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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of viral genome replication
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Accession:GO:0045071 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
Synonyms:exact_synonym: down regulation of viral genome replication;   downregulation of viral genome replication
 narrow_synonym: inhibition of viral genome replication


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negative regulation of viral genome replication term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07015596.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr14:65,152,594...65,153,013 JBrowse link
G AABR07021463.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr13:73,661,131...73,661,553 JBrowse link
G Adar adenosine deaminase, RNA-specific ISO MGI:4941203 (MGI:4939544|PMID:21173229) RGD PMID:21173229 MGI:4939544 NCBI chr 2:189,045,551...189,085,448
Ensembl chr 2:189,062,443...189,083,236
JBrowse link
G Apobec3 apolipoprotein B mRNA editing enzyme catalytic subunit 3 ISO (MGI:5486557|PMID:16378963) RGD PMID:16378963 MGI:5486557 NCBI chr 7:121,108,108...121,128,346
Ensembl chr 7:121,109,241...121,128,542
JBrowse link
G Banf1 BAF nuclear assembly factor 1 ISO (PMID:18005698) RGD PMID:18005698 NCBI chr 1:220,744,195...220,746,224
Ensembl chr 1:220,744,195...220,746,224
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 ISO
ISS
(PMID:20943977)
(MGI:5437405|PMID:22284121), (MGI:5448513|PMID:21919738)
GO_REF:0000024
RGD
UniProt
PMID:20943977, PMID:21919738, PMID:22284121 GO_REF:0000024, MGI:5437405, MGI:5448513 NCBI chr16:19,938,781...19,942,353
Ensembl chr16:19,938,784...19,942,353
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO
IEA
(PMID:10490959)
GO_REF:0000107
RGD
Ensembl
PMID:10490959 GO_REF:0000107 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 IEA
ISO
ISS
GO_REF:0000107
(MGI:5487533|PMID:20038207)
(PMID:19189853), (PMID:19840259)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:19189853, PMID:19840259, PMID:20038207 GO_REF:0000024, GO_REF:0000107, MGI:5487533 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
JBrowse link
G Fam111a FAM111 trypsin like peptidase A ISO (PMID:23093934) RGD PMID:23093934 NCBI chr 1:229,003,778...229,019,532
Ensembl chr 1:229,003,961...229,019,527
JBrowse link
G Ifitm1 interferon induced transmembrane protein 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:213,765,825...213,767,841
Ensembl chr 1:213,766,758...213,767,815
JBrowse link
G Ifitm2 interferon induced transmembrane protein 2 ISO
IBA
(PMID:21253575)
PMID:21873635
RGD PMID:21253575, PMID:21873635 RGD:13792537 NCBI chr 1:213,750,219...213,751,399
Ensembl chr 1:213,750,192...213,751,405
JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 ISO
IBA
(PMID:20943977), (PMID:21253575)
PMID:21873635
RGD PMID:20943977, PMID:21253575, PMID:21873635 RGD:13792537 NCBI chr 1:213,810,712...213,811,821
Ensembl chr 1:213,810,696...213,811,901
JBrowse link
G Ifitm6 interferon induced transmembrane protein 6 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:213,816,966...213,856,570
Ensembl chr 1:213,817,312...213,818,222
JBrowse link
G Ifnb1 interferon beta 1 ISO (PMID:19008854) RGD PMID:19008854 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Ilf3 interleukin enhancer binding factor 3 ISS
ISO
GO_REF:0000024
(MGI:4867319|PMID:21123651)
UniProt
RGD
PMID:21123651 GO_REF:0000024, MGI:4867319 NCBI chr 8:22,402,877...22,440,984
Ensembl chr 8:22,402,890...22,440,885
