ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of DNA-binding transcription factor activity
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Accession:GO:0043433 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
Synonyms:exact_synonym: down regulation of transcription factor activity;   downregulation of transcription factor activity;   negative regulation of sequence-specific DNA binding transcription factor activity
 narrow_synonym: inhibition of transcription factor activity;   negative regulation of androgen receptor activity;   negative regulation of thyroid hormone receptor activity
 broad_synonym: negative regulation of transcription factor activity
 alt_id: GO:1904168;   GO:2000824


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negative regulation of DNA-binding transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bhlhe40 basic helix-loop-helix family member e40 JBrowse link NW_004936577 4,316,099 4,321,193 RGD:9068941
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link NW_004936600 4,215,219 4,424,498 RGD:9068941
G Cebpg CCAAT enhancer binding protein gamma JBrowse link NW_004936570 2,435,672 2,439,056 RGD:9068941
G Ctnnbip1 catenin beta interacting protein 1 JBrowse link NW_004936623 3,782,005 3,806,616 RGD:9068941
G Ddit3 DNA damage inducible transcript 3 JBrowse link NW_004936646 1,665,019 1,669,212 RGD:9068941
G Egln1 egl-9 family hypoxia inducible factor 1 JBrowse link NW_004936484 19,343,770 19,386,087 RGD:9068941
G Eomes eomesodermin JBrowse link NW_004936473 18,825,969 18,833,179 RGD:9068941
G Esr1 estrogen receptor 1 JBrowse link NW_004936489 4,616,839 4,887,179 RGD:9068941
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit JBrowse link NW_004936527 5,024,077 5,069,152 RGD:9068941
G Flna filamin A JBrowse link NW_004936809 1,097,288 1,123,206 RGD:9068941
G Foxa2 forkhead box A2 JBrowse link NW_004936620 2,966,341 2,969,349 RGD:9068941
G Foxh1 forkhead box H1 JBrowse link NW_004936470 7,789,486 7,791,067 RGD:9068941
G Foxp3 forkhead box P3 JBrowse link NW_004936721 1,118,376 1,125,282 RGD:9068941
G Foxs1 forkhead box S1 JBrowse link NW_004936485 18,803,675 18,804,933 RGD:9068941
G Fzd6 frizzled class receptor 6 JBrowse link NW_004936470 40,416,254 40,454,717 RGD:9068941
G Gas6 growth arrest specific 6 JBrowse link NW_004936472 27,116 57,158 RGD:9068941
G Glis2 GLIS family zinc finger 2 JBrowse link NW_004936694 161,419 168,012 RGD:9068941
G Hand1 heart and neural crest derivatives expressed 1 JBrowse link NW_004936515 8,289,764 8,292,937 RGD:9068941
G Hand2 heart and neural crest derivatives expressed 2 JBrowse link NW_004936516 4,692,926 4,695,625 RGD:9068941
G Hdac2 histone deacetylase 2 JBrowse link NW_004936679 2,448,676 2,474,641 RGD:9068941
G Hdac4 histone deacetylase 4 JBrowse link NW_004936745 1,730,743 1,942,071 RGD:9068941
G Heyl hes related family bHLH transcription factor with YRPW motif like JBrowse link NW_004936474 21,503,763 21,513,392 RGD:9068941
G Hmox1 heme oxygenase 1 JBrowse link NW_004936492 5,042,353 5,049,216 RGD:9068941
G Id1 inhibitor of DNA binding 1, HLH protein JBrowse link NW_004936485 18,610,721 18,611,889 RGD:9068941
