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ONTOLOGY REPORT - ANNOTATIONS


Term:6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
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Accession:GO:0043540 term browser browse the term
Definition:A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis.
Comment:Note that we use this single class to represent all 4 isoforms of this complex. We decided to do this because the isoforms do not differ in function, rather in expression and regulation. We may want to revisit this in future.
Synonyms:narrow_synonym: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex;   6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 complex;   6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 complex;   6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 complex


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6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 IDA
ISO
ISS
IBA
(PMID:12379646)
GO_REF:0000024
PMID:21873635
RGD
UniProt
PMID:12379646, PMID:7619077, PMID:21873635 GO_REF:0000024, RGD:2302679, RGD:13792537 NCBI chr  X:23,092,143...23,145,923
Ensembl chr  X:23,092,159...23,144,324
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Term paths to the root
Path 1
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  cellular_component 20609
    cellular anatomical entity 20358
      cytosol 4163
        6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex 1
Path 2
Term Annotations click to browse term
  cellular_component 20609
    cellular anatomical entity 20358
      intracellular anatomical structure 14706
        cytoplasm 11457
          cytosol 4163
            6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.