ONTOLOGY REPORT - ANNOTATIONS


Term:cell dedifferentiation
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Accession:GO:0043697 term browser browse the term
Definition:The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors.
Comment:Note that this term should be used to annotate gene products involved in dedifferentiation that occurs as part of a normal process, such as regeneration. It should not be used for dedifferentiation that occurs in an abnormal or disease state such as cancer.


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cell dedifferentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:1624291
RGD:1600115
G Esrrb estrogen-related receptor beta JBrowse link 6 110,360,940 110,458,406 RGD:1624291
RGD:1600115
G Fezf1 Fez family zinc finger 1 JBrowse link 4 50,309,281 50,312,608 RGD:1624291
RGD:1600115
G Fezf2 Fez family zinc finger 2 JBrowse link 15 12,825,333 12,831,496 RGD:1624291
RGD:1600115
G Nanog Nanog homeobox JBrowse link 4 155,531,906 155,539,268 RGD:1624291
G Ncoa3 nuclear receptor coactivator 3 JBrowse link 3 162,692,176 162,788,582 RGD:1624291
RGD:1600115
hepatocyte dedifferentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hnrnpd heterogeneous nuclear ribonucleoprotein D JBrowse link 14 11,256,163 11,274,684 RGD:10042969
positive regulation of vascular smooth muscle cell dedifferentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:1624291
RGD:1600115
regulation of vascular smooth muscle cell dedifferentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Olfm2 olfactomedin 2 JBrowse link 8 21,684,307 21,762,000 RGD:13441204

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Term Annotations click to browse term
  biological_process 17896
    developmental process 6323
      dedifferentiation 9
        cell dedifferentiation 9
          cell dedifferentiation involved in phenotypic switching + 2
          hepatocyte dedifferentiation 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.