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ONTOLOGY REPORT - ANNOTATIONS


Term:intermediate filament polymerization
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Accession:GO:0045107 term browser browse the term
Definition:Assembly of intermediate filaments by the addition of component monomers to a filament. Polymerization of intermediate filament proteins results from interactions among several distinct binding sites on the constituent proteins. Nuclear lamin head-to-tail polymers arise from one such interaction. Deletion analysis localized the binding sites to the ends of the rod domain that are highly conserved among all intermediate filament proteins. Data indicate that one type of interaction in intermediate filament protein polymerization is the longitudinal binding of dimers via the conserved end segments of the coiled-coil rod domain.


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  biological_process 20028
    cellular process 18800
      intermediate filament-based process 58
        intermediate filament cytoskeleton organization 52
          intermediate filament polymerization or depolymerization 3
            intermediate filament polymerization 0
              negative regulation of intermediate filament polymerization 0
              positive regulation of intermediate filament polymerization 0
              regulation of intermediate filament polymerization + 0
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  biological_process 20028
    cellular process 18800
      cellular component organization or biogenesis 6789
        cellular component organization 6534
          organelle organization 4101
            cytoskeleton organization 1461
              intermediate filament cytoskeleton organization 52
                intermediate filament polymerization or depolymerization 3
                  intermediate filament polymerization 0
                    negative regulation of intermediate filament polymerization 0
                    positive regulation of intermediate filament polymerization 0
                    regulation of intermediate filament polymerization + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.