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Term:DNA-N1-methyladenine dioxygenase activity
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Accession:GO:0043734 term browser browse the term
Definition:Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde.
Synonyms:narrow_synonym: alkB;   alpha-ketoglutarate-dependent dioxygenase
 xref: reactome:R-HSA-112118 "Oxidative demethylation of 1-meA damaged DNA by ALKBH2";   reactome:R-HSA-112123 "Oxidative demethylation of 1-meA damaged DNA By ALKBH3"

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DNA-N1-methyladenine dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alkbh2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase JBrowse link 12 48,257,575 48,262,244 RGD:1624291
G Alkbh3 alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase JBrowse link 3 82,874,242 82,907,467 RGD:1600115
G Fto FTO, alpha-ketoglutarate dependent dioxygenase JBrowse link 19 16,774,549 17,115,098 RGD:1600115

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  molecular_function 19678
    catalytic activity 6023
      oxidoreductase activity 848
        dioxygenase activity 79
          2-oxoglutarate-dependent dioxygenase activity 49
            DNA-N1-methyladenine dioxygenase activity 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.