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ONTOLOGY REPORT - ANNOTATIONS


Term:isotype switching
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Accession:GO:0045190 term browser browse the term
Definition:The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.
Comment:Note that IgM and IgD can be coexpressed by B cells via an alternate splicing mechanism, but true recombinational isotype switching to IgD has been demonstrated as well. Note that this term is best used to annotate gene products which are involved in the mechanism of DNA recombination used in isotype switching, like the B cell specific Swap70 factor in the mouse, rather than gene products which promote isotype switching such as cytokines or co-stimulatory molecules, which should instead be annotated to 'regulation of isotype switching ; GO:0045191'.
Synonyms:exact_synonym: class switch recombination;   class switching;   isotype switch recombination
 xref: Wikipedia:Immunoglobulin_class_switching


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isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AICDA activation induced cytidine deaminase JBrowse link 12 8,602,170 8,612,970 RGD:2290271
G ATAD5 ATPase family AAA domain containing 5 JBrowse link 17 30,830,830 30,895,869 RGD:2290271
G BATF basic leucine zipper ATF-like transcription factor JBrowse link 14 75,522,469 75,546,992 RGD:2290271
G CD40LG CD40 ligand JBrowse link X 136,648,158 136,660,390 RGD:2290271
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 19 45,407,334 45,451,547 RGD:2290271
G EXO1 exonuclease 1 JBrowse link 1 241,847,967 241,889,939 RGD:2290271
G EXOSC3 exosome component 3 JBrowse link 9 37,779,714 37,785,092 RGD:2290271
G EXOSC6 exosome component 6 JBrowse link 16 70,246,778 70,251,940 RGD:2290271
G LIG4 DNA ligase 4 JBrowse link 13 108,207,442 108,218,349 RGD:2290271
G MLH1 mutL homolog 1 JBrowse link 3 36,993,350 37,050,846 RGD:2290271
G MSH2 mutS homolog 2 JBrowse link 2 47,403,067 47,634,501 RGD:2290271
G MSH6 mutS homolog 6 JBrowse link 2 47,783,082 47,806,954 RGD:2290271
G NBN nibrin JBrowse link 8 89,933,331 89,984,724 RGD:2290271
G RNF168 ring finger protein 168 JBrowse link 3 196,468,783 196,503,768 RGD:2290271
G RNF8 ring finger protein 8 JBrowse link 6 37,353,983 37,394,734 RGD:2290271
G SWAP70 switching B cell complex subunit SWAP70 JBrowse link 11 9,664,077 9,752,993 RGD:2290271
G UNG uracil DNA glycosylase JBrowse link 12 109,097,597 109,110,992 RGD:2290271
isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CCR6 C-C motif chemokine receptor 6 JBrowse link 6 167,111,807 167,139,141 RGD:2290271
isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HSPD1 heat shock protein family D (Hsp60) member 1 JBrowse link 2 197,486,584 197,500,274 RGD:2290271
negative regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PARP3 poly(ADP-ribose) polymerase family member 3 JBrowse link 3 51,942,290 51,948,867 RGD:2290271
negative regulation of isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G THOC1 THO complex 1 JBrowse link 18 214,348 268,047 RGD:2290271
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BCL6 BCL6 transcription repressor JBrowse link 3 187,721,377 187,745,472 RGD:2290271
G FOXP3 forkhead box P3 JBrowse link X 49,250,436 49,264,932 RGD:2290271
G NDFIP1 Nedd4 family interacting protein 1 JBrowse link 5 142,108,779 142,154,440 RGD:2290271
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G TNFSF4 TNF superfamily member 4 JBrowse link 1 173,183,729 173,462,208 RGD:2290271
positive regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EXOSC3 exosome component 3 JBrowse link 9 37,779,714 37,785,092 RGD:2290271
G EXOSC6 exosome component 6 JBrowse link 16 70,246,778 70,251,940 RGD:2290271
G HMCES 5-hydroxymethylcytosine binding, ES cell specific JBrowse link 3 129,278,832 129,306,186 RGD:2290271
G KMT5B lysine methyltransferase 5B JBrowse link 11 68,154,863 68,213,899 RGD:2290271
G KMT5C lysine methyltransferase 5C JBrowse link 19 55,339,876 55,348,121 RGD:2290271
G MAD2L2 mitotic arrest deficient 2 like 2 JBrowse link 1 11,674,480 11,691,621 RGD:2290271
G PAXIP1 PAX interacting protein 1 JBrowse link 7 154,943,690 155,003,419 RGD:2290271
G RIF1 replication timing regulatory factor 1 JBrowse link 2 151,409,902 151,534,200 RGD:2290271
G SHLD1 shieldin complex subunit 1 JBrowse link 20 5,750,286 5,864,407 RGD:2290271
G SHLD2 shieldin complex subunit 2 JBrowse link 10 87,094,478 87,191,468 RGD:2290271
G SHLD3 shieldin complex subunit 3 JBrowse link 5 65,625,027 65,630,928 RGD:2290271
G TFRC transferrin receptor JBrowse link 3 196,018,694 196,082,123 RGD:2290271
G TP53BP1 tumor protein p53 binding protein 1 JBrowse link 15 43,403,061 43,510,640 RGD:2290271
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MLH1 mutL homolog 1 JBrowse link 3 36,993,350 37,050,846 RGD:2290271
G MSH2 mutS homolog 2 JBrowse link 2 47,403,067 47,634,501 RGD:2290271
G NSD2 nuclear receptor binding SET domain protein 2 JBrowse link 4 1,871,393 1,982,207 RGD:2290271
G TGFB1 transforming growth factor beta 1 JBrowse link 19 41,330,323 41,353,922 RGD:2290271
G TNFSF12-TNFSF13 TNFSF12-TNFSF13 readthrough JBrowse link 17 7,549,058 7,561,601 RGD:2290271
G TNFSF13 TNF superfamily member 13 JBrowse link 17 7,558,292 7,561,608 RGD:2290271
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CLCF1 cardiotrophin like cytokine factor 1 JBrowse link 11 67,364,168 67,374,177 RGD:2290271
G IL4 interleukin 4 JBrowse link 5 132,673,986 132,682,678 RGD:2290271
G STAT6 signal transducer and activator of transcription 6 JBrowse link 12 57,095,408 57,111,413 RGD:2290271
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ATAD5 ATPase family AAA domain containing 5 JBrowse link 17 30,830,830 30,895,869 RGD:2290271
G CD28 CD28 molecule JBrowse link 2 203,706,475 203,739,756 RGD:2290271
G CD40 CD40 molecule JBrowse link 20 46,118,242 46,129,858 RGD:2290271
G IL2 interleukin 2 JBrowse link 4 122,449,479 122,456,725 RGD:2290271
G IL4 interleukin 4 JBrowse link 5 132,673,986 132,682,678 RGD:2290271
G MLH1 mutL homolog 1 JBrowse link 3 36,993,350 37,050,846 RGD:2290271
G MSH2 mutS homolog 2 JBrowse link 2 47,403,067 47,634,501 RGD:2290271
G PAXIP1 PAX interacting protein 1 JBrowse link 7 154,943,690 155,003,419 RGD:2290271
G PTPRC protein tyrosine phosphatase receptor type C JBrowse link 1 198,638,968 198,757,476 RGD:2290271
G TBX21 T-box transcription factor 21 JBrowse link 17 47,733,236 47,746,122 RGD:2290271
regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G APLF aprataxin and PNKP like factor JBrowse link 2 68,467,585 68,580,162 RGD:2290271
G IL10 interleukin 10 JBrowse link 1 206,767,602 206,772,494 RGD:2290271
G IL4 interleukin 4 JBrowse link 5 132,673,986 132,682,678 RGD:2290271
G SUPT6H SPT6 homolog, histone chaperone and transcription elongation factor JBrowse link 17 28,662,183 28,702,679 RGD:2290271
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FOXP3 forkhead box P3 JBrowse link X 49,250,436 49,264,932 RGD:2290271
G IL27RA interleukin 27 receptor subunit alpha JBrowse link 19 14,031,762 14,053,218 RGD:2290271
G NDFIP1 Nedd4 family interacting protein 1 JBrowse link 5 142,108,779 142,154,440 RGD:2290271

