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ONTOLOGY REPORT - ANNOTATIONS


Term:isotype switching
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Accession:GO:0045190 term browser browse the term
Definition:The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.
Comment:Note that IgM and IgD can be coexpressed by B cells via an alternate splicing mechanism, but true recombinational isotype switching to IgD has been demonstrated as well. Note that this term is best used to annotate gene products which are involved in the mechanism of DNA recombination used in isotype switching, like the B cell specific Swap70 factor in the mouse, rather than gene products which promote isotype switching such as cytokines or co-stimulatory molecules, which should instead be annotated to 'regulation of isotype switching ; GO:0045191'.
Synonyms:exact_synonym: class switch recombination;   class switching;   isotype switch recombination
 xref: Wikipedia:Immunoglobulin_class_switching


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isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AICDA activation induced cytidine deaminase JBrowse link 12 8,903,288 8,913,895 RGD:9068941
G ATAD5 ATPase family AAA domain containing 5 JBrowse link 17 25,435,787 25,496,752 RGD:9068941
G BATF basic leucine zipper ATF-like transcription factor JBrowse link 14 74,919,115 74,943,652 RGD:9068941
G CD40LG CD40 ligand JBrowse link X 136,042,849 136,055,158 RGD:9068941
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 19 50,951,674 50,994,600 RGD:9068941
G EXO1 exonuclease 1 JBrowse link 1 222,389,684 222,431,556 RGD:9068941
G EXOSC3 exosome component 3 JBrowse link 9 38,552,659 38,558,075 RGD:9068941
G EXOSC6 exosome component 6 JBrowse link 7 152,645,545 152,657,307 RGD:9068941
G LIG4 DNA ligase 4 JBrowse link 13 108,474,718 108,485,421 RGD:9068941
G MLH1 mutL homolog 1 JBrowse link 3 37,189,439 37,245,801 RGD:9068941
G MSH2 mutS homolog 2 JBrowse link 2A 48,447,207 48,525,638 RGD:9068941
G MSH6 mutS homolog 6 JBrowse link 2A 48,824,469 48,849,779 RGD:9068941
G NBN nibrin JBrowse link 8 88,575,198 88,626,200 RGD:9068941
G RNF168 ring finger protein 168 JBrowse link 3 203,755,988 203,791,324 RGD:9068941
G RNF8 ring finger protein 8 JBrowse link 6 38,108,414 38,145,949 RGD:9068941
G SWAP70 switching B cell complex subunit SWAP70 JBrowse link 11 9,526,752 9,614,422 RGD:9068941
G UNG uracil DNA glycosylase JBrowse link 12 110,067,882 110,080,891 RGD:9068941
isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CCR6 C-C motif chemokine receptor 6 JBrowse link 6 170,069,689 170,084,779 RGD:9068941
isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HSPD1 heat shock protein family D (Hsp60) member 1 JBrowse link 2B 202,623,497 202,637,045 RGD:9068941
negative regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PARP3 poly(ADP-ribose) polymerase family member 3 JBrowse link 3 53,112,494 53,119,053 RGD:9068941
negative regulation of isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G THOC1 THO complex 1 JBrowse link 18 17,692,797 17,742,572 RGD:9068941
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BCL6 BCL6 transcription repressor JBrowse link 3 193,308,296 193,332,452 RGD:9068941
G FOXP3 forkhead box P3 JBrowse link X 49,402,652 49,417,029 RGD:9068941
G NDFIP1 Nedd4 family interacting protein 1 JBrowse link 5 143,596,345 143,622,913 RGD:9068941
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G TNFSF4 TNF superfamily member 4 JBrowse link 1 152,391,450 152,699,026 RGD:9068941
positive regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EXOSC3 exosome component 3 JBrowse link 9 38,552,659 38,558,075 RGD:9068941
G EXOSC6 exosome component 6 JBrowse link 7 152,645,545 152,657,307 RGD:9068941
G HMCES 5-hydroxymethylcytosine binding, ES cell specific JBrowse link 3 133,694,676 133,721,519 RGD:9068941
G KMT5B lysine methyltransferase 5B JBrowse link 11 66,546,398 66,581,553 RGD:9068941
G KMT5C lysine methyltransferase 5C JBrowse link 19 61,073,185 61,079,389 RGD:9068941
G MAD2L2 mitotic arrest deficient 2 like 2 JBrowse link 1 11,654,963 11,671,364 RGD:9068941
G PAXIP1 PAX interacting protein 1 JBrowse link 7 158,274,193 158,329,139 RGD:9068941
G RIF1 replication timing regulatory factor 1 JBrowse link 2B 155,985,960 156,109,726 RGD:9068941
G SHLD1 shieldin complex subunit 1 JBrowse link 20 5,537,989 5,642,107 RGD:9068941
G SHLD2 shieldin complex subunit 2 JBrowse link 14 87,923,049 87,928,101 RGD:9068941
