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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of transcription from RNA polymerase II promoter in response to oxidative stress
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Accession:GO:0043619 term browser browse the term
Definition:Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.


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regulation of transcription from RNA polymerase II promoter in response to oxidative stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd2 ankyrin repeat domain 2 ISO (PMID:24434510) RGD PMID:24434510 NCBI chr 1:261,281,859...261,291,307
Ensembl chr 1:261,281,543...261,291,394
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator ISO
IEA
(PMID:8089148)
GO_REF:0000107
RGD
Ensembl
PMID:8089148 GO_REF:0000107 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Epas1 endothelial PAS domain protein 1 NOT ISO
IEA
MGI:MGI:106918 (MGI:MGI:2667513|PMID:12832481)
MGI:MGI:3710344 (MGI:MGI:2681387|PMID:14608355), (MGI:MGI:3703197|PMID:17284606)
GO_REF:0000107
RGD
Ensembl
PMID:12832481, PMID:14608355, PMID:17284606 GO_REF:0000107, MGI:MGI:2667513, MGI:MGI:2681387, MGI:MGI:3703197 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IMP
ISO
IEA
(PMID:8089148), (PMID:8387214)
GO_REF:0000107
MGI:MGI:2385358 (MGI:MGI:2667513|PMID:12832481)
RGD
Ensembl
PMID:8089148, PMID:8387214, PMID:12832481, PMID:18614764 GO_REF:0000107, MGI:MGI:2667513, RGD:2301848 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 IDA PMID:17430897 BHF-UCL PMID:17430897 RGD:8553479 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Sin3a SIN3 transcription regulator family member A IDA RGD PMID:18945670 RGD:2306468 NCBI chr 8:61,748,590...61,803,314
Ensembl chr 8:61,762,768...61,803,099
JBrowse link
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 ISO
IBA
IMP
(PMID:21113145)
PMID:21873635
PMID:23392669
RGD PMID:21113145, PMID:21873635, PMID:23392669 RGD:13792537, RGD:10047168 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Chd6 chromodomain helicase DNA binding protein 6 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:16314513)
Ensembl
UniProt
RGD
PMID:16314513 GO_REF:0000024, GO_REF:0000107 NCBI chr 3:156,937,746...157,099,328
Ensembl chr 3:156,937,733...157,099,306
JBrowse link
G Mt3 metallothionein 3 ISO
ISS
(PMID:18554677)
GO_REF:0000024
RGD
UniProt
PMID:18554677 GO_REF:0000024 NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 IMP PMID:16314513 UniProt PMID:16314513 RGD:8655528 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Sesn2 sestrin 2 ISO (PMID:23274085) RGD PMID:23274085 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    response to stimulus 10568
      response to stress 4059
        response to oxidative stress 541
          cellular response to oxidative stress 349
            regulation of transcription from RNA polymerase II promoter in response to oxidative stress 11
              negative regulation of transcription from RNA polymerase II promoter in response to oxidative stress 0
              positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress + 5
Path 2
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      cellular metabolic process 11065
        cellular aromatic compound metabolic process 5708
          nucleobase-containing compound metabolic process 5483
            nucleic acid metabolic process 4980
              RNA metabolic process 4470
                regulation of RNA metabolic process 3616
                  regulation of RNA biosynthetic process 3343
                    regulation of nucleic acid-templated transcription 3338
                      regulation of transcription, DNA-templated 3289
                        regulation of DNA-templated transcription in response to stress 55
                          regulation of transcription from RNA polymerase II promoter in response to stress 51
                            regulation of transcription from RNA polymerase II promoter in response to oxidative stress 11
                              negative regulation of transcription from RNA polymerase II promoter in response to oxidative stress 0
                              positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress + 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.