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ONTOLOGY REPORT - ANNOTATIONS


Term:double-strand break repair via single-strand annealing
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Accession:GO:0045002 term browser browse the term
Definition:Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats.


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double-strand break repair via single-strand annealing term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rad52 RAD52 homolog, DNA repair protein IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:152,429,826...152,451,875
Ensembl chr 4:152,430,187...152,451,609
JBrowse link
DNA double-strand break processing involved in repair via single-strand annealing term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07031480.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr18:15,148,983...15,167,311 JBrowse link
G Rad52 RAD52 homolog, DNA repair protein ISO (PMID:19506022)
(MGI:MGI:5619739|PMID:22912580)
RGD PMID:19506022, PMID:22912580 MGI:MGI:5619739 NCBI chr 4:152,429,826...152,451,875
Ensembl chr 4:152,430,187...152,451,609
JBrowse link
G Rbbp8 RB binding protein 8, endonuclease IEA
IBA
ISO
GO_REF:0000002
PMID:21873635
(PMID:18716619), (PMID:19202191)
InterPro
RGD
PMID:18716619, PMID:19202191, PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr18:3,134,630...3,227,702
Ensembl chr18:3,162,543...3,227,688
JBrowse link
G RGD1565844 similar to RIKEN cDNA 1700045I19 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:32,495,573...32,496,646
Ensembl chr  X:32,495,809...32,496,549
JBrowse link
G Rnf138 ring finger protein 138 ISO
IBA
ISS
(PMID:26502057)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:26502057, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr18:15,146,925...15,167,361 JBrowse link
G Slx1b SLX1 homolog B, structure-specific endonuclease subunit ISO (PMID:19595721) RGD PMID:19595721 NCBI chr 1:198,114,514...198,120,061
Ensembl chr 1:198,112,245...198,120,061
JBrowse link
G Slx4 SLX4 structure-specific endonuclease subunit ISO (PMID:19595721) RGD PMID:19595721 NCBI chr10:11,787,756...11,808,326
Ensembl chr10:11,786,121...11,807,928
JBrowse link
negative regulation of double-strand break repair via single-strand annealing term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ogg1 8-oxoguanine DNA glycosylase ISO (PMID:19506022) RGD PMID:19506022 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      cellular metabolic process 11085
        cellular macromolecule metabolic process 8554
          DNA metabolic process 923
            DNA repair 487
              non-recombinational repair 74
                double-strand break repair via single-strand annealing 8
                  DNA double-strand break processing involved in repair via single-strand annealing 7
                  DNA strand renaturation involved in double-strand break repair 0
                  DNA synthesis involved in double-strand break repair via single-strand annealing 0
                  double-strand break repair via single-strand annealing, removal of nonhomologous ends + 0
                  negative regulation of double-strand break repair via single-strand annealing 1
Path 2
Term Annotations click to browse term
  biological_process 20027
    cellular process 18798
      cellular metabolic process 11085
        cellular nitrogen compound metabolic process 6696
          nucleobase-containing compound metabolic process 5489
            nucleic acid metabolic process 4985
              DNA metabolic process 923
                DNA repair 487
                  non-recombinational repair 74
                    double-strand break repair via single-strand annealing 8
                      DNA double-strand break processing involved in repair via single-strand annealing 7
                      DNA strand renaturation involved in double-strand break repair 0
                      DNA synthesis involved in double-strand break repair via single-strand annealing 0
                      double-strand break repair via single-strand annealing, removal of nonhomologous ends + 0
                      negative regulation of double-strand break repair via single-strand annealing 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.