ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of DNA-binding transcription factor activity
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Accession:GO:0043433 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
Synonyms:exact_synonym: down regulation of transcription factor activity;   downregulation of transcription factor activity;   negative regulation of sequence-specific DNA binding transcription factor activity
 narrow_synonym: inhibition of transcription factor activity;   negative regulation of androgen receptor activity;   negative regulation of thyroid hormone receptor activity
 broad_synonym: negative regulation of transcription factor activity
 alt_id: GO:1904168;   GO:2000824


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negative regulation of DNA-binding transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bhlhe40 basic helix-loop-helix family, member e40 JBrowse link 6 108,660,629 108,666,925 RGD:2290270
G Cebpg CCAAT/enhancer binding protein (C/EBP), gamma JBrowse link 7 35,046,422 35,056,566 RGD:2290270
G Ctnnbip1 catenin beta interacting protein 1 JBrowse link 4 149,518,241 149,566,437 RGD:2290270
G Cys1 cystin 1 JBrowse link 12 24,665,833 24,681,819 RGD:2290270
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 10 127,290,793 127,296,291 RGD:2290270
G Egln1 egl-9 family hypoxia-inducible factor 1 JBrowse link 8 124,908,586 124,949,319 RGD:2290270
G Eomes eomesodermin JBrowse link 9 118,478,189 118,486,132 RGD:2290270
G Esr1 estrogen receptor 1 (alpha) JBrowse link 10 4,611,989 5,005,633 RGD:2290270
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit JBrowse link 6 47,530,274 47,595,340 RGD:2290270
G Flna filamin, alpha JBrowse link X 74,223,461 74,249,852 RGD:2290270
G Foxa2 forkhead box A2 JBrowse link 2 148,042,877 148,046,969 RGD:2290270
G Foxh1 forkhead box H1 JBrowse link 15 76,667,829 76,671,545 RGD:2290270
G Foxp3 forkhead box P3 JBrowse link X 7,579,676 7,595,243 RGD:2290270
G Foxs1 forkhead box S1 JBrowse link 2 152,931,898 152,933,208 RGD:2290270
G Fzd6 frizzled class receptor 6 JBrowse link 15 39,005,669 39,038,194 RGD:2290270
G Gas6 growth arrest specific 6 JBrowse link 8 13,465,374 13,494,535 RGD:2290270
G Glis2 GLIS family zinc finger 2 JBrowse link 16 4,594,713 4,625,141 RGD:2290270
G Hand1 heart and neural crest derivatives expressed 1 JBrowse link 11 57,828,713 57,832,147 RGD:2290270
G Hand2 heart and neural crest derivatives expressed 2 JBrowse link 8 57,320,983 57,324,517 RGD:2290270
G Hdac2 histone deacetylase 2 JBrowse link 10 36,974,544 37,001,889 RGD:2290270
G Hdac3 histone deacetylase 3 JBrowse link 18 37,936,971 37,954,988 RGD:2290270
G Hdac4 histone deacetylase 4 JBrowse link 1 91,928,779 92,195,670 RGD:2290270
G Heyl hairy/enhancer-of-split related with YRPW motif-like JBrowse link 4 123,233,556 123,249,870 RGD:2290270
G Hmox1 heme oxygenase 1 JBrowse link 8 75,093,618 75,100,593 RGD:2290270
G Hnf4a hepatic nuclear factor 4, alpha JBrowse link 2 163,506,809 163,572,907 RGD:2290270
G Hr lysine demethylase and nuclear receptor corepressor JBrowse link 14 70,554,056 70,573,548 RGD:2290270
G Id1 inhibitor of DNA binding 1, HLH protein JBrowse link 2 152,736,234 152,737,410 RGD:2290270
G Id2 inhibitor of DNA binding 2 JBrowse link 12 25,093,799 25,096,092 RGD:2290270
G Id3 inhibitor of DNA binding 3 JBrowse link 4 136,143,822 136,145,392 RGD:2290270
G Igf1r insulin-like growth factor I receptor JBrowse link 7 67,951,833 68,233,668 RGD:2290270
G Irak2 interleukin-1 receptor-associated kinase 2 JBrowse link 6 113,638,467 113,695,026 RGD:2290270
G Kat6a K(lysine) acetyltransferase 6A JBrowse link 8 22,859,516 22,943,262 RGD:2290270
