ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of DNA-binding transcription factor activity
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Accession:GO:0043433 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
Synonyms:exact_synonym: down regulation of transcription factor activity;   downregulation of transcription factor activity;   negative regulation of sequence-specific DNA binding transcription factor activity
 narrow_synonym: inhibition of transcription factor activity;   negative regulation of androgen receptor activity;   negative regulation of thyroid hormone receptor activity
 broad_synonym: negative regulation of transcription factor activity
 alt_id: GO:1904168;   GO:2000824


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negative regulation of DNA-binding transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BHLHE40 basic helix-loop-helix family member e40 JBrowse link 3 4,979,412 4,985,181 RGD:2290271
G BTRC beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link 10 101,353,808 101,557,321 RGD:2290271
G CEBPG CCAAT enhancer binding protein gamma JBrowse link 19 33,373,669 33,382,686 RGD:2290271
G CTNNBIP1 catenin beta interacting protein 1 JBrowse link 1 9,848,276 9,910,322 RGD:2290271
G DDIT3 DNA damage inducible transcript 3 JBrowse link 12 57,516,588 57,520,517 RGD:2290271
G EGLN1 egl-9 family hypoxia inducible factor 1 JBrowse link 1 231,363,751 231,425,044 RGD:2290271
G EOMES eomesodermin JBrowse link 3 27,715,949 27,722,715 RGD:2290271
G ESR1 estrogen receptor 1 JBrowse link 6 151,654,148 152,129,604 RGD:2290271
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit JBrowse link 7 148,807,372 148,884,349 RGD:2290271
G FLNA filamin A JBrowse link X 154,348,532 154,374,638 RGD:2290271
G FOXA2 forkhead box A2 JBrowse link 20 22,581,004 22,585,463 RGD:2290271
G FOXH1 forkhead box H1 JBrowse link 8 144,473,732 144,476,335 RGD:2290271
G FOXP3 forkhead box P3 JBrowse link X 49,250,436 49,264,932 RGD:2290271
G FOXS1 forkhead box S1 JBrowse link 20 31,844,300 31,845,617 RGD:2290271
G FZD6 frizzled class receptor 6 JBrowse link 8 103,298,433 103,332,866 RGD:2290271
G GAS6 growth arrest specific 6 JBrowse link 13 113,820,549 113,864,103 RGD:2290271
G GLIS2 GLIS family zinc finger 2 JBrowse link 16 4,314,761 4,339,597 RGD:2290271
G HAND1 heart and neural crest derivatives expressed 1 JBrowse link 5 154,474,972 154,478,264 RGD:2290271
G HAND2 heart and neural crest derivatives expressed 2 JBrowse link 4 173,526,501 173,530,227 RGD:2290271
G HDAC2 histone deacetylase 2 JBrowse link 6 113,936,156 113,971,195 RGD:2290271
G HDAC4 histone deacetylase 4 JBrowse link 2 239,048,168 239,401,647 RGD:2290271
G HEYL hes related family bHLH transcription factor with YRPW motif like JBrowse link 1 39,623,431 39,639,676 RGD:2290271
G HMOX1 heme oxygenase 1 JBrowse link 22 35,381,067 35,394,214 RGD:2290271
G ID1 inhibitor of DNA binding 1, HLH protein JBrowse link 20 31,605,283 31,606,515 RGD:2290271
G ID2 inhibitor of DNA binding 2 JBrowse link 2 8,681,983 8,684,453 RGD:2290271
