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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of translational initiation in response to stress
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Accession:GO:0043558 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress.
Synonyms:exact_synonym: regulation of translation initiation in response to stress


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regulation of translational initiation in response to stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 ISO (MGI:3589702|PMID:15937339) RGD PMID:15937339 MGI:3589702 NCBI chr 3:110,159,624...110,245,382
Ensembl chr 3:110,159,708...110,249,217
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha ISO (MGI:3589702|PMID:15937339) RGD PMID:15937339 MGI:3589702 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
eiF2alpha phosphorylation in response to endoplasmic reticulum stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO
ISS
(PMID:25329545)
(MGI:6467680|PMID:17707796)
GO_REF:0000024
RGD
UniProt
PMID:17707796, PMID:25329545 GO_REF:0000024, MGI:6467680 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 ISO (PMID:25329545) RGD PMID:25329545 NCBI chr 3:110,159,624...110,245,382
Ensembl chr 3:110,159,708...110,249,217
JBrowse link
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 ISO
ISS
(PMID:22064321)
(MGI:5617428|PMID:25329545)
GO_REF:0000024
RGD
UniProt
PMID:22064321, PMID:25329545 GO_REF:0000024, MGI:5617428 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329
JBrowse link
G Nck1 NCK adaptor protein 1 ISO (PMID:14676213), (PMID:16835242)
UniProtKB:O55033 (MGI:5613475|PMID:16835242), (MGI:5613478|PMID:14676213)
RGD PMID:14676213, PMID:16835242 MGI:5613475, MGI:5613478 NCBI chr 8:108,787,797...108,847,779
Ensembl chr 8:108,787,798...108,847,779
JBrowse link
G Nck2 NCK adaptor protein 2 ISO (PMID:16835242)
UniProtKB:Q99M51 (MGI:5613475|PMID:16835242), (MGI:5613478|PMID:14676213)
RGD PMID:14676213, PMID:16835242 MGI:5613475, MGI:5613478 NCBI chr 9:50,246,767...50,373,307
Ensembl chr 9:50,247,692...50,373,284
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A ISO (MGI:5613475|PMID:16835242) RGD PMID:16835242 MGI:5613475 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Ppp1r15b protein phosphatase 1, regulatory subunit 15B ISO (MGI:5613475|PMID:16835242) RGD PMID:16835242 MGI:5613475 NCBI chr13:49,933,155...49,940,961
Ensembl chr13:49,933,155...49,940,961
JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 ISO MGI:4456438 (MGI:5914333|PMID:28797121) RGD PMID:28797121 MGI:5914333 NCBI chr12:37,471,259...37,480,344
Ensembl chr12:37,471,260...37,480,297
JBrowse link
negative regulation of translational initiation in response to stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 ISO (MGI:5700311|PMID:12176355) RGD PMID:12176355 MGI:5700311 NCBI chr 3:110,159,624...110,245,382
Ensembl chr 3:110,159,708...110,249,217
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha ISS
ISO
GO_REF:0000024
(MGI:5700311|PMID:12176355)
UniProt
RGD
PMID:12176355 GO_REF:0000024, MGI:5700311 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A ISO (PMID:21518769) RGD PMID:21518769 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
positive regulation of translation initiation in response to endoplasmic reticulum stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 ISS
ISO
GO_REF:0000024
(MGI:5617428|PMID:25329545)
UniProt
RGD
PMID:25329545 GO_REF:0000024, MGI:5617428 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329
JBrowse link
positive regulation of translational initiation in response to starvation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 ISS
ISO
GO_REF:0000024
(MGI:2149467|PMID:10655230), (MGI:3589053|PMID:16121183)
UniProt
RGD
PMID:10655230, PMID:16121183 GO_REF:0000024, MGI:2149467, MGI:3589053 NCBI chr 3:110,159,624...110,245,382
Ensembl chr 3:110,159,708...110,249,217
JBrowse link
G Impact impact RWD domain protein ISS
ISO
IBA
GO_REF:0000024
(MGI:5494763|PMID:23447528)
PMID:21873635
UniProt
RGD
PMID:23447528, PMID:21873635 GO_REF:0000024, MGI:5494763, RGD:13792537 NCBI chr18:4,325,872...4,346,734
Ensembl chr18:4,325,875...4,346,769
JBrowse link
regulation of eIF2 alpha phosphorylation by amino acid starvation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 ISO
ISS
(PMID:26102367)
(MGI:2149467|PMID:10655230), (MGI:3582244|PMID:11106749), (MGI:3589053|PMID:16121183), (MGI:3770235|PMID:16054071), (MGI:5700278|PMID:26102367)
GO_REF:0000024
RGD
UniProt
PMID:10655230, PMID:11106749, PMID:16054071, PMID:16121183, PMID:26102367 GO_REF:0000024, MGI:2149467, MGI:3582244, MGI:3589053, MGI:3770235, MGI:5700278 NCBI chr 3:110,159,624...110,245,382
Ensembl chr 3:110,159,708...110,249,217
JBrowse link
G Impact impact RWD domain protein ISS
ISO
IBA
GO_REF:0000024
(MGI:5494763|PMID:23447528)
PMID:21873635
UniProt
RGD
PMID:23447528, PMID:21873635 GO_REF:0000024, MGI:5494763, RGD:13792537 NCBI chr18:4,325,872...4,346,734