G Id2 inhibitor of DNA binding 2 JBrowse link NW_004936532 5,236,175 5,238,689 RGD:9068941
G Id3 inhibitor of DNA binding 3, HLH protein JBrowse link NW_004936474 8,758,098 8,759,684 RGD:9068941
G Kdm1a lysine demethylase 1A JBrowse link NW_004936474 8,262,913 8,319,089 RGD:9068941
G Keap1 kelch like ECH associated protein 1 JBrowse link NW_004936659 785,059 793,775 RGD:9068941
G LOC101960864 group 10 secretory phospholipase A2 JBrowse link NW_004936501 2,841,209 2,857,570 RGD:9068941
G LOC101970885 lymphotactin JBrowse link NW_004936481 17,825,714 17,828,955 RGD:9068941
G Mad2l2 mitotic arrest deficient 2 like 2 JBrowse link NW_004936474 538,703 542,901 RGD:9068941
G Map3k10 mitogen-activated protein kinase kinase kinase 10 JBrowse link NW_004936661 2,623,356 2,638,218 RGD:9068941
G Med13 mediator complex subunit 13 JBrowse link NW_004936490 3,204,717 3,293,458 RGD:9068941
G Men1 menin 1 JBrowse link NW_004936599 4,504,489 4,510,085 RGD:9068941
G Nr0b1 nuclear receptor subfamily 0 group B member 1 JBrowse link NW_004936553 6,436,371 6,440,141 RGD:9068941
G Nr0b2 nuclear receptor subfamily 0 group B member 2 JBrowse link NW_004936474 11,316,857 11,319,669 RGD:9068941
G Nupr1 nuclear protein 1, transcriptional regulator JBrowse link NW_004936501 11,998,064 11,999,431 RGD:9068941
G Paxip1 PAX interacting protein 1 JBrowse link NW_004936527 9,440,129 9,488,215 RGD:9068941
G Pbx1 PBX homeobox 1 JBrowse link NW_004936481 20,200,236 20,440,623 RGD:9068941
G Pex14 peroxisomal biogenesis factor 14 JBrowse link NW_004936623 4,313,186 4,462,462 RGD:9068941
G Phb2 prohibitin 2 JBrowse link NW_004936709 854,493 859,182 RGD:9068941
G Pias2 protein inhibitor of activated STAT 2 JBrowse link NW_004936517 72,676 152,926 RGD:9068941
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase JBrowse link NW_004936476 22,295,023 22,300,155 RGD:9068941
G Pou4f2 POU class 4 homeobox 2 JBrowse link NW_004936535 2,705,184 2,711,785 RGD:9068941
G Prnp prion protein JBrowse link NW_004936485 14,104,829 14,118,614 RGD:9068941
G Prox1 prospero homeobox 1 JBrowse link NW_004936628 4,185,712 4,240,680 RGD:9068941
G Ptch1 patched 1 JBrowse link NW_004936626 4,241,993 4,301,919 RGD:9068941
G Rb1 RB transcriptional corepressor 1 JBrowse link NW_004936565 1,596,227 1,746,706 RGD:9068941
G Rlim ring finger protein, LIM domain interacting JBrowse link NW_004936683 930,537 961,792 RGD:9068941
G Rnf2 ring finger protein 2 JBrowse link NW_004936481 5,070,578 5,110,087 RGD:9068941
G Sfrp4 secreted frizzled related protein 4 JBrowse link NW_004936478 13,257,183 13,266,972 RGD:9068941
G Sfrp5 secreted frizzled related protein 5 JBrowse link NW_004936636 1,968,410 1,973,885 RGD:9068941
G Sigirr single Ig and TIR domain containing JBrowse link NW_004936888 280,748 284,706 RGD:9068941
G Sirt1 sirtuin 1 JBrowse link NW_004936521 10,296,097 10,316,673 RGD:9068941
G Smad7 SMAD family member 7 JBrowse link NW_004936497 13,894,586 13,921,978 RGD:9068941
G Sp100 SP100 nuclear antigen JBrowse link NW_004936525 6,136,343 6,231,051 RGD:9068941
G Sufu SUFU negative regulator of hedgehog signaling JBrowse link NW_004936600 3,270,662 3,381,722 RGD:9068941