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier ISO (PMID:19357168) RGD PMID:19357168 NCBI chr 5:173,624,862...173,629,124
Ensembl chr 5:173,624,310...173,626,248
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 ISO
IBA
(PMID:21036379)
PMID:21873635
RGD PMID:21036379, PMID:21873635 RGD:13792537 NCBI chr 1:140,602,553...140,608,892
Ensembl chr 1:140,601,791...140,608,946
JBrowse link
G LOC103689988 2'-5'-oligoadenylate synthase 1A-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:42,367,110...42,376,531
Ensembl chr12:42,367,535...42,376,426
JBrowse link
G Ltf lactotransferrin ISO (PMID:25193851) RGD PMID:25193851 NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
JBrowse link
G Mavs mitochondrial antiviral signaling protein ISO (PMID:20451243)
(MGI:4881394|PMID:20451243)
RGD PMID:20451243 MGI:4881394 NCBI chr 3:123,776,147...123,790,572
Ensembl chr 3:123,776,181...123,790,567
JBrowse link
G Mx2 MX dynamin like GTPase 2 IEA
ISO
GO_REF:0000107
(PMID:24500530)
(PMID:14687945), (PMID:15047845), (PMID:16202617)
Ensembl
RGD
PMID:14687945, PMID:15047845, PMID:16202617, PMID:24500530 GO_REF:0000107 NCBI chr11:38,035,306...38,066,185
Ensembl chr11:38,035,450...38,059,950
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A ISO
IBA
(PMID:18931074), (PMID:19923450)
PMID:21873635
(PMID:20844035)
RGD PMID:18931074, PMID:19923450, PMID:20844035, PMID:21873635 RGD:13792537 NCBI chr12:41,200,680...41,211,393
Ensembl chr12:41,200,718...41,211,909
JBrowse link
G Oas1b 2-5 oligoadenylate synthetase 1B ISS
IBA
GO_REF:0000024
PMID:21873635
UniProt PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr12:41,255,762...41,266,430
Ensembl chr12:41,227,825...41,307,352
JBrowse link
G Oas1e 2'-5' oligoadenylate synthetase 1E IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:41,281,479...41,290,500
Ensembl chr12:41,281,559...41,290,497
JBrowse link
G Oas1g 2'-5' oligoadenylate synthetase 1G IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:42,343,103...42,355,139
Ensembl chr12:42,343,123...42,355,131
JBrowse link
G Oas1h 2 ' -5 ' oligoadenylate synthetase 1H IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:41,214,587...41,224,254
Ensembl chr12:41,214,587...41,224,254
JBrowse link
G Oas1i 2 ' -5 ' oligoadenylate synthetase 1I IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:41,155,489...41,167,501
Ensembl chr12:41,155,497...41,167,505
JBrowse link
G Oas2 2'-5' oligoadenylate synthetase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:41,341,417...41,363,124
Ensembl chr12:41,340,815...41,363,161
JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 ISO
IBA
IEA
(PMID:19056102), (PMID:19923450)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:19056102, PMID:19923450, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr12:41,313,081...41,368,217
Ensembl chr12:41,316,764...41,336,562
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like ISO
IBA
(PMID:18931074), (PMID:20074559)
PMID:21873635
RGD PMID:18931074, PMID:20074559, PMID:21873635 RGD:13792537 NCBI chr12:47,444,138...47,456,680
Ensembl chr12:47,444,104...47,456,894
JBrowse link
G Oasl2 2'-5' oligoadenylate synthetase-like 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:47,470,074...47,483,131
Ensembl chr12:47,469,598...47,482,961
JBrowse link
G Parp10 poly (ADP-ribose) polymerase family, member 10 ISO (PMID:22176891) RGD PMID:22176891 NCBI chr 7:117,291,592...117,300,878
Ensembl chr 7:117,291,877...117,300,662
JBrowse link
G Plscr1 phospholipid scramblase 1 IEA
ISO
ISS
GO_REF:0000107
(MGI:5284800|PMID:15308695)
GO_REF:0000024
(PMID:15308695)
Ensembl
RGD
UniProt
