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ONTOLOGY REPORT - ANNOTATIONS


Term:engulfment of apoptotic cell
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Accession:GO:0043652 term browser browse the term
Definition:The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte.
Comment:This term should be used to annotate gene products from the engulfing cell that facilitate phagocytosis of apoptotic cells. It should not be mistaken with GO:0070782 'phosphatidylserine exposure on apoptotic cell surface', a process occurring in apoptotic cells that acts as a signal for engulfing cells. If gene products involved in such instances of phosphatidylserine exposure are shown to have a positive effect on engulfment, they may be annotated to GO:1901076 'positive regulation of engulfment of apoptotic cell'.
Synonyms:exact_synonym: engulfment of apoptotic cell corpse;   engulfment of cell corpse


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engulfment of apoptotic cell term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgrb1 adhesion G protein-coupled receptor B1 ISO
IBA
(PMID:24509909)
PMID:21873635
(MGI:MGI:3764740|PMID:17960134)
RGD PMID:17960134, PMID:24509909, PMID:21873635 MGI:MGI:3764740, RGD:13792537 NCBI chr 7:115,766,484...115,828,514 JBrowse link
G Becn1 beclin 1 ISO (MGI:MGI:5619450|PMID:22393062) RGD PMID:22393062 MGI:MGI:5619450 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Megf10 multiple EGF-like domains 10 ISO MGI:MGI:4454190 (MGI:MGI:5775214|PMID:27170117) RGD PMID:27170117 MGI:MGI:5775214 NCBI chr18:52,215,652...52,366,212
Ensembl chr18:52,215,682...52,366,238
JBrowse link
G Rac1 Rac family small GTPase 1 ISO
IBA
(MGI:MGI:4943793|PMID:20691665)
PMID:21873635
RGD PMID:20691665, PMID:21873635 MGI:MGI:4943793, RGD:13792537 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rac2 Rac family small GTPase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:119,769,708...119,797,111
Ensembl chr 7:119,783,849...119,797,098
JBrowse link
G Rhobtb1 Rho-related BTB domain containing 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:20,638,579...20,715,437
Ensembl chr20:20,638,579...20,713,128
JBrowse link
G Rhobtb2 Rho-related BTB domain containing 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:51,465,148...51,485,562
Ensembl chr15:51,465,148...51,485,692
JBrowse link
G Rhog ras homolog family member G IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:167,336,147...167,347,720
Ensembl chr 1:167,335,248...167,347,671
JBrowse link
G Rhoh ras homolog family member H IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:43,961,756...43,992,587
Ensembl chr14:43,961,756...43,992,587
JBrowse link
G Thbs1 thrombospondin 1 ISO (PMID:16882710) RGD PMID:16882710 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Xkr4 XK related 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:15,746,012...16,141,059
Ensembl chr 5:15,747,614...16,140,896
JBrowse link
G Xkr5 XK related 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:75,744,786...75,762,694
Ensembl chr16:75,744,786...75,762,693
JBrowse link
G Xkr6 XK related 6 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:46,784,963...47,173,352
Ensembl chr15:46,784,963...47,173,335
JBrowse link
G Xkr7 XK related 7 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:148,508,622...148,537,904
Ensembl chr 3:148,510,779...148,533,404
JBrowse link
G Xkr8 XK related 8 ISO
IBA
(PMID:23845944)
PMID:21873635
RGD PMID:23845944, PMID:21873635 RGD:13792537 NCBI chr 5:150,918,600...150,925,727
Ensembl chr 5:150,918,603...150,925,727
JBrowse link
G Xkr9 XK related 9 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:4,946,332...4,975,436
Ensembl chr 5:4,946,006...4,975,436
JBrowse link
positive regulation of engulfment of apoptotic cell term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 ISO
ISS
(MGI:MGI:3662940|PMID:16908670)
GO_REF:0000024
RGD
Alzheimers_University_of_Toronto
PMID:16908670 GO_REF:0000024, MGI:MGI:3662940 NCBI chr 7:12,742,433...12,762,423
Ensembl chr 7:12,742,433...12,762,341
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 ISO (PMID:24990881) RGD PMID:24990881 NCBI chr 9:14,611,541...14,618,076
Ensembl chr 9:14,611,561...14,618,013
JBrowse link
regulation of engulfment of apoptotic cell term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox15 arachidonate 15-lipoxygenase ISS
ISO
GO_REF:0000024
(MGI:MGI:5436199|PMID:22503541), (MGI:MGI:5508294|PMID:11278875)
UniProt
RGD
PMID:11278875, PMID:22503541 GO_REF:0000024, MGI:MGI:5436199, MGI:MGI:5508294 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      vesicle-mediated transport 1673
        phagocytosis 350
          phagocytosis, engulfment 180
            engulfment of apoptotic cell 19
              negative regulation of engulfment of apoptotic cell 0
              positive regulation of engulfment of apoptotic cell 2
              regulation of engulfment of apoptotic cell + 3
Path 2
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      cellular component organization or biogenesis 6789
        cellular component organization 6534
          membrane organization 865
            membrane invagination 197
              plasma membrane invagination 189
                phagocytosis, engulfment 180
                  engulfment of apoptotic cell 19
                    negative regulation of engulfment of apoptotic cell 0
                    positive regulation of engulfment of apoptotic cell 2
                    regulation of engulfment of apoptotic cell + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.