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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of DNA damage response, signal transduction by p53 class mediator
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Accession:GO:0043518 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
Synonyms:exact_synonym: down regulation of DNA damage response, signal transduction by p53 class mediator;   downregulation of DNA damage response, signal transduction by p53 class mediator;   negative regulation of p53 induced by DNA damage response
 narrow_synonym: inhibition of DNA damage response, signal transduction by p53 class mediator


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negative regulation of DNA damage response, signal transduction by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd44 CD44 antigen IMP
ISO
(MGI:MGI:3690285|PMID:17045821) BHF-UCL
MGI
PMID:17045821 GO_REF:0000096, MGI:MGI:3690285, MGI:MGI:4834177 NCBI chr 2:102,811,141...102,901,669
Ensembl chr 2:102,811,141...102,901,665
JBrowse link
G Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) IMP
IBA
ISO
(MGI:MGI:3690285|PMID:17045821)
(MGI:MGI:6201960|PMID:21873635)
BHF-UCL
GO_Central
MGI
PMID:17045821, PMID:21873635 GO_REF:0000096, MGI:MGI:3690285, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr18:60,803,849...60,812,652
Ensembl chr18:60,803,848...60,812,652
JBrowse link
G Dyrk1a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a IDA (MGI:MGI:5318016|PMID:20736167) BHF-UCL PMID:20736167 MGI:MGI:5318016 NCBI chr16:94,569,947...94,695,519
Ensembl chr16:94,570,010...94,695,517
JBrowse link
G Dyrk3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 IMP (MGI:MGI:4838949|PMID:20167603) UniProtKB PMID:20167603 MGI:MGI:4838949 NCBI chr 1:131,128,441...131,138,234
Ensembl chr 1:131,127,455...131,138,340
JBrowse link
G Kdm1a lysine (K)-specific demethylase 1A ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 4:136,550,533...136,602,787
Ensembl chr 4:136,550,540...136,602,723
JBrowse link
G Marchf7 membrane associated ring-CH-type finger 7 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 2:60,209,936...60,248,385
Ensembl chr 2:60,209,887...60,250,676
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr10:117,688,875...117,710,758
Ensembl chr10:117,688,875...117,710,758
JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) IDA
ISO
(MGI:MGI:3690285|PMID:17045821) BHF-UCL
MGI
PMID:17045821 GO_REF:0000096, MGI:MGI:3690285, MGI:MGI:4834177 NCBI chr10:75,859,353...75,860,277
Ensembl chr10:75,859,353...75,860,240
JBrowse link
G Psmd10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr  X:140,948,425...140,956,711
Ensembl chr  X:140,948,429...140,956,728
JBrowse link
G Pttg1ip pituitary tumor-transforming 1 interacting protein ISO MGI GO_REF:0000008, MGI:MGI:2154458 NCBI chr10:77,581,655...77,598,732
Ensembl chr10:77,581,720...77,598,732
JBrowse link
G Senp2 SUMO/sentrin specific peptidase 2 IDA (MGI:MGI:5433829|PMID:21183956) MGI PMID:21183956 MGI:MGI:5433829 NCBI chr16:22,009,432...22,049,269
Ensembl chr16:22,009,484...22,049,269
JBrowse link
G Sirt1 sirtuin 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704
JBrowse link
G Snai1 snail family zinc finger 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 2:167,538,195...167,542,814
Ensembl chr 2:167,538,195...167,542,814
JBrowse link
G Snai2 snail family zinc finger 2 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr16:14,705,852...14,709,395
Ensembl chr16:14,705,852...14,709,385
JBrowse link
G Twist1 twist basic helix-loop-helix transcription factor 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr12:33,957,671...33,959,831
Ensembl chr12:33,957,671...33,959,829
JBrowse link
negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pcbp4 poly(rC) binding protein 4 IMP (MGI:MGI:5050389|PMID:20817677) MGI PMID:20817677 MGI:MGI:5050389 NCBI chr 9:106,452,982...106,464,012
Ensembl chr 9:106,453,291...106,464,012
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23366
    negative regulation of biological process 5680
      negative regulation of cellular process 5100
        negative regulation of response to DNA damage stimulus 79
          negative regulation of DNA damage response, signal transduction by p53 class mediator 16
            negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 1
Path 2
Term Annotations click to browse term
  biological_process 23366
    biological regulation 13064
      regulation of biological process 12440
        regulation of cellular process 11888
          signal transduction 6321
            intracellular signal transduction 2562
              signal transduction in response to DNA damage 95
                DNA damage response, signal transduction by p53 class mediator 68
                  regulation of DNA damage response, signal transduction by p53 class mediator 35
                    negative regulation of DNA damage response, signal transduction by p53 class mediator 16
                      negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.