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18105
    immune system process 3316
      leukocyte activation 1330
        lymphocyte activation 776
          lymphocyte activation involved in immune response 186
            B cell activation involved in immune response 78
              isotype switching 52
                isotype switching to IgA isotypes + 8
                isotype switching to IgD isotypes + 0
                isotype switching to IgE isotypes + 7
                isotype switching to IgG isotypes + 14
                negative regulation of isotype switching + 5
                positive regulation of isotype switching + 29
                regulation of isotype switching + 38
Path 2
Term Annotations click to browse term
  biological_process 18105
    metabolic process 11848
      cellular metabolic process 10975
        heterocycle metabolic process 5963
          nucleobase-containing compound metabolic process 5784
            nucleic acid metabolic process 5252
              DNA metabolic process 971
                DNA recombination 303
                  somatic cell DNA recombination 69
                    somatic diversification of immune receptors via germline recombination within a single locus 69
                      somatic recombination of immunoglobulin gene segments 57
                        somatic recombination of immunoglobulin genes involved in immune response 52
                          isotype switching 52
                            isotype switching to IgA isotypes + 8
                            isotype switching to IgD isotypes + 0
                            isotype switching to IgE isotypes + 7
                            isotype switching to IgG isotypes + 14
                            negative regulation of isotype switching + 5
                            positive regulation of isotype switching + 29
                            regulation of isotype switching + 38
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.