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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA-N1-methyladenine dioxygenase activity
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Accession:GO:0043734 term browser browse the term
Definition:Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde.
Synonyms:narrow_synonym: alkB;   alpha-ketoglutarate-dependent dioxygenase
 xref: reactome:R-HSA-112118 "Oxidative demethylation of 1-meA damaged DNA by ALKBH2";   reactome:R-HSA-112123 "Oxidative demethylation of 1-meA damaged DNA By ALKBH3"


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DNA-N1-methyladenine dioxygenase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase ISO
IBA
(PMID:18432238)
PMID:21873635
RGD PMID:18432238, PMID:21873635 RGD:13792537 NCBI chr12:48,257,575...48,262,244
Ensembl chr12:48,257,609...48,262,243
JBrowse link
G Alkbh3 alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase ISS
ISO
GO_REF:0000024
(PMID:16858410), (PMID:22055184)
UniProt
RGD
PMID:16858410, PMID:22055184 GO_REF:0000024 NCBI chr 3:82,874,242...82,907,467
Ensembl chr 3:82,874,248...82,906,581
JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase IEA
ISO
IBA
ISS
GO_REF:0000107
(MGI:4430814|PMID:17991826)
PMID:21873635
GO_REF:0000024
(PMID:20376003)
Ensembl
RGD
UniProt
PMID:17991826, PMID:20376003, PMID:21873635 GO_REF:0000024, GO_REF:0000107, MGI:4430814, RGD:13792537 NCBI chr19:16,774,549...17,115,098
Ensembl chr19:16,772,744...17,115,113
JBrowse link

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Term Annotations click to browse term
  molecular_function 20457
    catalytic activity 6065
      oxidoreductase activity 877
        dioxygenase activity 91
          2-oxoglutarate-dependent dioxygenase activity 50
            DNA-N1-methyladenine dioxygenase activity 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.