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ONTOLOGY REPORT - ANNOTATIONS


Term:isotype switching
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Accession:GO:0045190 term browser browse the term
Definition:The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.
Comment:Note that IgM and IgD can be coexpressed by B cells via an alternate splicing mechanism, but true recombinational isotype switching to IgD has been demonstrated as well. Note that this term is best used to annotate gene products which are involved in the mechanism of DNA recombination used in isotype switching, like the B cell specific Swap70 factor in the mouse, rather than gene products which promote isotype switching such as cytokines or co-stimulatory molecules, which should instead be annotated to 'regulation of isotype switching ; GO:0045191'.
Synonyms:exact_synonym: class switch recombination;   class switching;   isotype switch recombination
 xref: Wikipedia:Immunoglobulin_class_switching


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isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atad5 ATPase family AAA domain containing 5 JBrowse link NW_004955481 6,986,128 7,031,113 RGD:9068941
G Batf basic leucine zipper ATF-like transcription factor JBrowse link NW_004955523 42,365 66,103 RGD:9068941
G Cd40lg CD40 ligand JBrowse link NW_004955489 8,465,571 8,477,714 RGD:9068941
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link NW_004955555 2,393,510 2,430,180 RGD:9068941
G Exo1 exonuclease 1 JBrowse link NW_004955406 10,248,981 10,276,207 RGD:9068941
G Exosc3 exosome component 3 JBrowse link NW_004955419 28,683,896 28,692,006 RGD:9068941
G Exosc6 exosome component 6 JBrowse link NW_004955484 3,088,133 3,089,551 RGD:9068941
G Lig4 DNA ligase 4 JBrowse link NW_004955404 3,606,077 3,615,193 RGD:9068941
G Mlh1 mutL homolog 1 JBrowse link NW_004955421 3,890,291 3,936,892 RGD:9068941
G Msh2 mutS homolog 2 JBrowse link NW_004955441 14,188,315 14,247,608 RGD:9068941
G Msh6 mutS homolog 6 JBrowse link NW_004955441 14,451,207 14,471,316 RGD:9068941
G Nbn nibrin JBrowse link NW_004955417 6,840,916 6,880,479 RGD:9068941
G Rnf168 ring finger protein 168 JBrowse link NW_004955420 12,656,815 12,676,836 RGD:9068941
G Rnf8 ring finger protein 8 JBrowse link NW_004955437 5,807,592 5,832,213 RGD:9068941
G Swap70 switching B cell complex subunit SWAP70 JBrowse link NW_004955414 25,385,648 25,444,743 RGD:9068941
G Ung uracil DNA glycosylase JBrowse link NW_004955455 10,266,989 10,282,196 RGD:9068941
isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccr6 C-C motif chemokine receptor 6 JBrowse link NW_004955439 14,921,524 14,949,493 RGD:9068941
isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hspd1 heat shock protein family D (Hsp60) member 1 JBrowse link NW_004955403 3,062,724 3,073,419 RGD:9068941
negative regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Parp3 poly(ADP-ribose) polymerase family member 3 JBrowse link NW_004955532 3,591,484 3,597,549 RGD:9068941
negative regulation of isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Thoc1 THO complex 1 JBrowse link NW_004955402 9,675,211 9,708,045 RGD:9068941
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl6 BCL6 transcription repressor JBrowse link NW_004955420 19,998,960 20,021,200 RGD:9068941
G Foxp3 forkhead box P3 JBrowse link NW_004955543 731,707 742,606 RGD:9068941
G Ndfip1 Nedd4 family interacting protein 1 JBrowse link NW_004955415 11,643,846 11,666,131 RGD:9068941
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tnfsf4 TNF superfamily member 4 JBrowse link NW_004955406 13,477,077 13,493,309 RGD:9068941
positive regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Exosc3 exosome component 3 JBrowse link NW_004955419 28,683,896 28,692,006 RGD:9068941
G Exosc6 exosome component 6 JBrowse link NW_004955484 3,088,133 3,089,551 RGD:9068941
G Hmces 5-hydroxymethylcytosine binding, ES cell specific JBrowse link NW_004955429 13,616,647 13,638,657 RGD:9068941
G Kmt5b lysine methyltransferase 5B JBrowse link NW_004955422 17,626,606 17,684,890 RGD:9068941
G Kmt5c lysine methyltransferase 5C JBrowse link NW_004955567 895,334 901,240 RGD:9068941
G Mad2l2 mitotic arrest deficient 2 like 2 JBrowse link NW_004955486 2,191,903 2,197,193 RGD:9068941
G Paxip1 PAX interacting protein 1 JBrowse link NW_004955491 8,177,422 8,219,764 RGD:9068941
G Rif1 replication timing regulatory factor 1 JBrowse link NW_004955440 16,977,710 17,047,809 RGD:9068941
G Shld1 shieldin complex subunit 1 JBrowse link NW_004955415 16,180,074 16,282,937 RGD:9068941
G Shld2 shieldin complex subunit 2 JBrowse link NW_004955510 6,021,477 6,114,745 RGD:9068941
