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ONTOLOGY REPORT - ANNOTATIONS


Term:PCNA complex
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Accession:GO:0043626 term browser browse the term
Definition:A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation.
Synonyms:exact_synonym: PCNA homotrimer;   proliferating cell nuclear antigen complex
 broad_synonym: sliding clamp


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PCNA complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pcna proliferating cell nuclear antigen JBrowse link 3 124,880,698 124,884,570 RGD:1624291
RGD:1600115
RGD:13792537

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  cellular_component 19949
    protein-containing complex 5829
      DNA polymerase processivity factor complex 1
        PCNA complex 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.