G Kdm1a lysine (K)-specific demethylase 1A JBrowse link 4 136,550,533 136,602,790 RGD:2290270
G Klf4 Kruppel-like factor 4 (gut) JBrowse link 4 55,527,137 55,532,475 RGD:2290270
G Mad2l2 MAD2 mitotic arrest deficient-like 2 JBrowse link 4 148,130,255 148,145,704 RGD:2290270
G Map3k10 mitogen-activated protein kinase kinase kinase 10 JBrowse link 7 27,656,375 27,674,611 RGD:2290270
G Med13 mediator complex subunit 13 JBrowse link 11 86,265,715 86,357,525 RGD:2290270
G Men1 multiple endocrine neoplasia 1 JBrowse link 19 6,334,979 6,340,894 RGD:2290270
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 JBrowse link X 86,191,775 86,195,947 RGD:2290270
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 JBrowse link 4 133,553,376 133,556,686 RGD:2290270
G Nupr1 nuclear protein transcription regulator 1 JBrowse link 7 126,623,246 126,625,470 RGD:2290270
G Pbx1 pre B cell leukemia homeobox 1 JBrowse link 1 168,119,364 168,432,264 RGD:2290270
G Pex14 peroxisomal biogenesis factor 14 JBrowse link 4 148,960,535 149,099,812 RGD:2290270
G Phb2 prohibitin 2 JBrowse link 6 124,712,273 124,716,950 RGD:2290270
G Pias2 protein inhibitor of activated STAT 2 JBrowse link 18 77,065,208 77,155,710 RGD:2290270
G Pim1 proviral integration site 1 JBrowse link 17 29,491,045 29,495,465 RGD:2290270
G Pla2g10 phospholipase A2, group X JBrowse link 16 13,715,057 13,731,018 RGD:2290270
G Pou4f2 POU domain, class 4, transcription factor 2 JBrowse link 8 78,433,009 78,436,652 RGD:2290270
G Prmt2 protein arginine N-methyltransferase 2 JBrowse link 10 76,207,226 76,237,865 RGD:2290270
G Prnp prion protein JBrowse link 2 131,909,928 131,938,436 RGD:2290270
G Prox1 prospero homeobox 1 JBrowse link 1 190,118,035 190,170,680 RGD:2290270
G Ptch1 patched 1 JBrowse link 13 63,508,328 63,573,616 RGD:2290270
G Pthlh parathyroid hormone-like peptide JBrowse link 6 147,252,109 147,264,013 RGD:2290270
G Rlim ring finger protein, LIM domain interacting JBrowse link X 103,957,165 103,981,296 RGD:2290270
G Rnf2 ring finger protein 2 JBrowse link 1 151,469,406 151,500,922 RGD:2290270
G Rpl11 ribosomal protein L11 JBrowse link 4 136,049,947 136,053,371 RGD:2290270
G Sfrp4 secreted frizzled-related protein 4 JBrowse link 13 19,623,175 19,632,825 RGD:2290270
G Sfrp5 secreted frizzled-related sequence protein 5 JBrowse link 19 42,197,971 42,202,252 RGD:2290270
G Sigirr single immunoglobulin and toll-interleukin 1 receptor (TIR) domain JBrowse link 7 141,091,175 141,100,605 RGD:2290270
G Sirt1 sirtuin 1 JBrowse link 10 63,319,005 63,339,035 RGD:2290270
G Smad7 SMAD family member 7 JBrowse link 18 75,367,365 75,395,935 RGD:2290270
G Spop speckle-type POZ protein JBrowse link 11 95,414,063 95,493,410 RGD:2290270
G Sufu SUFU negative regulator of hedgehog signaling JBrowse link 19 46,396,896 46,488,804 RGD:2290270
G Sumo1 small ubiquitin-like modifier 1 JBrowse link 1 59,639,434 59,670,834 RGD:2290270
G T brachyury, T-box transcription factor T JBrowse link 17 8,422,178 8,442,496 RGD:2290270
G Taf3 TATA-box binding protein associated factor 3 JBrowse link 2 9,914,552 10,048,609 RGD:2290270
G Tbx6 T-box 6 JBrowse link 7 126,781,483 126,785,548 RGD:2290270
G Tcf7l2 transcription factor 7 like 2, T cell specific, HMG box JBrowse link 19 55,741,785 55,933,661 RGD:2290270
G Thra thyroid hormone receptor alpha JBrowse link 11 98,741,776 98,769,006 RGD:2290270
G Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 JBrowse link 4 156,013,595 156,016,613 RGD:2290270
G Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 JBrowse link 1 161,395,438 161,418,206 RGD:2290270
G Trib1 tribbles pseudokinase 1 JBrowse link 15 59,648,654 59,657,099 RGD:2290270