PMID:15308695 GO_REF:0000024, GO_REF:0000107, MGI:5284800 NCBI chr 8:99,625,523...99,645,882
Ensembl chr 8:99,625,545...99,725,217
JBrowse link
G Prox1 prospero homeobox 1 ISO (PMID:19264593) RGD PMID:19264593 NCBI chr13:108,382,536...108,444,107
Ensembl chr13:108,382,399...108,443,294
JBrowse link
G RGD1561738 similar to interferon induced transmembrane protein 2 (1-8D) IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:73,661,005...73,661,699 JBrowse link
G RGD1565332 similar to interferon induced transmembrane protein 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:65,152,594...65,153,013 JBrowse link
G Rnasel ribonuclease L ISO
IBA
(PMID:19923450)
PMID:21873635
RGD PMID:19923450, PMID:21873635 RGD:13792537 NCBI chr13:71,188,712...71,202,636
Ensembl chr13:71,192,142...71,202,625
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 IEA
ISO
GO_REF:0000107
(MGI:5431072|PMID:21880757)
(PMID:21957124)
Ensembl
RGD
PMID:21880757, PMID:21957124 GO_REF:0000107, MGI:5431072 NCBI chr 6:45,655,947...45,669,083
Ensembl chr 6:45,655,954...45,669,148
JBrowse link
G Shfl shiftless antiviral inhibitor of ribosomal frameshifting IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:26735137)
Ensembl
UniProt
RGD
PMID:26735137 GO_REF:0000024, GO_REF:0000107 NCBI chr 8:21,890,214...21,896,045
Ensembl chr 8:21,890,319...21,896,031
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor ISO (PMID:19333378) RGD PMID:19333378 NCBI chr 3:160,799,979...160,802,228
Ensembl chr 3:160,799,981...160,802,433
JBrowse link
G Srpk1 SRSF protein kinase 1 ISO (PMID:12417631) RGD PMID:12417631 NCBI chr20:5,829,412...5,865,877
Ensembl chr20:5,831,119...5,865,854
JBrowse link
G Srpk2 SRSF protein kinase 2 ISO (PMID:12417631) RGD PMID:12417631 NCBI chr 4:7,994,025...8,187,455
Ensembl chr 4:8,066,737...8,185,935
JBrowse link
G Tnf tumor necrosis factor ISO (PMID:10490959) RGD PMID:10490959 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trim6 tripartite motif containing 6 ISO (PMID:24882218)
(MGI:5645191|PMID:24882218)
RGD PMID:24882218 MGI:5645191 NCBI chr 1:169,410,084...169,423,305
Ensembl chr 1:169,410,115...169,423,283
JBrowse link
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 IDA
ISO
IEA
PMID:21876179
(PMID:21102435), (PMID:21876179)
GO_REF:0000107
RGD
Ensembl
PMID:21102435, PMID:21876179, PMID:21876179 GO_REF:0000107, RGD:8554819 NCBI chr 4:66,012,111...66,062,160
Ensembl chr 4:66,011,915...66,062,089
JBrowse link
negative regulation by host of viral genome replication term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl12 chemokine (C-C motif) ligand 12 IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr10:69,476,866...69,478,416
Ensembl chr10:69,476,775...69,478,462
JBrowse link
G Ccnk cyclin K ISO (PMID:21555514) RGD PMID:21555514 NCBI chr 6:132,090,235...132,113,560
Ensembl chr 6:132,090,218...132,113,557
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 ISO MGI:3053078 (MGI:55926|PMID:6327825) RGD PMID:6327825 MGI:55926 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked ISO (PMID:24380861) RGD PMID:24380861 NCBI chr  X:10,400,363...10,414,010
Ensembl chr  X:10,400,366...10,413,995
JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 ISS
ISO
GO_REF:0000024
(MGI:5700304|PMID:16601681)
UniProt
RGD
PMID:16601681 GO_REF:0000024, MGI:5700304 NCBI chr 3:110,159,624...110,245,382
Ensembl chr 3:110,159,708...110,249,217
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO (PMID:25244949) RGD PMID:25244949 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Vapa VAMP associated protein A ISO (PMID:19515777) RGD PMID:19515777 NCBI chr 9:113,300,831...113,331,872