G ID3 inhibitor of DNA binding 3, HLH protein JBrowse link 1 23,557,930 23,559,794 RGD:2290271
G KDM1A lysine demethylase 1A JBrowse link 1 23,019,443 23,083,691 RGD:2290271
G KEAP1 kelch like ECH associated protein 1 JBrowse link 19 10,486,120 10,503,378 RGD:2290271
G MAD2L2 mitotic arrest deficient 2 like 2 JBrowse link 1 11,674,480 11,691,621 RGD:2290271
G MAP3K10 mitogen-activated protein kinase kinase kinase 10 JBrowse link 19 40,191,657 40,215,575 RGD:2290271
G MED13 mediator complex subunit 13 JBrowse link 17 61,942,605 62,065,983 RGD:2290271
G MEN1 menin 1 JBrowse link 11 64,803,514 64,811,294 RGD:2290271
G NR0B1 nuclear receptor subfamily 0 group B member 1 JBrowse link X 30,304,422 30,309,378 RGD:2290271
G NR0B2 nuclear receptor subfamily 0 group B member 2 JBrowse link 1 26,911,484 26,914,110 RGD:2290271
G NUPR1 nuclear protein 1, transcriptional regulator JBrowse link 16 28,537,341 28,539,174 RGD:2290271
G PAXIP1 PAX interacting protein 1 JBrowse link 7 154,943,690 155,003,419 RGD:2290271
G PBX1 PBX homeobox 1 JBrowse link 1 164,559,360 164,886,047 RGD:2290271
G PEX14 peroxisomal biogenesis factor 14 JBrowse link 1 10,474,946 10,630,758 RGD:2290271
G PHB2 prohibitin 2 JBrowse link 12 6,965,352 6,970,753 RGD:2290271
G PIAS2 protein inhibitor of activated STAT 2 JBrowse link 18 46,803,224 46,920,167 RGD:2290271
G PIM1 Pim-1 proto-oncogene, serine/threonine kinase JBrowse link 6 37,170,146 37,175,428 RGD:2290271
G PLA2G10 phospholipase A2 group X JBrowse link 16 14,672,548 14,694,662 RGD:2290271
G POU4F2 POU class 4 homeobox 2 JBrowse link 4 146,638,893 146,642,471 RGD:2290271
G PRNP prion protein JBrowse link 20 4,686,094 4,701,590 RGD:2290271
G PROX1 prospero homeobox 1 JBrowse link 1 213,983,239 214,041,510 RGD:2290271
G PTCH1 patched 1 JBrowse link 9 95,442,980 95,517,057 RGD:2290271
G RB1 RB transcriptional corepressor 1 JBrowse link 13 48,303,747 48,481,890 RGD:2290271
G RLIM ring finger protein, LIM domain interacting JBrowse link X 74,582,976 74,614,626 RGD:2290271
G RNF2 ring finger protein 2 JBrowse link 1 185,045,419 185,102,608 RGD:2290271
G SFRP4 secreted frizzled related protein 4 JBrowse link 7 37,905,932 37,916,923 RGD:2290271
G SFRP5 secreted frizzled related protein 5 JBrowse link 10 97,766,751 97,771,999 RGD:2290271
G SIGIRR single Ig and TIR domain containing JBrowse link 11 405,716 417,454 RGD:2290271
G SIRT1 sirtuin 1 JBrowse link 10 67,884,669 67,918,390 RGD:2290271
G SMAD7 SMAD family member 7 JBrowse link 18 48,919,853 48,950,711 RGD:2290271
G SP100 SP100 nuclear antigen JBrowse link 2 230,416,156 230,545,602 RGD:2290271
G SUFU SUFU negative regulator of hedgehog signaling JBrowse link 10 102,502,801 102,633,458 RGD:2290271
G SUMO1 small ubiquitin like modifier 1 JBrowse link 2 202,206,180 202,238,599 RGD:2290271
G TAF1 TATA-box binding protein associated factor 1 JBrowse link X 71,366,220 71,530,525 RGD:2290271
G TAF3 TATA-box binding protein associated factor 3 JBrowse link 10 7,818,504 8,016,631 RGD:2290271
G TBX6 T-box 6 JBrowse link 16 30,085,793 30,091,927 RGD:2290271
G TBXT T-box transcription factor T JBrowse link 6 166,157,644 166,168,669 RGD:2290271