Ensembl chr18:4,325,875...4,346,769
JBrowse link
regulation of eIF2 alpha phosphorylation by dsRNA term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Npm1 nucleophosmin 1 ISO
ISS
(PMID:12882984)
GO_REF:0000024
RGD
UniProt
PMID:12882984 GO_REF:0000024 NCBI chr10:18,080,949...18,091,062
Ensembl chr10:18,080,950...18,090,950
JBrowse link
regulation of eIF2 alpha phosphorylation by heme term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 ISO MGI:1353448|MGI:95513 (MGI:3581470|PMID:15931390) RGD PMID:15931390 MGI:3581470 NCBI chr12:12,749,026...12,782,078
Ensembl chr12:12,748,785...12,782,146
JBrowse link
G Fech ferrochelatase ISO MGI:1353448|MGI:1858114|MGI:95513 (MGI:3581470|PMID:15931390) RGD PMID:15931390 MGI:3581470 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Hbb hemoglobin subunit beta ISO MGI:1857179 (MGI:3581470|PMID:15931390) RGD PMID:15931390 MGI:3581470 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
JBrowse link
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISS
ISO
GO_REF:0000024
(MGI:3582244|PMID:11106749)
UniProt
RGD
PMID:11106749 GO_REF:0000024, MGI:3582244 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A ISO (MGI:5605960|PMID:11381086) RGD PMID:11381086 MGI:5605960 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
regulation of translational initiation by eIF2 alpha dephosphorylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A ISO (PMID:12556489) RGD PMID:12556489 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
regulation of translational initiation by eIF2 alpha phosphorylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr12:12,749,026...12,782,078
Ensembl chr12:12,748,785...12,782,146
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO (MGI:1858648|PMID:10882126), (MGI:3582244|PMID:11106749), (MGI:3722921|PMID:14729979), (MGI:5613478|PMID:14676213) RGD PMID:10882126, PMID:11106749, PMID:14676213, PMID:14729979 MGI:1858648, MGI:3582244, MGI:3722921, MGI:5613478 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 ISO
ISS
(PMID:26102367)
UniProtKB:Q9Z2B5 (MGI:2149467|PMID:10655230), (MGI:3582244|PMID:11106749), (MGI:3589053|PMID:16121183), (MGI:3722921|PMID:14729979), (MGI:5700278|PMID:26102367), (MGI:5700304|PMID:16601681), (MGI:5700311|PMID:12176355)
GO_REF:0000024
RGD
UniProt
PMID:10655230, PMID:11106749, PMID:12176355, PMID:14729979, PMID:16121183, PMID:16601681, PMID:26102367 GO_REF:0000024, MGI:2149467, MGI:3582244, MGI:3589053, MGI:3722921, MGI:5700278, MGI:5700304, MGI:5700311 NCBI chr 3:110,159,624...110,245,382
Ensembl chr 3:110,159,708...110,249,217
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    metabolic process 12263
      cellular metabolic process 11073
        translational initiation 131
          regulation of translational initiation 73
            regulation of translational initiation in response to stress 16
              negative regulation of translational initiation in response to stress + 3
              positive regulation of translational initiation in response to stress + 3
              regulation of cytoplasmic translational initiation in response to stress + 0
              regulation of translation initiation in response to endoplasmic reticulum stress + 8
              regulation of translational initiation by eIF2 alpha dephosphorylation + 1
              regulation of translational initiation by eIF2 alpha phosphorylation + 14
              regulation of translational initiation in response to osmotic stress + 0
              regulation of translational initiation in response to starvation + 2
Path 2
Term Annotations click to browse term
  biological_process 20020
    metabolic process 12263
      nitrogen compound metabolic process 10347
        cellular nitrogen compound metabolic process 6684
          cellular amide metabolic process 1510
            peptide metabolic process 1269
              peptide biosynthetic process 1114
                translation 1096
                  translational initiation 131
                    regulation of translational initiation 73
                      regulation of translational initiation in response to stress 16
                        negative regulation of translational initiation in response to stress + 3
                        positive regulation of translational initiation in response to stress + 3
                        regulation of cytoplasmic translational initiation in response to stress + 0
                        regulation of translation initiation in response to endoplasmic reticulum stress + 8
                        regulation of translational initiation by eIF2 alpha dephosphorylation + 1
                        regulation of translational initiation by eIF2 alpha phosphorylation + 14
                        regulation of translational initiation in response to osmotic stress + 0
                        regulation of translational initiation in response to starvation + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.