Ensembl chr 9:113,300,832...113,331,319
JBrowse link
G Vapb VAMP associated protein B and C ISO (PMID:19515777) RGD PMID:19515777 NCBI chr 3:171,832,558...171,871,042
Ensembl chr 3:171,832,500...171,868,647
JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A ISO (PMID:23355615) RGD PMID:23355615 NCBI chr 5:143,111,342...143,120,131
Ensembl chr 5:143,111,074...143,120,165
JBrowse link
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:155,359,909...155,371,104
Ensembl chr 4:155,359,921...155,369,671
JBrowse link
G Apobec3 apolipoprotein B mRNA editing enzyme catalytic subunit 3 ISO
IBA
(PMID:18779051), (PMID:21835787)
PMID:21873635
RGD PMID:18779051, PMID:21835787, PMID:21873635 RGD:13792537 NCBI chr 7:121,108,108...121,128,346
Ensembl chr 7:121,109,241...121,128,542
JBrowse link
G Hmga2 high mobility group AT-hook 2 ISO
ISS
(PMID:17005673)
GO_REF:0000024
RGD
UniProt
PMID:17005673 GO_REF:0000024 NCBI chr 7:65,159,944...65,275,408
Ensembl chr 7:65,159,944...65,275,408
JBrowse link
G Inpp5k inositol polyphosphate-5-phosphatase K ISO (PMID:18774950) RGD PMID:18774950 NCBI chr10:63,775,639...63,796,879
Ensembl chr10:63,776,378...63,795,899
JBrowse link
G Morc2 MORC family CW-type zinc finger 2 ISO (PMID:29211708)
(MGI:6271895|PMID:29728365)
RGD PMID:29211708, PMID:29728365 MGI:6271895 NCBI chr14:83,889,138...83,930,263
Ensembl chr14:83,889,089...83,930,522
JBrowse link
G Mphosph8 M-phase phosphoprotein 8 ISS
ISO
GO_REF:0000024
(PMID:29211708)
UniProt
RGD
PMID:29211708 GO_REF:0000024 NCBI chr15:36,918,843...36,946,712
Ensembl chr15:36,918,843...36,946,708
JBrowse link
G Resf1 retroelement silencing factor 1 ISO (MGI:6271895|PMID:29728365) RGD PMID:29728365 MGI:6271895 NCBI chr 4:183,879,177...183,905,807
Ensembl chr 4:183,896,303...183,905,297
JBrowse link
G Setdb1 SET domain bifurcated histone lysine methyltransferase 1 ISO (MGI:5440670|PMID:20164836), (MGI:6271895|PMID:29728365) RGD PMID:20164836, PMID:29728365 MGI:5440670, MGI:6271895 NCBI chr 2:196,495,867...196,527,412
Ensembl chr 2:196,495,867...196,527,127
JBrowse link
G Tasor transcription activation suppressor ISO (PMID:29211708) RGD PMID:29211708 NCBI chr16:3,050,506...3,108,168
Ensembl chr16:3,051,449...3,105,531
JBrowse link
G Trim28 tripartite motif-containing 28 ISO MGI:2143362 (MGI:3842857|PMID:19270682), (MGI:5440670|PMID:20164836) RGD PMID:19270682, PMID:20164836 MGI:3842857, MGI:5440670 NCBI chr 1:65,544,369...65,551,043
Ensembl chr 1:65,544,373...65,551,043
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    negative regulation of biological process 5689
      negative regulation of viral process 116
        negative regulation of viral genome replication 63
          negative regulation by host of viral genome replication 9
          negative regulation of single stranded viral RNA replication via double stranded DNA intermediate 10
Path 2
Term Annotations click to browse term
  biological_process 20020
    biological regulation 13769
      regulation of biological process 13071
        regulation of biological process involved in symbiotic interaction 226
          regulation of viral process 213
            regulation of viral life cycle 164
              regulation of viral genome replication 102
                negative regulation of viral genome replication 63
                  negative regulation by host of viral genome replication 9
                  negative regulation of single stranded viral RNA replication via double stranded DNA intermediate 10
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.