G TCF7L2 transcription factor 7 like 2 JBrowse link 10 112,950,220 113,167,678 RGD:2290271
G TNFRSF4 TNF receptor superfamily member 4 JBrowse link 1 1,211,326 1,216,812 RGD:2290271
G TNFSF4 TNF superfamily member 4 JBrowse link 1 173,183,729 173,462,208 RGD:2290271
G TRIB1 tribbles pseudokinase 1 JBrowse link 8 125,430,290 125,438,405 RGD:2290271
G TWIST1 twist family bHLH transcription factor 1 JBrowse link 7 19,113,047 19,117,672 RGD:2290271
G WFS1 wolframin ER transmembrane glycoprotein JBrowse link 4 6,260,368 6,303,265 RGD:2290271
G WWP2 WW domain containing E3 ubiquitin protein ligase 2 JBrowse link 16 69,762,284 69,941,741 RGD:2290271
G XCL1 X-C motif chemokine ligand 1 JBrowse link 1 168,574,128 168,582,077 RGD:2290271
G ZNF431 zinc finger protein 431 JBrowse link 19 21,142,009 21,196,053 RGD:2290271
cytoplasmic sequestering of NF-kappaB term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CCDC22 coiled-coil domain containing 22 JBrowse link X 49,235,467 49,250,526 RGD:2290271
G FAF1 Fas associated factor 1 JBrowse link 1 50,441,263 50,960,264 RGD:2290271
G G3BP2 G3BP stress granule assembly factor 2 JBrowse link 4 75,642,769 75,724,470 RGD:2290271
G IL10 interleukin 10 JBrowse link 1 206,767,603 206,772,494 RGD:2290271
G NFKBIA NFKB inhibitor alpha JBrowse link 14 35,401,510 35,404,754 RGD:2290271
G PSMD10 proteasome 26S subunit, non-ATPase 10 JBrowse link X 108,084,205 108,091,644 RGD:2290271
G TMSB4X thymosin beta 4 X-linked JBrowse link X 12,975,107 12,977,227 RGD:2290271
cytoplasmic sequestering of transcription factor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CREB3 cAMP responsive element binding protein 3 JBrowse link 9 35,732,320 35,737,008 RGD:2290271
G KEAP1 kelch like ECH associated protein 1 JBrowse link 19 10,486,120 10,503,378 RGD:2290271
G MDFI MyoD family inhibitor JBrowse link 6 41,637,020 41,654,246 RGD:2290271
G MXI1 MAX interactor 1, dimerization protein JBrowse link 10 110,207,605 110,287,365 RGD:2290271
G NFKBIA NFKB inhibitor alpha JBrowse link 14 35,401,510 35,404,754 RGD:2290271
G NFKBIE NFKB inhibitor epsilon JBrowse link 6 44,258,166 44,265,788 RGD:2290271
G NFKBIL1 NFKB inhibitor like 1 JBrowse link 6 31,546,851 31,558,829 RGD:2290271
G PKD1 polycystin 1, transient receptor potential channel interacting JBrowse link 16 2,088,708 2,135,898 RGD:2290271
G PKD2 polycystin 2, transient receptor potential cation channel JBrowse link 4 88,007,647 88,077,779 RGD:2290271
G SRI sorcin JBrowse link 7 88,205,115 88,226,993 RGD:2290271
G SUFU SUFU negative regulator of hedgehog signaling JBrowse link 10 102,502,801 102,633,458 RGD:2290271
G TONSL tonsoku like, DNA repair protein JBrowse link 8 144,428,780 144,444,488 RGD:2290271
negative regulation of CREB transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADGRG3 adhesion G protein-coupled receptor G3 JBrowse link 16 57,663,998 57,689,378 RGD:2290271
G DDIT3 DNA damage inducible transcript 3 JBrowse link 12 57,516,588 57,520,517 RGD:2290271
G EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 JBrowse link 15 39,934,101 40,036,153 RGD:2290271