G Sumo1 small ubiquitin like modifier 1 JBrowse link NW_004936726 1,402,977 1,413,974 RGD:9068941
G Taf1 TATA-box binding protein associated factor 1 JBrowse link NW_004936762 189,710 271,759 RGD:9068941
G Taf3 TATA-box binding protein associated factor 3 JBrowse link NW_004936484 6,834,935 7,002,167 RGD:9068941
G Tbx6 T-box 6 JBrowse link NW_004936501 12,402,709 12,407,571 RGD:9068941
G Tbxt T-box transcription factor T JBrowse link NW_004936489 16,027,359 16,035,041 RGD:9068941
G Tcf7l2 transcription factor 7 like 2 JBrowse link NW_004936486 3,473,877 3,660,565 RGD:9068941
G Tnfrsf4 TNF receptor superfamily member 4 JBrowse link NW_004936737 1,901,749 1,904,382 RGD:9068941
G Tnfsf4 TNF superfamily member 4 JBrowse link NW_004936481 14,391,359 14,409,514 RGD:9068941
G Trib1 tribbles pseudokinase 1 JBrowse link NW_004936470 22,401,713 22,408,808 RGD:9068941
G Twist1 twist family bHLH transcription factor 1 JBrowse link NW_004936546 5,331,220 5,332,669 RGD:9068941
G Wfs1 wolframin ER transmembrane glycoprotein JBrowse link NW_004936477 18,339,915 18,364,973 RGD:9068941
G Wwp2 WW domain containing E3 ubiquitin protein ligase 2 JBrowse link NW_004936475 19,835,909 19,944,426 RGD:9068941
cytoplasmic sequestering of NF-kappaB term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccdc22 coiled-coil domain containing 22 JBrowse link NW_004936721 1,107,697 1,118,313 RGD:9068941
G Faf1 Fas associated factor 1 JBrowse link NW_004936522 9,774,943 10,160,987 RGD:9068941
G G3bp2 G3BP stress granule assembly factor 2 JBrowse link NW_004936598 246,745 326,900 RGD:9068941
G Il10 interleukin 10 JBrowse link NW_004936557 5,834,874 5,838,502 RGD:9068941
G Nfkbia NFKB inhibitor alpha JBrowse link NW_004936494 9,537,793 9,541,187 RGD:9068941
G Psmd10 proteasome 26S subunit, non-ATPase 10 JBrowse link NW_004936499 6,691,758 6,698,515 RGD:9068941
G Tmsb4x thymosin beta 4 X-linked JBrowse link NW_004936470 2,668,525 2,670,611 RGD:9068941
cytoplasmic sequestering of transcription factor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Creb3 cAMP responsive element binding protein 3 JBrowse link NW_004936524 3,727,104 3,730,962 RGD:9068941
G Keap1 kelch like ECH associated protein 1 JBrowse link NW_004936659 785,059 793,775 RGD:9068941
G Mdfi MyoD family inhibitor JBrowse link NW_004936476 18,262,662 18,276,159 RGD:9068941
G Mxi1 MAX interactor 1, dimerization protein JBrowse link NW_004936486 1,103,908 1,173,982 RGD:9068941
G Nfkbia NFKB inhibitor alpha JBrowse link NW_004936494 9,537,793 9,541,187 RGD:9068941
G Nfkbie NFKB inhibitor epsilon JBrowse link NW_004936476 15,818,605 15,825,558 RGD:9068941
G Nfkbil1 NFKB inhibitor like 1 JBrowse link NW_004936727 1,950,356 1,963,847 RGD:9068941
G Pkd1 polycystin 1, transient receptor potential channel interacting JBrowse link NW_004936694 1,923,383 1,958,160 RGD:9068941
G Pkd2 polycystin 2, transient receptor potential cation channel JBrowse link NW_004936905 76,781 128,995 RGD:9068941
G Sri sorcin JBrowse link NW_004936763 715,884 728,548 RGD:9068941
G Sufu SUFU negative regulator of hedgehog signaling JBrowse link NW_004936600 3,270,662 3,381,722 RGD:9068941