G Trib2 tribbles pseudokinase 2 JBrowse link 12 15,791,725 15,816,962 RGD:2290270
G Twist1 twist basic helix-loop-helix transcription factor 1 JBrowse link 12 33,957,671 33,959,831 RGD:2290270
G Wfs1 wolframin ER transmembrane glycoprotein JBrowse link 5 36,966,104 36,988,982 RGD:2290270
G Wwp2 WW domain containing E3 ubiquitin protein ligase 2 JBrowse link 8 107,436,334 107,558,597 RGD:2290270
G Xcl1 chemokine (C motif) ligand 1 JBrowse link 1 164,931,648 164,935,510 RGD:2290270
G Zfp932 zinc finger protein 932 JBrowse link 5 109,996,502 110,012,266 RGD:2290270
cytoplasmic sequestering of NF-kappaB term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccdc22 coiled-coil domain containing 22 JBrowse link X 7,593,809 7,605,420 RGD:2290270
G Faf1 Fas-associated factor 1 JBrowse link 4 109,676,627 109,963,960 RGD:2290270
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha JBrowse link 12 55,489,409 55,492,647 RGD:2290270
G Nfkbib nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta JBrowse link 7 28,758,251 28,766,644 RGD:2290270
G Psmd10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 JBrowse link X 140,948,425 140,956,711 RGD:2290270
cytoplasmic sequestering of transcription factor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Creb3 cAMP responsive element binding protein 3 JBrowse link 4 43,562,634 43,567,060 RGD:2290270
G Keap1 kelch-like ECH-associated protein 1 JBrowse link 9 21,229,730 21,239,332 RGD:2290270
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha JBrowse link 12 55,489,409 55,492,647 RGD:2290270
G Pkd1 polycystin 1, transient receptor poteintial channel interacting JBrowse link 17 24,549,950 24,596,514 RGD:2290270
G Pkd2 polycystic kidney disease 2 JBrowse link 5 104,453,995 104,505,819 RGD:2290270
G Sri sorcin JBrowse link 5 8,046,078 8,069,314 RGD:2290270
G Sufu SUFU negative regulator of hedgehog signaling JBrowse link 19 46,396,896 46,488,804 RGD:2290270
G Tacc3 transforming, acidic coiled-coil containing protein 3 JBrowse link 5 33,658,128 33,672,203 RGD:2290270
G Thra thyroid hormone receptor alpha JBrowse link 11 98,741,776 98,769,006 RGD:2290270
negative regulation of CREB transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adgrg3 adhesion G protein-coupled receptor G3 JBrowse link 8 95,017,111 95,045,250 RGD:2290270
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 10 127,290,793 127,296,291 RGD:2290270
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 JBrowse link 2 118,388,581 118,475,234 RGD:2290270
G Foxp3 forkhead box P3 JBrowse link X 7,579,676 7,595,243 RGD:2290270
G Msx2 msh homeobox 2 JBrowse link 13 53,466,881 53,472,780 RGD:2290270
G Sik1 salt inducible kinase 1 JBrowse link 17 31,844,250 31,855,792 RGD:2290270
negative regulation of NF-kappaB transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acod1 aconitate decarboxylase 1 JBrowse link 14 103,047,012 103,056,573 RGD:2290270
G Adora3 adenosine A3 receptor JBrowse link 3 105,904,421 105,908,928 RGD:2290270
G Aim2 absent in melanoma 2 JBrowse link 1 173,349,246 173,466,040 RGD:2290270
G Anxa4 annexin A4 JBrowse link 6 86,736,840 86,793,593 RGD:2290270
G Arrb1 arrestin, beta 1 JBrowse link 7 99,535,486 99,606,772 RGD:2290270
G Arrb2 arrestin, beta 2 JBrowse link 11 70,432,580 70,440,828 RGD:2290270
G Brms1 breast cancer metastasis-suppressor 1 JBrowse link 19 5,041,232 5,049,917 RGD:2290270
G Cactin cactin, spliceosome C complex subunit JBrowse link 10 81,321,103 81,326,251 RGD:2290270
G Cat catalase JBrowse link 2 103,453,904 103,485,153 RGD:2290270
G Cd200 CD200 antigen JBrowse link 16 45,382,111 45,409,061 RGD:2290270
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 JBrowse link 11 96,907,425 96,916,533 RGD:2290270
