin specific peptidase 7 JBrowse link 6 33,277,328 33,315,601 RGD:13508589
RGD:9068941
G VHL von Hippel-Lindau tumor suppressor JBrowse link 20 8,206,616 8,211,347 RGD:9068941
G ZC3H12A zinc finger CCCH-type containing 12A JBrowse link 15 4,972,369 4,984,218 RGD:13508589
RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15735
    negative regulation of biological process 5072
      negative regulation of DNA-binding transcription factor activity 155
        cytoplasmic sequestering of transcription factor + 18
        negative regulation of CREB transcription factor activity 6
        negative regulation of NF-kappaB transcription factor activity + 78
Path 2
Term Annotations click to browse term
  biological_process 15735
    metabolic process 10450
      cellular metabolic process 9822
        cellular aromatic compound metabolic process 5376
          nucleobase-containing compound metabolic process 5177
            nucleic acid metabolic process 4667
              RNA metabolic process 4194
                RNA biosynthetic process 3337
                  nucleic acid-templated transcription 3322
                    transcription, DNA-templated 3282
                      regulation of transcription, DNA-templated 3123
                        regulation of DNA-binding transcription factor activity 408
                          negative regulation of DNA-binding transcription factor activity 155
                            cytoplasmic sequestering of transcription factor + 18
                            negative regulation of CREB transcription factor activity 6
                            negative regulation of NF-kappaB transcription factor activity + 78
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.