G Tonsl tonsoku like, DNA repair protein JBrowse link NW_004936470 7,817,444 7,829,124 RGD:9068941
negative regulation of CREB transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adgrg3 adhesion G protein-coupled receptor G3 JBrowse link NW_004936475 9,699,703 9,707,251 RGD:9068941
G Ddit3 DNA damage inducible transcript 3 JBrowse link NW_004936646 1,665,019 1,669,212 RGD:9068941
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 JBrowse link NW_004936471 3,423,792 3,527,089 RGD:9068941
G Foxp3 forkhead box P3 JBrowse link NW_004936721 1,118,376 1,125,282 RGD:9068941
G Msx2 msh homeobox 2 JBrowse link NW_004936609 1,216,436 1,221,528 RGD:9068941
G Sik1 salt inducible kinase 1 JBrowse link NW_004936500 774,749 784,326 RGD:9068941
negative regulation of NF-kappaB transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acod1 aconitate decarboxylase 1 JBrowse link NW_004936511 4,322,198 4,326,562 RGD:9068941
G Aim2 absent in melanoma 2 JBrowse link NW_004936740 1,447,869 1,460,836 RGD:9068941
G Anxa4 annexin A4 JBrowse link NW_004936491 13,982,926 14,047,690 RGD:9068941
G Arrb1 arrestin beta 1 JBrowse link NW_004936498 4,089,621 4,172,749 RGD:9068941
G Arrb2 arrestin beta 2 JBrowse link NW_004936677 3,173,054 3,181,475 RGD:9068941
G Bmp7 bone morphogenetic protein 7 JBrowse link NW_004936530 71,965 143,940 RGD:9068941
G Brms1 BRMS1 transcriptional repressor and anoikis regulator JBrowse link NW_004936599 3,259,868 3,267,172 RGD:9068941
G Cactin cactin, spliceosome C complex subunit JBrowse link NW_004936588 2,051,636 2,061,651 RGD:9068941
G Cat catalase JBrowse link NW_004936533 3,601,270 3,637,128 RGD:9068941
G Cd200 CD200 molecule JBrowse link NW_004936536 8,337 33,954 RGD:9068941
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 JBrowse link NW_004936490 13,345,443 13,355,841 RGD:9068941
G Chp1 calcineurin like EF-hand protein 1 JBrowse link NW_004936471 4,611,980 4,660,320 RGD:9068941
G Chuk component of inhibitor of nuclear factor kappa B kinase complex JBrowse link NW_004936636 33,933 78,990 RGD:9068941
G Cmklr1 chemerin chemokine-like receptor 1 JBrowse link NW_004936769 302,391 304,166 RGD:9068941
G Commd1 copper metabolism domain containing 1 JBrowse link NW_004936491 7,247,160 7,421,039 RGD:9068941
G Commd6 COMM domain containing 6 JBrowse link NW_004936511 5,591,851 5,596,998 RGD:9068941
G Commd7 COMM domain containing 7 JBrowse link NW_004936485 19,500,170 19,518,481 RGD:9068941
G Cyld CYLD lysine 63 deubiquitinase JBrowse link NW_004936475 3,750,917 3,812,118 RGD:9068941
G Dab2ip DAB2 interacting protein JBrowse link NW_004936487 10,056,809 10,243,021 RGD:9068941
G Dap death associated protein JBrowse link NW_004936643 2,705,057 2,752,072 RGD:9068941
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 JBrowse link NW_004936694 43,898 74,939 RGD:9068941
G Erbin erbb2 interacting protein JBrowse link NW_004936480 3,155,934 3,293,224 RGD:9068941
G Foxj1 forkhead box J1 JBrowse link NW_004936594 1,284,799 1,288,898 RGD:9068941
G Foxp3 forkhead box P3 JBrowse link NW_004936721 1,118,376 1,125,282 RGD:9068941
G Gfi1 growth factor independent 1 transcriptional repressor JBrowse link NW_004936537 6,610,565 6,618,509 RGD:9068941