G TFRC transferrin receptor JBrowse link 3 203,333,953 203,365,586 RGD:9068941
G TP53BP1 tumor protein p53 binding protein 1 JBrowse link 15 40,519,012 40,626,845 RGD:9068941
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MLH1 mutL homolog 1 JBrowse link 3 37,189,439 37,245,801 RGD:9068941
G MSH2 mutS homolog 2 JBrowse link 2A 48,447,207 48,525,638 RGD:9068941
G NSD2 nuclear receptor binding SET domain protein 2 JBrowse link 4 1,938,777 2,027,425 RGD:9068941
G TGFB1 transforming growth factor beta 1 JBrowse link 19 46,831,659 46,852,973 RGD:9068941
G TNFSF13 TNF superfamily member 13 JBrowse link 17 7,576,518 7,579,834 RGD:9068941
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CLCF1 cardiotrophin like cytokine factor 1 JBrowse link 11 66,034,536 66,042,114 RGD:9068941
G IL4 interleukin 4 JBrowse link 5 134,253,039 134,261,581 RGD:9068941
G STAT6 signal transducer and activator of transcription 6 JBrowse link 12 32,068,645 32,085,099 RGD:9068941
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ATAD5 ATPase family AAA domain containing 5 JBrowse link 17 25,435,787 25,496,752 RGD:9068941
G CD28 CD28 molecule JBrowse link 2B 209,076,388 209,111,213 RGD:9068941
G CD40 CD40 molecule JBrowse link 20 43,541,619 43,552,994 RGD:9068941
G IL2 interleukin 2 JBrowse link 4 125,782,563 125,787,819 RGD:9068941
G IL4 interleukin 4 JBrowse link 5 134,253,039 134,261,581 RGD:9068941
G MLH1 mutL homolog 1 JBrowse link 3 37,189,439 37,245,801 RGD:9068941
G MSH2 mutS homolog 2 JBrowse link 2A 48,447,207 48,525,638 RGD:9068941
G PAXIP1 PAX interacting protein 1 JBrowse link 7 158,274,193 158,329,139 RGD:9068941
G PTPRC protein tyrosine phosphatase receptor type C JBrowse link 1 178,555,803 178,674,089 RGD:9068941
G TBX21 T-box transcription factor 21 JBrowse link 17 9,973,343 9,988,131 RGD:9068941
regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G APLF aprataxin and PNKP like factor JBrowse link 2A 69,632,459 69,744,611 RGD:9068941
G IL10 interleukin 10 JBrowse link 1 186,648,289 186,653,155 RGD:9068941
G IL4 interleukin 4 JBrowse link 5 134,253,039 134,261,581 RGD:9068941
G SUPT6H SPT6 homolog, histone chaperone and transcription elongation factor JBrowse link 17 28,578,199 28,617,347 RGD:9068941
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FOXP3 forkhead box P3 JBrowse link X 49,402,652 49,417,029 RGD:9068941
G IL27RA interleukin 27 receptor subunit alpha JBrowse link 19 14,323,618 14,343,636 RGD:9068941
G NDFIP1 Nedd4 family interacting protein 1 JBrowse link 5 143,596,345 143,622,913 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15758
    immune system process 2763
      leukocyte activation 1166
        lymphocyte activation 645
          lymphocyte activation involved in immune response 172
            B cell activation involved in immune response 76
              isotype switching 50
                isotype switching to IgA isotypes + 7
                isotype switching to IgD isotypes + 0
                isotype switching to IgE isotypes + 7
                isotype switching to IgG isotypes + 14
                negative regulation of isotype switching + 5
                positive regulation of isotype switching + 27
                regulation of isotype switching + 36
Path 2
Term Annotations click to browse term
  biological_process 15758
    metabolic process 10722
      cellular metabolic process 9943
        heterocycle metabolic process 5367
          nucleobase-containing compound metabolic process 5212
            nucleic acid metabolic process 4710
              DNA metabolic process 906
                DNA recombination 288
                  somatic cell DNA recombination 67
                    somatic diversification of immune receptors via germline recombination within a single locus 67
                      somatic recombination of immunoglobulin gene segments 55
                        somatic recombination of immunoglobulin genes involved in immune response 50
                          isotype switching 50
                            isotype switching to IgA isotypes + 7
                            isotype switching to IgD isotypes + 0
                            isotype switching to IgE isotypes + 7
                            isotype switching to IgG isotypes + 14
                            negative regulation of isotype switching + 5
                            positive regulation of isotype switching + 27
                            regulation of isotype switching + 36
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.