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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of DNA damage response, signal transduction by p53 class mediator
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Accession:GO:0043517 term browser browse the term
Definition:Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
Synonyms:exact_synonym: positive regulation of p53 induced by DNA damage response;   up regulation of DNA damage response, signal transduction by p53 class mediator;   upregulation of DNA damage response, signal transduction by p53 class mediator
 narrow_synonym: activation of DNA damage response, signal transduction by p53 class mediator;   stimulation of DNA damage response, signal transduction by p53 class mediator


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positive regulation of DNA damage response, signal transduction by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd1 ankyrin repeat domain 1 (cardiac muscle) ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr19:36,111,965...36,119,844
Ensembl chr19:36,111,961...36,120,099
JBrowse link
G Atm ataxia telangiectasia mutated ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 9:53,437,122...53,536,828
Ensembl chr 9:53,439,149...53,536,740
JBrowse link
G Atr ataxia telangiectasia and Rad3 related ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 9:95,857,597...95,953,217
Ensembl chr 9:95,857,597...95,951,781
JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A IC
ISO
(MGI:MGI:1327100|PMID:9878046) BHF-UCL
MGI
PMID:9878046 GO_REF:0000096, MGI:MGI:1327100, MGI:MGI:4834177 NCBI chr 4:89,274,473...89,294,619
Ensembl chr 4:89,274,471...89,294,653
JBrowse link
G Ddx5 DEAD box helicase 5 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr11:106,780,355...106,789,185
Ensembl chr11:106,780,355...106,789,185
JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 IMP (MGI:MGI:3573962|PMID:15680327) MGI PMID:15680327 MGI:MGI:3573962 NCBI chr13:38,645,691...38,659,028
Ensembl chr13:38,644,207...38,659,058
JBrowse link
G Hic1 hypermethylated in cancer 1 IMP (MGI:MGI:5297787|PMID:16269335) UniProtKB PMID:16269335 MGI:MGI:5297787 NCBI chr11:75,161,377...75,170,255
Ensembl chr11:75,164,565...75,169,519
JBrowse link
G Pla2r1 phospholipase A2 receptor 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 2:60,417,543...60,553,326
Ensembl chr 2:60,417,543...60,553,308
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 IMP (MGI:MGI:2679929|PMID:14500851) UniProtKB PMID:14500851 MGI:MGI:2679929 NCBI chr18:66,458,604...66,465,558
Ensembl chr18:66,458,533...66,465,565
JBrowse link
G Spred1 sprouty protein with EVH-1 domain 1, related sequence IDA
IBA
(MGI:MGI:5318016|PMID:20736167)
(MGI:MGI:6201960|PMID:21873635)
BHF-UCL
GO_Central
PMID:20736167, PMID:21873635 MGI:MGI:5318016, MGI:MGI:6201960 NCBI chr 2:117,121,071...117,182,279
Ensembl chr 2:117,121,374...117,182,279
JBrowse link
G Spred2 sprouty-related EVH1 domain containing 2 IDA
IBA
(MGI:MGI:5318016|PMID:20736167)
(MGI:MGI:6201960|PMID:21873635)
BHF-UCL
GO_Central
PMID:20736167, PMID:21873635 MGI:MGI:5318016, MGI:MGI:6201960 NCBI chr11:19,924,442...20,024,026
Ensembl chr11:19,924,375...20,024,026
JBrowse link
G Spred3 sprouty-related EVH1 domain containing 3 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 7:29,157,783...29,170,070
Ensembl chr 7:29,158,829...29,170,411
JBrowse link
positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpl26 ribosomal protein L26 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr11:68,901,566...68,904,534
Ensembl chr11:68,901,583...68,906,989
JBrowse link
G Zfp385a zinc finger protein 385A ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr15:103,313,895...103,340,086
Ensembl chr15:103,313,895...103,340,093
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23369
    positive regulation of biological process 6576
      positive regulation of cellular process 6040
        positive regulation of response to DNA damage stimulus 115
          positive regulation of DNA damage response, signal transduction by p53 class mediator 14
            positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 2
Path 2
Term Annotations click to browse term
  biological_process 23369
    biological regulation 13071
      regulation of biological process 12448
        regulation of cellular process 11895
          signal transduction 6319
            intracellular signal transduction 2561
              signal transduction in response to DNA damage 95
                DNA damage response, signal transduction by p53 class mediator 68
                  regulation of DNA damage response, signal transduction by p53 class mediator 35
                    positive regulation of DNA damage response, signal transduction by p53 class mediator 14
                      positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.