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Term:interleukin-12 complex
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Accession:GO:0043514 term browser browse the term
Definition:A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space.
Comment:Note that this heterodimeric cytokine utilizes the IL-12p35 subunit as its alpha chain, which is also used by IL-35 as its alpha chain, and utilizes the IL-12p40 subunit as its beta chain, which is also used by IL-23 as its beta chain.
Synonyms:exact_synonym: IL-12 complex
 narrow_synonym: IL12A;   IL12B;   p35;   p40

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interleukin-12 complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:1600115
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:1600058

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  cellular_component 19843
    protein-containing complex 5779
      interleukin-12 complex 2
Path 2
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  cellular_component 19843
    cellular anatomical entity 19457
      extracellular region 2395
        extracellular space 1704
          interleukin-12 complex 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.