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Term:nuclear pore central transport channel
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Accession:GO:0044613 term browser browse the term
Definition:The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153.
Synonyms:exact_synonym: nuclear pore central channel;   nuclear pore central plug;   nuclear pore transport channel
 related_synonym: karyopherin docking complex

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nuclear pore central transport channel term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nup153 nucleoporin 153 JBrowse link 17 18,358,712 18,411,368 RGD:13792537
G Nup35 nucleoporin 35 JBrowse link 3 67,866,784 67,896,828 RGD:13792537
G Nup54 nucleoporin 54 JBrowse link 14 17,123,434 17,141,832 RGD:13792537
G Nup62 nucleoporin 62 JBrowse link 1 100,811,140 100,827,119 RGD:13792537
G Nup62cl nucleoporin 62 C-terminal like JBrowse link X 111,333,274 111,390,023 RGD:13792537
G Nutf2 nuclear transport factor 2 JBrowse link 19 37,830,917 37,852,192 RGD:9831376
G Nxt1 nuclear transport factor 2-like export factor 1 JBrowse link 3 142,993,658 142,996,580 RGD:13792537
G Nxt2 nuclear transport factor 2-like export factor 2 JBrowse link X 113,509,841 113,517,112 RGD:13792537

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  cellular_component 19843
    protein-containing complex 5779
      nuclear pore central transport channel 8
Path 2
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  cellular_component 19843
    cellular anatomical entity 19457
      organelle 12557
        membrane-bounded organelle 10879
          intracellular membrane-bounded organelle 9976
            nucleus 6783
              nuclear envelope 465
                nuclear pore 71
                  nuclear pore central transport channel 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.