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link NW_004936515 6,001,324 6,015,407 RGD:9068941
G Irak1 interleukin 1 receptor associated kinase 1 JBrowse link NW_004936809 891,407 900,311 RGD:9068941
G Irak2 interleukin 1 receptor associated kinase 2 JBrowse link NW_004936602 3,073,910 3,129,344 RGD:9068941
G Irak3 interleukin 1 receptor associated kinase 3 JBrowse link NW_004936545 4,233,353 4,284,324 RGD:9068941
G Itch itchy E3 ubiquitin protein ligase JBrowse link NW_004936561 6,140,236 6,265,734 RGD:9068941
G Klf4 Kruppel like factor 4 JBrowse link NW_004936559 5,105,456 5,109,970 RGD:9068941
G LOC101970101 cytochrome P450 1B1 JBrowse link NW_004936663 345,021 355,188 RGD:9068941
G LOC101973578 adenosine receptor A3 JBrowse link NW_004936690 152,777 168,411 RGD:9068941
G Lrrc14 leucine rich repeat containing 14 JBrowse link NW_004936470 7,751,426 7,755,272 RGD:9068941
G Map2k5 mitogen-activated protein kinase kinase 5 JBrowse link NW_004936471 27,491,255 27,728,572 RGD:9068941
G Nfkbia NFKB inhibitor alpha JBrowse link NW_004936494 9,537,793 9,541,187 RGD:9068941
G Nfkbid NFKB inhibitor delta JBrowse link NW_004936570 464,513 471,333 RGD:9068941
G Nfkbil1 NFKB inhibitor like 1 JBrowse link NW_004936727 1,950,356 1,963,847 RGD:9068941
G Nlrc3 NLR family CARD domain containing 3 JBrowse link NW_004936694 757,121 773,924 RGD:9068941
G Nlrc5 NLR family CARD domain containing 5 JBrowse link NW_004936475 9,137,929 9,218,682 RGD:9068941
G Nlrp12 NLR family pyrin domain containing 12 JBrowse link NW_004936994 20,848 36,757 RGD:9068941
G Nlrp2 NLR family pyrin domain containing 2 JBrowse link NW_004936886 280,872 292,452 RGD:9068941
G Nlrp3 NLR family pyrin domain containing 3 JBrowse link NW_004936864 709,693 732,119 RGD:9068941
G Nr1h4 nuclear receptor subfamily 1 group H member 4 JBrowse link NW_004936492 13,315,265 13,365,186 RGD:9068941
G Nwd1 NACHT and WD repeat domain containing 1 JBrowse link NW_004936596 3,882,259 3,948,664 RGD:9068941
G Otulin OTU deubiquitinase with linear linkage specificity JBrowse link NW_004936665 1,654,045 1,690,955 RGD:9068941
G Parp10 poly(ADP-ribose) polymerase family member 10 JBrowse link NW_004936470 8,179,416 8,194,041 RGD:9068941
G Peli1 pellino E3 ubiquitin protein ligase 1 JBrowse link NW_004936491 8,985,074 9,040,863 RGD:9068941
G Pias4 protein inhibitor of activated STAT 4 JBrowse link NW_004936588 2,287,941 2,302,875 RGD:9068941
G Pkhd1 PKHD1 ciliary IPT domain containing fibrocystin/polyductin JBrowse link NW_004936476 8,730,766 9,160,102 RGD:9068941
G Prdx2 peroxiredoxin 2 JBrowse link NW_004936659 1,894,423 1,897,690 RGD:9068941
G Prmt2 protein arginine methyltransferase 2 JBrowse link NW_004936778 12,988 31,217 RGD:9068941
G Psmd10 proteasome 26S subunit, non-ATPase 10 JBrowse link NW_004936499 6,691,758 6,698,515 RGD:9068941
G Ptgis prostaglandin I2 synthase JBrowse link NW_004936514 4,775,884 4,814,574 RGD:9068941
G Pycard PYD and CARD domain containing JBrowse link NW_004936501 13,550,702 13,552,774 RGD:9068941
G Pydc1 pyrin domain containing 1 JBrowse link NW_004936501 13,561,927 13,564,392 RGD:9068941
