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ONTOLOGY REPORT - ANNOTATIONS


Term:T cell selection
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Accession:GO:0045058 term browser browse the term
Definition:The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.
Synonyms:exact_synonym: T lymphocyte selection
 xref: Wikipedia:Thymocyte


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T cell selection term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd4 Cd4 molecule JBrowse link 4 157,381,862 157,408,357 RGD:1624291
RGD:8554348
beta selection term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:1624291
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:1624291
RGD:1600115
G Zap70 zeta chain of T cell receptor associated protein kinase 70 JBrowse link 9 43,331,149 43,353,097 RGD:1624291
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:1624291
G Cyld CYLD lysine 63 deubiquitinase JBrowse link 19 19,264,984 19,323,817 RGD:1624291
RGD:1600115
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:1624291
RGD:1600115
CD4-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ctsl cathepsin L JBrowse link 17 1,873,105 1,879,266 RGD:1600115
RGD:1624291
G Tox thymocyte selection-associated high mobility group box JBrowse link 5 19,892,698 20,189,721 RGD:1624291
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tox thymocyte selection-associated high mobility group box JBrowse link 5 19,892,698 20,189,721 RGD:1624291
CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:1624291
RGD:1600115
G Tox thymocyte selection-associated high mobility group box JBrowse link 5 19,892,698 20,189,721 RGD:1624291
extrathymic T cell selection term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il15 interleukin 15 JBrowse link 19 23,542,606 23,624,366 RGD:1624291
negative regulation of positive thymic T cell selection term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Loxl3 lysyl oxidase-like 3 JBrowse link 4 113,866,782 113,883,713 RGD:1624291
G Tbx21 T-box transcription factor 21 JBrowse link 10 85,032,799 85,049,331 RGD:1624291
G Tnfsf18 TNF superfamily member 18 JBrowse link 13 79,378,412 79,388,687 RGD:1624291
negative T cell selection term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Themis thymocyte selection associated JBrowse link 1 17,152,973 17,378,225 RGD:1624291
negative thymic T cell selection term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aire autoimmune regulator JBrowse link 20 11,365,630 11,380,636 RGD:1624291
RGD:13792537
G Atg5 autophagy related 5 JBrowse link 20 49,301,783 49,393,147 RGD:1624291
RGD:1600115
G Ccr7 C-C motif chemokine receptor 7 JBrowse link 10 87,057,335 87,067,444 RGD:1624291
G Cd28 Cd28 molecule JBrowse link 9 67,546,408 67,573,858 RGD:1624291
RGD:1600115
G Cd3e CD3e molecule JBrowse link 8 49,297,604 49,309,370 RGD:1624291
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:1624291
G Dock2 dedicator of cytokinesis 2 JBrowse link 10 19,181,512 19,603,171 RGD:1624291
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:1624291
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:1624291
G Mink1 misshapen-like kinase 1 JBrowse link 10 57,185,310 57,238,531 RGD:1624291
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:1624291
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:1624291
RGD:1600115
G Spn sialophorin JBrowse link 1 198,572,999 198,585,664 RGD:1624291
G Zap70 zeta chain of T cell receptor associated protein kinase 70 JBrowse link 9 43,331,149 43,353,097 RGD:1624291
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il23a interleukin 23 subunit alpha JBrowse link 7 2,710,609 2,712,723 RGD:1624291
RGD:13792537
positive T cell selection term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl11b BAF chromatin remodeling complex subunit BCL11B JBrowse link 6 131,834,097 131,927,251 RGD:1624291
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:1624291
G Themis thymocyte selection associated JBrowse link 1 17,152,973 17,378,225 RGD:1624291
positive thymic T cell selection term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd1d1 CD1d1 molecule JBrowse link 2 186,330,298 186,333,805 RGD:1624291
