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Term:Ku70:Ku80 complex
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Accession:GO:0043564 term browser browse the term
Definition:Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK.
Synonyms:exact_synonym: Ku70:Ku80 heterodimer

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Ku70:Ku80 complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Paxx PAXX, non-homologous end joining factor JBrowse link 3 2,678,987 2,681,668 RGD:1624291
G Xrcc5 X-ray repair cross complementing 5 JBrowse link 9 79,659,275 79,748,050 RGD:1624291
G Xrcc6 X-ray repair cross complementing 6 JBrowse link 7 123,259,881 123,280,613 RGD:1624291

Term paths to the root
Path 1
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  cellular_component 19843
    protein-containing complex 5779
      Ku70:Ku80 complex 3
Path 2
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  cellular_component 19843
    cellular anatomical entity 19457
      organelle 12557
        membrane-bounded organelle 10879
          intracellular membrane-bounded organelle 9976
            nucleus 6783
              Ku70:Ku80 complex 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.