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ONTOLOGY REPORT - ANNOTATIONS


Term:T cell selection
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Accession:GO:0045058 term browser browse the term
Definition:The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.
Synonyms:exact_synonym: T lymphocyte selection
 xref: Wikipedia:Thymocyte


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T cell selection term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd4 Cd4 molecule JBrowse link 4 157,381,862 157,408,357 RGD:1624291
RGD:8554348
beta selection term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:1624291
RGD:1600115
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:1624291
RGD:1600115
G Zap70 zeta chain of T cell receptor associated protein kinase 70 JBrowse link 9 43,331,149 43,353,097 RGD:1624291
RGD:1600115
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:1624291
RGD:1600115
G Cyld CYLD lysine 63 deubiquitinase JBrowse link 19 19,264,984 19,323,817 RGD:1624291
RGD:1600115
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:1624291
RGD:1600115
CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:1624291
RGD:1600115
extrathymic T cell selection term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il15 interleukin 15 JBrowse link 19 23,542,606 23,624,366 RGD:1624291
RGD:1600115
negative regulation of positive thymic T cell selection term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Loxl3 lysyl oxidase-like 3 JBrowse link 4 113,866,782 113,883,713 RGD:1624291
RGD:1600115
G Tbx21 T-box 21 JBrowse link 10 85,032,799 85,049,331 RGD:1624291
RGD:1600115
G Tnfsf18 TNF superfamily member 18 JBrowse link 13 79,378,412 79,388,687 RGD:1624291
RGD:1600115
negative T cell selection term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Themis thymocyte selection associated JBrowse link 1 17,152,973 17,378,225 RGD:1624291
RGD:1600115
negative thymic T cell selection term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aire autoimmune regulator JBrowse link 20 11,365,630 11,380,636 RGD:1624291
RGD:13792537
G Atg5 autophagy related 5 JBrowse link 20 49,301,783 49,393,147 RGD:1624291
RGD:1600115
G Ccr7 C-C motif chemokine receptor 7 JBrowse link 10 87,057,335 87,067,444 RGD:1624291
RGD:1600115
G Cd28 Cd28 molecule JBrowse link 9 67,546,408 67,573,858 RGD:1624291
RGD:1600115
G Cd3e CD3e molecule JBrowse link 8 49,297,604 49,309,370 RGD:1624291
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:1624291
RGD:1600115
G Dock2 dedicator of cytokinesis 2 JBrowse link 10 19,181,512 19,603,171 RGD:1624291
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:1624291
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:1624291
RGD:1600115
G Mink1 misshapen-like kinase 1 JBrowse link 10 57,185,310 57,238,531 RGD:1624291
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:1624291
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:1624291
RGD:1600115
G Spn sialophorin JBrowse link 1 198,572,999 198,585,664 RGD:1624291
G Zap70 zeta chain of T cell receptor associated protein kinase 70 JBrowse link 9 43,331,149 43,353,097 RGD:1624291
RGD:1600115
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il23a interleukin 23 subunit alpha JBrowse link 7 2,710,609 2,712,723 RGD:1624291
RGD:13792537
positive T cell selection term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl11b BCL11B, BAF complex component JBrowse link 6 131,834,097 131,927,251 RGD:1624291
RGD:1600115
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:1624291
G Themis thymocyte selection associated JBrowse link 1 17,152,973 17,378,225 RGD:1624291
RGD:1600115
positive thymic T cell selection term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd1d1 CD1d1 molecule JBrowse link 2 186,330,298 186,333,805 RGD:1624291
G Cd3d CD3d molecule JBrowse link 8 49,282,502 49,287,095 RGD:1624291
RGD:13792537
RGD:1600115
G Cd3e CD3e molecule JBrowse link 8 49,297,604 49,309,370 RGD:13792537
G Cd3g CD3g molecule JBrowse link 8 49,274,553 49,280,943 RGD:13792537
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:1624291
RGD:1600115
G Dock2 dedicator of cytokinesis 2 JBrowse link 10 19,181,512 19,603,171 RGD:1624291
G Itpkb inositol-trisphosphate 3-kinase B JBrowse link 13 98,615,287 98,710,426 RGD:1624291
RGD:1600115
G LOC100909593 class II histocompatibility antigen, M alpha chain-like JBrowse link 20 3,935,501 3,938,915 RGD:1624291
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:1624291
G RT1-DMa RT1 class II, locus DMa JBrowse link 20 3,935,512 3,938,915 RGD:1624291
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:1624291
RGD:1600115
G Srf serum response factor JBrowse link 9 16,737,637 16,747,226 RGD:1624291
RGD:1600115
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:1624291
RGD:1600115
G Zap70 zeta chain of T cell receptor associated protein kinase 70 JBrowse link 9 43,331,149 43,353,097 RGD:1624291
RGD:1600115
regulation of positive thymic T cell selection term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxn1 forkhead box N1 JBrowse link 10 65,621,142 65,634,666 RGD:1624291
T-helper 1 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1624291
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:1600115
RGD:1624291
G Spn sialophorin JBrowse link 1 198,572,999 198,585,664 RGD:1600115
RGD:1624291
G Stat6 signal transducer and activator of transcription 6 JBrowse link 7 70,946,228 70,963,542 RGD:1624291
RGD:1600115
T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Batf basic leucine zipper ATF-like transcription factor JBrowse link 6 109,562,415 109,584,541 RGD:1600115
RGD:1624291
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:1624291
RGD:1600115
G Irf4 interferon regulatory factor 4 JBrowse link 17 34,886,746 34,905,191 RGD:1624291
RGD:1600115
G Ly9 lymphocyte antigen 9 JBrowse link 13 90,002,779 90,022,346 RGD:1624291
RGD:1600115
G Otud5 OTU deubiquitinase 5 JBrowse link X 15,471,212 15,504,372 RGD:1624291
G Slamf6 SLAM family member 6 JBrowse link 13 90,300,160 90,321,781 RGD:1624291
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:1624291
RGD:1600115
thymic T cell selection term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Card11 caspase recruitment domain family, member 11 JBrowse link 12 15,700,600 15,844,512 RGD:1624291
G Gata3 GATA binding protein 3 JBrowse link 17 72,419,752 72,452,043 RGD:1624291
RGD:1600115
G Itpkb inositol-trisphosphate 3-kinase B JBrowse link 13 98,615,287 98,710,426 RGD:1624291
G Jag2 jagged 2 JBrowse link 6 137,711,144 137,733,331 RGD:1600115
RGD:8553281
RGD:1624291
G Zap70 zeta chain of T cell receptor associated protein kinase 70 JBrowse link 9 43,331,149 43,353,097 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17883
    immune system process 2295
      T cell selection 50
        beta selection 3
        extrathymic T cell selection + 1
        negative T cell selection + 15
        positive T cell selection + 36
        thymic T cell selection + 27
Path 2
Term Annotations click to browse term
  biological_process 17883
    developmental process 6309
      anatomical structure development 5916
        multicellular organism development 5414
          system development 4992
            immune system development 1006
              hematopoietic or lymphoid organ development 946
                hemopoiesis 895
                  leukocyte differentiation 556
                    lymphocyte differentiation 376
                      T cell differentiation 264
                        T cell selection 50
                          beta selection 3
                          extrathymic T cell selection + 1
                          negative T cell selection + 15
                          positive T cell selection + 36
                          thymic T cell selection + 27
paths to the root