G FOXP3 forkhead box P3 JBrowse link X 49,250,436 49,264,932 RGD:2290271
G MSX2 msh homeobox 2 JBrowse link 5 174,724,496 174,730,899 RGD:2290271
G SIK1 salt inducible kinase 1 JBrowse link 21 43,414,490 43,427,132 RGD:2290271
G SIK1B salt inducible kinase 1B (putative) JBrowse link 21 6,111,073 6,123,778 RGD:2290271
negative regulation of NF-kappaB transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACOD1 aconitate decarboxylase 1 JBrowse link 13 76,948,559 76,958,642 RGD:2290271
G ADORA3 adenosine A3 receptor JBrowse link 1 111,499,429 111,504,121 RGD:2290271
G AIM2 absent in melanoma 2 JBrowse link 1 159,059,226 159,132,351 RGD:2290271
G ANXA4 annexin A4 JBrowse link 2 69,643,805 69,826,477 RGD:2290271
G ARRB1 arrestin beta 1 JBrowse link 11 75,260,122 75,351,831 RGD:2290271
G ARRB2 arrestin beta 2 JBrowse link 17 4,710,494 4,721,500 RGD:2290271
G BMP7 bone morphogenetic protein 7 JBrowse link 20 57,168,753 57,266,651 RGD:2290271
G BRMS1 BRMS1 transcriptional repressor and anoikis regulator JBrowse link 11 66,337,333 66,345,125 RGD:2290271
G CACTIN cactin, spliceosome C complex subunit JBrowse link 19 3,610,628 3,626,815 RGD:2290271
G CARD8 caspase recruitment domain family member 8 JBrowse link 19 48,203,148 48,256,264 RGD:2290271
G CAT catalase JBrowse link 11 34,438,925 34,472,060 RGD:2290271
G CD200 CD200 molecule JBrowse link 3 112,332,224 112,362,812 RGD:2290271
G CDK5RAP3 CDK5 regulatory subunit associated protein 3 JBrowse link 17 47,967,904 47,981,786 RGD:2290271
G CDKN2A cyclin dependent kinase inhibitor 2A JBrowse link 9 21,967,752 21,995,043 RGD:2290271
G CHP1 calcineurin like EF-hand protein 1 JBrowse link 15 41,231,156 41,281,887 RGD:2290271
G CHUK component of inhibitor of nuclear factor kappa B kinase complex JBrowse link 10 100,188,298 100,229,610 RGD:2290271
G CMKLR1 chemerin chemokine-like receptor 1 JBrowse link 12 108,288,044 108,339,347 RGD:2290271
G COMMD1 copper metabolism domain containing 1 JBrowse link 2 61,888,723 62,136,070 RGD:2290271
G COMMD6 COMM domain containing 6 JBrowse link 13 75,525,214 75,549,439 RGD:2290271
G COMMD7 COMM domain containing 7 JBrowse link 20 32,702,691 32,744,008 RGD:2290271
G CYLD CYLD lysine 63 deubiquitinase JBrowse link 16 50,742,026 50,801,935 RGD:2290271
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 JBrowse link 2 38,067,603 38,076,181 RGD:2290271
G DAB2IP DAB2 interacting protein JBrowse link 9 121,566,883 121,785,530 RGD:2290271
G DAP death associated protein JBrowse link 5 10,679,230 10,761,275 RGD:2290271
G DNAJA3 DnaJ heat shock protein family (Hsp40) member A3 JBrowse link 16 4,425,805 4,456,775 RGD:2290271
G ERBIN erbb2 interacting protein JBrowse link 5 65,926,554 66,081,023 RGD:2290271
G FOXJ1 forkhead box J1 JBrowse link 17 76,136,333 76,141,299 RGD:2290271
G FOXP3 forkhead box P3 JBrowse link X 49,250,436 49,264,932 RGD:2290271
G GFI1 growth factor independent 1 transcriptional repressor JBrowse link 1 92,473,043 92,486,876 RGD:2290271
G HAVCR2 hepatitis A virus cellular receptor 2 JBrowse link 5 157,085,832 157,109,237 RGD:2290271