G Cd3d CD3d molecule JBrowse link 8 49,282,502 49,287,095 RGD:1624291
RGD:13792537
RGD:1600115
G Cd3e CD3e molecule JBrowse link 8 49,297,604 49,309,370 RGD:13792537
G Cd3g CD3g molecule JBrowse link 8 49,274,553 49,280,943 RGD:13792537
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:1624291
G Dock2 dedicator of cytokinesis 2 JBrowse link 10 19,181,512 19,603,171 RGD:1624291
G Itpkb inositol-trisphosphate 3-kinase B JBrowse link 13 98,615,287 98,710,426 RGD:1624291
G LOC100909593 class II histocompatibility antigen, M alpha chain-like JBrowse link 20 3,935,501 3,938,915 RGD:1624291
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:1624291
G RT1-DMa RT1 class II, locus DMa JBrowse link 20 3,935,512 3,938,915 RGD:1624291
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:1624291
RGD:1600115
G Srf serum response factor JBrowse link 9 16,737,637 16,747,226 RGD:1624291
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:1624291
RGD:1600115
G Zap70 zeta chain of T cell receptor associated protein kinase 70 JBrowse link 9 43,331,149 43,353,097 RGD:1624291
regulation of positive thymic T cell selection term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxn1 forkhead box N1 JBrowse link 10 65,621,142 65,634,666 RGD:1624291
G Tox thymocyte selection-associated high mobility group box JBrowse link 5 19,892,698 20,189,721 RGD:1624291
T-helper 1 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1624291
G Spn sialophorin JBrowse link 1 198,572,999 198,585,664 RGD:1600115
RGD:1624291
G Stat6 signal transducer and activator of transcription 6 JBrowse link 7 70,946,228 70,963,542 RGD:1624291
T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Batf basic leucine zipper ATF-like transcription factor JBrowse link 6 109,562,415 109,584,541 RGD:1600115
RGD:1624291
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:1600115
RGD:1624291
G Il6r interleukin 6 receptor JBrowse link 2 189,196,180 189,255,987 RGD:1600115
RGD:1624291
G Irf4 interferon regulatory factor 4 JBrowse link 17 34,886,746 34,905,191 RGD:1624291
G Ly9 lymphocyte antigen 9 JBrowse link 13 90,002,779 90,022,346 RGD:1624291
G Otud5 OTU deubiquitinase 5 JBrowse link X 15,471,212 15,504,372 RGD:1624291
G Slamf6 SLAM family member 6 JBrowse link 13 90,300,160 90,321,781 RGD:1624291
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:1624291
RGD:1600115
thymic T cell selection term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Card11 caspase recruitment domain family, member 11 JBrowse link 12 15,700,600 15,844,512 RGD:1624291
G Gata3 GATA binding protein 3 JBrowse link 17 72,419,752 72,452,043 RGD:1624291
G Itpkb inositol-trisphosphate 3-kinase B JBrowse link 13 98,615,287 98,710,426 RGD:1624291
G Jag2 jagged canonical Notch ligand 2 JBrowse link 6 137,711,144 137,733,331 RGD:1600115
RGD:8553281
RGD:1624291
G Zap70 zeta chain of T cell receptor associated protein kinase 70 JBrowse link 9 43,331,149 43,353,097 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    immune system process 2798
      T cell selection 52
        beta selection 3
        extrathymic T cell selection + 1
        negative T cell selection + 15
        positive T cell selection + 38
        thymic T cell selection + 28
Path 2
Term Annotations click to browse term
  biological_process 19858
    developmental process 6735
      anatomical structure development 6181
        multicellular organism development 5638
          system development 5212
            immune system development 1054
              hematopoietic or lymphoid organ development 991
                hemopoiesis 939
                  leukocyte differentiation 582
                    lymphocyte differentiation 398
                      T cell differentiation 282
                        T cell selection 52
                          beta selection 3
                          extrathymic T cell selection + 1
                          negative T cell selection + 15
                          positive T cell selection + 38
                          thymic T cell selection + 28
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.