G Tfrc transferrin receptor JBrowse link NW_004955420 12,348,392 12,372,714 RGD:9068941
G Tp53bp1 tumor protein p53 binding protein 1 JBrowse link NW_004955416 9,962,736 10,035,433 RGD:9068941
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mlh1 mutL homolog 1 JBrowse link NW_004955421 3,890,291 3,936,892 RGD:9068941
G Msh2 mutS homolog 2 JBrowse link NW_004955441 14,188,315 14,247,608 RGD:9068941
G Nsd2 nuclear receptor binding SET domain protein 2 JBrowse link NW_004955514 1,084,522 1,162,624 RGD:9068941
G Tgfb1 transforming growth factor beta 1 JBrowse link NW_004955555 274,405 288,441 RGD:9068941
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clcf1 cardiotrophin like cytokine factor 1 JBrowse link NW_004955422 18,097,779 18,108,628 RGD:9068941
G Il4 interleukin 4 JBrowse link NW_004955408 4,058,052 4,065,999 RGD:9068941
G Stat6 signal transducer and activator of transcription 6 JBrowse link NW_004955458 4,833,417 4,847,956 RGD:9068941
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atad5 ATPase family AAA domain containing 5 JBrowse link NW_004955481 6,986,128 7,031,113 RGD:9068941
G Cd28 CD28 molecule JBrowse link NW_004955457 11,159,769 11,253,099 RGD:9068941
G Cd40 CD40 molecule JBrowse link NW_004955445 11,191,817 11,202,156 RGD:9068941
G Il2 interleukin 2 JBrowse link NW_004955428 18,163,010 18,168,157 RGD:9068941
G Il4 interleukin 4 JBrowse link NW_004955408 4,058,052 4,065,999 RGD:9068941
G Mlh1 mutL homolog 1 JBrowse link NW_004955421 3,890,291 3,936,892 RGD:9068941
G Msh2 mutS homolog 2 JBrowse link NW_004955441 14,188,315 14,247,608 RGD:9068941
G Paxip1 PAX interacting protein 1 JBrowse link NW_004955491 8,177,422 8,219,764 RGD:9068941
G Ptprc protein tyrosine phosphatase receptor type C JBrowse link NW_004955406 35,005,577 35,127,395 RGD:9068941
G Tbx21 T-box transcription factor 21 JBrowse link NW_004955451 13,315,237 13,317,888 RGD:9068941
regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aplf aprataxin and PNKP like factor JBrowse link NW_004955424 16,338,546 16,449,074 RGD:9068941
G Il10 interleukin 10 JBrowse link NW_004955406 42,307,789 42,312,255 RGD:9068941
G Il4 interleukin 4 JBrowse link NW_004955408 4,058,052 4,065,999 RGD:9068941
G Supt6h SPT6 homolog, histone chaperone and transcription elongation factor JBrowse link NW_004955481 4,462,270 4,497,364 RGD:9068941
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp3 forkhead box P3 JBrowse link NW_004955543 731,707 742,606 RGD:9068941
G Il27ra interleukin 27 receptor subunit alpha JBrowse link NW_004955415 32,749,682 32,762,532 RGD:9068941
G Ndfip1 Nedd4 family interacting protein 1 JBrowse link NW_004955415 11,643,846 11,666,131 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14616
    immune system process 2526
      leukocyte activation 1097
        lymphocyte activation 621
          lymphocyte activation involved in immune response 161
            B cell activation involved in immune response 74
              isotype switching 48
                isotype switching to IgA isotypes + 6
                isotype switching to IgD isotypes + 0
                isotype switching to IgE isotypes + 7
                isotype switching to IgG isotypes + 14
                negative regulation of isotype switching + 5
                positive regulation of isotype switching + 26
                regulation of isotype switching + 35
Path 2
Term Annotations click to browse term
  biological_process 14616
    metabolic process 10124
      cellular metabolic process 9423
        heterocycle metabolic process 5057
          nucleobase-containing compound metabolic process 4909
            nucleic acid metabolic process 4426
              DNA metabolic process 884
                DNA recombination 280
                  somatic cell DNA recombination 65
                    somatic diversification of immune receptors via germline recombination within a single locus 65
                      somatic recombination of immunoglobulin gene segments 53
                        somatic recombination of immunoglobulin genes involved in immune response 48
                          isotype switching 48
                            isotype switching to IgA isotypes + 6
                            isotype switching to IgD isotypes + 0
                            isotype switching to IgE isotypes + 7
                            isotype switching to IgG isotypes + 14
                            negative regulation of isotype switching + 5
                            positive regulation of isotype switching + 26
                            regulation of isotype switching + 35
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.