G IRAK1 interleukin 1 receptor associated kinase 1 JBrowse link X 154,010,506 154,019,984 RGD:2290271
G IRAK2 interleukin 1 receptor associated kinase 2 JBrowse link 3 10,164,879 10,243,743 RGD:2290271
G IRAK3 interleukin 1 receptor associated kinase 3 JBrowse link 12 66,189,198 66,254,622 RGD:2290271
G ITCH itchy E3 ubiquitin protein ligase JBrowse link 20 34,363,235 34,511,773 RGD:2290271
G KLF4 Kruppel like factor 4 JBrowse link 9 107,484,852 107,489,720 RGD:2290271
G LRRC14 leucine rich repeat containing 14 JBrowse link 8 144,517,965 144,525,178 RGD:2290271
G MAP2K5 mitogen-activated protein kinase kinase 5 JBrowse link 15 67,542,683 67,807,117 RGD:2290271
G NFKBIA NFKB inhibitor alpha JBrowse link 14 35,401,510 35,404,754 RGD:2290271
G NFKBID NFKB inhibitor delta JBrowse link 19 35,887,630 35,902,301 RGD:2290271
G NFKBIL1 NFKB inhibitor like 1 JBrowse link 6 31,546,851 31,558,829 RGD:2290271
G NLRC3 NLR family CARD domain containing 3 JBrowse link 16 3,539,033 3,577,782 RGD:2290271
G NLRC5 NLR family CARD domain containing 5 JBrowse link 16 56,989,485 57,083,524 RGD:2290271
G NLRP12 NLR family pyrin domain containing 12 JBrowse link 19 53,793,584 53,824,403 RGD:2290271
G NLRP2 NLR family pyrin domain containing 2 JBrowse link 19 54,965,279 55,001,142 RGD:2290271
G NLRP2B NLR family pyrin domain containing 2B JBrowse link X 57,677,067 57,680,260 RGD:2290271
G NLRP3 NLR family pyrin domain containing 3 JBrowse link 1 247,416,156 247,449,108 RGD:2290271
G NR1H4 nuclear receptor subfamily 1 group H member 4 JBrowse link 12 100,473,773 100,563,867 RGD:2290271
G NWD1 NACHT and WD repeat domain containing 1 JBrowse link 19 16,719,526 16,817,963 RGD:2290271
G OTULIN OTU deubiquitinase with linear linkage specificity JBrowse link 5 14,660,794 14,716,552 RGD:2290271
G PARP10 poly(ADP-ribose) polymerase family member 10 JBrowse link 8 143,977,152 143,986,471 RGD:2290271
G PELI1 pellino E3 ubiquitin protein ligase 1 JBrowse link 2 64,092,652 64,144,471 RGD:2290271
G PIAS4 protein inhibitor of activated STAT 4 JBrowse link 19 4,007,598 4,039,386 RGD:2290271
G PKHD1 PKHD1 ciliary IPT domain containing fibrocystin/polyductin JBrowse link 6 51,614,685 52,087,625 RGD:2290271
G PRDX2 peroxiredoxin 2 JBrowse link 19 12,796,820 12,801,910 RGD:2290271
G PRMT2 protein arginine methyltransferase 2 JBrowse link 21 46,635,156 46,665,685 RGD:2290271
G PSMD10 proteasome 26S subunit, non-ATPase 10 JBrowse link X 108,084,205 108,091,644 RGD:2290271
G PTGIS prostaglandin I2 synthase JBrowse link 20 49,503,874 49,568,170 RGD:2290271
G PYCARD PYD and CARD domain containing JBrowse link 16 31,201,486 31,202,776 RGD:2290271
G PYDC1 pyrin domain containing 1 JBrowse link 16 31,215,962 31,217,093 RGD:2290271
G PYDC2 pyrin domain containing 2 JBrowse link 3 191,461,163 191,461,456 RGD:2290271
G RBCK1 RANBP2-type and C3HC4-type zinc finger containing 1 JBrowse link 20 408,050 432,139 RGD:2290271
G RWDD3 RWD domain containing 3 JBrowse link 1 95,234,155 95,247,225 RGD:2290271
G SETD6 SET domain containing 6, protein lysine methyltransferase JBrowse link 16 58,515,479 58,521,990 RGD:2290271
