Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:post-translational protein modification
go back to main search page
Accession:GO:0043687 term browser browse the term
Definition:The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
Comment:This term should only be used to annotate a protein modification process that occurs after the protein has been released from the ribosome, and is therefore strictly post-translational. Modification of a free protein (one not attached to a ribosome) and modification of a C-terminal residue are post-translational processes. Some protein modifications occur while the protein is still in the ribosome but before translation has been completed; these modification processes are considered co-translational and should not be annotated using this term.
Synonyms:exact_synonym: PTM;   post-translational amino acid modification;   post-translational modification;   posttranslational amino acid modification;   posttranslational modification;   posttranslational protein modification
 xref: Wikipedia:Posttranslational_modification


show annotations for term's descendants       view all columns           Sort by:
 
post-translational protein modification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atg5 autophagy related 5 JBrowse link 20 49,301,783 49,393,147 RGD:1624291
G Rhbdd1 rhomboid domain containing 1 JBrowse link 9 88,110,731 88,229,462 RGD:1624291
RGD:1600115
G Stt3b STT3 oligosaccharyltransferase complex catalytic subunit B JBrowse link 8 123,303,910 123,370,729 RGD:1624291
RGD:13792537
G Sumf1 sulfatase modifying factor 1 JBrowse link 4 140,139,017 140,220,482 RGD:1624291
G Vipas39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog JBrowse link 6 111,271,283 111,296,013 RGD:1624291
RGD:1600115
C-terminal protein deglutamylation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agbl1 ATP/GTP binding protein-like 1 JBrowse link 1 137,798,862 138,711,126 RGD:1624291
G Agbl4 ATP/GTP binding protein-like 4 JBrowse link 5
5
130,742,297
130,286,393
131,656,581
130,305,884
RGD:1624291
G Agtpbp1 ATP/GTP binding protein 1 JBrowse link 17 5,510,009 5,614,416 RGD:1600115
G Folh1 folate hydrolase 1 JBrowse link 1 150,323,768 150,395,415 RGD:1600115
RGD:1624291
C-terminal protein lipidation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atg12 autophagy related 12 JBrowse link 18 40,721,799 40,732,143 RGD:13792537
G Atg5 autophagy related 5 JBrowse link 20 49,301,783 49,393,147 RGD:13792537
G Atg7 autophagy related 7 JBrowse link 4 146,570,113 146,777,093 RGD:13792537
C-terminal protein methylation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Icmt isoprenylcysteine carboxyl methyltransferase JBrowse link 5 169,475,270 169,482,031 RGD:2289655
RGD:13792537
RGD:1600115
RGD:1624291
G Lcmt1 leucine carboxyl methyltransferase 1 JBrowse link 1 193,335,629 193,391,620 RGD:1624291
RGD:13792537
RGD:1600115
C-terminal protein-tyrosinylation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ttl tubulin tyrosine ligase JBrowse link 3 121,596,773 121,626,581 RGD:1600115
RGD:1624291
negative regulation of post-translational protein modification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Crtap cartilage associated protein JBrowse link 8 122,382,613 122,402,209 RGD:1624291
G Flcn folliculin JBrowse link 10 46,153,185 46,172,331 RGD:1624291
G P3h1 prolyl 3-hydroxylase 1 JBrowse link 5 138,279,597 138,294,280 RGD:1600115
RGD:1624291
post-translational protein acetylation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dscc1 DNA replication and sister chromatid cohesion 1 JBrowse link 7 94,759,076 94,774,787 RGD:1624291
G Esco1 establishment of sister chromatid cohesion N-acetyltransferase 1 JBrowse link 18 1,789,796 1,857,271 RGD:1624291
RGD:13792537
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 JBrowse link 15 42,500,929 42,519,019 RGD:1624291
RGD:13792537
protein lipidation involved in autophagosome assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atg16l1 autophagy related 16-like 1 JBrowse link 9 94,879,876 94,915,231 RGD:1624291
G Atg5 autophagy related 5 JBrowse link 20 49,301,783 49,393,147 RGD:1624291
RGD:1600115
G Irgm immunity-related GTPase M JBrowse link 10 34,213,885 34,221,968 RGD:1624291
G Wipi2 WD repeat domain, phosphoinositide interacting 2 JBrowse link 12 13,969,704 13,998,134 RGD:1624291
regulation of post-translational protein modification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca2 ATP binding cassette subfamily A member 2 JBrowse link 3 2,648,787 2,668,770 RGD:1624291
RGD:1600115
G Ppib peptidylprolyl isomerase B JBrowse link 8 71,719,681 71,725,538 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19334
    metabolic process 11555
      cellular metabolic process 10567
        cellular macromolecule metabolic process 8127
          cellular protein metabolic process 5293
            cellular protein modification process 3851
              post-translational protein modification 25
                C-terminal protein amino acid modification + 13
                CAAX-box protein modification 0
                N-terminal protein amino acid propionylation 0
                negative regulation of post-translational protein modification 3
                positive regulation of post-translational protein modification 0
                post-translational protein acetylation 3
                regulation of post-translational protein modification + 5
Path 2
Term Annotations click to browse term
  biological_process 19334
    metabolic process 11555
      organic substance metabolic process 10949
        macromolecule metabolic process 9418
          protein metabolic process 5973
            protein modification process 3851
              cellular protein modification process 3851
                post-translational protein modification 25
                  C-terminal protein amino acid modification + 13
                  CAAX-box protein modification 0
                  N-terminal protein amino acid propionylation 0
                  negative regulation of post-translational protein modification 3
                  positive regulation of post-translational protein modification 0
                  post-translational protein acetylation 3
                  regulation of post-translational protein modification + 5
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.