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ONTOLOGY REPORT - ANNOTATIONS


Term:6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
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Accession:GO:0043540 term browser browse the term
Definition:A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis.
Comment:Note that we use this single class to represent all 4 isoforms of this complex. We decided to do this because the isoforms do not differ in function, rather in expression and regulation. We may want to revisit this in future.
Synonyms:narrow_synonym: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex;   6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 complex;   6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 complex;   6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 complex


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6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 JBrowse link X 23,092,143 23,145,923 RGD:2302679
RGD:1624291
RGD:1600115
RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20300
    cellular anatomical entity 19956
      cytosol 4143
        6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex 1
Path 2
Term Annotations click to browse term
  cellular_component 20300
    protein-containing complex 6095
      catalytic complex 1479
        transferase complex 823
          transferase complex, transferring phosphorus-containing groups 267
            6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.