G SIRT1 sirtuin 1 JBrowse link 10 67,884,669 67,918,390 RGD:2290271
G SIVA1 SIVA1 apoptosis inducing factor JBrowse link 14 104,752,420 104,759,659 RGD:2290271
G TAX1BP1 Tax1 binding protein 1 JBrowse link 7 27,739,373 27,829,767 RGD:2290271
G TCEAL7 transcription elongation factor A like 7 JBrowse link X 103,330,186 103,332,326 RGD:2290271
G TLR9 toll like receptor 9 JBrowse link 3 52,221,080 52,226,163 RGD:2290271
G TMIGD3 transmembrane and immunoglobulin domain containing 3 JBrowse link 1 111,483,348 111,564,003 RGD:2290271
G TMSB4X thymosin beta 4 X-linked JBrowse link X 12,975,107 12,977,227 RGD:2290271
G TNFAIP3 TNF alpha induced protein 3 JBrowse link 6 137,866,317 137,883,314 RGD:2290271
G TRAF3 TNF receptor associated factor 3 JBrowse link 14 102,777,479 102,911,500 RGD:2290271
G TRAIP TRAF interacting protein JBrowse link 3 49,828,595 49,856,584 RGD:2290271
G TRIM21 tripartite motif containing 21 JBrowse link 11 4,384,897 4,393,696 RGD:2290271
G TRIM37 tripartite motif containing 37 JBrowse link 17 58,968,010 59,106,964 RGD:2290271
G TRIM40 tripartite motif containing 40 JBrowse link 6 30,135,998 30,148,773 RGD:2290271
G TUT4 terminal uridylyl transferase 4 JBrowse link 1 52,423,275 52,553,463 RGD:2290271
G UFL1 UFM1 specific ligase 1 JBrowse link 6 96,521,826 96,555,276 RGD:2290271
G USP7 ubiquitin specific peptidase 7 JBrowse link 16 8,892,094 8,963,912 RGD:2290271
G ZC3H12A zinc finger CCCH-type containing 12A JBrowse link 1 37,474,518 37,484,377 RGD:2290271
G ZNF675 zinc finger protein 675 JBrowse link 19 23,652,906 23,687,215 RGD:2290271

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17597
    negative regulation of biological process 5352
      negative regulation of DNA-binding transcription factor activity 166
        cytoplasmic sequestering of transcription factor + 18
        negative regulation of CREB transcription factor activity 7
        negative regulation of NF-kappaB transcription factor activity + 85
Path 2
Term Annotations click to browse term
  biological_process 17597
    metabolic process 11348
      cellular metabolic process 10672
        cellular aromatic compound metabolic process 5907
          nucleobase-containing compound metabolic process 5692
            nucleic acid metabolic process 5166
              RNA metabolic process 4672
                RNA biosynthetic process 3735
                  nucleic acid-templated transcription 3718
                    transcription, DNA-templated 3673
                      regulation of transcription, DNA-templated 3500
                        regulation of DNA-binding transcription factor activity 430
                          negative regulation of DNA-binding transcription factor activity 166
                            cytoplasmic sequestering of transcription factor + 18
                            negative regulation of CREB transcription factor activity 7
                            negative regulation of NF-kappaB transcription factor activity + 85
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.