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 JBrowse link NW_004936485 18,057,569 18,071,787 RGD:9068941
G Rwdd3 RWD domain containing 3 JBrowse link NW_004936537 4,019,337 4,031,951 RGD:9068941
G Setd6 SET domain containing 6, protein lysine methyltransferase JBrowse link NW_004936475 10,297,468 10,300,778 RGD:9068941
G Sirt1 sirtuin 1 JBrowse link NW_004936521 10,296,097 10,316,673 RGD:9068941
G Siva1 SIVA1 apoptosis inducing factor JBrowse link NW_004936621 641,456 650,067 RGD:9068941
G Tax1bp1 Tax1 binding protein 1 JBrowse link NW_004936478 4,305,859 4,375,785 RGD:9068941
G Tceal7 transcription elongation factor A like 7 JBrowse link NW_004936547 7,916,172 7,918,010 RGD:9068941
G Tmsb4x thymosin beta 4 X-linked JBrowse link NW_004936470 2,668,525 2,670,611 RGD:9068941
G Tnfaip3 TNF alpha induced protein 3 JBrowse link NW_004936560 5,124,955 5,138,988 RGD:9068941
G Traf3 TNF receptor associated factor 3 JBrowse link NW_004936835 844,747 955,900 RGD:9068941
G Traip TRAF interacting protein JBrowse link NW_004936529 1,434,629 1,466,382 RGD:9068941
G Trim21 tripartite motif containing 21 JBrowse link NW_004936498 690,481 697,305 RGD:9068941
G Trim37 tripartite motif containing 37 JBrowse link NW_004936490 4,163,871 4,310,016 RGD:9068941
G Trim40 tripartite motif containing 40 JBrowse link NW_004936723 897,213 909,263 RGD:9068941
G Tut4 terminal uridylyl transferase 4 JBrowse link NW_004936522 8,468,092 8,560,453 RGD:9068941
G Ufl1 UFM1 specific ligase 1 JBrowse link NW_004936699 1,131,385 1,163,310 RGD:9068941
G Usp7 ubiquitin specific peptidase 7 JBrowse link NW_004936530 7,693,681 7,724,215 RGD:9068941
G Zc3h12a zinc finger CCCH-type containing 12A JBrowse link NW_004936474 19,714,145 19,722,512 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14770
    negative regulation of biological process 4914
      negative regulation of DNA-binding transcription factor activity 157
        cytoplasmic sequestering of transcription factor + 18
        negative regulation of CREB transcription factor activity 6
        negative regulation of NF-kappaB transcription factor activity + 78
Path 2
Term Annotations click to browse term
  biological_process 14770
    metabolic process 10058
      cellular metabolic process 9476
        cellular aromatic compound metabolic process 5209
          nucleobase-containing compound metabolic process 5025
            nucleic acid metabolic process 4540
              RNA metabolic process 4073
                RNA biosynthetic process 3228
                  nucleic acid-templated transcription 3214
                    transcription, DNA-templated 3175
                      regulation of transcription, DNA-templated 3018
                        regulation of DNA-binding transcription factor activity 408
                          negative regulation of DNA-binding transcription factor activity 157
                            cytoplasmic sequestering of transcription factor + 18
                            negative regulation of CREB transcription factor activity 6
                            negative regulation of NF-kappaB transcription factor activity + 78
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.