G Cdkn2a cyclin dependent kinase inhibitor 2A JBrowse link 4 89,274,473 89,294,619 RGD:2290270
G Chp1 calcineurin-like EF hand protein 1 JBrowse link 2 119,547,707 119,587,024 RGD:2290270
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 19 44,073,334 44,107,509 RGD:2290270
G Cmklr1 chemokine-like receptor 1 JBrowse link 5 113,612,355 113,650,474 RGD:2290270
G Commd1 COMM domain containing 1 JBrowse link 11 22,899,728 22,983,108 RGD:2290270
G Commd6 COMM domain containing 6 JBrowse link 14 101,633,766 101,640,471 RGD:2290270
G Commd7 COMM domain containing 7 JBrowse link 2 153,616,930 153,632,797 RGD:2290270
G Cyld CYLD lysine 63 deubiquitinase JBrowse link 8 88,697,001 88,751,946 RGD:2290270
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 17 79,696,282 79,715,330 RGD:2290270
G Dab2ip disabled 2 interacting protein JBrowse link 2 35,558,458 35,730,994 RGD:2290270
G Dap death-associated protein JBrowse link 15 31,224,385 31,274,338 RGD:2290270
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 JBrowse link 16 4,684,070 4,707,695 RGD:2290270
G Erbin Erbb2 interacting protein JBrowse link 13 103,818,786 103,920,586 RGD:2290270
G Foxj1 forkhead box J1 JBrowse link 11 116,330,704 116,335,516 RGD:2290270
G Foxp3 forkhead box P3 JBrowse link X 7,579,676 7,595,243 RGD:2290270
G Gfi1 growth factor independent 1 transcription repressor JBrowse link 5 107,716,655 107,726,031 RGD:2290270
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link 11 46,454,931 46,481,255 RGD:2290270
G Irak1 interleukin-1 receptor-associated kinase 1 JBrowse link X 74,013,914 74,023,921 RGD:2290270
G Irak2 interleukin-1 receptor-associated kinase 2 JBrowse link 6 113,638,467 113,695,026 RGD:2290270
G Irak3 interleukin-1 receptor-associated kinase 3 JBrowse link 10 120,141,648 120,201,744 RGD:2290270
G Itch itchy, E3 ubiquitin protein ligase JBrowse link 2 155,133,376 155,226,855 RGD:2290270
G Klf4 Kruppel-like factor 4 (gut) JBrowse link 4 55,527,137 55,532,475 RGD:2290270
G Lrrc14 leucine rich repeat containing 14 JBrowse link 15 76,710,641 76,715,130 RGD:2290270
G Map2k5 mitogen-activated protein kinase kinase 5 JBrowse link 9 63,163,768 63,381,682 RGD:2290270
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha JBrowse link 12 55,489,409 55,492,647 RGD:2290270
G Nfkbid nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta JBrowse link 7 30,421,728 30,428,748 RGD:2290270
G Nfkbil1 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1 JBrowse link 17 35,220,175 35,236,476 RGD:2290270
G Nlrc3 NLR family, CARD domain containing 3 JBrowse link 16 3,943,807 3,979,017 RGD:2290270
G Nlrc5 NLR family, CARD domain containing 5 JBrowse link 8 94,434,354 94,527,272 RGD:2290270
G Nlrp12 NLR family, pyrin domain containing 12 JBrowse link 7 3,219,495 3,250,159 RGD:2290270
G Nlrp2 NLR family, pyrin domain containing 2 JBrowse link 7 5,298,547 5,351,035 RGD:2290270
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 11 59,541,569 59,566,956 RGD:2290270
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 8 88,647,280 88,688,474 RGD:2290270
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 10 89,454,234 89,533,646 RGD:2290270
G Nwd1 NACHT and WD repeat domain containing 1 JBrowse link 8 72,646,225 72,716,880 RGD:2290270
G Otulin OTU deubiquitinase with linear linkage specificity JBrowse link 15 27,605,917 27,630,980 RGD:2290270
G Parp10 poly (ADP-ribose) polymerase family, member 10 JBrowse link 15 76,232,995 76,243,440 RGD:2290270
G Peli1 pellino 1 JBrowse link 11 21,091,324 21,150,327 RGD:2290270
G Pias4 protein inhibitor of activated STAT 4 JBrowse link 10 81,153,961 81,167,720 RGD:2290270
G Pkhd1 polycystic kidney and hepatic disease 1 JBrowse link 1 20,057,779 20,618,082 RGD:2290270
G Prdx2 peroxiredoxin 2 JBrowse link 8 84,969,622 84,974,811 RGD:2290270
G Prmt2 protein arginine N-methyltransferase 2 JBrowse link 10 76,207,226 76,237,865 RGD:2290270
G Psmd10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 JBrowse link X 140,948,425 140,956,711 RGD:2290270
G Ptgis prostaglandin I2 (prostacyclin) synthase JBrowse link 2 167,203,196 167,240,537 RGD:2290270
G Pycard PYD and CARD domain containing JBrowse link 7 127,991,373 127,993,867 RGD:2290270
G Rbck1 RanBP-type and C3HC4-type zinc finger containing 1 JBrowse link 2 152,316,334 152,332,643 RGD:2290270
G Rwdd3 RWD domain containing 3 JBrowse link 3 121,155,400 121,171,782 RGD:2290270
G Setd6 SET domain containing 6 JBrowse link 8 95,715,113 95,719,004 RGD:2290270
G Sirt1 sirtuin 1 JBrowse link 10 63,319,005 63,339,035 RGD:2290270
G Siva1 SIVA1, apoptosis-inducing factor JBrowse link 12 112,644,828 112,649,152 RGD:2290270
G Tax1bp1 Tax1 (human T cell leukemia virus type I) binding protein 1 JBrowse link 6 52,713,573 52,766,780 RGD:2290270
G Tceal7 transcription elongation factor A (SII)-like 7 JBrowse link X 136,214,914 136,226,100 RGD:2290270
G Tlr9 toll-like receptor 9 JBrowse link 9 106,222,598 106,226,876 RGD:2290270
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 JBrowse link 10 19,000,910 19,015,410 RGD:2290270
G Traf3 TNF receptor-associated factor 3 JBrowse link 12 111,166,370 111,267,155 RGD:2290270
G Traip TRAF-interacting protein JBrowse link 9 107,950,963 107,972,268 RGD:2290270
G Trim21 tripartite motif-containing 21 JBrowse link 7 102,557,920 102,565,482 RGD:2290270
G Trim37 tripartite motif-containing 37 JBrowse link 11 87,127,051 87,250,874 RGD:2290270
G Trim40 tripartite motif-containing 40 JBrowse link 17 36,881,596 36,890,157 RGD:2290270
G Tut4 terminal uridylyl transferase 4 JBrowse link 4 108,459,426 108,560,734 RGD:2290270
G Ufl1 UFM1 specific ligase 1 JBrowse link 4 25,247,820 25,281,930 RGD:2290270
G Usp7 ubiquitin specific peptidase 7 JBrowse link 16 8,688,722 8,757,067 RGD:2290270
G Zc3h12a zinc finger CCCH type containing 12A JBrowse link 4 125,118,414 125,127,881 RGD:2290270

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22957
    negative regulation of biological process 5247
      negative regulation of DNA-binding transcription factor activity 160
        cytoplasmic sequestering of transcription factor + 13
        negative regulation of CREB transcription factor activity 6
        negative regulation of NF-kappaB transcription factor activity + 77
Path 2
Term Annotations click to browse term
  biological_process 22957
    metabolic process 10197
      cellular metabolic process 9255
        cellular aromatic compound metabolic process 4827
          nucleobase-containing compound metabolic process 4624
            nucleic acid metabolic process 4208
              RNA metabolic process 3737
                RNA biosynthetic process 2883
                  nucleic acid-templated transcription 2871
                    transcription, DNA-templated 2864
                      regulation of transcription, DNA-templated 2769
                        regulation of DNA-binding transcription factor activity 396
                          negative regulation of DNA-binding transcription factor activity 160
                            cytoplasmic sequestering of transcription factor + 13
                            negative regulation of CREB transcription factor activity 6
                            negative regulation of NF-kappaB transcription factor activity + 77
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.